Registered substances

Registered substances

Registered substances

In this table, you will find all public data submitted to ECHA in REACH registration dossiers by substance manufacturers, importers, or their representatives, as laid out by the REACH Regulation (see Understanding REACH regulation).

ECHA makes available this information as REACH registered substance factsheets, which contain the full set of non-confidential information from related registration dossiers for a substance. Depending on the number of registrations that have been made for a substance, one factsheet can thus represent data from anything between hundreds of registration dossiers in a joint submission, to data from just one registration dossier.

As noted in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission. Please also note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).

In the portal results table are presented:

  • Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
  • Registration status – indicating the calculated registration status: Active - being actively manufactured or imported to the EEA; Cease manufacture - is no longer being manufactured or imported, but still considered to have a valid registration under REACH, and capable of resuming manufacture or import at any time; or No longer valid - no longer considered registered under REACH and not currently permitted to be manufactured or imported to the EEA unless and until properly registered again.
  • Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
  • Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
  • Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
  • Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
  • Link to the full factsheet.

A subset of the key chemical properties (physico-chemical, environmental fate, ecotoxicological and toxicological data) of registered substances can be searched and accessed via the OECD eChemPortal.

Please note:
  • The ‘Substance has nanoform’ search filter returns all factsheets containing any data related to nanomaterials. NB: This does not mean that a registration covering nanoforms has been submitted in line with the revised annexes of REACH. Since 1 January 2020, before manufacturing or importing a nanoform of a substance, the operators concerned must submit the required nano-specific information to ECHA in a new or updated registration dossier.
  • Please be aware that the annual IUCLID format change is coming soon. We will be adapting the Dissemination platform to the new format, which means that as of 15th October 2021 until early 2022 there will be a break in publication of newly submitted registration dossiers. We appreciate your understanding in this matter.
Last updated 13 October 2021. Database contains 23445 unique substances and contains information from 104986 dossiers.
Substance identity
Administrative data
Submission type:
First published date:
Last update date:
Substance data
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Uses and exposure
Life cycle:
  • Consumer Uses
  • Article service life
  • Widespread uses by professional workers
  • Formulation or re-packing
  • Uses at industrial sites
  • Manufacture
Category:
No results were found
Details
Cholesterol
200-353-2 57-88-5 Active Full Joint ≥ 100 to < 1 000 tonnes 21-04-2021 View substance registered dossier
Caffeine
200-362-1 58-08-2 Active Full Joint ≥ 1 000 to < 10 000 tonnes 24-06-2021 View substance registered dossier
Testosterone
