Registered substances

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The new ECHA CHEM database has been released by ECHA. At first this system will contain only substances and data from REACH registration dossiers. For new and updated REACH registration data please check ECHA CHEM. See for more information on the transition to ECHA CHEM. More

Please be aware that REACH registration data here on the current Dissemination Platform is no longer maintained; it remains frozen as of 19th May 2023.

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Registered Substances Factsheets

Substances which have been registered and can be placed on the EEA market by those companies with a valid registration

Showing 7,601 - 7,650 of 26,865 results.

Name	EC / List no.	CAS no.	Registration Status	Registration type	Submission type	Total tonnage band	Last Updated	Details
N-(3',4'-dichloro-5-fluorobiphenyl-2-yl)acetamide	620-313-1	877179-03-8	Active	Intermediate	Joint	Intermediate use only	03-09-2019	View substance registered dossier
N-(2-{[C16-18 (even numbered) alkanoyl]amino}ethyl)-N-(2-hydroxyethyl)[C16-18 (even numbered) alkylamide]	701-349-8	-	Active	Full	Joint	≥ 10 to < 100 tonnes	30-08-2022	View substance registered dossier
N-(2-thienylmethyl)-1H-pyrazol-5-amine	815-539-4	1374750-27-2	Active	Intermediate	Joint	Intermediate use only	07-02-2019	View substance registered dossier
N-(2-phenoxyphenyl)methanesulphonamide	257-399-1	51765-51-6	Active	Full	Joint	≥ 1 to < 10 tonnes	19-01-2018	View substance registered dossier
N-(2-phenoxyphenyl)methanesulphonamide	257-399-1	51765-51-6	Cease Manufacture	Intermediate	Joint	Cease manufacture	22-01-2018	View substance registered dossier
N-(2-oxo-2-(1-(phenylsulfonyl)-1H-pyrrol-3-yl)ethyl)-N-tosylformamide	813-874-0	1627136-88-2	Cease Manufacture	Intermediate	Individual	Cease manufacture	24-03-2017	View substance registered dossier
N-(2-nitrophenyl)phosphoric triamide	477-690-9	874819-71-3	Active	Full	Joint	≥ 100 to < 1 000 tonnes	28-11-2022	View substance registered dossier
N-(2-methylsulfinyl-1,1-dimethyl-ethyl)-N'-{2-methyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl}phthalamide	609-338-9	371771-07-2	Active	Intermediate	Joint	Intermediate use only	07-11-2013	View substance registered dossier
N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)-1,3-thiazol-2-amine	700-564-4	1048007-94-8	Active	Intermediate	Individual	Intermediate use only	08-03-2011	View substance registered dossier
N-(2-Methyl-4,5,6,7-tetrahydro-benzothiazol-6-yl)-acetamide hydrobromide	600-588-4	104617-50-7	Active	Intermediate	Joint	Intermediate use only	13-10-2022	View substance registered dossier
N-(2-Methoxy-5-octadecanoylaminophenyl)-2-(3-benzyl-2,5-dioxoimidazolidin-1-yl)-4,4-dimethyl-3-oxopentanoic acidamide	431-330-7	142776-95-2	Active	NONS	Individual	Tonnage data confidential	10-11-2008	View substance registered dossier
N-(2-methoxy-5-methylphenyl)acetamide	230-157-2	6962-44-3	Active	Intermediate	Joint	Intermediate use only	15-02-2016	View substance registered dossier
N-(2-hydroxypropyl)oleamide	203-828-2	111-05-7	Cease Manufacture	Full	Joint	Cease manufacture	26-03-2018	View substance registered dossier
N-(2-hydroxypropyl)benzenesulphonamide	252-512-0	35325-02-1	Active	Full	Joint	≥ 10 to < 100 tonnes	06-10-2017	View substance registered dossier
N-(2-hydroxyphenyl)-2-[(4-hydroxyphenyl)thio]acetamide	464-370-9	443965-81-9	Active	NONS	Joint	Tonnage data confidential	10-11-2008	View substance registered dossier
N-(2-hydroxyethyl)undec-10-enamide	243-870-9	20545-92-0	Active	Intermediate	Joint	Intermediate use only	12-05-2017	View substance registered dossier
N-(2-hydroxyethyl)stearamide	203-883-2	111-57-9	Active	Full	Joint	≥ 100 to < 1 000 tonnes	17-11-2021	View substance registered dossier
N-(2-hydroxyethyl)stearamide	203-883-2	111-57-9	Active	Full	Joint	≥ 100 to < 1 000 tonnes	07-03-2023	View substance registered dossier
N-(2-hydroxyethyl)prop-2-enamide	700-169-7	-	Active	Full	Joint	≥ 1 to < 10 tonnes	15-12-2021	View substance registered dossier
N-(2-hydroxyethyl)phthalimide	223-434-4	3891-07-4	Active	Full	Joint	≥ 0 to < 10 tonnes	24-05-2018	View substance registered dossier
N-(2-hydroxyethyl)phthalimide	223-434-4	3891-07-4	Active	Intermediate	Joint	Intermediate use only	30-05-2018	View substance registered dossier
N-(2-hydroxyethyl)oleamide	203-884-8	111-58-0	Active	Intermediate	Joint	Intermediate use only	11-05-2018	View substance registered dossier
N-(2-hydroxyethyl)nicotinamide	811-328-6	6265-73-2	Active	Intermediate	Joint	Intermediate use only	18-07-2018	View substance registered dossier
