Registered substances

Registered substances

Registered substances

In this table, you will find all public data submitted to ECHA in REACH registration dossiers by substance manufacturers, importers, or their representatives, as laid out by the REACH Regulation (see Understanding REACH regulation).

ECHA makes available this information as REACH registered substance factsheets, which contain the full set of non-confidential information from related registration dossiers for a substance. Depending on the number of registrations that have been made for a substance, one factsheet can thus represent data from anything between hundreds of registration dossiers in a joint submission, to data from just one registration dossier.

As noted in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission. Please also note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).

In the portal results table are presented:

  • Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
  • Registration status – indicating the calculated registration status: Active - being actively manufactured or imported to the EEA; Cease manufacture - is no longer being manufactured or imported, but still considered to have a valid registration under REACH, and capable of resuming manufacture or import at any time; or No longer valid - no longer considered registered under REACH and not currently permitted to be manufactured or imported to the EEA unless and until properly registered again.
  • Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
  • Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
  • Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
  • Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
  • Link to the full factsheet.

A subset of the key chemical properties (physico-chemical, environmental fate, ecotoxicological and toxicological data) of registered substances can be searched and accessed via the OECD eChemPortal.

Please note:
  • The ‘Substance has nanoform’ search filter returns all factsheets containing any data related to nanomaterials. NB: This does not mean that a registration covering nanoforms has been submitted in line with the revised annexes of REACH. Since 1 January 2020, before manufacturing or importing a nanoform of a substance, the operators concerned must submit the required nano-specific information to ECHA in a new or updated registration dossier.
  • Please be aware that the annual IUCLID format change is coming soon. We will be adapting the Dissemination platform to the new format, which means that as of 15th October 2021 until early 2022 there will be a break in publication of newly submitted registration dossiers. We appreciate your understanding in this matter.
Last updated 13 October 2021. Database contains 23445 unique substances and contains information from 104986 dossiers.
Substance identity
Administrative data
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First published date:
Last update date:
Substance data
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Uses and exposure
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  • Consumer Uses
  • Article service life
  • Widespread uses by professional workers
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  • Uses at industrial sites
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Details
4-aminobenzoic acid
205-753-0 150-13-0 Active Intermediate Individual Intermediate use only 19-08-2013 View substance registered dossier
4-aminophenol
204-616-2 123-30-8 Active Intermediate Individual Intermediate use only 30-04-2014 View substance registered dossier
4-aminophenol
204-616-2 123-30-8 Active Intermediate Individual Intermediate use only 16-05-2013 View substance registered dossier
4-benzyl-1-(2-hydroxymethylphenyl)-2-phenylpiperazine-fumarate