200-370-5 58-22-0 Active Full Joint ≥ 1 to < 10 tonnes 05-06-2018 View substance registered dossier
Testosterone
200-370-5 58-22-0 Active Intermediate Joint Intermediate use only 12-04-2021 View substance registered dossier
Chlordiazepoxide
200-371-0 58-25-3 Active Intermediate Joint Intermediate use only 25-02-2020 View substance registered dossier
Menadione
200-372-6 58-27-5 Active Full Joint ≥ 0 to < 10 tonnes 27-10-2020 View substance registered dossier
Desipramine hydrochloride
200-373-1 58-28-6 Active Intermediate Joint Intermediate use only 07-12-2017 View substance registered dossier
Theophylline
200-385-7 58-55-9 Active Full Joint ≥ 1 to < 10 tonnes 17-07-2019 View substance registered dossier
Theophylline
200-385-7 58-55-9 Cease Manufacture Intermediate Individual Cease manufacture 25-06-2014 View substance registered dossier
Pyridoxine hydrochloride
200-386-2 58-56-0 Active Full Joint ≥ 100 to < 1 000 tonnes 16-07-2020 View substance registered dossier
Adenosine
200-389-9 58-61-7 Active Full Joint ≥ 10 to < 100 tonnes 20-11-2019 View substance registered dossier
Inosine
200-390-4 58-63-9 Active Intermediate Joint Intermediate use only 30-05-2018 View substance registered dossier
Cefalotin sodium
200-394-6 58-71-9 Active Intermediate Joint Intermediate use only 22-03-2018 View substance registered dossier
Diphenhydramine
200-396-7 58-73-1 Active Intermediate Joint Intermediate use only 19-10-2017 View substance registered dossier
Papaverine
200-397-2 58-74-2 Active Intermediate Joint Intermediate use only 23-06-2016 View substance registered dossier
Xylose
200-400-7 58-86-6 Active Full Joint ≥ 100 to < 1 000 tonnes 08-09-2021 View substance registered dossier
Xylose
200-400-7 58-86-6 Active Intermediate Individual Intermediate use only 29-11-2010 View substance registered dossier
Uridine
200-407-5 58-96-8 Active Intermediate Joint Intermediate use only 12-10-2020 View substance registered dossier
α-tocopherol
200-412-2 59-02-9 Active Full Joint ≥ 10 to < 100 tonnes 13-11-2019 View substance registered dossier
Nikethamide
200-418-5 59-26-7 Active Intermediate Joint Intermediate use only 02-10-2019 View substance registered dossier
Folic acid
200-419-0 59-30-3 Active Full Joint ≥ 1 to < 10 tonnes 20-09-2019 View substance registered dossier
Folic acid
200-419-0 59-30-3 Active Intermediate Joint Intermediate use only 27-09-2017 View substance registered dossier
Chloropyramine
200-421-1 59-32-5 Active Intermediate Joint Intermediate use only 03-08-2016 View substance registered dossier
Mepyramine maleate
200-422-7 59-33-6 Active Intermediate Joint Intermediate use only 04-05-2018 View substance registered dossier
Phenylephrine
200-424-8 59-42-7 Active Intermediate Individual Intermediate use only 07-12-2012 View substance registered dossier
Registrant/Supplier Address Country Registration Status Name EC / List no. CAS no. Last update year Details
Lubrizol Advanced Materials Europe B.V.B.A Nijverheidsstraat 30 2260 Westerlo-Oevel Belgium Belgium Active Cholesterol 200-353-2 57-88-5 - View substance registered dossier
Evonik Operations GmbH Rellinghauser Straße 1-11 45128 Essen Germany Germany Active Cholesterol 200-353-2 57-88-5 2021 View substance registered dossier
H. Erhard Wagner GmbH Auf dem Pasch 18 28717 Bremen Germany Germany Active Cholesterol 200-353-2 57-88-5 2018 View substance registered dossier
CARBOGEN AMCIS B.V. Nieuweweg 2a 3901 BE Veenendaal Netherlands Netherlands Active Cholesterol 200-353-2 57-88-5 - View substance registered dossier