N-(2-hydroxyethyl)ethylenediaminetriacetic acid	205-759-3	150-39-0	Active	Full	Joint	≥ 100 to < 1 000 tonnes	05-10-2022	View substance registered dossier
N-(2-hydroxyethyl)dodecanamide	205-560-1	142-78-9	Active	Full	Joint	≥ 10 to < 100 tonnes	23-04-2019	View substance registered dossier
N-(2-hydroxyethyl)dodecanamide	205-560-1	142-78-9	Active	Intermediate	Joint	Intermediate use only	27-12-2017	View substance registered dossier
N-(2-hydroxyethyl)-N-[2-[(1-oxooctyl)amino]ethyl]-β-alanine	264-761-2	64265-45-8	Active	Full	Joint	≥ 10 to < 100 tonnes	20-11-2020	View substance registered dossier
N-(2-hydroxyethyl)-N,N-dimethyl alkyl-C12-14-(even numbered)-1-aminium chloride	931-275-3	1125503-33-4	Active	Full	Joint	≥ 1 000 to < 10 000 tonnes	12-04-2017	View substance registered dossier
N-(2-hydroxyethyl)-N'-{1-methyl-1-[3-(1-methylethenyl)phenyl]ethyl}urea	700-173-9	1072896-13-9	Active	Intermediate	Individual	Intermediate use only	24-06-2010	View substance registered dossier
N-(2-hydroxyethyl)-3,5,5-trimethylhexanamide	800-884-5	1154308-86-7	Active	Full	Individual	≥ 10 to < 100 tonnes	29-04-2022	View substance registered dossier
N-(2-ethylhexyl)naphthalen-2-amine	260-126-9	56358-17-9	Cease Manufacture	Intermediate	Joint	Cease manufacture	13-05-2016	View substance registered dossier
N-(2-ethylhexyl)-8,9,10-trinorborn-5-ene-2,3-dicarboximide	204-029-1	113-48-4	Active	Full	Joint	≥ 1 to < 10 tonnes	24-05-2019	View substance registered dossier
N-(2-ethylhexyl)-3,5,5-trimethylhexanamide	810-288-7	1700656-13-8	Active	Full	Joint	≥ 100 to < 1 000 tonnes	29-04-2021	View substance registered dossier
N-(2-ethylhexyl)-1-[[3-methyl-4-[(3-methylphenyl)azo]phenyl]azo]naphthalen-2-amine	260-125-3	56358-10-2	Active	Full	Joint	≥ 1 to < 10 tonnes	23-07-2018	View substance registered dossier
N-(2-ethylhexyl)-1-[[2-methyl-4-[(2-methylphenyl)azo]phenyl]azo]naphthalen-2-amine	260-124-8	56358-09-9	Active	Full	Joint	≥ 100 to < 1 000 tonnes	30-09-2020	View substance registered dossier
N-(2-ethoxyphenyl)-N'-(4-isododecylphenyl)oxamide	279-979-3	82493-14-9	Active	Full	Joint	≥ 10 to < 100 tonnes	13-12-2017	View substance registered dossier
N-(2-ethoxyphenyl)-N'-(2-ethylphenyl)oxamide	245-950-9	23949-66-8	Active	Full	Joint	≥ 10 tonnes	19-12-2019	View substance registered dossier
N-(2-ethoxy-2-oxoethyl)-N,N-dimethylhexadecan-1-aminium chloride	605-404-6	16535-55-0	Active	Full	Joint	≥ 0 to < 10 tonnes	30-07-2019	View substance registered dossier
N-(2-chloropyrimidin-4-yl)-2,3-dimethyl-2H-indazol-6-amine	810-051-8	444731-74-2	Active	Intermediate	Joint	Intermediate use only	25-11-2021	View substance registered dossier
N-(2-chloroethyl)pyrrolidine hydrochloride	230-660-7	7250-67-1	Cease Manufacture	Full	Joint	Cease manufacture	02-02-2019	View substance registered dossier
N-(2-chloroethyl)pyrrolidine hydrochloride	230-660-7	7250-67-1	No longer Valid	Intermediate	Joint	No longer valid	07-03-2019	View substance registered dossier
N-(2-chloroethyl)-N-ethylaniline	245-082-0	22564-43-8	Active	Intermediate	Joint	Intermediate use only	30-11-2018	View substance registered dossier
N-(2-chloroethyl)-4-[(2,6-dichloro-4-nitrophenyl)azo]-N-ethyl-m-toluidine	264-439-1	63741-10-6	Active	Full	Joint	≥ 10 to < 100 tonnes	01-12-2021	View substance registered dossier
N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide	801-607-0	302962-49-8	Active	Intermediate	Joint	Intermediate use only	23-10-2017	View substance registered dossier
N-(2-chloro-4-pyrimidinyl)-N,2,3-trimethyl-2H-indazole-6-amine	810-050-2	444731-75-3	Active	Intermediate	Joint	Intermediate use only	26-11-2021	View substance registered dossier
N-(2-chloro-3-phenyliminoprop-1-ene-1-yl)aniline monohydrochloride 2-CHLORMALONDIANIL-HYDROCHLORID	434-520-8	55526-63-1	Active	NONS	Individual	Tonnage data confidential	10-11-2008	View substance registered dossier
N-(2-carboxyethyl)-N-octyl-β-alanine	258-081-5	52663-87-3	Active	Full	Joint	≥ 10 to < 100 tonnes	07-02-2023	View substance registered dossier
N-(2-BROMO-5-HYDROXY-4-METHOXYBENZYL)-N-[2-(4-HYDROXYPHENYL)ETHYL]FORMAMIDE	602-791-3	122584-18-3	Active	Intermediate	Individual	Intermediate use only	16-07-2012	View substance registered dossier
N-(2-BROMO-5-HYDROXY-4-METHOXYBENZYL)-N-[2-(4-HYDROXYPHENYL)ETHYL]FORMAMIDE	602-791-3	122584-18-3	Cease Manufacture	Full	Joint	Cease manufacture	23-04-2018	View substance registered dossier
N-(2-bromo-4-fluorophenyl)acetamide	600-141-3	1009-22-9	Active	Intermediate	Joint	Intermediate use only	05-11-2018	View substance registered dossier

Showing 7,601 - 7,650 of 26,865 results.