700-842-5 1192015-20-5 Active Intermediate Individual Intermediate use only 21-05-2012 View substance registered dossier
4-benzyl-2,6-dihydroxy-4-aza-heptylene bis(2,2-dimethyloctanoate)
418-100-1 172964-15-7 Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
4-benzyloxy-4'-(2,3-epoxy-2-methylprop-1-yloxy)diphenylsulfone
408-220-2 141420-50-0 Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
4-bromo-1-(1-ethoxyethyl)-1H-pyrazole
692-014-4 1024120-52-2 Active Intermediate Individual Intermediate use only 29-11-2018 View substance registered dossier
4-bromo-2-fluoro-1-trifluoromethoxybenzene
430-850-1 105529-58-6 Cease Manufacture NONS Individual Cease manufacture 10-11-2008 View substance registered dossier
4-bromoanisole
203-252-1 104-92-7 Active Intermediate Individual Intermediate use only 30-01-2015 View substance registered dossier
4-Bromobenzo[b]thiophene
814-115-6 5118-13-8 Active Intermediate Individual Intermediate use only 24-05-2018 View substance registered dossier
4-butylbenzene-1,3-diol
606-191-2 18979-61-8 Active Full Individual ≥ 1 to < 10 tonnes 27-08-2010 View substance registered dossier
4-chloro-2,5-dimethoxyaniline
228-782-0 6358-64-1 Active Intermediate Individual Intermediate use only 08-03-2012 View substance registered dossier
4-chloro-2-nitroaniline 201-925-4 89-63-4 Active Intermediate Individual Intermediate use only 14-05-2013 View substance registered dossier
4-chloro-3,5-dinitro-α,α,α-trifluorotoluene
206-889-3 393-75-9 Active Intermediate Individual Intermediate use only 26-04-2011 View substance registered dossier
4-chloro-3,5-dinitro-α,α,α-trifluorotoluene
206-889-3 393-75-9 Cease Manufacture Intermediate Individual Cease manufacture 24-05-2013 View substance registered dossier
4-chloro-3-methoxy-2-methylpyridine 1-oxide
602-491-2 122307-41-9 Active Intermediate Individual Intermediate use only 30-10-2014 View substance registered dossier
4-chloro-3-nitrobenzonitrile
213-364-2 939-80-0 Active Intermediate Individual Intermediate use only 12-07-2018 View substance registered dossier
4-chloro-6-(2-chlorophenoxy)-5-fluoropyrimidine
606-738-5 213265-81-7 Active Intermediate Individual Intermediate use only 18-03-2013 View substance registered dossier
4-chloro-6-methoxypyrimidine
435-030-7 - Active Intermediate Individual Intermediate use only 10-12-2020 View substance registered dossier
4-chloro-N-methylpyridine-2-carboxamide hydrochloride (1:1)
692-719-7 882167-77-3 Active Intermediate Individual Intermediate use only 07-06-2019 View substance registered dossier
4-chloro-α,α,α-trifluoro-3-nitrotoluene
204-451-6 121-17-5 Active Intermediate Individual Intermediate use only 30-10-2012 View substance registered dossier
4-chloro-α,α,α-trifluorotoluene
202-681-1 98-56-6 Cease Manufacture Intermediate Individual Cease manufacture 24-05-2013 View substance registered dossier
4-chloroaniline
203-401-0 106-47-8 Active Intermediate Individual Intermediate use only 12-10-2010 View substance registered dossier
4-chloroaniline
203-401-0 106-47-8 Active Intermediate Individual Intermediate use only 25-09-2012 View substance registered dossier
4-chloroaniline
203-401-0 106-47-8 No longer Valid Intermediate Individual No longer valid 21-02-2014 View substance registered dossier
4-chlorobenzaldehyde
203-247-4 104-88-1 Active Intermediate Individual Intermediate use only 30-11-2012 View substance registered dossier
4-chlorobenzhydryl alcohol
204-333-4 119-56-2 Active Intermediate Individual Intermediate use only 14-07-2011 View substance registered dossier
4-Chlorobutyl 3-chloropropanoate
617-343-2 82530-64-1 Active Intermediate Individual Intermediate use only 16-11-2012 View substance registered dossier
4-chlorobutyl veratrate
410-950-1 69788-75-6 Active Intermediate Individual Intermediate use only 17-02-2010 View substance registered dossier
