Registered substances

Registered substances

Registered substances

Please note:

As of end June 2022 we have processed and published all dossiers that had been pending since 14 October 2021. While daily processing has resumed there remains a processing queue. New submissions will be at the back of the processing queue, and may be slightly delayed before publication. We appreciate your understanding in this matter.

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REACH - Registration, Evaluation, Authorisation and Restriction of Chemicals Regulation

Registered Substances Factsheets

Substances which have been registered and can be placed on the EEA market by those companies with a valid registration



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Details
(S)-2-(5-Methylheteromonocycle-2-carboxamido)-alkenoic acid
- - Active Intermediate Joint Intermediate use only 09-10-2013 View substance registered dossier
(S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(1-trityl-1H-imidazol-4-yl)propionic acid
FMOC AMINO ACID 4
439-640-4 109425-51-6 Active NONS Joint Tonnage data confidential 17-08-2010 View substance registered dossier
(S)-2-acetamido-N-benzyl-3-methoxypropanamide
806-591-9 175481-37-5 Active Full Joint ≥ 10 to < 100 tonnes 09-02-2021 View substance registered dossier
(S)-2-amino-3-(3,4-dimethoxyphenyl)-2-methylpropiononitrile monohydrochloride
219-823-3 2544-13-0 Cease Manufacture Intermediate Joint Cease manufacture 03-12-2013 View substance registered dossier
(S)-2-amino-5-methoxytetralin hydrochloride
611-645-8 58349-17-0 Active Intermediate Joint Intermediate use only 02-03-2018 View substance registered dossier
(S)-2-Amino-butylacetamide
615-935-5 7324-11-0 Active Intermediate Joint Intermediate use only 15-10-2019 View substance registered dossier
(S)-2-chloropropionic acid
L-2-CHLOROPROPIONIC ACID; L-2-CHLORPROPIONSÄURE
411-150-5 29617-66-1 Active Intermediate Joint Intermediate use only 24-03-2021 View substance registered dossier
(S)-2-methyl-3,4,5,6-tetrahydropyrimidine-4-carboxylic acid
ECTOIN
431-910-1 96702-03-3 Active NONS Joint Tonnage data confidential 20-07-2022 View substance registered dossier
(S)-2-methyl-5-(1-methylvinyl)cyclohex-2-en-1-one 218-827-2 2244-16-8 Active Full Joint ≥ 0 to < 10 tonnes 28-05-2018 View substance registered dossier
(S)-2-methylpyrrolidine-2-carboxylic acid hydrochloride
820-170-7 1508261-86-6 Active Intermediate Joint Intermediate use only 11-05-2022 View substance registered dossier
(S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoic acid
871-918-4 666832-71-9 Active Intermediate Joint Intermediate use only 23-09-2021 View substance registered dossier
(S)-3,7-dimethyloct-6-enal
227-707-9 5949-05-3 Active Intermediate Joint Intermediate use only 16-12-2021 View substance registered dossier
(S)-3-(acetylthio)-2-methylpropionic acid
278-480-8 76497-39-7 Active Intermediate Joint Intermediate use only 08-10-2021 View substance registered dossier
(S)-3-(benzoylthio)-2-methylpropionic acid
276-764-6 72679-02-8 Active Intermediate Joint Intermediate use only 18-11-2021 View substance registered dossier
(S)-3-(tert-butylamino)propane-1,2-diol
250-125-1 30315-46-9 Active Intermediate Joint Intermediate use only 21-12-2016 View substance registered dossier
(S)-3-(tert-butylamino)propane-1,2-diol
250-125-1 30315-46-9 Cease Manufacture Full Joint Cease manufacture 27-08-2020 View substance registered dossier
(S)-3-[5-(4-Fluorophenyl)-1,5-dioxopentyl]-4-phenyloxazolidin-2-one
480-320-9 - Active Full Joint ≥ 0 tonnes 06-02-2009 View substance registered dossier
(S)-3-[5-(4-Fluorophenyl)-1,5-dioxopentyl]-4-phenyloxazolidin-2-one
480-320-9 - Active Intermediate Joint Intermediate use only 10-07-2019 View substance registered dossier
(S)-3-benzyloxycarbonyl-1,2,3,4-tetrahydro-isoquinolinium 4-methylbenzenesulfonate
BENZYL THIQ TOSYLATE; PD 114683-10; TIC-B
406-960-0 77497-97-3 Active NONS Joint Tonnage data confidential 14-11-2011 View substance registered dossier