Registrant/Supplier	Address	Country	Registration Status	Name	EC / List no.	CAS no.	Last update year	Details
Bayer AG	Kaiser-Wilhelm-Allee 1 51373 Leverkusen Germany	Germany	Active	N-(3',4'-dichloro-5-fluorobiphenyl-2-yl)acetamide	620-313-1	877179-03-8	2017; 2019	View substance registered dossier
OMNOVA Solutions SAS (OR of OMNOVA Solutions Inc)	14 avenue des Tropiques ZA de Courtaboeuf 2, Villejust 91955 Courtaboeuf Cedex France	France	Active	N-(2-{[C16-18 (even numbered) alkanoyl]amino}ethyl)-N-(2-hydroxyethyl)[C16-18 (even numbered) alkylamide]	701-349-8	-	2020	View substance registered dossier
Nalco Limited	P.O. Box 11, Winnington Avenue, CW8 4DX Northwich, Cheshire United Kingdom	United Kingdom	No longer Valid	N-(2-{[C16-18 (even numbered) alkanoyl]amino}ethyl)-N-(2-hydroxyethyl)[C16-18 (even numbered) alkylamide]	701-349-8	-	2021	View substance registered dossier
Nalco Europe B.V.	Oude Rhijnhofweg 17 2342 BB Oegstgeest Netherlands	Netherlands	Active	N-(2-{[C16-18 (even numbered) alkanoyl]amino}ethyl)-N-(2-hydroxyethyl)[C16-18 (even numbered) alkylamide]	701-349-8	-	2019; 2020; 2022	View substance registered dossier
[Confidential]	-	-	-	N-(2-thienylmethyl)-1H-pyrazol-5-amine	815-539-4	1374750-27-2	-	View substance registered dossier
FIRMENICH GRASSE SAS OR 1	Parc Industriel Les Bois de Grasse 06130 Grasse France	France	Active	N-(2-thienylmethyl)-1H-pyrazol-5-amine	815-539-4	1374750-27-2	-	View substance registered dossier
Flamma S.p.a.	via Bedeschi, 22 24040 Chignolo d'Isola Bergamo Italy	Italy	Active	N-(2-phenoxyphenyl)methanesulphonamide	257-399-1	51765-51-6	-	View substance registered dossier
Global Product Compliance (Europe) AB	IDEON, Beta 5, Scheelevägen 17 22363 Lund Sweden	Sweden	Active	N-(2-phenoxyphenyl)methanesulphonamide	257-399-1	51765-51-6	2017	View substance registered dossier
ERREGIERRE SPA	Via Francesco Baracca, 19 24060 SAN PAOLO D'ARGON BERGAMO Italy	Italy	Active	N-(2-phenoxyphenyl)methanesulphonamide	257-399-1	51765-51-6	-	View substance registered dossier
OLON Spa	Strada Rivoltana Km 6/7 20053 RODANO Milano Italy	Italy	Cease Manufacture	N-(2-phenoxyphenyl)methanesulphonamide	257-399-1	51765-51-6	2022	View substance registered dossier
N.V. Ajinomoto OmniChem S.A.	Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium	Belgium	Cease Manufacture	N-(2-oxo-2-(1-(phenylsulfonyl)-1H-pyrrol-3-yl)ethyl)-N-tosylformamide	813-874-0	1627136-88-2	2019	View substance registered dossier
ORGANICA Feinchemie GmbH Wolfen	Ortsteil Wolfen Kunstseidestraße 5 06766 Bitterfeld-Wolfen Germany	Germany	Active	N-(2-nitrophenyl)phosphoric triamide	477-690-9	874819-71-3	2012	View substance registered dossier
SKW Stickstoffwerke Piesteritz GmbH	Möllensdorfer Straße 13 06886 Lutherstadt Wittenberg Germany	Germany	Active	N-(2-nitrophenyl)phosphoric triamide	477-690-9	874819-71-3	2011; 2015; 2018; 2020; 2022	View substance registered dossier
Alzchem Trostberg GmbH	Dr.-Albert-Frank-Straße 32 83308 Trostberg Bayern Germany	Germany	Active	N-(2-nitrophenyl)phosphoric triamide	477-690-9	874819-71-3	-	View substance registered dossier
Novasol S.A.	Mechelsesteenweg 455 1950 Kraainem Belgium	Belgium	Active	N-(2-nitrophenyl)phosphoric triamide	477-690-9	874819-71-3	2022	View substance registered dossier
AGC Chemicals Europe, Ltd	World Trade Centre Zuidplein 80 1077XV Amsterdam Netherlands	Netherlands	Active	N-(2-methylsulfinyl-1,1-dimethyl-ethyl)-N'-{2-methyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl}phthalamide	609-338-9	371771-07-2	-	View substance registered dossier
Bayer AG	Kaiser-Wilhelm-Allee 1 51373 Leverkusen Germany	Germany	Active	N-(2-methylsulfinyl-1,1-dimethyl-ethyl)-N'-{2-methyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl}phthalamide	609-338-9	371771-07-2	2010; 2013	View substance registered dossier
Excella GmbH & Co. KG	Nuernberger Str. 12 90537 Feucht Germany	Germany	Active	N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)-1,3-thiazol-2-amine	700-564-4	1048007-94-8	2011	View substance registered dossier
Boehringer Ingelheim Pharma GmbH & Co. KG	Binger Strasse 173 55216 Ingelheim am Rhein Germany	Germany	Active	N-(2-Methyl-4,5,6,7-tetrahydro-benzothiazol-6-yl)-acetamide hydrobromide	600-588-4	104617-50-7	2019; 2022	View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant German competent national authority.	-	-	Active	N-(2-Methoxy-5-octadecanoylaminophenyl)-2-(3-benzyl-2,5-dioxoimidazolidin-1-yl)-4,4-dimethyl-3-oxopentanoic acidamide	431-330-7	142776-95-2	-	View substance registered dossier
