Registered substances

Registered substances

Registered substances

Please note:

As of end June 2022 we have processed and published all dossiers that had been pending since 14 October 2021. While daily processing has resumed there remains a processing queue. New submissions will be at the back of the processing queue, and may be slightly delayed before publication. We appreciate your understanding in this matter.

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REACH - Registration, Evaluation, Authorisation and Restriction of Chemicals Regulation

Registered Substances Factsheets

Substances which have been registered and can be placed on the EEA market by those companies with a valid registration



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Details
4,4'-bis(2-methyl-2-(4-methylphenyl)-1-propionyl)diphenylsulfide
ESACURE L 244
415-410-9 - Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
4,4'-methylenediphenyl diisocyanate and its oligomeric reaction products with oxydipropanol and [(methylethylene)bis(oxy)]dipropanol
701-072-2 - Active Full Joint ≥ 1 000 to < 10 000 tonnes 24-08-2022 View substance registered dossier
4,4'-methylenediphenyldiisocyanate and 2,4'-diisocyanatodiphenylmethane and their oligomerisation reaction products with 2,2'-oxydiethanol, propane-1,2-diol and butane-1,3-diol
701-276-1 - Cease Manufacture Full Joint Cease manufacture 13-02-2019 View substance registered dossier
4,4'-Sulfonylbisphenol polymer with 1,1'-oxybis[2-chloroethane]
427-620-8 - Active NONS Joint Tonnage data confidential 05-09-2019 View substance registered dossier
4,4,19,19-tetraethoxy-3,20-dioxa-8,15-dithia-4,19-disiladocosaneand S-(6-{[3-(triethoxysilyl)propyl]thio}hexyl) ethanethioate
951-696-6 - Active Full Joint ≥ 1 to < 10 tonnes 22-02-2021 View substance registered dossier
4,4’-isopropylidenediphenol, reaction products with 1-chloro-2,3-epoxypropane, mono, di and triesters with acrylic acid
948-054-2 - Active Full Joint ≥ 1 to < 10 tonnes 21-10-2019 View substance registered dossier
4,5-di-tert-butyl-6-ethoxy-2,2-dimethyl-3,7-dioxa-4-aza-6-phosphanonan-1-oic acid 6-oxide
449-920-8 - Active NONS Individual Tonnage data confidential 16-12-2010 View substance registered dossier
4,5-Dihydro-5-methyl-3,4-diphenyl-5-isoxazolol
443-400-4 - Active Intermediate Joint Intermediate use only 20-08-2018 View substance registered dossier
4,5-Dihydro-5-methyl-3,4-diphenyl-5-isoxazolol
443-400-4 - Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
4,5-dihydro-5-oxo-1-(4-sulfophenyl)-4-(4-{2-[1,2,7,8-tetrahydro-7-(4-nitro-2-sulfophenylhydrazono)-1,8-dioxo-3,6-disulfo-2-naphthylidene]hydrazino}-3-sulfophenylhydrazono)pyrazole-3-carboxylic acid, lithium sodium salt
445-080-1 - No longer Valid NONS Individual No longer valid 24-11-2010 View substance registered dossier
4,5-dihydro-5-oxo-1-(4-sulfophenyl)-4-(4-{2-[1,2,7,8-tetrahydro-7-(4-nitro-2-sulfophenylhydrazono)-1,8-dioxo-3,6-disulfo-2-naphthylidene]hydrazino}-3-sulfophenylhydrazono)pyrazole-3-carboxylic acid, lithium sodium salt
445-080-1 - Active NONS Individual Tonnage data confidential 29-04-2021 View substance registered dossier
4,7-methanooctahydro-1H-indene-diyldimethyl bis(2-carboxybenzoate)
TCD EMULGATOR
407-410-2 - Active Full Individual ≥ 100 to < 1 000 tonnes 08-12-2016 View substance registered dossier
4,7-methanooctahydro-1H-indene-diyldimethyl bis(2-carboxybenzoate)
TCD EMULGATOR
407-410-2 - Active NONS Joint Tonnage data confidential 09-11-2011 View substance registered dossier
4-(1-((3-((2-(tert-butoxycarbonyl(methyl)amino)acetoxy)methyl)pyridin-2-yl)(methyl)carbamoyloxy)ethyl)-1-((2R,3S)-3-(4-(4-cyanophenyl)thiazol-2-yl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-1H-1,2,4-triazol-4-ium)hemisulphate
