Registered substances

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The new ECHA CHEM database has been released by ECHA. At first this system will contain only substances and data from REACH registration dossiers. For new and updated REACH registration data please check ECHA CHEM. See for more information on the transition to ECHA CHEM.  More

Please be aware that REACH registration data here on the current Dissemination Platform is no longer maintained; it remains frozen as of 19th May 2023.


 

DISSEMINATION
PLATFORM

REACH - Registration, Evaluation, Authorisation and Restriction of Chemicals Regulation

Registered Substances Factsheets

Substances which have been registered and can be placed on the EEA market by those companies with a valid registration



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Details
(2S)-2-Aminobutyramide Hydrochloride
471-490-5 7682-20-4 Active Full Joint ≥ 0 tonnes 23-11-2020 View substance registered dossier
(2S)-2-hydrazinyl-3-[4-hydroxy-3-(substituted)phenyl]-2-alkylpropanoic acid
- - Active Intermediate Joint Intermediate use only 04-06-2021 View substance registered dossier
(2S)-2-hydrazinyl-3-[4-hyrdoxy-3-(substituted)phenyl]-2-alkylpropanoic acid — tert-alkylamine (1/1)
- - Active Intermediate Joint Intermediate use only 04-06-2021 View substance registered dossier
(2S)-2-hydroxy-2-(3-phenoxyphenyl)acetonitrile
441-070-6 61826-76-4 Active Intermediate Joint Intermediate use only 12-03-2019 View substance registered dossier
(2S)-2-{[(1E)-(5-chloro-2-hydroxyphenyl)(phenyl)methylene]amino}-3-methylbutanoic acid
609-516-6 38075-43-3 Cease Manufacture Intermediate Joint Cease manufacture 18-01-2018 View substance registered dossier
(2S)-3-(dimethylamino)-1-(3-methoxyphenyl)-2-methyl-1-propanonone
477-290-4 - Active NONS Joint Tonnage data confidential 01-03-2013 View substance registered dossier
(2S)-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanoic acid
430-900-2 192725-50-1 Active Intermediate Joint Intermediate use only 14-06-2018 View substance registered dossier
(2S)-3-methyl-2-(N-{[2'-(1H-1,2,3,4-tetrazol-5-yl)-[1,1-biphenyl]-4-yl]methyl}pentanamido)butanoic acid
604-045-2 137862-53-4 Active Full Joint ≥ 0 to < 10 tonnes 12-02-2020 View substance registered dossier
(2S)-5-amino-2-[(aminoacetyl)amino]-5-oxopentanoic acid
700-144-0 13115-71-4 Active Full Joint ≥ 1 to < 10 tonnes 10-03-2023 View substance registered dossier
(2S)-5-amino-2-{[(2S)-2-aminopropanoyl]amino}-5-oxopentanoic acid
475-290-9 - Active Full Joint ≥ 1 to < 10 tonnes 15-11-2022 View substance registered dossier
(2S)-5-amino-2-{[(2S)-2-aminopropanoyl]amino}-5-oxopentanoic acid
475-290-9 - Active NONS Joint Tonnage data confidential 10-11-2008 View substance registered dossier
(2S)-5-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride (1:1)
695-797-0 93601-86-6 Cease Manufacture Full Joint Cease manufacture 04-07-2018 View substance registered dossier
(2S)-5-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride (1:1)
695-797-0 93601-86-6 Active Intermediate Joint Intermediate use only 13-11-2018 View substance registered dossier
(2S)-5-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-aminium (2R)-(2-chlorophenyl)(hydroxy)acetate
814-350-4 1352917-66-8 Cease Manufacture Full Joint Cease manufacture 04-07-2018 View substance registered dossier
(2S)-6-fluoro-2-[(2S)-oxiran-2-yl]chromane [S-(R*,R*)]
603-314-1 129050-23-3 Active Full Joint ≥ 0 to < 10 tonnes 03-06-2019 View substance registered dossier
(2S)-6-fluoro-2-[(2S)-oxiran-2-yl]chromane [S-(R*,R*)]
603-314-1 129050-23-3 Active Intermediate Joint Intermediate use only 18-11-2022 View substance registered dossier
(2S)-[(tert-butoxycarbonyl)amino](3-hydroxytricyclo[3.3.1.1 3,7]dec-1-yl)acetic acid
700-361-0 361442-00-4 Active Full Joint ≥ 1 to < 10 tonnes 08-01-2014 View substance registered dossier
(2S)-N, N’-dibutyl-2-(2-ethylhexanamido)pentanediamide
700-664-8 486455-65-6 Active Full Joint ≥ 0 to < 10 tonnes 23-04-2019 View substance registered dossier
(2S)-propane-1,2-diamine dihydrochloride
606-377-3 19777-66-3 Active Intermediate Joint Intermediate use only 11-01-2021 View substance registered dossier