Heubach Colorants Germany GmbH	Brüningstrasse 50 65929 Frankfurt am Main Germany	Germany	Active	N-(2-methoxy-5-methylphenyl)acetamide	230-157-2	6962-44-3	-	View substance registered dossier
AllessaProduktion GmbH	Alt-Fechenheim 34 60386 Frankfurt am Main Germany	Germany	Active	N-(2-methoxy-5-methylphenyl)acetamide	230-157-2	6962-44-3	2016	View substance registered dossier
seppic sa	50 boulevard National CS 90020 92257 La Garenne Colombes ile de france France	France	Cease Manufacture	N-(2-hydroxypropyl)oleamide	203-828-2	111-05-7	2021	View substance registered dossier
Proviron Functional Chemicals nv	Oudenburgsesteenweg 100 8400 Oostende Belgium	Belgium	Active	N-(2-hydroxypropyl)benzenesulphonamide	252-512-0	35325-02-1	-	View substance registered dossier
Nisso Chemical Europe GmbH	Berliner Allee 42 40212 Düsseldorf Germany	Germany	Cease Manufacture	N-(2-hydroxyphenyl)-2-[(4-hydroxyphenyl)thio]acetamide	464-370-9	443965-81-9	2021	View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant German competent national authority.	-	-	Active	N-(2-hydroxyphenyl)-2-[(4-hydroxyphenyl)thio]acetamide	464-370-9	443965-81-9	-	View substance registered dossier
Evonik Operations GmbH	Rellinghauser Straße 1-11 45128 Essen Germany	Germany	Active	N-(2-hydroxyethyl)undec-10-enamide	243-870-9	20545-92-0	-	View substance registered dossier
Verdant Specialty Solutions GmbH	Fritz-Henkel-Straße, 8 39307 Genthin Germany	Germany	Active	N-(2-hydroxyethyl)stearamide	203-883-2	111-57-9	2021	View substance registered dossier
SO.G.I.S. Industria Chimica S.p.A.	Via Giuseppina, 132 26048 Sospiro (CR) Italy	Italy	Active	N-(2-hydroxyethyl)stearamide	203-883-2	111-57-9	2016; 2017; 2020; 2021	View substance registered dossier
Evonik Operations GmbH	Rellinghauser Straße 1-11 45128 Essen Germany	Germany	Active	N-(2-hydroxyethyl)stearamide	203-883-2	111-57-9	2015; 2019	View substance registered dossier
Only representative (No publishable name)	-	-	Active	N-(2-hydroxyethyl)stearamide	203-883-2	111-57-9	-	View substance registered dossier
Schill & Seilacher "Struktol" GmbH	Moorfleeter Straße 28 22113 Hamburg Germany	Germany	Active	N-(2-hydroxyethyl)stearamide	203-883-2	111-57-9	2019	View substance registered dossier
Schill + Seilacher GmbH	Schoenaicher Str. 205 71032 Boeblingen Germany	Germany	Active	N-(2-hydroxyethyl)stearamide	203-883-2	111-57-9	-	View substance registered dossier
WTH Walter Thieme Handel GmbH	Beguinenstrasse 13 21682 Stade Niedersachsen Germany	Germany	Active	N-(2-hydroxyethyl)stearamide	203-883-2	111-57-9	2021	View substance registered dossier
Labcorp Development SA 034	Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 – 5 Planta 28050 Madrid Spain	Spain	Active	N-(2-hydroxyethyl)stearamide	203-883-2	111-57-9	2021; 2023	View substance registered dossier
DOG Deutsche Oelfabrik Gesellschaft für chemische Erzeugnisse mbH & Co. KG	Ellerholzdamm 50 20457 Hamburg Germany	Germany	Active	N-(2-hydroxyethyl)stearamide	203-883-2	111-57-9	2017; 2021	View substance registered dossier
DyStar Colours Distribution GmbH	Am Prime-Parc 12 65479 Raunheim Germany	Germany	Active	N-(2-hydroxyethyl)stearamide	203-883-2	111-57-9	2021	View substance registered dossier
CRCP GmbH	Am Römerhof 51 60486 Frankfurt am Main Germany	Germany	Active	N-(2-hydroxyethyl)stearamide	203-883-2	111-57-9	2021	View substance registered dossier
IMCD Benelux OR4	Wilheminaplein 32 3072 DE Rotterdam Netherlands	Netherlands	Active	N-(2-hydroxyethyl)stearamide	203-883-2	111-57-9	2021; 2022	View substance registered dossier
Schill+Seilacher "Struktol" GmbH Hamburg	Moorfleeter Straße 28 22113 Hamburg Germany	Germany	Active	N-(2-hydroxyethyl)stearamide	203-883-2	111-57-9	2017; 2019; 2021	View substance registered dossier
Arcerion GmbH	Gabrielenstr. 15 80636 München Germany	Germany	Active	N-(2-hydroxyethyl)stearamide	203-883-2	111-57-9	2018; 2021	View substance registered dossier
RSI ChemRep Europe Ltd (K004)	27-30 Merchants Quay Merchants House 8 Dublin Ireland	Ireland	Active	N-(2-hydroxyethyl)prop-2-enamide	700-169-7	-	2009; 2010; 2014; 2021	View substance registered dossier