926-418-1 - Active Intermediate Individual Intermediate use only 09-05-2018 View substance registered dossier
4-(2-methylpropyl)benzaldehyde
464-400-0 - Active NONS Joint Tonnage data confidential 22-07-2014 View substance registered dossier
4-(4'-Trifluoromethylphenyl)benzaldehyde
473-430-3 - Cease Manufacture NONS Individual Cease manufacture 10-11-2008 View substance registered dossier
4-(4-Brom-5-ethyl-tetrahydropyran-2-yl)-phenol
919-822-4 - Active Intermediate Joint Intermediate use only 25-05-2018 View substance registered dossier
4-(4-Brom-5-propyl-tetrahydropyran-2-yl)-phenol
917-991-9 - Active Intermediate Joint Intermediate use only 16-02-2018 View substance registered dossier
4-(4-chloro-3-nitro-phenyl)-3-methyl-4-oxo-butanoic acid
918-019-6 - Active Intermediate Joint Intermediate use only 31-05-2018 View substance registered dossier
4-(4-trans-vinyl-[1,1'-bicyclohexyl]-4'-trans-yl)-1,2-difluorobenzene
430-860-6 - Active NONS Individual Tonnage data confidential 05-11-2019 View substance registered dossier
4-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl)-N-(2-ethyl-3-oxo-1,2-oxazolidin-4-yl)-2-methylbenzamide
954-921-6 - Active Full Joint ≥ 0 to < 10 tonnes 17-12-2021 View substance registered dossier
4-(5-Ethyl-tetrahydropyran-2-yl)-phenol
921-114-5 - Active Full Joint ≥ 0 to < 10 tonnes 23-10-2020 View substance registered dossier
4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide
VALDECOXIB
448-010-8 - Active NONS Individual Tonnage data confidential 15-12-2008 View substance registered dossier
4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide
VALDECOXIB
448-010-8 - Active Intermediate Joint Intermediate use only 20-08-2018 View substance registered dossier
4-(5-Propyl-tetrahydropyran-2-yl)-phenol
919-949-5 - Active Full Joint ≥ 0 to < 10 tonnes 17-12-2021 View substance registered dossier
Registrant/Supplier Address Country Registration Status Name EC / List no. CAS no. Last update year Details
- - - - 4,4'-bis(2-methyl-2-(4-methylphenyl)-1-propionyl)diphenylsulfide 415-410-9 - - View substance registered dossier
Rohm and Haas Italia Srl Via Trieste 25 22076 Mozzate Como Italy Italy Active 4,4'-methylenediphenyl diisocyanate and its oligomeric reaction products with oxydipropanol and [(methylethylene)bis(oxy)]dipropanol 701-072-2 - 2019; 2022 View substance registered dossier
DOW BENELUX B.V. Postbus 48 4530 AA Terneuzen Netherlands Netherlands Active 4,4'-methylenediphenyl diisocyanate and its oligomeric reaction products with oxydipropanol and [(methylethylene)bis(oxy)]dipropanol 701-072-2 - 2012; 2014; 2016; 2017; 2019; 2021; 2022 View substance registered dossier
DOW DEUTSCHLAND ANLAGENGESELLSCHAFT mbH Buetzflether Sand 2 D-21683 Stade Germany Germany Active 4,4'-methylenediphenyl diisocyanate and its oligomeric reaction products with oxydipropanol and [(methylethylene)bis(oxy)]dipropanol 701-072-2 - 2022 View substance registered dossier
BASF Polyurethanes GmbH Elastogranstr. 60 49448 Lemförde Niedersachsen Germany Germany Cease Manufacture 4,4'-methylenediphenyldiisocyanate and 2,4'-diisocyanatodiphenylmethane and their oligomerisation reaction products with 2,2'-oxydiethanol, propane-1,2-diol and butane-1,3-diol 701-276-1 - 2020 View substance registered dossier
BASF Espanola S.L. Calle Can Ràbia, n. 3-5 8017 Barcelona Spain Spain Cease Manufacture 4,4'-methylenediphenyldiisocyanate and 2,4'-diisocyanatodiphenylmethane and their oligomerisation reaction products with 2,2'-oxydiethanol, propane-1,2-diol and butane-1,3-diol 701-276-1 - 2020 View substance registered dossier
Nisso Chemical Europe GmbH Berliner Allee 42 40212 Düsseldorf Germany Germany Active 4,4'-Sulfonylbisphenol polymer with 1,1'-oxybis[2-chloroethane] 427-620-8 - 2011; 2014 View substance registered dossier
