Registered substances

Registered substances

Registered substances

In this table, you will find all public data submitted to ECHA in REACH registration dossiers by substance manufacturers, importers, or their representatives, as laid out by the REACH Regulation (see Understanding REACH regulation).

ECHA makes available this information as REACH registered substance factsheets, which contain the full set of non-confidential information from related registration dossiers for a substance. Depending on the number of registrations that have been made for a substance, one factsheet can thus represent data from anything between hundreds of registration dossiers in a joint submission, to data from just one registration dossier.

As noted in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission. Please also note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).

In the portal results table are presented:

  • Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
  • Registration status – indicating the calculated registration status: Active - being actively manufactured or imported to the EEA; Cease manufacture - is no longer being manufactured or imported, but still considered to have a valid registration under REACH, and capable of resuming manufacture or import at any time; or No longer valid - no longer considered registered under REACH and not currently permitted to be manufactured or imported to the EEA unless and until properly registered again.
  • Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
  • Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
  • Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
  • Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
  • Link to the full factsheet.

A subset of the key chemical properties (physico-chemical, environmental fate, ecotoxicological and toxicological data) of registered substances can be searched and accessed via the OECD eChemPortal.

Please note:
  • The ‘Substance has nanoform’ search filter returns all factsheets containing any data related to nanomaterials. NB: This does not mean that a registration covering nanoforms has been submitted in line with the revised annexes of REACH. Since 1 January 2020, before manufacturing or importing a nanoform of a substance, the operators concerned must submit the required nano-specific information to ECHA in a new or updated registration dossier.
  • Please be aware that the annual IUCLID format change is coming soon. We will be adapting the Dissemination platform to the new format, which means that as of 15th October 2021 until early 2022 there will be a break in publication of newly submitted registration dossiers. We appreciate your understanding in this matter.
Last updated 13 October 2021. Database contains 23445 unique substances and contains information from 104978 dossiers.
Substance identity
Administrative data
Submission type:
First published date:
Last update date:
Substance data
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Uses and exposure
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  • Consumer Uses
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Details
4-ethyl-2-fluoro-4'-(2-(trans-4-pentylcyclohexyl)ethyl)biphenyl
433-390-1 95379-18-3 Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
4-ethyl-2-fluoro-4'-(2-(trans-4-propylcyclohexyl)ethyl)biphenyl
433-190-2 - Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
4-ethyl-2-methyl-2-isopentyl-1,3-oxazolidine
410-470-2 137796-06-6 Active NONS Individual Tonnage data confidential 23-10-2012 View substance registered dossier
4-Fluoro-3-hydroxybenzoic acid
434-190-5 - No longer Valid NONS Individual No longer valid 10-11-2008 View substance registered dossier
4-fluoro-3-nitrobenzonitrile
640-317-7 1009-35-4 Active Intermediate Individual Intermediate use only 20-08-2020 View substance registered dossier
4-fluorobenzonitrile
214-784-9 1194-02-1 Active Intermediate Individual Intermediate use only 19-06-2020 View substance registered dossier