UMCO GmbH	Georg-Wilhelm-Straße 187 21107 Hamburg Germany	Germany	Active	N-(2-hydroxyethyl)phthalimide	223-434-4	3891-07-4	-	View substance registered dossier
Katwijk Chemie BV	Snijderstraat 6 Steenbakkerstraat 26 2222 BA Katwijk ZH Netherlands	Netherlands	Active	N-(2-hydroxyethyl)phthalimide	223-434-4	3891-07-4	-	View substance registered dossier
Zschimmer & Schwarz GmbH & Co KG	Max-Schwarz-Str. 3-5 56112 Lahnstein Germany	Germany	Active	N-(2-hydroxyethyl)oleamide	203-884-8	111-58-0	-	View substance registered dossier
INDUSTRIA CHIMICA PANZERI SRL	via cavour n. 18 24050 orio al serio Italy	Italy	Active	N-(2-hydroxyethyl)oleamide	203-884-8	111-58-0	-	View substance registered dossier
PROCOS SpA	via Matteotti 249 28062 Cameri Piemonte Italy	Italy	Active	N-(2-hydroxyethyl)nicotinamide	811-328-6	6265-73-2	2018	View substance registered dossier
Nouryon Functional Chemicals B.V.	Haaksbergweg 88 1101 BZ Amsterdam The Netherlands Netherlands	Netherlands	Active	N-(2-hydroxyethyl)ethylenediaminetriacetic acid	205-759-3	150-39-0	2019	View substance registered dossier
[Confidential]	-	-	-	N-(2-hydroxyethyl)ethylenediaminetriacetic acid	205-759-3	150-39-0	-	View substance registered dossier
Henkel Nederland B.V.	Brugwal 11 3432 NZ Nieuwegein Netherlands	Netherlands	Cease Manufacture	N-(2-hydroxyethyl)dodecanamide	205-560-1	142-78-9	2018	View substance registered dossier
Beautyge, S.L.	C/ Tirso de Molina, 40 08490 Cornella de Llobregat Spain	Spain	Active	N-(2-hydroxyethyl)dodecanamide	205-560-1	142-78-9	2019	View substance registered dossier
Ecolab Production Belgium B.V.B.A.	Havenlaan 4 3980 Tessenderlo Belgium	Belgium	Active	N-(2-hydroxyethyl)dodecanamide	205-560-1	142-78-9	-	View substance registered dossier
Henkel Global Supply Chain B.V.	Gustav Mahlerlaan 2970 1081 LA Amsterdam Netherlands	Netherlands	Cease Manufacture	N-(2-hydroxyethyl)dodecanamide	205-560-1	142-78-9	2023	View substance registered dossier
Evonik Operations GmbH	Rellinghauser Straße 1-11 45128 Essen Germany	Germany	Active	N-(2-hydroxyethyl)dodecanamide	205-560-1	142-78-9	-	View substance registered dossier
Granollers Química, S.L.U.	Av. Sant Julià 156-166 08403 Granollers Spain	Spain	No longer Valid	N-(2-hydroxyethyl)-N-[2-[(1-oxooctyl)amino]ethyl]-β-alanine	264-761-2	64265-45-8	2020	View substance registered dossier
Evonik Operations GmbH	Rellinghauser Straße 1-11 45128 Essen Germany	Germany	Active	N-(2-hydroxyethyl)-N-[2-[(1-oxooctyl)amino]ethyl]-β-alanine	264-761-2	64265-45-8	2020	View substance registered dossier
Clariant Produkte (Deutschland) GmbH	August-Laubenheimer-Straße 1 Global Product Stewardship 65929 Frankfurt am Main Germany	Germany	Active	N-(2-hydroxyethyl)-N,N-dimethyl alkyl-C12-14-(even numbered)-1-aminium chloride	931-275-3	1125503-33-4	2010; 2013; 2014; 2015; 2017	View substance registered dossier
Clariant Ibérica Producción S.A.	Avda. Baix Llobregat, 3-5 08970 Sant Joan Despí Barcelona Spain	Spain	Active	N-(2-hydroxyethyl)-N,N-dimethyl alkyl-C12-14-(even numbered)-1-aminium chloride	931-275-3	1125503-33-4	2014	View substance registered dossier
BASF Coatings GmbH	Glasuritstrasse 1 Postfach 6123 48136 Münster Nordrhein-Westfalen Germany	Germany	Active	N-(2-hydroxyethyl)-N'-{1-methyl-1-[3-(1-methylethenyl)phenyl]ethyl}urea	700-173-9	1072896-13-9	-	View substance registered dossier
Allnex Austria GmbH	Bundesstraße 175 8402 Werndorf Austria	Austria	Active	N-(2-hydroxyethyl)-3,5,5-trimethylhexanamide	800-884-5	1154308-86-7	2019; 2022	View substance registered dossier
BASF SE	Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany	Germany	Cease Manufacture	N-(2-ethylhexyl)naphthalen-2-amine	260-126-9	56358-17-9	2016	View substance registered dossier
CSI-OR02DUB	Block C Ardilaun Court 112-114 St. Stephen’s Green D02 TD28 Dublin Ireland	Ireland	Active	N-(2-ethylhexyl)-8,9,10-trinorborn-5-ene-2,3-dicarboximide	204-029-1	113-48-4	2019	View substance registered dossier
TEXTILCOLOR GmbH (OR)	Schlossgartenstrasse 2 72793 Pfullingen Baden-Wuerttemberg Germany	Germany	Active	N-(2-ethylhexyl)-3,5,5-trimethylhexanamide	810-288-7	1700656-13-8	-	View substance registered dossier
Pulcra Chemicals GmbH	Isardamm 79-83 82538 Geretsried Germany	Germany	Active	N-(2-ethylhexyl)-3,5,5-trimethylhexanamide	810-288-7	1700656-13-8	2018	View substance registered dossier