(S)-3-benzyloxycarbonyl-1,2,3,4-tetrahydro-isoquinolinium 4-methylbenzenesulfonate
BENZYL THIQ TOSYLATE; PD 114683-10; TIC-B
406-960-0 77497-97-3 Active Intermediate Joint Intermediate use only 07-01-2020 View substance registered dossier
(S)-3-methyl-2-(2-oxotetrahydropyrimidine-1-yl)butyric acid
430-900-2 192725-50-1 Active Intermediate Joint Intermediate use only 14-06-2018 View substance registered dossier
(S)-4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-one
S EDIN; S TETRALONE
444-830-5 124379-29-9 Active Intermediate Joint Intermediate use only 31-03-2020 View substance registered dossier
(S)-4-[4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-hydroxymethylbenzonitrile hemi(+)-di-toluoyltartrate
603-261-4 128173-53-5 Active Intermediate Joint Intermediate use only 11-05-2018 View substance registered dossier
(S)-4-methyloxazolidine-2,5-dione
218-750-4 2224-52-4 Active Intermediate Joint Intermediate use only 13-04-2018 View substance registered dossier
(S)-5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-ium benzenesulfonate
848-452-5 2097130-30-6 Active Full Joint ≥ 1 to < 10 tonnes 28-02-2021 View substance registered dossier
Registrant/Supplier Address Country Registration Status Name EC / List no. CAS no. Last update year Details
[Confidential] - - - (S)-2-(5-Methylheteromonocycle-2-carboxamido)-alkenoic acid - - - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant German competent national authority. - - Active (S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(1-trityl-1H-imidazol-4-yl)propionic acid 439-640-4 109425-51-6 - View substance registered dossier
Roche Pharma AG (1) Emil-Barell-Strasse 1 79639 Grenzach-Wyhlen Germany Germany Cease Manufacture (S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(1-trityl-1H-imidazol-4-yl)propionic acid 439-640-4 109425-51-6 2019 View substance registered dossier
FINORGA - MOURENX avenue du lac 64150 MOURENX France France Active (S)-2-acetamido-N-benzyl-3-methoxypropanamide 806-591-9 175481-37-5 - View substance registered dossier
UCB Pharma S.A.(Belgium) Allée de la recherche, 60 1070 Brussels Belgium Belgium Active (S)-2-acetamido-N-benzyl-3-methoxypropanamide 806-591-9 175481-37-5 2019; 2021 View substance registered dossier
Sicor - Società Italiana Corticosteroidi S.r.l. Piazzale Luigi Cadorna 4 20123 Milano (MI) Italy Italy Cease Manufacture (S)-2-amino-3-(3,4-dimethoxyphenyl)-2-methylpropiononitrile monohydrochloride 219-823-3 2544-13-0 2022 View substance registered dossier
Cambrex Karlskoga AB Bjorkborns Industriomrade 69185 Karlskoga Sweden Sweden Active (S)-2-amino-5-methoxytetralin hydrochloride 611-645-8 58349-17-0 - View substance registered dossier
N.V. Ajinomoto OmniChem S.A. Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium Belgium Active (S)-2-Amino-butylacetamide 615-935-5 7324-11-0 2019 View substance registered dossier
Sterling Pharma Solutions Ltd Dudley NE23 7QG Cramlington Northumberland United Kingdom United Kingdom No longer Valid (S)-2-Amino-butylacetamide 615-935-5 7324-11-0 2021 View substance registered dossier
Nufarm GmbH & Co.KG OR St.-Peter-Str.25 4021 Linz Austria Austria Active (S)-2-chloropropionic acid 411-150-5 29617-66-1 2010; 2011; 2018; 2021 View substance registered dossier
CIECH Sarzyna Spółka Akcyjna ul. Chemikow 1 37-310 Nowa Sarzyna Podkarpackie Poland Poland Active (S)-2-chloropropionic acid 411-150-5 29617-66-1 - View substance registered dossier
D’Orland GmbH Kutschkergasse 42/16 1180 Vienna Austria Austria Active (S)-2-chloropropionic acid 411-150-5 29617-66-1 - View substance registered dossier
[Confidential] - - - (S)-2-methyl-3,4,5,6-tetrahydropyrimidine-4-carboxylic acid 431-910-1 96702-03-3 - View substance registered dossier
Global Product Compliance (Europe) AB IDEON, Beta 5, Scheelevägen 17 223 63 Lund Sweden Sweden Active (S)-2-methyl-5-(1-methylvinyl)cyclohex-2-en-1-one 218-827-2 2244-16-8 2018 View substance registered dossier
