Registered substances

Registered substances

Registered substances

In this table, you will find all public data submitted to ECHA in REACH registration dossiers by substance manufacturers, importers, or their representatives, as laid out by the REACH Regulation (see Understanding REACH regulation).

ECHA makes available this information as REACH registered substance factsheets, which contain the full set of non-confidential information from related registration dossiers for a substance. Depending on the number of registrations that have been made for a substance, one factsheet can thus represent data from anything between hundreds of registration dossiers in a joint submission, to data from just one registration dossier.

As noted in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission. Please also note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).

In the portal results table are presented:

  • Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
  • Registration status – indicating the calculated registration status: Active - being actively manufactured or imported to the EEA; Cease manufacture - is no longer being manufactured or imported, but still considered to have a valid registration under REACH, and capable of resuming manufacture or import at any time; or No longer valid - no longer considered registered under REACH and not currently permitted to be manufactured or imported to the EEA unless and until properly registered again.
  • Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
  • Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
  • Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
  • Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
  • Link to the full factsheet.

A subset of the key chemical properties (physico-chemical, environmental fate, ecotoxicological and toxicological data) of registered substances can be searched and accessed via the OECD eChemPortal.

Please note:
  • The ‘Substance has nanoform’ search filter returns all factsheets containing any data related to nanomaterials. NB: This does not mean that a registration covering nanoforms has been submitted in line with the revised annexes of REACH. Since 1 January 2020, before manufacturing or importing a nanoform of a substance, the operators concerned must submit the required nano-specific information to ECHA in a new or updated registration dossier.
  • Please be aware that the annual IUCLID format change is coming soon. We will be adapting the Dissemination platform to the new format, which means that as of 15th October 2021 until early 2022 there will be a break in publication of newly submitted registration dossiers. We appreciate your understanding in this matter.
Last updated 13 October 2021. Database contains 23445 unique substances and contains information from 104978 dossiers.
Substance identity
Administrative data
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First published date:
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Substance data
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Details
Methyl 4-[4-(4-methoxybenzoylamino)-3-nitrophenyl]-3-methyl-4-oxo-butyrate
426-290-2 - Active Intermediate Individual Intermediate use only 13-03-2015 View substance registered dossier
Methyl 4-bromobenzoate
210-596-6 619-42-1 Active Intermediate Individual Intermediate use only 30-11-2016 View substance registered dossier
Methyl 4-bromomethyl-3-methoxybenzoate
410-310-1 70264-94-7 No longer Valid NONS Individual No longer valid 15-12-2008 View substance registered dossier
methyl 4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoate
700-542-4 917392-54-2 Active Intermediate Individual Intermediate use only 10-12-2010 View substance registered dossier
Methyl 4-tert-butylbenzoate
247-768-5 26537-19-9 Active Intermediate Individual Intermediate use only 11-09-2019 View substance registered dossier
methyl 5-(bis(methoxycarbonylmethylamino))-4-cyano-3-methoxycarbonylmethylthiophen-2-carboxylate
451-540-2 - Active Intermediate Individual Intermediate use only 26-10-2009 View substance registered dossier