Clariant Ibérica Producción S.A.	Avda. Baix Llobregat, 3-5 08970 Sant Joan Despí Barcelona Spain	Spain	Active	N-(2-ethylhexyl)-3,5,5-trimethylhexanamide	810-288-7	1700656-13-8	2017; 2019; 2021	View substance registered dossier
DyStar Colours Distribution GmbH	Am Prime-Parc 12 65479 Raunheim Germany	Germany	Active	N-(2-ethylhexyl)-3,5,5-trimethylhexanamide	810-288-7	1700656-13-8	2021	View substance registered dossier
CS Regulatory IRL Ltd 2M-6	Alexandra House The Sweepstakes D04 C7H2 Dublin Ballsbridge Ireland	Ireland	Active	N-(2-ethylhexyl)-1-[[3-methyl-4-[(3-methylphenyl)azo]phenyl]azo]naphthalen-2-amine	260-125-3	56358-10-2	2018	View substance registered dossier
CS Regulatory IRL Ltd 1L-18	Alexandra House The Sweepstakes D04 C7H2 Dublin Ballsbridge Ireland	Ireland	Active	N-(2-ethylhexyl)-1-[[2-methyl-4-[(2-methylphenyl)azo]phenyl]azo]naphthalen-2-amine	260-124-8	56358-09-9	-	View substance registered dossier
Steiner	9, route de Rouen 27950 Saint Marcel France	France	Active	N-(2-ethylhexyl)-1-[[2-methyl-4-[(2-methylphenyl)azo]phenyl]azo]naphthalen-2-amine	260-124-8	56358-09-9	-	View substance registered dossier
CHROMATOURGIA TRIPOLEOS SA	SCHIMATARI 32009 SCHIMATARI VIOTIAS Greece	Greece	Active	N-(2-ethylhexyl)-1-[[2-methyl-4-[(2-methylphenyl)azo]phenyl]azo]naphthalen-2-amine	260-124-8	56358-09-9	-	View substance registered dossier
CS Regulatory IRL Ltd 2M-6	Alexandra House The Sweepstakes D04 C7H2 Dublin Ballsbridge Ireland	Ireland	Active	N-(2-ethylhexyl)-1-[[2-methyl-4-[(2-methylphenyl)azo]phenyl]azo]naphthalen-2-amine	260-124-8	56358-09-9	2013; 2015; 2016; 2017; 2018; 2019	View substance registered dossier
Global Product Compliance (Europe) AB	IDEON, Beta 5, Scheelevägen 17 22363 Lund Sweden	Sweden	Active	N-(2-ethylhexyl)-1-[[2-methyl-4-[(2-methylphenyl)azo]phenyl]azo]naphthalen-2-amine	260-124-8	56358-09-9	-	View substance registered dossier
NDT Europa BV	Damsluisweg 77 1332 EB Almere Netherlands	Netherlands	Active	N-(2-ethylhexyl)-1-[[2-methyl-4-[(2-methylphenyl)azo]phenyl]azo]naphthalen-2-amine	260-124-8	56358-09-9	2018	View substance registered dossier
Gladeveer GmbH	Huchzermeierstr. 8a D-33611 BIELEFELD Ostwestfalen-Lippe Germany	Germany	Active	N-(2-ethylhexyl)-1-[[2-methyl-4-[(2-methylphenyl)azo]phenyl]azo]naphthalen-2-amine	260-124-8	56358-09-9	-	View substance registered dossier
Clariant SE - CH77	Brueningstrasse 50 65929 Frankfurt am Main Germany	Germany	Active	N-(2-ethoxyphenyl)-N'-(4-isododecylphenyl)oxamide	279-979-3	82493-14-9	-	View substance registered dossier
Clariant Plastics & Coatings (Deutschland) GmbH	August-Laubenheimer-Straße 1 Global Product Stewardship 65929 Frankfurt am Main Germany	Germany	Active	N-(2-ethoxyphenyl)-N'-(4-isododecylphenyl)oxamide	279-979-3	82493-14-9	-	View substance registered dossier
Clariant Plastics & Coatings (Deutschland) GmbH	August-Laubenheimer-Straße 1 Global Product Stewardship 65929 Frankfurt am Main Germany	Germany	Active	N-(2-ethoxyphenyl)-N'-(2-ethylphenyl)oxamide	245-950-9	23949-66-8	-	View substance registered dossier
Clariant SE - CH77	Brueningstrasse 50 65929 Frankfurt am Main Germany	Germany	Active	N-(2-ethoxyphenyl)-N'-(2-ethylphenyl)oxamide	245-950-9	23949-66-8	-	View substance registered dossier
SABO SPA	Via Caravaggi 24040 Levate Bergamo Italy	Italy	Active	N-(2-ethoxyphenyl)-N'-(2-ethylphenyl)oxamide	245-950-9	23949-66-8	2019	View substance registered dossier
REACH24H CONSULTING GROUP	Paramount Court, Corrig Road, Sandyford, Dublin 18, Ireland Dublin 18 Dublin Ireland	Ireland	Active	N-(2-ethoxyphenyl)-N'-(2-ethylphenyl)oxamide	245-950-9	23949-66-8	-	View substance registered dossier
Agfa-Gevaert N.V.	Septestraat 27 2640 Mortsel Belgium	Belgium	Active	N-(2-ethoxy-2-oxoethyl)-N,N-dimethylhexadecan-1-aminium chloride	605-404-6	16535-55-0	-	View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a.	Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy	Italy	Active	N-(2-chloropyrimidin-4-yl)-2,3-dimethyl-2H-indazol-6-amine	810-051-8	444731-74-2	-	View substance registered dossier
Thermofisher Scientific Cork Ltd.	Currabinny P43 AY66 Carrigaline Co. Cork Ireland	Ireland	Active	N-(2-chloropyrimidin-4-yl)-2,3-dimethyl-2H-indazol-6-amine	810-051-8	444731-74-2	2018; 2021	View substance registered dossier