4-hexenal , 6-(2,2,3-trimethyl-3-cyclopenten-1-yl)-
484-020-9 1016902-02-5 Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
4-hexylresorcinol
205-257-4 136-77-6 Active Full Individual ≥ 1 to < 10 tonnes 21-02-2017 View substance registered dossier
4-Hydroxy-3,5-dimethylbenzonitrile
452-810-2 - Cease Manufacture NONS Individual Cease manufacture 14-09-2010 View substance registered dossier
4-hydroxy-7-(2-aminoethyl)-1,3-benzothiazol-2(3H)-one hydrochloride
432-470-1 189012-93-9 Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
4-hydroxybenzohydrazide
226-326-5 5351-23-5 Active Intermediate Individual Intermediate use only 08-03-2018 View substance registered dossier
4-hydroxybutane-1-sulfonic acid
928-903-3 - Active Intermediate Individual Intermediate use only 29-04-2015 View substance registered dossier
4-hydroxyphenyl-alpha-D-glucopyranoside
440-470-8 84380-01-8 Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
4-isobutyl-2-methylbenzaldehyde
811-502-1 73206-60-7 Active Intermediate Individual Intermediate use only 10-05-2016 View substance registered dossier
4-isocyanato-2-methyl-1-{4-[(trifluoromethyl)thio]phenoxy}benzene
690-654-9 106310-19-4 Active Intermediate Individual Intermediate use only 19-08-2019 View substance registered dossier
4-isothiocyanato-2-(trifluoromethyl)benzonitrile
700-928-2 143782-23-4 No longer Valid Intermediate Individual No longer valid 24-05-2013 View substance registered dossier
4-methoxy-3-nitro-N-phenylbenzamide
202-572-9 97-32-5 Active Intermediate Individual Intermediate use only 01-06-2016 View substance registered dossier
4-methoxy-N-methyl-3-nitrobenzamide
812-957-9 333350-60-0 Active Intermediate Individual Intermediate use only 27-07-2017 View substance registered dossier
4-methoxybenzyl (6R,7R)-7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride (1:1)
601-254-0 113479-65-5 Active Intermediate Individual Intermediate use only 26-04-2013 View substance registered dossier
4-methoxybenzyl (6R,7R)-7-{[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-{[(1-tert-butoxy-2-methyl-1-oxopropan-2-yl)oxy]imino}acetyl]amino}-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
939-996-5 689294-28-8 Active Intermediate Individual Intermediate use only 26-02-2014 View substance registered dossier
4-methoxybenzyl 3-chloromethyl-5-oxo-6-phenylacetamido-(2H)5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
403-040-0 - Active Intermediate Individual Intermediate use only 16-11-2011 View substance registered dossier
4-methoxyphenyl-4(5,6-epoxyhexyloxy)benzoate
435-360-1 144447-11-0 Cease Manufacture Full Individual Cease manufacture 03-01-2012 View substance registered dossier
4-methoxyphenylacetone
204-578-7 122-84-9 Active Intermediate Individual Intermediate use only 18-02-2016 View substance registered dossier
4-methyl-2,6-bis(phenylamino)nicotinonitrile
810-804-0 51566-48-4 No longer Valid Intermediate Individual No longer valid 28-08-2018 View substance registered dossier
4-Methyl-2,6-bis[(4-methylphenyl)amino]-5-{[2-(trifluoromethyl)phenyl]azo}pyridine-3-carbonitrile
444-370-5 669005-94-1 Active Full Individual ≥ 10 to < 100 tonnes 08-02-2011 View substance registered dossier
4-Methyl-2-propylbenzimidazole-6-carboxylic acid
424-450-6 - Active Intermediate Individual Intermediate use only 21-04-2010 View substance registered dossier
4-methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-amine dihydrobromide
946-432-1 - Active Intermediate Individual Intermediate use only 09-01-2018 View substance registered dossier
4-methyl-5-propoxy-2,4-dihydro-3H-1,2,4-triazol-3-one
809-941-9 145027-96-9 Active Intermediate Individual Intermediate use only 18-05-2015 View substance registered dossier
4-methyl-8-methylenetricyclo[3.3.1.13,7]decan-2-ol
406-330-5 122760-84-3 Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
4-methyl-N,N-bis(2-(((4-methylphenyl)sulfonyl)amino)ethyl)benzenesulfonamide
DIETHYLEN-TRIAMIN-TRITOSYLAT