(2S)‐2‐{[(2S)‐1‐(2‐{[(benzyloxy)carbonyl]amino}acetyl)‐2‐methylpyrrolidin‐2‐yl]formamido}pentanedioic acid
949-609-1 - Active Intermediate Joint Intermediate use only 29-04-2022 View substance registered dossier
(2S,3aS,7aS)-Octahydro-1H-indole-2-carboxylic acid
617-180-7 80875-98-5 Active Intermediate Joint Intermediate use only 21-07-2022 View substance registered dossier
(2S,3R,4R,5R)-2,4-bis(acetyloxy)-5-methyloxolan-3-yl acetate
612-957-7 62211-93-2 Active Intermediate Joint Intermediate use only 16-04-2020 View substance registered dossier
(2S,3R,4S,5R,6R)-3,4,5-tris(phenylmethoxy)-6-(phenylmethoxymethyl)oxan-2-ol
667-304-9 6564-72-3 Active Intermediate Joint Intermediate use only 31-12-2020 View substance registered dossier
(2S,3R,4S,5S,6R)-2-(1,3-dihydroxypropan-2-yloxy)-6-(hydroxymethyl)oxane-3,4,5-triol
824-773-6 22160-26-5 Active Full Joint ≥ 1 to < 10 tonnes 09-09-2022 View substance registered dossier
(2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol with 2-butyne-1, 4-diol (1:1)
619-496-0 960404-59-5 Active Full Joint ≥ 10 to < 100 tonnes 17-06-2022 View substance registered dossier
(2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol with 2-butyne-1, 4-diol (1:1)
619-496-0 960404-59-5 Active Intermediate Joint Intermediate use only 10-12-2021 View substance registered dossier
(2S,3S)-2,3-Bis[(4-methylbenzoyl)oxy]butanedioic acid — methyl {(4S)-8-fluoro-2-[4-(3methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydroquinazolin-4yl}acetate — ethyl acetate (1:1:1)
947-432-4 - Active Intermediate Joint Intermediate use only 04-09-2020 View substance registered dossier
(2S,3S)-2,3-dihydroxysuccinic acid - 2-[(3R)-piperidin-3-yl]-1H-isoindole-1,3(2H)-dione (1:1)
692-713-4 886588-62-1 Active Intermediate Joint Intermediate use only 20-12-2019 View substance registered dossier
(2S,3S)-2-benzhydryl-N-[(5-tert-butyl-2-methoxy-phenyl)methyl]quinuclidin-3-amine
831-973-7 147116-67-4 Active Full Joint ≥ 1 to < 10 tonnes 15-08-2019 View substance registered dossier
(2S,3S)-3-(2-Ethoxyphenoxy)-2-hydroxy-3-phenylpropylammonium methanesulfonate
425-530-3 98769-75-6 Active NONS Joint Tonnage data confidential 10-11-2008 View substance registered dossier
(2S,3S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride
478-270-8 - No longer Valid Intermediate Joint No longer valid 04-09-2012 View substance registered dossier
(2S,3S)-di-tert-butyl 3-ethyl-4-oxopyrrolidine-1,2-dicarboxylate
942-044-1 - Active Intermediate Joint Intermediate use only 27-02-2017 View substance registered dossier
(2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-aminium sulfate
917-270-9 29790-50-9 Active Full Joint ≥ 1 to < 10 tonnes 26-08-2022 View substance registered dossier
(2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-aminium sulfate
917-270-9 29790-50-9 Active Intermediate Joint Intermediate use only 10-06-2020 View substance registered dossier
(2S,3S,4R)-2-aminooctadecane-1,3,4-triol
439-210-6 554-62-1 Active Full Joint ≥ 10 to < 100 tonnes 19-08-2022 View substance registered dossier
(2S,3S,4R)-3-ethyl-4-hydroxy-2-(methoxycarbonyl)pyrrolidinium 4-methylbenzenesulfonate
813-641-3 1799733-43-9 Active Intermediate Joint Intermediate use only 18-04-2018 View substance registered dossier
(2S,3S,4R)-methyl 4-((3-(1,1-difluorobut-3-en-1-yl)-7-methoxyquinoxalin-2-yl)oxy)-3-ethylpyrrolidine-2-carboxylate 4-methylbenzenesulfonate
942-021-6 1799733-71-3 Active Intermediate Joint Intermediate use only 14-02-2018 View substance registered dossier
(2S,3S,5R)-2-hexyl-3-hydroxy-5-(phenylmethoxy)-Hexadecanoic acid compd. with (S)-α-methylbenzenemethanamine (1:1)
604-018-5 137433-01-3 Cease Manufacture Intermediate Joint Cease manufacture 04-12-2012 View substance registered dossier
(2S,3S,5R)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide
618-303-7 89786-04-9 Active Intermediate Joint Intermediate use only 12-03-2018 View substance registered dossier
(2S,3S,5S)-5-amino-2-(dibenzylamino)-1,6-diphenylhexan-3-ol succinate
938-481-2 - Active Intermediate Joint Intermediate use only 31-10-2018 View substance registered dossier