Methyl 5-amino-4-cyano-3-methylthiophene-2-carboxylate
700-422-1 61320-65-8 Active Full Individual ≥ 1 to < 10 tonnes 14-11-2011 View substance registered dossier
Methyl 5-chlorosalicylate
223-778-5 4068-78-4 Active Intermediate Individual Intermediate use only 31-05-2017 View substance registered dossier
methyl 5-fluoropyridine-2-carboxylate
813-296-9 107504-07-4 Cease Manufacture Intermediate Individual Cease manufacture 20-10-2016 View substance registered dossier
Methyl 5-methyl-1,2-oxazole-4-carboxylate
600-020-5 100047-54-9 Active Intermediate Individual Intermediate use only 14-06-2018 View substance registered dossier
methyl [(2S)-1-{[4-(3-{5-chloro-3-[(diphenylmethylene)amino]-2-fluorophenyl}-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-yl]amino}propan-2-yl]carbamate
941-175-1 - Active Intermediate Individual Intermediate use only 13-11-2015 View substance registered dossier
methyl [(2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl]carbamate
619-880-8 176972-62-6 Cease Manufacture Intermediate Individual Cease manufacture 29-10-2012 View substance registered dossier
Methyl [[(methoxycarbonyl)amino](methylthio)methylene]carbamate
252-240-2 34840-23-8 Active Intermediate Individual Intermediate use only 11-11-2015 View substance registered dossier
Methyl [S-(E)]-2-[3-[3-[2-(7-chloro-quinolin-2-yl)ethenyl]phenyl]-3-hydroxypropyl]benzoate monohydrate
431-050-5 287930-78-3 Active NONS Individual Tonnage data confidential 28-04-2011 View substance registered dossier
Methyl acetoacetate
203-299-8 105-45-3 Active Intermediate Individual Intermediate use only 14-11-2013 View substance registered dossier
Methyl benzoate
202-259-7 93-58-3 Cease Manufacture Intermediate Individual Cease manufacture 12-04-2013 View substance registered dossier
Methyl benzoylformate
239-263-3 15206-55-0 Cease Manufacture Intermediate Individual Cease manufacture 18-04-2013 View substance registered dossier
Methyl chloroformate
201-187-3 79-22-1 Active Intermediate Individual Intermediate use only 15-10-2012 View substance registered dossier
Methyl cholate
215-903-7 1448-36-8 Active Intermediate Individual Intermediate use only 28-05-2013 View substance registered dossier
methyl cis-1-{[(2,5-dimethylphenyl)acetyl]amino}-4-methoxycyclohexanecarboxylate
606-524-1 203313-47-7 Active Intermediate Individual Intermediate use only 17-05-2016 View substance registered dossier
Methyl cyanoacetate
203-288-8 105-34-0 Active Intermediate Individual Intermediate use only 28-05-2013 View substance registered dossier
Methyl cyclohexylacetate
700-789-8 14352-61-5 Active Full Individual ≥ 1 to < 10 tonnes 31-08-2012 View substance registered dossier
Methyl dichloroacetate
204-146-8 116-54-1 Active Intermediate Individual Intermediate use only 31-05-2016 View substance registered dossier
Methyl DL-serinate hydrochloride
227-047-1 5619-04-5 Active Intermediate Individual Intermediate use only 22-03-2018 View substance registered dossier
Methyl dodec-9-enoate
700-618-7 39202-17-0 Active Full Individual ≥ 1 000 to < 10 000 tonnes 15-04-2016 View substance registered dossier
Methyl ester of fatty acids, Cx-Cy, Hydroxymethylated
- - Active Full Individual ≥ 100 to < 1 000 tonnes 20-02-2013 View substance registered dossier
Methyl esters of fatty acids, C16-C18 and C18 unsaturated, branched and linear
457-390-4 - No longer Valid NONS Individual No longer valid 10-11-2008 View substance registered dossier
Methyl hydrogen 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate
278-034-2 74936-72-4 Active Intermediate Individual Intermediate use only 25-09-2015 View substance registered dossier
Methyl hydrogen maleate
221-271-3 3052-50-4 Active Intermediate Individual Intermediate use only 08-01-2021 View substance registered dossier
Methyl isobutyrate
208-929-5 547-63-7 Active Intermediate Individual Intermediate use only 21-01-2021 View substance registered dossier
Methyl mercaptoacetate
219-121-7 2365-48-2 Active Intermediate Individual Intermediate use only 23-10-2015 View substance registered dossier
Methyl N-(1-oxohexadecyl)serinate; methyl N-(1-oxohexadecyl)glycinate; methyl N-(1-oxohexadecyl)alaninate