413-300-5 56187-04-3 Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
4-methyl-N-(methylsulfonyl)benzenesulfonamide
415-040-8 14653-91-9 Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
4-Methyl-N-[[[3-(trifluoromethyl)phenyl]amino]carbonyl] benzenesulfonamide
850-929-8 1584-79-8 Active Full Individual ≥ 1 to < 10 tonnes 30-09-2021 View substance registered dossier
4-methyl-N-phenyl-6-(prop-1-yn-1-yl)pyrimidin-2-amine
432-140-7 110235-47-7 Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
4-Methyl-N3-[4-(pyridin-3-yl)-1,3-thiazol-2-yl]benzene-1,3-diamine dihydrochloride
700-594-8 1143459-92-0 Active Intermediate Individual Intermediate use only 25-10-2012 View substance registered dossier
4-methyl-salicylamide
444-900-5 49667-22-3 Active Full Individual ≥ 0 to < 10 tonnes 25-01-2018 View substance registered dossier
4-methylanisole
203-253-7 104-93-8 Active Intermediate Individual Intermediate use only 25-06-2013 View substance registered dossier
4-methylanisole
203-253-7 104-93-8 No longer Valid Full Individual No longer valid 22-10-2010 View substance registered dossier
4-methylphenyl 4-methoxybenzoate
439-300-5 - Cease Manufacture NONS Individual Cease manufacture 10-11-2008 View substance registered dossier
4-methylpyrazole
231-445-0 7554-65-6 Active Intermediate Individual Intermediate use only 08-10-2014 View substance registered dossier
4-MORPHOLINO-2-NAPHTHOL
435-700-9 - Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
4-morpholinopropanesulphonic acid
214-478-5 1132-61-2 Active Intermediate Individual Intermediate use only 09-11-2017 View substance registered dossier
4-nitro-o-anisidine
202-588-6 97-52-9 Active Intermediate Individual Intermediate use only 14-10-2013 View substance registered dossier
4-nitro-o-anisidine
202-588-6 97-52-9 Active Intermediate Individual Intermediate use only 30-05-2013 View substance registered dossier
4-nitroaniline
202-810-1 100-01-6 Active Intermediate Individual Intermediate use only 10-05-2013 View substance registered dossier
4-nitrobenzoic acid
200-526-2 62-23-7 Active Intermediate Individual Intermediate use only 21-12-2012 View substance registered dossier
4-nitrotoluene
202-808-0 99-99-0 Active Intermediate Individual Intermediate use only 04-07-2012 View substance registered dossier
4-nitrotoluene-2-sulphonic acid
204-445-3 121-03-9 Active Intermediate Individual Intermediate use only 21-01-2015 View substance registered dossier
4-nitrotoluene-2-sulphonic acid
204-445-3 121-03-9 Active Intermediate Individual Intermediate use only 22-10-2012 View substance registered dossier
4-nitrotoluene-2-sulphonic acid
204-445-3 121-03-9 Active Intermediate Individual Intermediate use only 17-07-2013 View substance registered dossier
4-Oxo-butyramide
464-950-1 - Cease Manufacture NONS Individual Cease manufacture 14-12-2012 View substance registered dossier
Registrant/Supplier Address Country Registration Status Name EC / List no. CAS no. Last update year Details
Former NONS notifier unknown to ECHA - Contact the relevant German competent national authority. - - Active 4-ethyl-2-fluoro-4'-(2-(trans-4-pentylcyclohexyl)ethyl)biphenyl 433-390-1 95379-18-3 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant German competent national authority. - - Active 4-ethyl-2-fluoro-4'-(2-(trans-4-propylcyclohexyl)ethyl)biphenyl 433-190-2 - - View substance registered dossier
ANGUS CHEMIE GMBH Zeppelinstr. 30 Postfach 4003 D-49479 Ibbenbueren-Uffeln Germany Germany Active 4-ethyl-2-methyl-2-isopentyl-1,3-oxazolidine 410-470-2 137796-06-6 2011; 2012 View substance registered dossier
- - - - 4-Fluoro-3-hydroxybenzoic acid 434-190-5 - - View substance registered dossier
N.V. Ajinomoto OmniChem S.A. Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium Belgium Active 4-fluoro-3-nitrobenzonitrile 640-317-7 1009-35-4 - View substance registered dossier
Siegfried PharmaChemikalien Minden GmbH Karlstr. 15-39, 42-44 32423 Minden Nordrhein-Westphalen Germany Germany Active 4-fluorobenzonitrile 214-784-9 1194-02-1 - View substance registered dossier