(2S,4aR)-1,1,5,5-tetramethyl-1,3,4,5,6,7-hexahydro-2H-2,4a-methanonaphthalen-7-ol
942-036-8 645413-57-6 Active Intermediate Joint Intermediate use only 01-07-2020 View substance registered dossier
(2S,4R)-1-benzoyl-4-hydroxy-pyrrolydin-2-carboxylic acid methyl ester
411-020-8 - Active Intermediate Joint Intermediate use only 09-12-2013 View substance registered dossier
(2S,4R)-1-hexadecanoyl-4-hydroxy-pyrrolidine-2-carboxylic acid
944-347-4 - Active Intermediate Joint Intermediate use only 13-03-2017 View substance registered dossier
(2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
604-011-7 13726-69-7 Active Intermediate Joint Intermediate use only 20-04-2022 View substance registered dossier
(2S,4S)-1-(tert-butoxycarbonyl)-4-(methoxymethyl)pyrrolidine-2-carboxylic acid
807-416-9 1378388-16-9 Active Intermediate Joint Intermediate use only 20-04-2018 View substance registered dossier
(2S,4Z)-5-Amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one
423-090-7 156732-13-7 Active Intermediate Joint Intermediate use only 12-06-2018 View substance registered dossier
(2S,4Z)-5-Amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one
423-090-7 156732-13-7 Active NONS Joint Tonnage data confidential 10-11-2008 View substance registered dossier
(2S,5R)-6,6-Dibromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid 4,4-dioxide
427-200-4 76646-91-8 Active NONS Joint Tonnage data confidential 15-12-2008 View substance registered dossier
(2S,5S)-1-((S)-2-((Methoxycarbonyl)amino)-3-methylbutanoyl)-5-methylpyrrolidine-2-carboxylic acid
811-415-9 1335316-40-9 Active Intermediate Joint Intermediate use only 07-03-2018 View substance registered dossier
(2S-cis)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
255-799-0 42399-49-5 Active Intermediate Joint Intermediate use only 19-10-2018 View substance registered dossier
No results were found
Registrant/Supplier Address Country Registration Status Name EC / List no. CAS no. Last update year Details
N.V. Ajinomoto OmniChem S.A. Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium Belgium Active (2S)-2-Aminobutyramide Hydrochloride 471-490-5 7682-20-4 - View substance registered dossier
UCB Pharma S.A.(Belgium) Allée de la recherche, 60 1070 Brussels Belgium Belgium Active (2S)-2-Aminobutyramide Hydrochloride 471-490-5 7682-20-4 2013; 2017; 2019; 2020 View substance registered dossier
Sterling Pharma Solutions Ltd Dudley NE23 7QG Cramlington Northumberland United Kingdom United Kingdom No longer Valid (2S)-2-Aminobutyramide Hydrochloride 471-490-5 7682-20-4 2021 View substance registered dossier
[Confidential] - - - (2S)-2-hydrazinyl-3-[4-hydroxy-3-(substituted)phenyl]-2-alkylpropanoic acid - - - View substance registered dossier
[Confidential] - - - (2S)-2-hydrazinyl-3-[4-hyrdoxy-3-(substituted)phenyl]-2-alkylpropanoic acid — tert-alkylamine (1/1) - - - View substance registered dossier
[Confidential] - - - (2S)-2-hydroxy-2-(3-phenoxyphenyl)acetonitrile 441-070-6 61826-76-4 - View substance registered dossier
ESIM Chemicals GmbH St.-Peter-Strasse 25 4020 Linz Austria Austria Cease Manufacture (2S)-2-hydroxy-2-(3-phenoxyphenyl)acetonitrile 441-070-6 61826-76-4 2023 View substance registered dossier
OLON Spa Strada Rivoltana Km 6/7 20053 RODANO Milano Italy Italy Cease Manufacture (2S)-2-{[(1E)-(5-chloro-2-hydroxyphenyl)(phenyl)methylene]amino}-3-methylbutanoic acid 609-516-6 38075-43-3 2022 View substance registered dossier
Első Vegyi Industria ZRt. Kartács utca 6. H-1139 BUDAPEST Hungary Hungary Active (2S)-3-(dimethylamino)-1-(3-methoxyphenyl)-2-methyl-1-propanonone 477-290-4 - - View substance registered dossier
Janssen Pharmaceutica N.V. Turnhoutseweg 30 2340 Beerse Belgium Belgium Cease Manufacture (2S)-3-(dimethylamino)-1-(3-methoxyphenyl)-2-methyl-1-propanonone 477-290-4 - 2019 View substance registered dossier
Gruenenthal GmbH Zieglerstrasse 6 52078 Aachen Germany Germany Active (2S)-3-(dimethylamino)-1-(3-methoxyphenyl)-2-methyl-1-propanonone 477-290-4 - - View substance registered dossier