Chemical Inspection & Regulation Service Limited Room 002, Regus Harcourt Centre D02 HW77 D02 Dublin Ireland Ireland Active Cholesterol 200-353-2 57-88-5 - View substance registered dossier
CHEMICAL INSPECTION & REGULATION SERVICE LIMITED Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland Ireland Cease Manufacture Cholesterol 200-353-2 57-88-5 2020 View substance registered dossier
Lonza Cologne GmbH - REACH Nattermannallee 1 50829 Cologne Germany Germany Active Cholesterol 200-353-2 57-88-5 - View substance registered dossier
Nestlé España S.A. Avinguda Paisos Catalans 25-50 08950 Esplugues del Llobregat Barcelona Spain Spain Active Caffeine 200-362-1 58-08-2 - View substance registered dossier
Andenex-Chemie Engelhard+Partner GmbH Albert-Einstein-Ring 11 22761 Hamburg Germany Germany Active Caffeine 200-362-1 58-08-2 - View substance registered dossier
Chemical Inspection & Regulation Service Limited Regus Harcourt Centre D02 HW77 Dublin Ireland Ireland Active Caffeine 200-362-1 58-08-2 2020 View substance registered dossier
Dr. Kurt Wolff GmbH & Co. KG Johanneswerkstrasse 34-36 33611 Bielefeld Germany Germany Active Caffeine 200-362-1 58-08-2 - View substance registered dossier
demus spa Via Caboto 31 34147 Trieste Italy Italy Active Caffeine 200-362-1 58-08-2 - View substance registered dossier
Stabilimento farmaceutico "Cav. G. Testa" S.r.l. a Socio Unico Regione Abissinia - Località Lago Azzurro Frazione Bastia 17031 Albenga Savona Italy Italy Active Caffeine 200-362-1 58-08-2 2017; 2018; 2019 View substance registered dossier
SIGMA-ALDRICH CHEMIE GMBH Riedstrasse 2 89555 Steinheim Germany Germany Active Caffeine 200-362-1 58-08-2 - View substance registered dossier
Prinova Benelux & France N.V. / S.A. Landries 6 9420 Erpe Mere Belgium Belgium Active Caffeine 200-362-1 58-08-2 - View substance registered dossier
Siegfried PharmaChemikalien Minden GmbH Karlstr. 15-39, 42-44 32423 Minden Nordrhein-Westphalen Germany Germany Active Caffeine 200-362-1 58-08-2 - View substance registered dossier
CPC Wolfgang Mühlbauer GmbH Albert-Einstein-Ring 11-13 22761 Hamburg Germany Germany Active Caffeine 200-362-1 58-08-2 - View substance registered dossier
Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany Germany Active Caffeine 200-362-1 58-08-2 - View substance registered dossier
BASF SE Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany Germany Active Caffeine 200-362-1 58-08-2 - View substance registered dossier
ALCHEMIE INDUSTRIES CHEMICAL SPAIN, S.L. Atlantida, 21 1º3º 08930 Sant Adria de Besos Spain Spain Active Caffeine 200-362-1 58-08-2 - View substance registered dossier
Bayer AG Kaiser-Wilhelm-Allee 51373 Leverkusen Germany Germany Active Testosterone 200-370-5 58-22-0 2012; 2018 View substance registered dossier
Aspen Oss BV Kloosterstraat 6 5349 AB Oss Netherlands Netherlands Active Testosterone 200-370-5 58-22-0 2012; 2018 View substance registered dossier
Bayer AG Kaiser-Wilhelm-Allee 51373 Leverkusen Germany Germany No longer Valid Testosterone 200-370-5 58-22-0 2012 View substance registered dossier
Bayer AG Kaiser-Wilhelm-Allee 51373 Leverkusen Germany Germany No longer Valid Testosterone 200-370-5 58-22-0 2012 View substance registered dossier
RSI ChemRep Europe Ltd (P001) 27-30 Merchants Quay Merchants House 8 Dublin Ireland Ireland Active Testosterone 200-370-5 58-22-0 2021 View substance registered dossier
Steroid SpA Viale Spagna 156 20093 Cologno Monzese Milano Italy Italy Active Testosterone 200-370-5 58-22-0 - View substance registered dossier