434-950-6 - Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
Methyl N-[3-acetylamino)-4-(2-cyano-4-nitrophenylazo)phenyl]-N-[(1-methoxy)acetyl]glycinate
413-040-2 149850-30-6 Active NONS Individual Tonnage data confidential 15-12-2008 View substance registered dossier
Methyl N-benzyloxycarbonyl-L-tyrosinate
426-320-4 - Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
Methyl tetrahydro-2-furancarboxylate
420-670-1 37443-42-8 Active NONS Individual Tonnage data confidential 15-12-2008 View substance registered dossier
Methyl trans-3-oxo-2-pentylcyclopentanecarboxylate
700-527-2 1271488-66-4 Active Full Individual ≥ 1 to < 10 tonnes 25-01-2012 View substance registered dossier
methyl {[4-(4-cyclopropyl-1-naphthyl)-4H-1,2,4-triazol-3-yl]thio}acetate
938-816-2 1533519-85-5 Cease Manufacture Intermediate Individual Cease manufacture 24-07-2015 View substance registered dossier
Methyl α-((4,6-dimethoxypyrimidin-2-yl)ureidosulfonyl)-o-toluate
401-340-6 83055-99-6 Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
methyl(2S,5R)-5-[(benzyloxy)amino]piperidine-2-carboxylatedihydrochloride
817-190-3 1501976-34-6 Active Intermediate Individual Intermediate use only 12-01-2018 View substance registered dossier
Methyl-3-acetyl-1H-pyrazole-5-carboxylate
807-401-7 684236-66-6 Active Intermediate Individual Intermediate use only 16-08-2019 View substance registered dossier
methyl-5-nitrophenyl-guanidine
435-500-1 152460-07-6 No longer Valid Intermediate Individual No longer valid 28-09-2010 View substance registered dossier
Methylacetate norbornene
439-830-7 - No longer Valid NONS Individual No longer valid 02-11-2011 View substance registered dossier
Methylenediphenyl diisocyanate, oligomers, reaction products with 2-ethylhexan-l-ol
700-674-2 - Active Full Individual ≥ 100 to < 1 000 tonnes 24-08-2011 View substance registered dossier
Methylhydrazine
200-471-4 60-34-4 Cease Manufacture Intermediate Individual Cease manufacture 15-11-2012 View substance registered dossier
Methylhydrazine
200-471-4 60-34-4 Active Intermediate Individual Intermediate use only 22-03-2011 View substance registered dossier
Methylium, triphenyl-, tetrakis(pentafluorophenyl)borate(1-).
472-690-5 - Active Intermediate Individual Intermediate use only 29-05-2020 View substance registered dossier
Methylium, triphenyl-, tetrakis(pentafluorophenyl)borate(1-).
472-690-5 - Cease Manufacture NONS Individual Cease manufacture 10-11-2008 View substance registered dossier
Methylmagnesium chloride
211-629-7 676-58-4 Active Intermediate Individual Intermediate use only 10-12-2015 View substance registered dossier
Methyloxirane
200-879-2 75-56-9 Active Intermediate Individual Intermediate use only 31-10-2012 View substance registered dossier
Methyloxirane
200-879-2 75-56-9 Active Intermediate Individual Intermediate use only 06-03-2015 View substance registered dossier
Registrant/Supplier Address Country Registration Status Name EC / List no. CAS no. Last update year Details
KINSY, S.L. Avda. Europa s/n Parque Industrial de Alhama 30840 Alhama de Murcia Murcia Spain Spain Active Methyl 4-[4-(4-methoxybenzoylamino)-3-nitrophenyl]-3-methyl-4-oxo-butyrate 426-290-2 - - View substance registered dossier
AlzChem Trostberg GmbH Dr.-Albert-Frank-Straße 32 83308 Trostberg Bayern Germany Germany Active Methyl 4-bromobenzoate 210-596-6 619-42-1 - View substance registered dossier
AstraZeneca Alderley Park AZ SHE Chemical Registration SK10 4TF Macclesfield Cheshire United Kingdom United Kingdom No longer Valid Methyl 4-bromomethyl-3-methoxybenzoate 410-310-1 70264-94-7 2021 View substance registered dossier
Novartis Ringaskiddy Limited . . Ringaskiddy County Cork Ireland Ireland Active methyl 4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoate 700-542-4 917392-54-2 - View substance registered dossier
Merck S.L.U. Calle Maria de Molina 28006 Madrid Spain Spain Active Methyl 4-tert-butylbenzoate 247-768-5 26537-19-9 2013; 2014; 2019 View substance registered dossier
EGIS Pharmaceuticals PLC Keresztúri út 30-38 H-1106 Budapest Hungary Hungary Active methyl 5-(bis(methoxycarbonylmethylamino))-4-cyano-3-methoxycarbonylmethylthiophen-2-carboxylate 451-540-2 - 2009 View substance registered dossier