4-chlorophenol
203-402-6 106-48-9 Active Intermediate Individual Intermediate use only 17-07-2015 View substance registered dossier
4-chlorophenyl cyclopropyl ketone O-(4-aminobenzyl)oxime
405-260-2 94050-51-8 Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
4-chlorophenyl isocyanate
203-176-9 104-12-1 Active Intermediate Individual Intermediate use only 17-10-2012 View substance registered dossier
4-CPH
428-130-7 - Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
4-cyanobenzoyl chloride
228-005-5 6068-72-0 Active Intermediate Individual Intermediate use only 30-05-2018 View substance registered dossier
4-dichloroacetyl-1-oxa-4-azaspiro[4.5]decane
401-130-4 71526-07-3 Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
4-dimethylaminobenzenediazonium 3-carboxy-4-hydroxybenzenesulfonate
404-980-4 124737-31-1 Cease Manufacture NONS Individual Cease manufacture 10-11-2008 View substance registered dossier
4-ethenylphenyl acetate
434-600-2 2628-16-2 Active NONS Individual Tonnage data confidential 15-12-2008 View substance registered dossier
4-Ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl) benzenesulfonic acid
610-141-5 437717-43-6 Active Full Individual ≥ 0 to < 10 tonnes 16-12-2013 View substance registered dossier
4-ethyl-2-fluoro-4'-(2-(trans-4-pentylcyclohexyl)ethyl)biphenyl
433-390-1 95379-18-3 Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
4-ethyl-2-fluoro-4'-(2-(trans-4-propylcyclohexyl)ethyl)biphenyl
433-190-2 - Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
4-ethyl-2-methyl-2-isopentyl-1,3-oxazolidine
410-470-2 137796-06-6 Active NONS Individual Tonnage data confidential 23-10-2012 View substance registered dossier
4-Fluoro-3-hydroxybenzoic acid
434-190-5 - No longer Valid NONS Individual No longer valid 10-11-2008 View substance registered dossier
4-fluoro-3-nitrobenzonitrile
640-317-7 1009-35-4 Active Intermediate Individual Intermediate use only 20-08-2020 View substance registered dossier
4-fluorobenzonitrile
214-784-9 1194-02-1 Active Intermediate Individual Intermediate use only 19-06-2020 View substance registered dossier
4-hexenal , 6-(2,2,3-trimethyl-3-cyclopenten-1-yl)-
484-020-9 1016902-02-5 Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
4-hexylresorcinol
205-257-4 136-77-6 Active Full Individual ≥ 1 to < 10 tonnes 21-02-2017 View substance registered dossier
4-Hydroxy-3,5-dimethylbenzonitrile
452-810-2 - Cease Manufacture NONS Individual Cease manufacture 14-09-2010 View substance registered dossier
4-hydroxy-7-(2-aminoethyl)-1,3-benzothiazol-2(3H)-one hydrochloride
432-470-1 189012-93-9 Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
4-hydroxybenzohydrazide
226-326-5 5351-23-5 Active Intermediate Individual Intermediate use only 08-03-2018 View substance registered dossier
4-hydroxybutane-1-sulfonic acid
928-903-3 - Active Intermediate Individual Intermediate use only 29-04-2015 View substance registered dossier
Registrant/Supplier Address Country Registration Status Name EC / List no. CAS no. Last update year Details
[Confidential] - - - 4-aminobenzoic acid 205-753-0 150-13-0 - View substance registered dossier
[Confidential] - - - 4-aminophenol 204-616-2 123-30-8 - View substance registered dossier
CHEMI S.p.A. Via dei lavoratori, 54 20092 Cinisello balsamo Lombardia Italy Italy Active 4-aminophenol 204-616-2 123-30-8 - View substance registered dossier
VALDEPHARM Parc Industriel d'Incarville CS10606 27106 Val de Reuil France France Active 4-benzyl-1-(2-hydroxymethylphenyl)-2-phenylpiperazine-fumarate 700-842-5 1192015-20-5 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Belgian competent national authority. - - Active 4-benzyl-2,6-dihydroxy-4-aza-heptylene bis(2,2-dimethyloctanoate) 418-100-1 172964-15-7 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active 4-benzyloxy-4'-(2,3-epoxy-2-methylprop-1-yloxy)diphenylsulfone 408-220-2 141420-50-0 - View substance registered dossier