Cambrex Profarmaco Milano Srl via Curiel, 34 20067 Paullo MI Italy Italy Active Chlordiazepoxide 200-371-0 58-25-3 - View substance registered dossier
DSM Nutritional Products France SAS 1 boulevard d'Alsace F-68128 Village-Neuf France France Active Menadione 200-372-6 58-27-5 2020 View substance registered dossier
Lundbeck Pharmaceuticals Italy S.p.A via quarta strada 2 35129 padova Italy Italy Active Desipramine hydrochloride 200-373-1 58-28-6 - View substance registered dossier
Siegfried PharmaChemikalien Minden GmbH Karlstr. 15-39, 42-44 32423 Minden Nordrhein-Westphalen Germany Germany Active Theophylline 200-385-7 58-55-9 - View substance registered dossier
Aceto France SAS 3 Place Giovanni da Verrazzano 69009 Lyon France France Active Theophylline 200-385-7 58-55-9 2019 View substance registered dossier
LA MESTA CHIMIE FINE 1336 Route de l'Estéron 06830 GILETTE France France Active Theophylline 200-385-7 58-55-9 - View substance registered dossier
OLON Spa Strada Rivoltana Km 6/7 20053 RODANO Milano Italy Italy Cease Manufacture Theophylline 200-385-7 58-55-9 2017 View substance registered dossier
DSM Nutritional Products GmbH- OR15 Emil-Barell-Str. 3 79639 Grenzach-Wyhlen Germany Germany Active Pyridoxine hydrochloride 200-386-2 58-56-0 2018; 2020 View substance registered dossier
DSM Nutritional Products GmbH Emil-Barell-Str. 3 79639 Grenzach-Wyhlen Germany Germany Active Pyridoxine hydrochloride 200-386-2 58-56-0 2016; 2018; 2020 View substance registered dossier
CHEMICAL INSPECTION & REGULATION SERVICE LIMITED Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland Ireland Active Pyridoxine hydrochloride 200-386-2 58-56-0 - View substance registered dossier
Derivados Químicos S.A. Camino de Pliego, 150 30820 Alcantarilla Murcia Spain Spain Active Pyridoxine hydrochloride 200-386-2 58-56-0 2017 View substance registered dossier
Pharma Waldhof GmbH Hansaallee 159 40549 Duesseldorf Germany Germany Active Adenosine 200-389-9 58-61-7 - View substance registered dossier
FARMAK, a.s. Na vlcinci 16/3 779 00 Olomouc Czech Republic Czech Republic Active Adenosine 200-389-9 58-61-7 - View substance registered dossier
Chemical Inspection & Regulation Service Limited Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland Ireland Active Adenosine 200-389-9 58-61-7 2019 View substance registered dossier
Charles River Laboratories Den Bosch B.V. OR50 Hambakenwetering 7 5231 DD 's-Hertogenbosch Netherlands Netherlands Active Adenosine 200-389-9 58-61-7 - View substance registered dossier
Roche Diagnostics GmbH Sandhoferstrasse 116 68305 Mannheim Germany Germany Active Adenosine 200-389-9 58-61-7 - View substance registered dossier
Clarochem Ireland Ltd damastown mulhuddart dn 15 dublin Ireland Ireland Active Inosine 200-390-4 58-63-9 - View substance registered dossier
DKSH France S.A. 1475 Quai du Rhone 01702 Miribel France France Active Inosine 200-390-4 58-63-9 - View substance registered dossier
ABC FARMACEUTICI Unibios Division Via S. Pellico, 3 28069 TRECATE Italy Italy Active Inosine 200-390-4 58-63-9 - View substance registered dossier
ACS DOBFAR S.p.A Viale Addetta 4/12 20067 Tribiano Milano Italy Italy Active Cefalotin sodium 200-394-6 58-71-9 - View substance registered dossier
Chemische Fabrik Berg GmbH Mainthalstrasse 3 06749 Bitterfeld-Wolfen Germany Germany Active Diphenhydramine 200-396-7 58-73-1 - View substance registered dossier
Aceto France SAS 3 Place Giovanni da Verrazzano 69009 Lyon France France Active Diphenhydramine 200-396-7 58-73-1 - View substance registered dossier