Lanxess Deutschland GmbH Kennedyplatz 1 50569 Köln Germany Germany Active Methyl 5-amino-4-cyano-3-methylthiophene-2-carboxylate 700-422-1 61320-65-8 2011 View substance registered dossier
Cambrex Profarmaco Milano Srl via Curiel, 34 20067 Paullo MI Italy Italy Active Methyl 5-chlorosalicylate 223-778-5 4068-78-4 - View substance registered dossier
MINAKEM Beuvry Production SAS 145, Chemin des Lilas 59310 Beuvry-la-Forêt France France Cease Manufacture methyl 5-fluoropyridine-2-carboxylate 813-296-9 107504-07-4 2019 View substance registered dossier
MINAKEM Beuvry Production SAS 145, Chemin des Lilas 59310 Beuvry-la-Forêt France France Active Methyl 5-methyl-1,2-oxazole-4-carboxylate 600-020-5 100047-54-9 - View substance registered dossier
FINORGA SAS 497 route de Givors 38670 CHASSE SUR RHONE France France Active methyl [(2S)-1-{[4-(3-{5-chloro-3-[(diphenylmethylene)amino]-2-fluorophenyl}-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-yl]amino}propan-2-yl]carbamate 941-175-1 - - View substance registered dossier
Roche Ireland Limited Clarehill . Clarecastle Ireland Ireland Cease Manufacture methyl [(2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl]carbamate 619-880-8 176972-62-6 2020 View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active Methyl [[(methoxycarbonyl)amino](methylthio)methylene]carbamate 252-240-2 34840-23-8 - View substance registered dossier
MSD International GmbH Ballydine - Kilsheelan 0 Clonmel Ireland Ireland Active Methyl [S-(E)]-2-[3-[3-[2-(7-chloro-quinolin-2-yl)ethenyl]phenyl]-3-hydroxypropyl]benzoate monohydrate 431-050-5 287930-78-3 2011 View substance registered dossier
MOEHS CATALANA Cesar Martinell i Brunet 12 A 08191 Rubi Barcelona Spain Spain Active Methyl acetoacetate 203-299-8 105-45-3 - View substance registered dossier
Indorama Ventures Polymers Germany GmbH Philipp Reis Strasse 4 65795 Hattersheim Germany Germany Cease Manufacture Methyl benzoate 202-259-7 93-58-3 2015 View substance registered dossier
Colors & Effects France S.A.S. Rue de la Chapelle 28 68330 Huningue France France Cease Manufacture Methyl benzoylformate 239-263-3 15206-55-0 2021 View substance registered dossier
Synthesia, a.s. Semtín103 53002 Pardubice Czech Republic Czech Republic Active Methyl chloroformate 201-187-3 79-22-1 - View substance registered dossier
DIPHARMA FRANCIS srl Bissone, 5 20021 Baranzate Milano Italy Italy Active Methyl cholate 215-903-7 1448-36-8 - View substance registered dossier
Bayer AG Kaiser-Wilhelm-Allee 51373 Leverkusen Germany Germany Active methyl cis-1-{[(2,5-dimethylphenyl)acetyl]amino}-4-methoxycyclohexanecarboxylate 606-524-1 203313-47-7 2016 View substance registered dossier
Katwijk Chemie BV Snijderstraat 6 Steenbakkerstraat 26 2222 BA Katwijk ZH Netherlands Netherlands Active Methyl cyanoacetate 203-288-8 105-34-0 - View substance registered dossier
PFW Aroma Ingredients BV Veemweg 29-31 3771 MT Barneveld Netherlands Netherlands Active Methyl cyclohexylacetate 700-789-8 14352-61-5 - View substance registered dossier
QUIMICA SINTETICA, S.A. C/ Dulcinea, s/n 28805 Alcalá de Henares Madrid Spain Spain Active Methyl dichloroacetate 204-146-8 116-54-1 - View substance registered dossier
SP QUIMICA SA Crta. Reus a Riudoms Km. 4, 1 43330 RIUDOMS TARRAGONA Spain Spain Active Methyl DL-serinate hydrochloride 227-047-1 5619-04-5 - View substance registered dossier
Wilmar Europe Trading B.V. Central Post – Entrance West, 7th floor Delftseplein 27G 3013 AA Rotterdam Netherlands Netherlands Active Methyl dodec-9-enoate 700-618-7 39202-17-0 2014; 2015; 2016 View substance registered dossier
Only representative (No publishable name) - - Active Methyl ester of fatty acids, Cx-Cy, Hydroxymethylated - - 2009; 2010; 2011; 2013 View substance registered dossier
Kraton Chemical Ltd Vigo Lane DH3 2RB Chester-le-Street Co.Durham United Kingdom United Kingdom No longer Valid Methyl esters of fatty acids, C16-C18 and C18 unsaturated, branched and linear 457-390-4 - 2021 View substance registered dossier
