Registered substances

Registered substances

Registered substances

In this table, you will find all public data submitted to ECHA in REACH registration dossiers by substance manufacturers, importers, or their representatives, as laid out by the REACH Regulation (see Understanding REACH regulation).

ECHA makes available this information as REACH registered substance factsheets, which contain the full set of non-confidential information from related registration dossiers for a substance. Depending on the number of registrations that have been made for a substance, one factsheet can thus represent data from anything between hundreds of registration dossiers in a joint submission, to data from just one registration dossier.

As noted in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission. Please also note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).

In the portal results table are presented:

  • Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
  • Registration status – indicating the calculated registration status: Active - being actively manufactured or imported to the EEA; Cease manufacture - is no longer being manufactured or imported, but still considered to have a valid registration under REACH, and capable of resuming manufacture or import at any time; or No longer valid - no longer considered registered under REACH and not currently permitted to be manufactured or imported to the EEA unless and until properly registered again.
  • Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
  • Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
  • Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
  • Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
  • Link to the full factsheet.

A subset of the key chemical properties (physico-chemical, environmental fate, ecotoxicological and toxicological data) of registered substances can be searched and accessed via the OECD eChemPortal.

Please note:
  • The ‘Substance has nanoform’ search filter returns all factsheets containing any data related to nanomaterials. NB: This does not mean that a registration covering nanoforms has been submitted in line with the revised annexes of REACH. Since 1 January 2020, before manufacturing or importing a nanoform of a substance, the operators concerned must submit the required nano-specific information to ECHA in a new or updated registration dossier.
  • Please be aware that the annual IUCLID format change is coming soon. We will be adapting the Dissemination platform to the new format, which means that as of 15th October 2021 until early 2022 there will be a break in publication of newly submitted registration dossiers. We appreciate your understanding in this matter.
Last updated 13 October 2021. Database contains 23445 unique substances and contains information from 104978 dossiers.
Substance identity
Administrative data
Submission type:
First published date:
Last update date:
Substance data
Select total tonnage band range:



Uses and exposure
Life cycle:
  • Consumer Uses
  • Article service life
  • Widespread uses by professional workers
  • Formulation or re-packing
  • Uses at industrial sites
  • Manufacture
No results were found
700-683-1 853950-77-3 Active Intermediate Individual Intermediate use only 21-12-2011 View substance registered dossier
700-662-7 950773-38-3 Active Intermediate Individual Intermediate use only 17-08-2011 View substance registered dossier
430-560-5 180637-89-2 Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
435-560-9 57090-45-6 Cease Manufacture NONS Individual Cease manufacture 10-11-2008 View substance registered dossier
(R)-4-(4-dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile hemi (2R, 3R)-2,3-bis((4-methylbenzoyl)oxy)succinoate
949-784-4 - Active Intermediate Individual Intermediate use only 25-03-2019 View substance registered dossier
419-800-1 - Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
(R)-5-bromo-3-(1-methyl-2-pyrrolidinyl methyl)-1H-indole
422-390-5 143322-57-0 Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
224-957-0 4573-50-6 Active Intermediate Individual Intermediate use only 11-06-2019 View substance registered dossier
(R)-[[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino]phenylacetic acid
264-133-8 63422-71-9 Active Intermediate Individual Intermediate use only 21-08-2013 View substance registered dossier
(R)-α-phenylethylammonium (-)-(1R, 2S)-(1,2-epoxypropyl)phosphonate monohydrate
418-570-8 25383-07-7 Active Full Individual ≥ 10 to < 100 tonnes 14-06-2016 View substance registered dossier
Registrant/Supplier Address Country Registration Status Name EC / List no. CAS no. Last update year Details
Amino Chemicals Ltd Industrial Estate, A61 MRS3000 Marsa Malta Malta Active (R)-2-{[(3-methyl-4-nitropyridine-2-yl)methyl]sulfinyl}-1H-benzimidazole 700-683-1 853950-77-3 - View substance registered dossier
Pfizer Ireland Pharmaceuticals n/a P43 X3336 Ringaskiddy Cork Ireland Ireland Active (R)-3-(2-benzyloxy)-5-bromophenyl)-N,N-diisopropyl-3-phenylpropan-1-amine 700-662-7 950773-38-3 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active (R)-3-[(1-methylpyrrolidin-2-yl)methyl]-5-[2-(phenylsulfonyl)ethenyl]-1H-indole 430-560-5 180637-89-2 - View substance registered dossier
COVANCE CLINICAL DEVELOPMENT SA 171 Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 – 5 Planta 28050 Madrid Spain Spain Cease Manufacture (R)-3-chloropropane-1,2-diol 435-560-9 57090-45-6 2012 View substance registered dossier
Lundbeck Pharmaceuticals Italy S.p.A via quarta strada 2 35129 padova Italy Italy Active (R)-4-(4-dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile hemi (2R, 3R)-2,3-bis((4-methylbenzoyl)oxy)succinoate 949-784-4 - - View substance registered dossier
- - - - (R)-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide 419-800-1 - - View substance registered dossier
ORGAPHARM Rue du Moulin de la Canne 45300 PITHIVIERS France France Active (R)-5-bromo-3-(1-methyl-2-pyrrolidinyl methyl)-1H-indole 422-390-5 143322-57-0 - View substance registered dossier
Pfizer Ireland Pharmaceuticals n/a P43 X3336 Ringaskiddy Cork Ireland Ireland No longer Valid (R)-5-bromo-3-(1-methyl-2-pyrrolidinyl methyl)-1H-indole 422-390-5 143322-57-0 2013 View substance registered dossier
TAKASAGO TICSA-Producer/Importer Avenida de Mazarrón, 49 30120 El Palmar Murcia Spain Spain Active (R)-6-(isopropyl)-3-methylcyclohex-2-en-1-one 224-957-0 4573-50-6 - View substance registered dossier
FRESENIUS KABI iPSUM s.r.l. Via Roma, 108 20060 Cassina de' Pecchi (MI) Italy Italy Active (R)-[[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino]phenylacetic acid 264-133-8 63422-71-9 - View substance registered dossier
Clarochem Ireland Ltd damastown mulhuddart dn 15 dublin Ireland Ireland Active (R)-α-phenylethylammonium (-)-(1R, 2S)-(1,2-epoxypropyl)phosphonate monohydrate 418-570-8 25383-07-7 2016 View substance registered dossier

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