Nisso Chemical Europe Berliner Allee 42 40212 Duesseldorf Germany Germany Active 4,4'-Sulfonylbisphenol polymer with 1,1'-oxybis[2-chloroethane] 427-620-8 - 2011; 2019 View substance registered dossier
[Confidential] - - - 4,4,19,19-tetraethoxy-3,20-dioxa-8,15-dithia-4,19-disiladocosaneand S-(6-{[3-(triethoxysilyl)propyl]thio}hexyl) ethanethioate 951-696-6 - - View substance registered dossier
Evonik Operations GmbH Rellinghauser Straße 1-11 45128 Essen Germany Germany Active 4,4,19,19-tetraethoxy-3,20-dioxa-8,15-dithia-4,19-disiladocosaneand S-(6-{[3-(triethoxysilyl)propyl]thio}hexyl) ethanethioate 951-696-6 - - View substance registered dossier
Yordas GmbH Äußere Nürnberger Str. 62, 91301 Forchheim Germany Germany Active 4,4’-isopropylidenediphenol, reaction products with 1-chloro-2,3-epoxypropane, mono, di and triesters with acrylic acid 948-054-2 - 2019 View substance registered dossier
ARKEMA FRANCE 420 rue d'Estienne d'Orves 92700 COLOMBES France France Active 4,5-di-tert-butyl-6-ethoxy-2,2-dimethyl-3,7-dioxa-4-aza-6-phosphanonan-1-oic acid 6-oxide 449-920-8 - 2010 View substance registered dossier
Pfizer Ireland Pharmaceuticals n/a P43 X336 Ringaskiddy Cork Ireland Ireland Active 4,5-Dihydro-5-methyl-3,4-diphenyl-5-isoxazolol 443-400-4 - 2016 View substance registered dossier
Piramal Healthcare UK Ltd Whalton Road NE61 3YA Morpeth Northumberland United Kingdom United Kingdom No longer Valid 4,5-Dihydro-5-methyl-3,4-diphenyl-5-isoxazolol 443-400-4 - 2021 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active 4,5-Dihydro-5-methyl-3,4-diphenyl-5-isoxazolol 443-400-4 - - View substance registered dossier
Fujifilm Imaging Colorants Limited Patricia Way Pysons Road Industrial Estate CT10 2LE Broadstairs Kent United Kingdom United Kingdom No longer Valid 4,5-dihydro-5-oxo-1-(4-sulfophenyl)-4-(4-{2-[1,2,7,8-tetrahydro-7-(4-nitro-2-sulfophenylhydrazono)-1,8-dioxo-3,6-disulfo-2-naphthylidene]hydrazino}-3-sulfophenylhydrazono)pyrazole-3-carboxylic acid, lithium sodium salt 445-080-1 - 2021 View substance registered dossier
Fujifilm Europe GmbH (OR1) Balcke-Dürr-Allee 6 40882 Ratingen Germany Germany Active 4,5-dihydro-5-oxo-1-(4-sulfophenyl)-4-(4-{2-[1,2,7,8-tetrahydro-7-(4-nitro-2-sulfophenylhydrazono)-1,8-dioxo-3,6-disulfo-2-naphthylidene]hydrazino}-3-sulfophenylhydrazono)pyrazole-3-carboxylic acid, lithium sodium salt 445-080-1 - 2021 View substance registered dossier
ELIX Polymers, S.L. Poligono Industrial s/n Ctra. de Vilaseca - La Pineda 43006 Tarragona Spain Spain Active 4,7-methanooctahydro-1H-indene-diyldimethyl bis(2-carboxybenzoate) 407-410-2 - 2016 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant German competent national authority. - - Active 4,7-methanooctahydro-1H-indene-diyldimethyl bis(2-carboxybenzoate) 407-410-2 - - View substance registered dossier
INEOS Styrolution Köln GmbH Alte Str. 201 50769 Köln NRW Germany Germany Active 4,7-methanooctahydro-1H-indene-diyldimethyl bis(2-carboxybenzoate) 407-410-2 - 2011 View substance registered dossier
[Confidential] - - - 4-(1-((3-((2-(tert-butoxycarbonyl(methyl)amino)acetoxy)methyl)pyridin-2-yl)(methyl)carbamoyloxy)ethyl)-1-((2R,3S)-3-(4-(4-cyanophenyl)thiazol-2-yl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-1H-1,2,4-triazol-4-ium)hemisulphate 926-418-1 - - View substance registered dossier
MITSUBISHI GAS CHEMICAL EUROPE GMBH Immermannstr.13 40210 Duesseldorf Germany Germany Active 4-(2-methylpropyl)benzaldehyde 464-400-0 - 2014 View substance registered dossier
MITSUBISHI GAS CHEMICAL EUROPE GMBH Immermannstr. 13 40210 Duesseldorf Germany Germany Active 4-(2-methylpropyl)benzaldehyde 464-400-0 - 2014 View substance registered dossier
- - - - 4-(4'-Trifluoromethylphenyl)benzaldehyde 473-430-3 - - View substance registered dossier
Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany Germany Active 4-(4-Brom-5-ethyl-tetrahydropyran-2-yl)-phenol 919-822-4 - - View substance registered dossier
Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany Germany Active 4-(4-Brom-5-propyl-tetrahydropyran-2-yl)-phenol 917-991-9 - - View substance registered dossier
All'Chem rue Marceau 03108 MONTLUCON CEDEX France France Active 4-(4-chloro-3-nitro-phenyl)-3-methyl-4-oxo-butanoic acid 918-019-6 - - View substance registered dossier
Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany Germany Active 4-(4-trans-vinyl-[1,1'-bicyclohexyl]-4'-trans-yl)-1,2-difluorobenzene 430-860-6 - 2019 View substance registered dossier
Syngenta Hellas Single Member S.A.C.I. Anthousas Avenue 153 49 Anthousa-Attiki Greece Greece Active 4-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl)-N-(2-ethyl-3-oxo-1,2-oxazolidin-4-yl)-2-methylbenzamide 954-921-6 - 2021 View substance registered dossier
Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany Germany Active 4-(5-Ethyl-tetrahydropyran-2-yl)-phenol 921-114-5 - 2020 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Irish competent national authority. - - Active 4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide 448-010-8 - - View substance registered dossier
Piramal Healthcare UK Ltd Whalton Road NE61 3YA Morpeth Northumberland United Kingdom United Kingdom No longer Valid 4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide 448-010-8 - 2021 View substance registered dossier
Pfizer Ireland Pharmaceuticals n/a P43 X336 Ringaskiddy Cork Ireland Ireland Active 4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide 448-010-8 - 2016 View substance registered dossier
Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany Germany Active 4-(5-Propyl-tetrahydropyran-2-yl)-phenol 919-949-5 - 2021 View substance registered dossier

In this table, you will find all public data submitted to ECHA in REACH registration dossiers by substance manufacturers, importers, or their representatives, as laid out by the REACH Regulation (see Understanding REACH regulation).

ECHA makes available this information as REACH registered substance factsheets, which contain the full set of non-confidential information from related registration dossiers for a substance. Depending on the number of registrations that have been made for a substance, one factsheet can thus represent data from anything between hundreds of registration dossiers in a joint submission, to data from just one registration dossier.

As noted in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission. Please also note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).

In the portal results table are presented:

  • Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
  • Registration status – indicating the calculated registration status for the whole factsheet: Active – is being manufactured or imported to the EEA by one or more registrants; Cease Manufacture - is no longer being manufactured or imported above 1 tone per calendar year. All registrants of the substance have reported a cease of manufacture or import; or No longer valid - no longer considered registered under REACH and not currently allowed to be manufactured or imported to the EEA, until the substance is registered again.
  • Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
  • Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
  • Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
  • Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
  • Link to the full factsheet.

A subset of the key chemical properties (physico-chemical, environmental fate, ecotoxicological and toxicological data) of registered substances can be searched and accessed via the OECD eChemPortal.

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