RECORDATI SPA Via Mediana Cisterna, 4 04011 Campoverde di Aprilia lazio Italy Italy Active Methyl hydrogen 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate 278-034-2 74936-72-4 - View substance registered dossier
Lamberti S.p.A. via Piave 18 21041 Albizzate Varese Italy Italy Active Methyl hydrogen maleate 221-271-3 3052-50-4 - View substance registered dossier
BYK-Chemie GmbH Abelstr. 45 DE-46483 Wesel Germany Germany Active Methyl isobutyrate 208-929-5 547-63-7 2021 View substance registered dossier
HH Compliance Ltd Rubicon Building CIT Campus T12 Y275 Bishopstown Cork Ireland Ireland Active Methyl mercaptoacetate 219-121-7 2365-48-2 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant French competent national authority. - - Active Methyl N-(1-oxohexadecyl)serinate; methyl N-(1-oxohexadecyl)glycinate; methyl N-(1-oxohexadecyl)alaninate 434-950-6 - - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active Methyl N-[3-acetylamino)-4-(2-cyano-4-nitrophenylazo)phenyl]-N-[(1-methoxy)acetyl]glycinate 413-040-2 149850-30-6 - View substance registered dossier
- - - - Methyl N-benzyloxycarbonyl-L-tyrosinate 426-320-4 - - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active Methyl tetrahydro-2-furancarboxylate 420-670-1 37443-42-8 - View substance registered dossier
PFW Aroma Ingredients B.V. Veemweg 29-31 3771 MT Barneveld Gelderland Netherlands Netherlands Active Methyl trans-3-oxo-2-pentylcyclopentanecarboxylate 700-527-2 1271488-66-4 - View substance registered dossier
[Confidential] - - - methyl {[4-(4-cyclopropyl-1-naphthyl)-4H-1,2,4-triazol-3-yl]thio}acetate 938-816-2 1533519-85-5 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active Methyl α-((4,6-dimethoxypyrimidin-2-yl)ureidosulfonyl)-o-toluate 401-340-6 83055-99-6 - View substance registered dossier
Flamma S.p.a. via Bedeschi, 22 24040 Chignolo d'Isola Bergamo Italy Italy Active methyl(2S,5R)-5-[(benzyloxy)amino]piperidine-2-carboxylatedihydrochloride 817-190-3 1501976-34-6 - View substance registered dossier
Fermion Oy Koivu-Mankkaan tie 6 A FI-02101 Espoo Finland Finland Active Methyl-3-acetyl-1H-pyrazole-5-carboxylate 807-401-7 684236-66-6 2019 View substance registered dossier
Novartis Grimsby Limited Moody Lane, Pyewipe DN31 2SR Grimsby N.E. Lincolnshire United Kingdom United Kingdom No longer Valid methyl-5-nitrophenyl-guanidine 435-500-1 152460-07-6 2021 View substance registered dossier
Harlan Laboratories Ltd 07 Shardlow Business Park London Road DE72 2GD Shardlow Derbyshire United Kingdom United Kingdom No longer Valid Methylacetate norbornene 439-830-7 - 2021 View substance registered dossier
Covestro Deutschland AG Kaiser-Wilhelm-Allee 60 51373 Leverkusen Germany Germany Active Methylenediphenyl diisocyanate, oligomers, reaction products with 2-ethylhexan-l-ol 700-674-2 - - View substance registered dossier
Chemical Inspection & Regulation Service Limited Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland Ireland Cease Manufacture Methylhydrazine 200-471-4 60-34-4 2019 View substance registered dossier
BASF SE Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany Germany Active Methylhydrazine 200-471-4 60-34-4 - View substance registered dossier
AGC Chemicals Europe, Ltd World Trade Centre Zuidplein 80 1077VX Amsterdam Netherlands Netherlands Active Methylium, triphenyl-, tetrakis(pentafluorophenyl)borate(1-). 472-690-5 - - View substance registered dossier
- - - - Methylium, triphenyl-, tetrakis(pentafluorophenyl)borate(1-). 472-690-5 - - View substance registered dossier
H. Lundbeck A/S Ottiliavej 7-9 2500 Copenhagen Denmark Denmark Active Methylmagnesium chloride 211-629-7 676-58-4 - View substance registered dossier
Chemical Inspection & Regulation Service Limited Regus Harcourt Centre D02 HW77, Dublin, Ireland D02 Dublin Ireland Ireland Active Methyloxirane 200-879-2 75-56-9 2012 View substance registered dossier
REACH COMPLIANCE SERVICES LIMITED 306 The Capel Building, Mary's Abbey, Dublin 7, Ireland Dublin 7 Dublin Ireland Ireland Active Methyloxirane 200-879-2 75-56-9 2011; 2015 View substance registered dossier

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