Chr. Olesen ChemPharm GmbH Gustav-Becker-Strasse 20B 21218 Seevetal Germany Germany Active (S)-2-methylpyrrolidine-2-carboxylic acid hydrochloride 820-170-7 1508261-86-6 - View substance registered dossier
Flamma S.p.a. via Bedeschi, 22 24040 Chignolo d'Isola Bergamo Italy Italy Active (S)-2-methylpyrrolidine-2-carboxylic acid hydrochloride 820-170-7 1508261-86-6 - View substance registered dossier
REACH24H CONSULTING GROUP Paramount Court, Corrig Road, Sandyford Dublin18 Dublin Ireland Ireland Active (S)-2-methylpyrrolidine-2-carboxylic acid hydrochloride 820-170-7 1508261-86-6 - View substance registered dossier
Flamma S.p.a.- OR Via Bedeschi, 22 24040 Chignolo D'Isola Italy Italy Active (S)-2-methylpyrrolidine-2-carboxylic acid hydrochloride 820-170-7 1508261-86-6 - View substance registered dossier
Pfizer Ireland Pharmaceuticals n/a P43 X336 Ringaskiddy Cork Ireland Ireland Active (S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoic acid 871-918-4 666832-71-9 - View substance registered dossier
Arran Chemical Company Ltd Monksland Industrial Estate N37DN24 Athlone Co. Roscommon Ireland Ireland Active (S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoic acid 871-918-4 666832-71-9 - View substance registered dossier
TAKASAGO TICSA-Producer/Importer Avenida de Mazarrón, 49 30120 El Palmar Murcia Spain Spain Active (S)-3,7-dimethyloct-6-enal 227-707-9 5949-05-3 2021 View substance registered dossier
FERRANIA CHEMICALS S.R.L. Viale della Libertà, 57 17014 Cairo Montenotte (SV) Italy Italy Active (S)-3-(acetylthio)-2-methylpropionic acid 278-480-8 76497-39-7 - View substance registered dossier
LusoChimica S.p.A. Via Giotto, 9 23871 Lomagna (Lecco) Italy Italy Active (S)-3-(acetylthio)-2-methylpropionic acid 278-480-8 76497-39-7 - View substance registered dossier
FERRANIA CHEMICALS S.R.L. Viale della Libertà, 57 17014 Cairo Montenotte (SV) Italy Italy Active (S)-3-(benzoylthio)-2-methylpropionic acid 276-764-6 72679-02-8 - View substance registered dossier
Lodichem S.r.l. Via delle Rimembranze, 1 26582 Mairano di Casaletto Lodigiano (Lodi) Italy Italy Active (S)-3-(benzoylthio)-2-methylpropionic acid 276-764-6 72679-02-8 - View substance registered dossier
L.C.M. TRADING SPA via Mazzini 33 20099 Sesto San Giovanni Lombardia Italy Italy Active (S)-3-(benzoylthio)-2-methylpropionic acid 276-764-6 72679-02-8 2020 View substance registered dossier
Biesterfeld Spezialchemie GmbH Ferdinandstr. 41 20095 Hamburg Germany Germany Active (S)-3-(tert-butylamino)propane-1,2-diol 250-125-1 30315-46-9 - View substance registered dossier
Sicor - Società Italiana Corticosteroidi S.r.l. Piazzale Luigi Cadorna 4 20123 Milano (MI) Italy Italy Cease Manufacture (S)-3-(tert-butylamino)propane-1,2-diol 250-125-1 30315-46-9 2022 View substance registered dossier
- - - - (S)-3-[5-(4-Fluorophenyl)-1,5-dioxopentyl]-4-phenyloxazolidin-2-one 480-320-9 - - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant German competent national authority. - - Active (S)-3-[5-(4-Fluorophenyl)-1,5-dioxopentyl]-4-phenyloxazolidin-2-one 480-320-9 - - View substance registered dossier
[Confidential] - - - (S)-3-[5-(4-Fluorophenyl)-1,5-dioxopentyl]-4-phenyloxazolidin-2-one 480-320-9 - - View substance registered dossier
Krka, d. d., Novo mesto Smarjeska cesta 6 SI-8501 Novo mesto Slovenia Slovenia Active (S)-3-[5-(4-Fluorophenyl)-1,5-dioxopentyl]-4-phenyloxazolidin-2-one 480-320-9 - - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant German competent national authority. - - Active (S)-3-benzyloxycarbonyl-1,2,3,4-tetrahydro-isoquinolinium 4-methylbenzenesulfonate 406-960-0 77497-97-3 - View substance registered dossier
Pfizer Ireland Pharmaceuticals n/a P43 X3336 Ringaskiddy Cork Ireland Ireland Active (S)-3-benzyloxycarbonyl-1,2,3,4-tetrahydro-isoquinolinium 4-methylbenzenesulfonate 406-960-0 77497-97-3 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active (S)-3-benzyloxycarbonyl-1,2,3,4-tetrahydro-isoquinolinium 4-methylbenzenesulfonate 406-960-0 77497-97-3 - View substance registered dossier