AbbVie Srl S.R. 148 Pontina Km 52 snc 04011 Campoverde di Aprilia (LT) Italy Italy Active (2S)-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanoic acid 430-900-2 192725-50-1 2011; 2018 View substance registered dossier
Novartis Grimsby Limited Moody Lane, Pyewipe DN31 2SR Grimsby N.E. Lincolnshire United Kingdom United Kingdom No longer Valid (2S)-3-methyl-2-(N-{[2'-(1H-1,2,3,4-tetrazol-5-yl)-[1,1-biphenyl]-4-yl]methyl}pentanamido)butanoic acid 604-045-2 137862-53-4 2021 View substance registered dossier
Novartis Ringaskiddy Limited . . Ringaskiddy County Cork Ireland Ireland Active (2S)-3-methyl-2-(N-{[2'-(1H-1,2,3,4-tetrazol-5-yl)-[1,1-biphenyl]-4-yl]methyl}pentanamido)butanoic acid 604-045-2 137862-53-4 2014 View substance registered dossier
Evonik Rexim S.A.S. 33, Rue de Verdun 80400 Ham France France Active (2S)-5-amino-2-[(aminoacetyl)amino]-5-oxopentanoic acid 700-144-0 13115-71-4 2023 View substance registered dossier
Evonik Rexim S.A.S. 33, Rue de Verdun 80400 Ham France France Active (2S)-5-amino-2-{[(2S)-2-aminopropanoyl]amino}-5-oxopentanoic acid 475-290-9 - 2022 View substance registered dossier
- - - - (2S)-5-amino-2-{[(2S)-2-aminopropanoyl]amino}-5-oxopentanoic acid 475-290-9 - - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant German competent national authority. - - Active (2S)-5-amino-2-{[(2S)-2-aminopropanoyl]amino}-5-oxopentanoic acid 475-290-9 - - View substance registered dossier
Avara Shannon Pharmaceutical Services Limited Shannon Industrial Estate V14 FX09 Shannon Clare Ireland Ireland Cease Manufacture (2S)-5-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride (1:1) 695-797-0 93601-86-6 2021 View substance registered dossier
[Confidential] - - - (2S)-5-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride (1:1) 695-797-0 93601-86-6 - View substance registered dossier
Avara Shannon Pharmaceutical Services Limited Shannon Industrial Estate V14 FX09 Shannon Clare Ireland Ireland Cease Manufacture (2S)-5-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-aminium (2R)-(2-chlorophenyl)(hydroxy)acetate 814-350-4 1352917-66-8 2021 View substance registered dossier
Janssen Pharmaceutica N.V. Turnhoutseweg 30 2340 Beerse Belgium Belgium Active (2S)-6-fluoro-2-[(2S)-oxiran-2-yl]chromane [S-(R*,R*)] 603-314-1 129050-23-3 2019 View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active (2S)-6-fluoro-2-[(2S)-oxiran-2-yl]chromane [S-(R*,R*)] 603-314-1 129050-23-3 2022 View substance registered dossier
Patheon Austria GmbH & Co KG St. Peterstrasse 25 A-4020 Linz Austria Austria Cease Manufacture (2S)-[(tert-butoxycarbonyl)amino](3-hydroxytricyclo[3.3.1.1 3,7]dec-1-yl)acetic acid 700-361-0 361442-00-4 2021 View substance registered dossier
Piramal Healthcare UK Ltd Whalton Road NE61 3YA Morpeth Northumberland United Kingdom United Kingdom No longer Valid (2S)-[(tert-butoxycarbonyl)amino](3-hydroxytricyclo[3.3.1.1 3,7]dec-1-yl)acetic acid 700-361-0 361442-00-4 2021 View substance registered dossier
SK BIOTEK IRELAND LIMITED Watery Lane Swords K67 AY91 Swords Co. Dublin Ireland Ireland Active (2S)-[(tert-butoxycarbonyl)amino](3-hydroxytricyclo[3.3.1.1 3,7]dec-1-yl)acetic acid 700-361-0 361442-00-4 2010; 2014 View substance registered dossier
Ajinomoto OmniChem (OR) Cooppallaan 91 9230 Wetteren Belgium Belgium Active (2S)-N, N’-dibutyl-2-(2-ethylhexanamido)pentanediamide 700-664-8 486455-65-6 2019 View substance registered dossier
Esteve Quimica, S.A. Torre Esteve Passeig de la Zona Franca, 109, 4ª Planta 08038 Barcelona Barcelona Spain Spain Active (2S)-propane-1,2-diamine dihydrochloride 606-377-3 19777-66-3 - View substance registered dossier
Arran Chemical Company Ltd Monksland Industrial Estate N37DN24 Athlone Co. Roscommon Ireland Ireland Active (2S)-propane-1,2-diamine dihydrochloride 606-377-3 19777-66-3 - View substance registered dossier
CU Chemie Uetikon GmbH Raiffeisenstrasse 4 77933 Lahr Baden-Württemberg Germany Germany Active (2S)-propane-1,2-diamine dihydrochloride 606-377-3 19777-66-3 - View substance registered dossier