RECORDATI SPA Via Mediana Cisterna, 4 04011 Campoverde di Aprilia lazio Italy Italy Active Diphenhydramine 200-396-7 58-73-1 2017 View substance registered dossier
RECORDATI SPA Via Mediana Cisterna, 4 04011 Campoverde di Aprilia lazio Italy Italy Active Papaverine 200-397-2 58-74-2 - View substance registered dossier
SIGMA-ALDRICH CHEMIE GMBH Riedstrasse 2 89555 Steinheim Germany Germany Active Xylose 200-400-7 58-86-6 2021 View substance registered dossier
Beckmann-Kenko GmbH Auf dem Scheunenbrink 10 27211 Bassum Germany Germany Active Xylose 200-400-7 58-86-6 - View substance registered dossier
Ardilla Technologies Oy Tekniikantie 2 FI-02150 Espoo Finland Finland Active Xylose 200-400-7 58-86-6 - View substance registered dossier
Danisco Austria GmbH Arnbrucker Strasse 1 A-4860 Lenzing Lenzing Austria Austria Active Xylose 200-400-7 58-86-6 2013; 2021 View substance registered dossier
DHW Deutsche Hydrierwerke GmbH Rodleben Brambacher Weg 1 06861 Dessau - Rosslau Saxony - Anhalt Germany Germany Active Xylose 200-400-7 58-86-6 - View substance registered dossier
Lenzing AG Werkstraße 4860 Lenzing Austria Austria Active Xylose 200-400-7 58-86-6 - View substance registered dossier
MSD International GmbH Ballydine - Kilsheelan 0 Clonmel Ireland Ireland Active Uridine 200-407-5 58-96-8 - View substance registered dossier
OLON Spa Strada Rivoltana Km 6/7 20053 RODANO Milano Italy Italy Active Uridine 200-407-5 58-96-8 - View substance registered dossier
Thermofisher Scientific Cork Ltd. Currabinny P43 AY66 Carrigaline Co. Cork Ireland Ireland Active Uridine 200-407-5 58-96-8 - View substance registered dossier
BASF SE Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany Germany Active α-tocopherol 200-412-2 59-02-9 2015; 2019 View substance registered dossier
BTSA, BIOTECNOLOGIAS APLICADAS S.L. Arroba 4 28805 Alcalá de Henares Madrid Spain Spain Active α-tocopherol 200-412-2 59-02-9 2018 View substance registered dossier
Biología Natural Industrial SL Calle Daniel de Urrabieta, Num 11 28002 Madrid Spain Spain Active α-tocopherol 200-412-2 59-02-9 - View substance registered dossier
ADM Services B.V. Kingsfordweg 83 1043 GP Amsterdam Netherlands Netherlands Active α-tocopherol 200-412-2 59-02-9 - View substance registered dossier
Vitae Caps S.A. C/Gutenberg nº 356. Polígono Industrial Torrehierro 45614 Talavera de la Reina Toledo Spain Spain Active α-tocopherol 200-412-2 59-02-9 - View substance registered dossier
[Confidential] - - - Nikethamide 200-418-5 59-26-7 - View substance registered dossier
Saltigo GmbH HSEQ-RA Kaiser-Wilhelm-Allee 40 51373 Leverkusen Germany Germany Active Nikethamide 200-418-5 59-26-7 - View substance registered dossier
ALFARIN QUIMICA, S.A. C/. Ibiza 35 -5º C 28009 MADRID Spain Spain Active Folic acid 200-419-0 59-30-3 2019 View substance registered dossier
DSM Nutritional Products GmbH - OR1 Emil-Barell-Str. 3 79639 Grenzach-Wyhlen Germany Germany Active Folic acid 200-419-0 59-30-3 - View substance registered dossier
PROCOS SpA via Matteotti 249 28062 Cameri Piemonte Italy Italy Active Chloropyramine 200-421-1 59-32-5 - View substance registered dossier
Clarochem Ireland Ltd damastown mulhuddart dn 15 dublin Ireland Ireland Active Mepyramine maleate 200-422-7 59-33-6 - View substance registered dossier
Siegfried PharmaChemikalien Minden GmbH Karlstr. 15-39, 42-44 32423 Minden Nordrhein-Westphalen Germany Germany Active Phenylephrine 200-424-8 59-42-7 - View substance registered dossier

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