Global Product Compliance (Europe) AB	IDEON, Beta 5, Scheelevägen 17 22363 Lund Sweden	Sweden	Cease Manufacture	N-(2-chloroethyl)pyrrolidine hydrochloride	230-660-7	7250-67-1	2023	View substance registered dossier
Syntor Fine Chemicals Ltd	Unit 11 Boleyn Court Manor Park WA7 1SR Runcorn Cheshire United Kingdom	United Kingdom	No longer Valid	N-(2-chloroethyl)pyrrolidine hydrochloride	230-660-7	7250-67-1	2021	View substance registered dossier
Lanxess Deutschland GmbH	Kennedyplatz 1 50569 Köln Germany	Germany	Active	N-(2-chloroethyl)-N-ethylaniline	245-082-0	22564-43-8	2018	View substance registered dossier
Saltigo GmbH	HSEQ-RA Kaiser-Wilhelm-Allee 40 51373 Leverkusen Germany	Germany	Active	N-(2-chloroethyl)-N-ethylaniline	245-082-0	22564-43-8	-	View substance registered dossier
JK GROUP SPA	SP 32 Novedratese, 33 22060 Novedrate (Co) Italy	Italy	Active	N-(2-chloroethyl)-4-[(2,6-dichloro-4-nitrophenyl)azo]-N-ethyl-m-toluidine	264-439-1	63741-10-6	2021	View substance registered dossier
Yorkshire Farben GmbH	Mevissenstrasse 72 D-47803 Krefeld Germany	Germany	Active	N-(2-chloroethyl)-4-[(2,6-dichloro-4-nitrophenyl)azo]-N-ethyl-m-toluidine	264-439-1	63741-10-6	-	View substance registered dossier
CHEMICAL INSPECTION & REGULATION SERVICE LIMITED	Regus Harcourt Centre HW77 D02 Dublin Ireland	Ireland	Active	N-(2-chloroethyl)-4-[(2,6-dichloro-4-nitrophenyl)azo]-N-ethyl-m-toluidine	264-439-1	63741-10-6	-	View substance registered dossier
EFI Cretaprint S.L.U	Pol. Ind. SUPOI-8 C/Dels Ibers, 54 12550 Almazora Castellon Spain	Spain	Active	N-(2-chloroethyl)-4-[(2,6-dichloro-4-nitrophenyl)azo]-N-ethyl-m-toluidine	264-439-1	63741-10-6	2018; 2021	View substance registered dossier
LAMBROCHIMICA S.R.L.	VIA GIUSEPPE ROVANI 7 20123 MILANO Italy	Italy	Active	N-(2-chloroethyl)-4-[(2,6-dichloro-4-nitrophenyl)azo]-N-ethyl-m-toluidine	264-439-1	63741-10-6	-	View substance registered dossier
CHEMICAL INSPECTION & REGULATION SERVICE LIMITED	Regus Harcourt Centre D02 HW77 Dublin Ireland	Ireland	Active	N-(2-chloroethyl)-4-[(2,6-dichloro-4-nitrophenyl)azo]-N-ethyl-m-toluidine	264-439-1	63741-10-6	-	View substance registered dossier
REACH24H CONSULTING GROUP	Suite 1E, Paramount Court, Corrig Road, Sandyford Dublin18 Dublin Ireland	Ireland	Active	N-(2-chloroethyl)-4-[(2,6-dichloro-4-nitrophenyl)azo]-N-ethyl-m-toluidine	264-439-1	63741-10-6	-	View substance registered dossier
SK BIOTEK IRELAND LIMITED	Watery Lane Swords K67 AY91 Swords Co. Dublin Ireland	Ireland	Active	N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide	801-607-0	302962-49-8	-	View substance registered dossier
Swords Laboratories Unlimited Company	Cruiserath Road Mulhuddart D15H6EF Dublin 15 Co Dublin Ireland	Ireland	Active	N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide	801-607-0	302962-49-8	-	View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a.	Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy	Italy	Active	N-(2-chloro-4-pyrimidinyl)-N,2,3-trimethyl-2H-indazole-6-amine	810-050-2	444731-75-3	-	View substance registered dossier
Thermofisher Scientific Cork Ltd.	Currabinny P43 AY66 Carrigaline Co. Cork Ireland	Ireland	Active	N-(2-chloro-4-pyrimidinyl)-N,2,3-trimethyl-2H-indazole-6-amine	810-050-2	444731-75-3	2018; 2021	View substance registered dossier
-	-	-	-	N-(2-chloro-3-phenyliminoprop-1-ene-1-yl)aniline monohydrochloride	434-520-8	55526-63-1	-	View substance registered dossier
Only representative (No publishable name)	-	-	Active	N-(2-carboxyethyl)-N-octyl-β-alanine	258-081-5	52663-87-3	2018; 2023	View substance registered dossier
N.V. Ajinomoto OmniChem S.A.	Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium	Belgium	Active	N-(2-BROMO-5-HYDROXY-4-METHOXYBENZYL)-N-[2-(4-HYDROXYPHENYL)ETHYL]FORMAMIDE	602-791-3	122584-18-3	-	View substance registered dossier
Janssen Pharmaceutica N.V.	Turnhoutseweg 30 2340 Beerse Belgium	Belgium	Cease Manufacture	N-(2-BROMO-5-HYDROXY-4-METHOXYBENZYL)-N-[2-(4-HYDROXYPHENYL)ETHYL]FORMAMIDE	602-791-3	122584-18-3	2022	View substance registered dossier
Bayer AG	Kaiser-Wilhelm-Allee 1 51373 Leverkusen Germany	Germany	Cease Manufacture	N-(2-bromo-4-fluorophenyl)acetamide	600-141-3	1009-22-9	2023	View substance registered dossier
CHEMICAL INSPECTION & REGULATION SERVICE LIMITED	Regus Harcourt Centre D02 HW77 Dublin Ireland	Ireland	Active	N-(2-bromo-4-fluorophenyl)acetamide	600-141-3	1009-22-9	2013; 2016; 2017	View substance registered dossier