Corden Pharma Bergamo S.p.A. Via Bergamo, 121 IT-24047 Treviglio BG Italy Italy Active (2S)‐2‐{[(2S)‐1‐(2‐{[(benzyloxy)carbonyl]amino}acetyl)‐2‐methylpyrrolidin‐2‐yl]formamido}pentanedioic acid 949-609-1 - 2022 View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active (2S)‐2‐{[(2S)‐1‐(2‐{[(benzyloxy)carbonyl]amino}acetyl)‐2‐methylpyrrolidin‐2‐yl]formamido}pentanedioic acid 949-609-1 - - View substance registered dossier
ORIL INDUSTRIE 13 rue Auguste Desgenétais 76210 BOLBEC France France Active (2S,3aS,7aS)-Octahydro-1H-indole-2-carboxylic acid 617-180-7 80875-98-5 2019; 2020; 2021; 2022 View substance registered dossier
Krka, d. d., Novo mesto Smarjeska cesta 6 SI-8501 Novo mesto Slovenia Slovenia Active (2S,3aS,7aS)-Octahydro-1H-indole-2-carboxylic acid 617-180-7 80875-98-5 2019 View substance registered dossier
DKSH France S.A. 1475 Quai du Rhone 01702 Miribel France France Active (2S,3aS,7aS)-Octahydro-1H-indole-2-carboxylic acid 617-180-7 80875-98-5 - View substance registered dossier
ROLABO OUTSOURCING, S.L. Polígono Industrial Malpica. Calle J, nº 3-4 50016 Zaragoza Zaragoza Spain Spain Active (2S,3aS,7aS)-Octahydro-1H-indole-2-carboxylic acid 617-180-7 80875-98-5 - View substance registered dossier
LABORATORIOS SERVIER S.L. RIO JARAMA 59 45007 TOLEDO Spain Spain Active (2S,3aS,7aS)-Octahydro-1H-indole-2-carboxylic acid 617-180-7 80875-98-5 - View substance registered dossier
Roche Ireland Limited Clarehill . Clarecastle Ireland Ireland Active (2S,3R,4R,5R)-2,4-bis(acetyloxy)-5-methyloxolan-3-yl acetate 612-957-7 62211-93-2 2012; 2020 View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active (2S,3R,4R,5R)-2,4-bis(acetyloxy)-5-methyloxolan-3-yl acetate 612-957-7 62211-93-2 2020 View substance registered dossier
Patheon Austria GmbH & Co KG St. Peter Strasse 25 4020 Linz Austria Austria Cease Manufacture (2S,3R,4R,5R)-2,4-bis(acetyloxy)-5-methyloxolan-3-yl acetate 612-957-7 62211-93-2 2020 View substance registered dossier
REACH24H CONSULTING GROUP Suite 1E, Paramount Court, Corrig Road, Sandyford Dublin 18 Dublin Ireland Ireland Active (2S,3R,4S,5R,6R)-3,4,5-tris(phenylmethoxy)-6-(phenylmethoxymethyl)oxan-2-ol 667-304-9 6564-72-3 2020 View substance registered dossier
CHEMICAL INSPECTION & REGULATION SERVICE LIMITED Regus Harcourt Centre D02 HW77 Dublin Ireland Ireland Active (2S,3R,4S,5R,6R)-3,4,5-tris(phenylmethoxy)-6-(phenylmethoxymethyl)oxan-2-ol 667-304-9 6564-72-3 2019 View substance registered dossier
REACHLaw Ltd. Aleksanterinkatu 19 00100 Helsinki Finland Finland Active (2S,3R,4S,5S,6R)-2-(1,3-dihydroxypropan-2-yloxy)-6-(hydroxymethyl)oxane-3,4,5-triol 824-773-6 22160-26-5 - View substance registered dossier
bitop AG Carlo-Schmid-Allee 5 44263 Dortmund Germany Germany Active (2S,3R,4S,5S,6R)-2-(1,3-dihydroxypropan-2-yloxy)-6-(hydroxymethyl)oxane-3,4,5-triol 824-773-6 22160-26-5 2018; 2021 View substance registered dossier
SK BIOTEK IRELAND LIMITED Watery Lane Swords K67 AY91 Swords Co. Dublin Ireland Ireland Active (2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol with 2-butyne-1, 4-diol (1:1) 619-496-0 960404-59-5 2014; 2017; 2022 View substance registered dossier
AstraZeneca B 313:5 AZ GlobalSHE- Chem.Reg. 15185 Södertälje Sweden Sweden Active (2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol with 2-butyne-1, 4-diol (1:1) 619-496-0 960404-59-5 - View substance registered dossier
FINORGA SAS 497 route de Givors 38670 CHASSE SUR RHONE France France Active (2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol with 2-butyne-1, 4-diol (1:1) 619-496-0 960404-59-5 2021 View substance registered dossier
MSD International GmbH (Ballydine Branch) Ballydine - Kilsheelan 0 Clonmel Ireland Ireland Active (2S,3S)-2,3-Bis[(4-methylbenzoyl)oxy]butanedioic acid — methyl {(4S)-8-fluoro-2-[4-(3methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydroquinazolin-4yl}acetate — ethyl acetate (1:1:1) 947-432-4 - 2018; 2020 View substance registered dossier
Bidachem S.p.A. S.S. 11 Padana Superiore No. 8 24040 Fornovo San Giovanni BG Italy Italy Active (2S,3S)-2,3-dihydroxysuccinic acid - 2-[(3R)-piperidin-3-yl]-1H-isoindole-1,3(2H)-dione (1:1) 692-713-4 886588-62-1 2019 View substance registered dossier