- - - - 4-hexenal , 6-(2,2,3-trimethyl-3-cyclopenten-1-yl)- 484-020-9 1016902-02-5 - View substance registered dossier
Sytheon France 112 rue de Paris 92100 Boulogne Billancourt France France Active 4-hexylresorcinol 205-257-4 136-77-6 - View substance registered dossier
Janssen Pharmaceutica N.V. Turnhoutseweg 30 2340 Beerse Belgium Belgium Cease Manufacture 4-Hydroxy-3,5-dimethylbenzonitrile 452-810-2 - 2019 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active 4-hydroxy-7-(2-aminoethyl)-1,3-benzothiazol-2(3H)-one hydrochloride 432-470-1 189012-93-9 - View substance registered dossier
SP QUIMICA SA Crta. Reus a Riudoms Km. 4, 1 43330 RIUDOMS TARRAGONA Spain Spain Active 4-hydroxybenzohydrazide 226-326-5 5351-23-5 - View substance registered dossier
ORGANICA Feinchemie GmbH Wolfen Ortsteil Wolfen Kunstseidestraße 5 06766 Bitterfeld-Wolfen Germany Germany Active 4-hydroxybutane-1-sulfonic acid 928-903-3 - - View substance registered dossier
- - - - 4-hydroxyphenyl-alpha-D-glucopyranoside 440-470-8 84380-01-8 - View substance registered dossier
[Confidential] - - - 4-isobutyl-2-methylbenzaldehyde 811-502-1 73206-60-7 - View substance registered dossier
Bayer Animal Health GmbH Alfred Nobel Straße 50 40789 Monheim Germany Germany Active 4-isocyanato-2-methyl-1-{4-[(trifluoromethyl)thio]phenoxy}benzene 690-654-9 106310-19-4 - View substance registered dossier
Fine Organics Limited Seal Sands TS2 1UB Middlesbrough Teesside United Kingdom United Kingdom No longer Valid 4-isothiocyanato-2-(trifluoromethyl)benzonitrile 700-928-2 143782-23-4 2021 View substance registered dossier
Colorants Solutions Deutschland GmbH Brüningstrasse 50 65929 Frankfurt am Main Germany Germany Active 4-methoxy-3-nitro-N-phenylbenzamide 202-572-9 97-32-5 - View substance registered dossier
Colorants Solutions Deutschland GmbH Brüningstrasse 50 65929 Frankfurt am Main Germany Germany Active 4-methoxy-N-methyl-3-nitrobenzamide 812-957-9 333350-60-0 - View substance registered dossier
ACS DOBFAR S.p.A Viale Addetta 4/12 20067 Tribiano Milano Italy Italy Active 4-methoxybenzyl (6R,7R)-7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride (1:1) 601-254-0 113479-65-5 - View substance registered dossier
ACS DOBFAR S.p.A Viale Addetta 4/12 20067 Tribiano Milano Italy Italy Active 4-methoxybenzyl (6R,7R)-7-{[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-{[(1-tert-butoxy-2-methyl-1-oxopropan-2-yl)oxy]imino}acetyl]amino}-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 939-996-5 689294-28-8 2014 View substance registered dossier
ACS DOBFAR S.p.A Viale Addetta 4/12 20067 Tribiano Milano Italy Italy Active 4-methoxybenzyl 3-chloromethyl-5-oxo-6-phenylacetamido-(2H)5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 403-040-0 - - View substance registered dossier
Nouryon Functional Chemicals B.V. Velperweg 76 6824 BM Arnhem Netherlands Netherlands Cease Manufacture 4-methoxyphenyl-4(5,6-epoxyhexyloxy)benzoate 435-360-1 144447-11-0 2021 View substance registered dossier
BENECHIM René Magritte 163 7860 Lessines Belgium Belgium Active 4-methoxyphenylacetone 204-578-7 122-84-9 - View substance registered dossier
Fujifilm Imaging Colorants Limited Patricia Way Pysons Road Industrial Estate CT10 2LE Broadstairs Kent United Kingdom United Kingdom No longer Valid 4-methyl-2,6-bis(phenylamino)nicotinonitrile 810-804-0 51566-48-4 2021 View substance registered dossier
BASF Colors & Effects GmbH An der Rheinschanze 1 67059 Ludwigshafen Germany Germany Active 4-Methyl-2,6-bis[(4-methylphenyl)amino]-5-{[2-(trifluoromethyl)phenyl]azo}pyridine-3-carbonitrile 444-370-5 669005-94-1 - View substance registered dossier
AGC Pharma Chemicals Europe, S.L.U. Camí de la Pomereda, 13 08380 Malgrat de Mar (Barcelona) Spain Spain Active 4-Methyl-2-propylbenzimidazole-6-carboxylic acid 424-450-6 - - View substance registered dossier
Lek Pharmaceuticals d.d. Verovskova 57 1526 Ljubljana Slovenia Slovenia Active 4-methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-amine dihydrobromide 946-432-1 - - View substance registered dossier