MAPIC Europe NV EXCELSIORLAAN 83 1930 ZAVENTEM Belgium Belgium Cease Manufacture (S)-3-benzyloxycarbonyl-1,2,3,4-tetrahydro-isoquinolinium 4-methylbenzenesulfonate 406-960-0 77497-97-3 2019 View substance registered dossier
Fine Organics Limited Seal Sands TS2 1UB Middlesbrough Teesside United Kingdom United Kingdom No longer Valid (S)-3-benzyloxycarbonyl-1,2,3,4-tetrahydro-isoquinolinium 4-methylbenzenesulfonate 406-960-0 77497-97-3 2021 View substance registered dossier
ROLABO OUTSOURCING, S.L. Polígono Industrial Malpica. Calle J, nº 3-4 50016 Zaragoza Zaragoza Spain Spain Active (S)-3-benzyloxycarbonyl-1,2,3,4-tetrahydro-isoquinolinium 4-methylbenzenesulfonate 406-960-0 77497-97-3 2020 View substance registered dossier
AbbVie Srl S.R. 148 Pontina Km 52 snc 04011 Campoverde di Aprilia (LT) Italy Italy Active (S)-3-methyl-2-(2-oxotetrahydropyrimidine-1-yl)butyric acid 430-900-2 192725-50-1 2011; 2018 View substance registered dossier
MOEHS BCN, S.L. C/ Zenc, 12 08755 Castellbisbal Barcelona Spain Spain Active (S)-4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-one 444-830-5 124379-29-9 - View substance registered dossier
FINORGA SAS 497 route de Givors 38670 CHASSE SUR RHONE France France Active (S)-4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-one 444-830-5 124379-29-9 2010; 2020 View substance registered dossier
Lundbeck Pharmaceuticals Italy S.p.A via quarta strada 2 35129 padova Italy Italy Active (S)-4-[4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-hydroxymethylbenzonitrile hemi(+)-di-toluoyltartrate 603-261-4 128173-53-5 2018 View substance registered dossier
PMC ISOCHEM 32 rue Lavoisier 91710 VERT LE PETIT France France Active (S)-4-methyloxazolidine-2,5-dione 218-750-4 2224-52-4 - View substance registered dossier
Zoetis Belgium S.A. Rue Laid Burniat, 1 1348 Louvain-La-Neuve Belgium Belgium Active (S)-5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-ium benzenesulfonate 848-452-5 2097130-30-6 - View substance registered dossier

In this table, you will find all public data submitted to ECHA in REACH registration dossiers by substance manufacturers, importers, or their representatives, as laid out by the REACH Regulation (see Understanding REACH regulation).

ECHA makes available this information as REACH registered substance factsheets, which contain the full set of non-confidential information from related registration dossiers for a substance. Depending on the number of registrations that have been made for a substance, one factsheet can thus represent data from anything between hundreds of registration dossiers in a joint submission, to data from just one registration dossier.

As noted in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission. Please also note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).

In the portal results table are presented:

  • Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
  • Registration status – indicating the calculated registration status for the whole factsheet: Active – is being manufactured or imported to the EEA by one or more registrants; Cease Manufacture - is no longer being manufactured or imported above 1 tone per calendar year. All registrants of the substance have reported a cease of manufacture or import; or No longer valid - no longer considered registered under REACH and not currently allowed to be manufactured or imported to the EEA, until the substance is registered again.
  • Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
  • Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
  • Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
  • Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
  • Link to the full factsheet.

A subset of the key chemical properties (physico-chemical, environmental fate, ecotoxicological and toxicological data) of registered substances can be searched and accessed via the OECD eChemPortal.

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