Boehringer Ingelheim Pharma GmbH & Co. KG Binger Strasse 173 55216 Ingelheim am Rhein Germany Germany Active (2S,3S)-2,3-dihydroxysuccinic acid - 2-[(3R)-piperidin-3-yl]-1H-isoindole-1,3(2H)-dione (1:1) 692-713-4 886588-62-1 2016; 2019 View substance registered dossier
AGC Pharma Chemicals Europe, S.L.U. Camí de la Pomereda, 13 08380 Malgrat de Mar (Barcelona) Spain Spain Active (2S,3S)-2,3-dihydroxysuccinic acid - 2-[(3R)-piperidin-3-yl]-1H-isoindole-1,3(2H)-dione (1:1) 692-713-4 886588-62-1 - View substance registered dossier
Zoetis Belgium S.A. Rue Laid Burniat, 1 1348 Louvain-La-Neuve Belgium Belgium Active (2S,3S)-2-benzhydryl-N-[(5-tert-butyl-2-methoxy-phenyl)methyl]quinuclidin-3-amine 831-973-7 147116-67-4 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant French competent national authority. - - Active (2S,3S)-3-(2-Ethoxyphenoxy)-2-hydroxy-3-phenylpropylammonium methanesulfonate 425-530-3 98769-75-6 - View substance registered dossier
Sterling Pharma Solutions Ltd Dudley NE23 7QG Cramlington Northumberland United Kingdom United Kingdom No longer Valid (2S,3S)-3-(2-Ethoxyphenoxy)-2-hydroxy-3-phenylpropylammonium methanesulfonate 425-530-3 98769-75-6 2021 View substance registered dossier
Envigo Consulting Limited Woolley Road Alconbury PE28 4HS Huntingdon Cambridgeshire United Kingdom United Kingdom No longer Valid (2S,3S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride 478-270-8 - 2021 View substance registered dossier
OLON Spa Strada Rivoltana Km 6/7 20053 RODANO Milano Italy Italy Active (2S,3S)-di-tert-butyl 3-ethyl-4-oxopyrrolidine-1,2-dicarboxylate 942-044-1 - 2017 View substance registered dossier
Evonik Operations GmbH Rellinghauser Straße 1-11 45128 Essen Germany Germany Active (2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-aminium sulfate 917-270-9 29790-50-9 - View substance registered dossier
[Confidential] - - - (2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-aminium sulfate 917-270-9 29790-50-9 - View substance registered dossier
N.V. Ajinomoto OmniChem S.A. Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium Belgium Active (2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-aminium sulfate 917-270-9 29790-50-9 2020 View substance registered dossier
Evonik Operations GmbH Rellinghauser Straße 1-11 45128 Essen Germany Germany Active (2S,3S,4R)-2-aminooctadecane-1,3,4-triol 439-210-6 554-62-1 - View substance registered dossier
[Confidential] - - - (2S,3S,4R)-2-aminooctadecane-1,3,4-triol 439-210-6 554-62-1 - View substance registered dossier
SCC Scientific Consulting Company GmbH Am Grenzgraben 11 55545 Bad Kreuznach Germany Germany Active (2S,3S,4R)-2-aminooctadecane-1,3,4-triol 439-210-6 554-62-1 2022 View substance registered dossier
Gilead Sciences Ireland UC IDA Business &Technology Park Carrigtohill Cork Cork Ireland Ireland Active (2S,3S,4R)-3-ethyl-4-hydroxy-2-(methoxycarbonyl)pyrrolidinium 4-methylbenzenesulfonate 813-641-3 1799733-43-9 - View substance registered dossier
OLON Spa Strada Rivoltana Km 6/7 20053 RODANO Milano Italy Italy Active (2S,3S,4R)-methyl 4-((3-(1,1-difluorobut-3-en-1-yl)-7-methoxyquinoxalin-2-yl)oxy)-3-ethylpyrrolidine-2-carboxylate 4-methylbenzenesulfonate 942-021-6 1799733-71-3 - View substance registered dossier
Gilead Sciences Ireland UC IDA Business &Technology Park Carrigtohill Cork Cork Ireland Ireland Active (2S,3S,4R)-methyl 4-((3-(1,1-difluorobut-3-en-1-yl)-7-methoxyquinoxalin-2-yl)oxy)-3-ethylpyrrolidine-2-carboxylate 4-methylbenzenesulfonate 942-021-6 1799733-71-3 - View substance registered dossier
Esteve Quimica, S.A. Torre Esteve Passeig de la Zona Franca, 109, 4ª Planta 08038 Barcelona Barcelona Spain Spain Active (2S,3S,4R)-methyl 4-((3-(1,1-difluorobut-3-en-1-yl)-7-methoxyquinoxalin-2-yl)oxy)-3-ethylpyrrolidine-2-carboxylate 4-methylbenzenesulfonate 942-021-6 1799733-71-3 - View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Cease Manufacture (2S,3S,5R)-2-hexyl-3-hydroxy-5-(phenylmethoxy)-Hexadecanoic acid compd. with (S)-α-methylbenzenemethanamine (1:1) 604-018-5 137433-01-3 2015 View substance registered dossier
Patheon Austria GmbH & Co KG St. Peter Strasse 25 4020 Linz Austria Austria Cease Manufacture (2S,3S,5R)-2-hexyl-3-hydroxy-5-(phenylmethoxy)-Hexadecanoic acid compd. with (S)-α-methylbenzenemethanamine (1:1) 604-018-5 137433-01-3 2020 View substance registered dossier