Curia France SAS ZI de Laville 47240 BON-ENCONTRE France France Active 4-bromo-1-(1-ethoxyethyl)-1H-pyrazole 692-014-4 1024120-52-2 - View substance registered dossier
Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany Germany Cease Manufacture 4-bromo-2-fluoro-1-trifluoromethoxybenzene 430-850-1 105529-58-6 2019 View substance registered dossier
REACh ChemConsult GmbH Strehlener Str. 14 01069 Dresden Germany Germany Active 4-bromoanisole 203-252-1 104-92-7 - View substance registered dossier
QUIMICA SINTETICA, S.A. C/ Dulcinea, s/n 28805 Alcalá de Henares Madrid Spain Spain Active 4-Bromobenzo[b]thiophene 814-115-6 5118-13-8 - View substance registered dossier
Clariant Produkte (Deutschland) GmbH Am Unisys-Park 1 65843 Sulzbach am Taunus Germany Germany Active 4-butylbenzene-1,3-diol 606-191-2 18979-61-8 - View substance registered dossier
Only representative (No publishable name) - - Active 4-chloro-2,5-dimethoxyaniline 228-782-0 6358-64-1 - View substance registered dossier
Only representative (No publishable name) - - Active 4-chloro-2-nitroaniline 201-925-4 89-63-4 - View substance registered dossier
Finchimica S.p.A. Via Lazio 13, 25025 Manerbio (BS) Italy Italy Active 4-chloro-3,5-dinitro-α,α,α-trifluorotoluene 206-889-3 393-75-9 - View substance registered dossier
LAXMI ORGANIC INDUSTRIES (EUROPE) B.V. BURGEMEESTER FEITHPLEIN 11 2273 BZ VOORBURG Netherlands Netherlands Cease Manufacture 4-chloro-3,5-dinitro-α,α,α-trifluorotoluene 206-889-3 393-75-9 2019 View substance registered dossier
QUIMICA SINTETICA, S.A. C/ Dulcinea, s/n 28805 Alcalá de Henares Madrid Spain Spain Active 4-chloro-3-methoxy-2-methylpyridine 1-oxide 602-491-2 122307-41-9 - View substance registered dossier
N.V. Ajinomoto OmniChem S.A. Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium Belgium Active 4-chloro-3-nitrobenzonitrile 213-364-2 939-80-0 - View substance registered dossier
Bayer AG Kaiser-Wilhelm-Allee 51373 Leverkusen Germany Germany Active 4-chloro-6-(2-chlorophenoxy)-5-fluoropyrimidine 606-738-5 213265-81-7 - View substance registered dossier
Syngenta Hellas Single Member S.A.C.I. Anthousas Avenue 153 49 Anthousa-Attiki Greece Greece Active 4-chloro-6-methoxypyrimidine 435-030-7 - 2014; 2015; 2020 View substance registered dossier
Bayer AG Kaiser-Wilhelm-Allee 51373 Leverkusen Germany Germany Active 4-chloro-N-methylpyridine-2-carboxamide hydrochloride (1:1) 692-719-7 882167-77-3 2019 View substance registered dossier
CHEMICAL INSPECTION & REGULATION SERVICE LIMITED Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland Ireland Active 4-chloro-α,α,α-trifluoro-3-nitrotoluene 204-451-6 121-17-5 2012 View substance registered dossier
LAXMI ORGANIC INDUSTRIES (EUROPE) B.V. BURGEMEESTER FEITHPLEIN 11 2273 BZ VOORBURG Netherlands Netherlands Cease Manufacture 4-chloro-α,α,α-trifluorotoluene 202-681-1 98-56-6 2019 View substance registered dossier
Synthesia, a.s. Semtín103 53002 Pardubice Czech Republic Czech Republic Active 4-chloroaniline 203-401-0 106-47-8 - View substance registered dossier
ALCHEMIE INDUSTRIES CHEMICAL SPAIN, S.L. Atlantida, 21 1º3º 08930 Sant Adria de Besos Spain Spain Active 4-chloroaniline 203-401-0 106-47-8 2012 View substance registered dossier
Fine Organics Limited Seal Sands TS2 1UB Middlesbrough Teesside United Kingdom United Kingdom No longer Valid 4-chloroaniline 203-401-0 106-47-8 2018 View substance registered dossier
UNION QUIMICO FARMACÉUTICA S.A. Mallorca 262 08008 Barcelona Barcelona Spain Spain Active 4-chlorobenzaldehyde 203-247-4 104-88-1 - View substance registered dossier
Cosma S.p.A. Via Colleoni 15/17 24040 Ciserano (BG) Italy Italy Active 4-chlorobenzhydryl alcohol 204-333-4 119-56-2 - View substance registered dossier