Showing 7,601 - 7,650 of 26,865 results.

In this table, you will find all public data submitted to ECHA in REACH registration dossiers by substance manufacturers, importers, or their representatives, as laid out by the REACH Regulation (see Understanding REACH regulation).

ECHA makes available this information as REACH registered substance factsheets, which contain the full set of non-confidential information from related registration dossiers for a substance. Depending on the number of registrations that have been made for a substance, one factsheet can thus represent data from anything between hundreds of registration dossiers in a joint submission, to data from just one registration dossier.

As noted in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission. Please also note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).

In the portal results table are presented:

Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
Registration status – indicating the calculated registration status for the whole factsheet: Active – is being manufactured or imported to the EEA by one or more registrants; Cease Manufacture - is no longer being manufactured or imported above 1 tone per calendar year. All registrants of the substance have reported a cease of manufacture or import; or No longer valid - no longer considered registered under REACH and not currently allowed to be manufactured or imported to the EEA, until the substance is registered again.
Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
Link to the full factsheet.

Chemical Property Data Search

A subset of the key chemical properties (physico-chemical, environmental fate, ecotoxicological and toxicological data) of registered substances can be searched and accessed via the OECD eChemPortal.

RELATED INFORMATION

Welcome to the REACH Registered Substance Factsheets

Here you will find details from REACH registrations submitted to ECHA. Registrations under REACH can be submitted either jointly – where a group of legal entities pool their data – or individually. The set of details from each published joint or individual submission is presented as a row in the results table. For each row there is also an ‘eye’ icon leading to the detailed factsheet which contains the entire public dataset, following the IUCLID format.

Note that there can be more than one joint or individual submission for the same substance, thus there can be cases where one substance is covered by many REACH registered substance factsheets.

Note too, that as mentioned in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission.

Finally, please note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).

All substances table

The “All substances” table gives an overview of all the REACH registered substance factsheets on file at ECHA. Since this covers all data ever submitted since the entry into force of the REACH Regulation, there are some substances which are no longer considered registered under REACH in the EU / EEA. These can be for example substances that were registered only in the UK; since Brexit they are no longer registered in the EU / EEA.

The following columns are presented in the “All substances” table:

Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
Registration status – indicating the calculated registration status for the whole factsheet: Active – is being manufactured or imported to the EEA by one or more registrants; Cease Manufacture - is no longer being manufactured or imported above 1 tone per calendar year. All registrants of the substance have reported a cease of manufacture or import; or No longer valid - no longer considered registered under REACH and not currently allowed to be manufactured or imported to the EEA, until the substance is registered again.
Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
‘Eye’ icon linking to the full factsheet.

Searching

The search for REACH registered substance factsheets is divided into logically separated blocks of related search filters. Note that the search works so that if you provide filters in different blocks, then the results returned must match the filters in block 1 AND those in block 2 etc. Searches are conducted on all the public data included in all published REACH registrations.

Substance identity

In this block you can search by substance identifiers, under filters for Name, EC / List number, and CAS number. Full or partial identifiers can be used. And under the Name filter you can search by any substance name of any kind from any source. Other numerical identifiers such as Harmonised C&L Index number, or PIC CN code can also optionally be used.

Administrative data

In this block you can search by administrative information relating to REACH registered substance factsheets:

Registration type – picklist of Full, Intermediate, NONS
Registration status – picklist of Active, Cease Manufacture, No longer valid
Submission type – Individual or Joint
Country in which registered – picklist of current and former EU / EEA member states from which REACH registrations were received
First published date – the date when a REACH registration factsheet was first published
Last update date – the last date when any registrant / supplier submission contributing to a given REACH registration factsheet was submitted
Last update year – the year in which any registrant / supplier last made an update submission included in a given REACH registration factsheet
Registrant / supplier name – where available and not claimed confidential
Registration number – where available and not claimed confidential
Registrant address – where available and not claimed confidential

Substance data

In this block you can search by substance related data from REACH registered substance factsheets:

Tonnage band – picklist of Tonnage range, Tonnage Confidential, Intermediate use only
Selected total tonnage band range – available only if Tonnage range is selected, and allows to filter REACH registered substance factsheets within any selected min and max value
Substance has nanoform – picklist of Yes, No
PBT assessment outcome – picklist of all possible PBT assessment outcomes
CSA performed – picklist of Yes, No

Use and exposure

In this block you can search by elements relating to how use and exposure are encoded in REACH registrations.

Under the Life cycle option you can select one or more life cycle stages. The search results returned will include only factsheets containing uses reported under the selected life cycle stages.

Under the Category option there are modal popups for each of the use descriptor categories – Product, Sector of use, Process, Environmental release, and Article categories. In each of these are multi select picklists for all the related descriptor codes. The search results returned will include only factsheets containing uses which include the selected descriptor codes.

Note that the Life cycle and Category options work together, so that if a life cycle stage and Category options are both selected the search results will include factsheets containing specific uses in the selected life cycle stage, and where the use includes the selected descriptor codes.

With the search operator option you can select to refine how the search works. AND refines results and returns only those factsheets where ALL the search filter criteria are met. OR broadens the results and returns factsheets where ANY of the selected search filter criteria are met.

The factsheets

There is always a detailed factsheet per joint or individual submission, and it is generated based primarily on the IUCLID format.

The factsheet header begins with the identity of the substance in question, to which the factsheet is linked. The substance identity should always be aligned with that shown in the related substance Infocard. Note that since the Infocard refreshes daily, whereas the factsheet sometimes refreshes on a slower pace, sometimes the data may be out of alignment. In such cases it will always realign as quickly as possible.

The substance identification is enriched with the data provided in the relevant IUCLID section of the primary submitted dossier – either the joint submission lead, or the single individual submission.

In this section are also provided the type of substance, all other identifiers such as trade names, common names, other names etc, as well as all distinct submitted compositions for the substance.

Next is a page covering administrative type information from the data submitted, including:

Registration details, on the total tonnage band informed to ECHA, the registration type, first published and last updated dates, and whether a chemical safety assessment has been performed.

Registrant / supplier details, giving the identity and status of registrants / suppliers, except where the identity has been claimed confidential.

Registration numbers, giving again the identity and status of registration numbers, except where claimed confidential.

Contact persons responsible for the SDS, giving the non-confidential SDS contacts provided to ECHA.

The remainder of the factsheet faithfully follows the IUCLID structure, covering the C&L and PBT, Manufacture, use, and exposure, Physical and chemical properties, Environmental fate and pathways, Ecotoxicological information, Toxicological information, Analytical methods (if available), Guidance on safe use, Assessment reports, and Reference substances.