FRESENIUS KABI iPSUM s.r.l. Via Roma, 108 20060 Cassina de' Pecchi (MI) Italy Italy Active (2S,3S,5R)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide 618-303-7 89786-04-9 - View substance registered dossier
IBI - Istituto Biochimico Italiano Giovanni Lorenzini Spa Via Fossignano, 2 04011 Aprilia (LT) Italy Italy Active (2S,3S,5R)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide 618-303-7 89786-04-9 - View substance registered dossier
AbbVie Srl S.R. 148 Pontina Km 52 snc 04011 Campoverde di Aprilia (LT) Italy Italy Active (2S,3S,5S)-5-amino-2-(dibenzylamino)-1,6-diphenylhexan-3-ol succinate 938-481-2 - - View substance registered dossier
Symrise AG Mühlenfeldstraße 1 37603 Holzminden Germany Germany Active (2S,4aR)-1,1,5,5-tetramethyl-1,3,4,5,6,7-hexahydro-2H-2,4a-methanonaphthalen-7-ol 942-036-8 645413-57-6 2020 View substance registered dossier
Corden Pharma Latina S.p.A. Via Murillo, 7 IT04013 Sermoneta (LT) Lazio Italy Italy Cease Manufacture (2S,4R)-1-benzoyl-4-hydroxy-pyrrolydin-2-carboxylic acid methyl ester 411-020-8 - 2017 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Italian competent national authority. - - Active (2S,4R)-1-benzoyl-4-hydroxy-pyrrolydin-2-carboxylic acid methyl ester 411-020-8 - - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant German competent national authority. - - Active (2S,4R)-1-benzoyl-4-hydroxy-pyrrolydin-2-carboxylic acid methyl ester 411-020-8 - - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Irish competent national authority. - - Active (2S,4R)-1-benzoyl-4-hydroxy-pyrrolydin-2-carboxylic acid methyl ester 411-020-8 - - View substance registered dossier
Symrise AG Mühlenfeldstraße 1 37603 Holzminden Germany Germany Active (2S,4R)-1-hexadecanoyl-4-hydroxy-pyrrolidine-2-carboxylic acid 944-347-4 - - View substance registered dossier
Flamma S.p.a. via Bedeschi, 22 24040 Chignolo d'Isola Bergamo Italy Italy Active (2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid 604-011-7 13726-69-7 - View substance registered dossier
Evonik Operations GmbH Rellinghauser Straße 1-11 45128 Essen Germany Germany Active (2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid 604-011-7 13726-69-7 2019; 2022 View substance registered dossier
Lundbeck Pharmaceuticals Italy S.p.A via quarta strada 2 35129 padova Italy Italy Active (2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid 604-011-7 13726-69-7 - View substance registered dossier
Gilead Sciences Ireland UC IDA Business &Technology Park Carrigtohill Cork Cork Ireland Ireland Active (2S,4S)-1-(tert-butoxycarbonyl)-4-(methoxymethyl)pyrrolidine-2-carboxylic acid 807-416-9 1378388-16-9 - View substance registered dossier
Derivados Químicos S.A. Camino de Pliego, 150 30820 Alcantarilla Murcia Spain Spain Active (2S,4S)-1-(tert-butoxycarbonyl)-4-(methoxymethyl)pyrrolidine-2-carboxylic acid 807-416-9 1378388-16-9 - View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active (2S,4S)-1-(tert-butoxycarbonyl)-4-(methoxymethyl)pyrrolidine-2-carboxylic acid 807-416-9 1378388-16-9 - View substance registered dossier
AbbVie Srl S.R. 148 Pontina Km 52 snc 04011 Campoverde di Aprilia (LT) Italy Italy Active (2S,4Z)-5-Amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one 423-090-7 156732-13-7 2011; 2018 View substance registered dossier
ITELYUM Purification S.P.A. Via S. Intini n. 2 27015 Landriano (PV) Italy Italy Active (2S,4Z)-5-Amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one 423-090-7 156732-13-7 2014 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant German competent national authority. - - Active (2S,4Z)-5-Amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one 423-090-7 156732-13-7 - View substance registered dossier
POLPHARMA 19 Pelplińska 83-200 Starogard Gdański Poland Poland Cease Manufacture (2S,4Z)-5-Amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one 423-090-7 156732-13-7 2022 View substance registered dossier