Wacker Chemie AG Hanns-Seidel-Platz 4 81737 Muenchen Germany Germany Active 4-Chlorobutyl 3-chloropropanoate 617-343-2 82530-64-1 2012 View substance registered dossier
RECORDATI SPA Via Mediana Cisterna, 4 04011 Campoverde di Aprilia lazio Italy Italy Active 4-chlorobutyl veratrate 410-950-1 69788-75-6 - View substance registered dossier
[Confidential] - - - 4-chlorophenol 203-402-6 106-48-9 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active 4-chlorophenyl cyclopropyl ketone O-(4-aminobenzyl)oxime 405-260-2 94050-51-8 - View substance registered dossier
Synthesia, a.s. Semtín103 53002 Pardubice Czech Republic Czech Republic Active 4-chlorophenyl isocyanate 203-176-9 104-12-1 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active 4-CPH 428-130-7 - - View substance registered dossier
Chemische Fabrik Karl Bucher GmbH An der Guenz 1 89367 Waldstetten Germany Germany Active 4-cyanobenzoyl chloride 228-005-5 6068-72-0 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Belgian competent national authority. - - Active 4-dichloroacetyl-1-oxa-4-azaspiro[4.5]decane 401-130-4 71526-07-3 - View substance registered dossier
Merck Performance Materials GmbH Rheingaustrasse 190-196 65203 Wiesbaden Germany Germany Cease Manufacture 4-dimethylaminobenzenediazonium 3-carboxy-4-hydroxybenzenesulfonate 404-980-4 124737-31-1 2019 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active 4-ethenylphenyl acetate 434-600-2 2628-16-2 - View substance registered dossier
Bayer AG Kaiser-Wilhelm-Allee 51373 Leverkusen Germany Germany Active 4-Ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl) benzenesulfonic acid 610-141-5 437717-43-6 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant German competent national authority. - - Active 4-ethyl-2-fluoro-4'-(2-(trans-4-pentylcyclohexyl)ethyl)biphenyl 433-390-1 95379-18-3 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant German competent national authority. - - Active 4-ethyl-2-fluoro-4'-(2-(trans-4-propylcyclohexyl)ethyl)biphenyl 433-190-2 - - View substance registered dossier
ANGUS CHEMIE GMBH Zeppelinstr. 30 Postfach 4003 D-49479 Ibbenbueren-Uffeln Germany Germany Active 4-ethyl-2-methyl-2-isopentyl-1,3-oxazolidine 410-470-2 137796-06-6 2011; 2012 View substance registered dossier
- - - - 4-Fluoro-3-hydroxybenzoic acid 434-190-5 - - View substance registered dossier
N.V. Ajinomoto OmniChem S.A. Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium Belgium Active 4-fluoro-3-nitrobenzonitrile 640-317-7 1009-35-4 - View substance registered dossier
Siegfried PharmaChemikalien Minden GmbH Karlstr. 15-39, 42-44 32423 Minden Nordrhein-Westphalen Germany Germany Active 4-fluorobenzonitrile 214-784-9 1194-02-1 - View substance registered dossier
- - - - 4-hexenal , 6-(2,2,3-trimethyl-3-cyclopenten-1-yl)- 484-020-9 1016902-02-5 - View substance registered dossier
Sytheon France 112 rue de Paris 92100 Boulogne Billancourt France France Active 4-hexylresorcinol 205-257-4 136-77-6 - View substance registered dossier
Janssen Pharmaceutica N.V. Turnhoutseweg 30 2340 Beerse Belgium Belgium Cease Manufacture 4-Hydroxy-3,5-dimethylbenzonitrile 452-810-2 - 2019 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active 4-hydroxy-7-(2-aminoethyl)-1,3-benzothiazol-2(3H)-one hydrochloride 432-470-1 189012-93-9 - View substance registered dossier
SP QUIMICA SA Crta. Reus a Riudoms Km. 4, 1 43330 RIUDOMS TARRAGONA Spain Spain Active 4-hydroxybenzohydrazide 226-326-5 5351-23-5 - View substance registered dossier
ORGANICA Feinchemie GmbH Wolfen Ortsteil Wolfen Kunstseidestraße 5 06766 Bitterfeld-Wolfen Germany Germany Active 4-hydroxybutane-1-sulfonic acid 928-903-3 - - View substance registered dossier

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