Bayer AG Kaiser-Wilhelm-Allee 51373 Leverkusen Germany Germany Active 4-methyl-5-propoxy-2,4-dihydro-3H-1,2,4-triazol-3-one 809-941-9 145027-96-9 - View substance registered dossier
IFF Benicarlo, S.L. Avda. Felipe Klein 2 12580 Benicarlo Castellon Spain Spain Active 4-methyl-8-methylenetricyclo[3.3.1.13,7]decan-2-ol 406-330-5 122760-84-3 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant German competent national authority. - - Active 4-methyl-N,N-bis(2-(((4-methylphenyl)sulfonyl)amino)ethyl)benzenesulfonamide 413-300-5 56187-04-3 - View substance registered dossier
Cytec Industries BV Burgemeester van Lierplein 75 3134 ZB Vlaardingen Netherlands Netherlands Active 4-methyl-N-(methylsulfonyl)benzenesulfonamide 415-040-8 14653-91-9 - View substance registered dossier
Mitsubishi Chemical Europe GmbH 08 Willstätterstraße 30 40549 Düsseldorf Germany Germany Active 4-Methyl-N-[[[3-(trifluoromethyl)phenyl]amino]carbonyl] benzenesulfonamide 850-929-8 1584-79-8 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Dutch competent national authority. - - Active 4-methyl-N-phenyl-6-(prop-1-yn-1-yl)pyrimidin-2-amine 432-140-7 110235-47-7 - View substance registered dossier
Excella GmbH & Co. KG Nuernberger Str. 12 90537 Feucht Germany Germany Active 4-Methyl-N3-[4-(pyridin-3-yl)-1,3-thiazol-2-yl]benzene-1,3-diamine dihydrochloride 700-594-8 1143459-92-0 2012 View substance registered dossier
Agfa-Gevaert N.V. Septestraat 27 2640 Mortsel Belgium Belgium Active 4-methyl-salicylamide 444-900-5 49667-22-3 2010; 2016; 2018 View substance registered dossier
BASF SE Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany Germany Active 4-methylanisole 203-253-7 104-93-8 - View substance registered dossier
BASF SE Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany Germany No longer Valid 4-methylanisole 203-253-7 104-93-8 2013 View substance registered dossier
- - - - 4-methylphenyl 4-methoxybenzoate 439-300-5 - - View substance registered dossier
[Confidential] - - - 4-methylpyrazole 231-445-0 7554-65-6 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant German competent national authority. - - Active 4-MORPHOLINO-2-NAPHTHOL 435-700-9 - - View substance registered dossier
Raschig GmbH Mundenheimerstraße 100 D-67061 Ludwigshafen Germany Germany Active 4-morpholinopropanesulphonic acid 214-478-5 1132-61-2 - View substance registered dossier
Only representative (No publishable name) - - Active 4-nitro-o-anisidine 202-588-6 97-52-9 - View substance registered dossier
Ferro Performance Pigments Belgium N.V. Kortrijkstraat 153 8930 Menen Belgium Belgium Active 4-nitro-o-anisidine 202-588-6 97-52-9 - View substance registered dossier
Only representative (No publishable name) - - Active 4-nitroaniline 202-810-1 100-01-6 - View substance registered dossier
Chemical Inspection & Regulation Service Limited Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland Ireland Active 4-nitrobenzoic acid 200-526-2 62-23-7 - View substance registered dossier
Synthesia, a.s. Semtín103 53002 Pardubice Czech Republic Czech Republic Active 4-nitrotoluene 202-808-0 99-99-0 - View substance registered dossier
Only representative (No publishable name) - - Active 4-nitrotoluene-2-sulphonic acid 204-445-3 121-03-9 2013; 2015 View substance registered dossier
Synthesia, a.s. Semtín103 53002 Pardubice Czech Republic Czech Republic Active 4-nitrotoluene-2-sulphonic acid 204-445-3 121-03-9 - View substance registered dossier
REACH24H CONSULTING GROUP Suite 1E, Paramount Court, Corrig Road, Sandyford Dublin 18 Dublin Ireland Ireland Active 4-nitrotoluene-2-sulphonic acid 204-445-3 121-03-9 - View substance registered dossier
Boehringer Ingelheim Pharma GmbH & Co. KG Binger Strasse 173 55216 Ingelheim am Rhein Germany Germany Cease Manufacture 4-Oxo-butyramide 464-950-1 - 2015 View substance registered dossier

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