Curia Italy S.r.l. VIA DEL VECCHIO POLITECNICO, n. 9 20121 Milano Italy Italy Active (2S,4Z)-5-Amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one 423-090-7 156732-13-7 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Italian competent national authority. - - Active (2S,4Z)-5-Amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one 423-090-7 156732-13-7 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Irish competent national authority. - - Active (2S,5R)-6,6-Dibromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid 4,4-dioxide 427-200-4 76646-91-8 - View substance registered dossier
Pfizer Ireland Pharmaceuticals n/a P43 X3336 Ringaskiddy Cork Ireland Ireland Active (2S,5R)-6,6-Dibromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid 4,4-dioxide 427-200-4 76646-91-8 - View substance registered dossier
ACS DOBFAR S.p.A Viale Addetta 4/12 20067 Tribiano Milano Italy Italy Active (2S,5R)-6,6-Dibromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid 4,4-dioxide 427-200-4 76646-91-8 - View substance registered dossier
Gilead Sciences Ireland UC IDA Business &Technology Park Carrigtohill Cork Cork Ireland Ireland Active (2S,5S)-1-((S)-2-((Methoxycarbonyl)amino)-3-methylbutanoyl)-5-methylpyrrolidine-2-carboxylic acid 811-415-9 1335316-40-9 - View substance registered dossier
Flamma S.p.a. via Bedeschi, 22 24040 Chignolo d'Isola Bergamo Italy Italy Active (2S,5S)-1-((S)-2-((Methoxycarbonyl)amino)-3-methylbutanoyl)-5-methylpyrrolidine-2-carboxylic acid 811-415-9 1335316-40-9 2018 View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active (2S-cis)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one 255-799-0 42399-49-5 2018 View substance registered dossier
Cambrex Profarmaco Milano Srl via Curiel, 34 20067 Paullo MI Italy Italy Active (2S-cis)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one 255-799-0 42399-49-5 - View substance registered dossier
LusoChimica S.p.A. Via Giotto, 9 23871 Lomagna (Lecco) Italy Italy Active (2S-cis)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one 255-799-0 42399-49-5 - View substance registered dossier
Fermion Oy Koivu-Mankkaan tie 6 A FI-02101 Espoo Finland Finland Active (2S-cis)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one 255-799-0 42399-49-5 2018 View substance registered dossier

In this table, you will find all public data submitted to ECHA in REACH registration dossiers by substance manufacturers, importers, or their representatives, as laid out by the REACH Regulation (see Understanding REACH regulation).

ECHA makes available this information as REACH registered substance factsheets, which contain the full set of non-confidential information from related registration dossiers for a substance. Depending on the number of registrations that have been made for a substance, one factsheet can thus represent data from anything between hundreds of registration dossiers in a joint submission, to data from just one registration dossier.

As noted in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission. Please also note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).

In the portal results table are presented:

  • Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
  • Registration status – indicating the calculated registration status for the whole factsheet: Active – is being manufactured or imported to the EEA by one or more registrants; Cease Manufacture - is no longer being manufactured or imported above 1 tone per calendar year. All registrants of the substance have reported a cease of manufacture or import; or No longer valid - no longer considered registered under REACH and not currently allowed to be manufactured or imported to the EEA, until the substance is registered again.
  • Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
  • Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
  • Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
  • Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
  • Link to the full factsheet.

A subset of the key chemical properties (physico-chemical, environmental fate, ecotoxicological and toxicological data) of registered substances can be searched and accessed via the OECD eChemPortal.