Registered substances

Registered substances

Registered substances

Please note:

As of end June 2022 we have processed and published all dossiers that had been pending since 14 October 2021. While daily processing has resumed there remains a processing queue. New submissions will be at the back of the processing queue, and may be slightly delayed before publication. We appreciate your understanding in this matter.

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REACH - Registration, Evaluation, Authorisation and Restriction of Chemicals Regulation

Registered Substances Factsheets

Substances which have been registered and can be placed on the EEA market by those companies with a valid registration



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Details
(1R, 3r, 5S)-3-hydroxyspiro[8-azoniabicyclo[3.2.1]octane-8,1’-pyrrolidinium]chloride
609-015-2 3464-71-9 Active Intermediate Joint Intermediate use only 12-03-2018 View substance registered dossier
(1R,11aS)-1-acetyl-11a-methyl-2,3,3a,3b,4,5,6,8,9,11-decahydrospiro[cyclopenta[a]phenanthrene-7,2'-[1,3]dioxolan]-1-yl acetate
607-316-3 240806-31-9 Active Intermediate Joint Intermediate use only 19-06-2018 View substance registered dossier
(1R,11aS)-1-hydroxy-11a-methyl-2,3,3a,5,6,8,9,11-octahydrospiro[cyclopenta[a]phenanthrene-7,2'-[1,3]dioxolane]-1-carbonitrile
608-856-2 33300-19-5 Active Intermediate Joint Intermediate use only 19-06-2018 View substance registered dossier
(1R,2R)-1,2-Cyclohexanedimethanol
692-053-7 65376-05-8 Active Intermediate Joint Intermediate use only 24-10-2018 View substance registered dossier
(1R,2R)-1,3-Dihydroxy-1-(4-nitrophenyl)propyl-2-ammonium (1R, 5S)-5-(dimethylphenylsilyl)-2-(hydroxymethyl)cyclopent-2-ene-1-carboxylate
445-910-2 649761-22-8 Active Full Joint ≥ 1 to < 10 tonnes 14-10-2016 View substance registered dossier
(1R,2R)-1-Amino-2-(difluoromethyl)-N-(1-methylcyclopropylsulfonyl)cyclopropanecarboxamide hydrochloride
943-460-6 1360828-80-3 Active Intermediate Joint Intermediate use only 16-06-2020 View substance registered dossier
(1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carboxamide
600-115-1 1006376-62-0 Active Intermediate Individual Intermediate use only 29-01-2018 View substance registered dossier
(1R,2R)-cyclohexane-1,2-diamine (2R,3R)-2,3-dihydroxybutanedioic acid
609-759-8 39961-95-0 Active Intermediate Joint Intermediate use only 29-01-2018 View substance registered dossier
(1R,2R,3S,4S)-1-(1,1,3,3-tetraoxido-1,3-dithian-2-yl)pentane-1,2,3,4-tetrol
936-126-6 1352707-53-9 Active Intermediate Joint Intermediate use only 16-02-2018 View substance registered dossier
(1R,2R,3S,4S)-1-(1,3-dithian-2-yl)pentane-1,2,3,4-tetrol
936-125-0 1352707-52-8 Active Intermediate Joint Intermediate use only 16-02-2018 View substance registered dossier
Registrant/Supplier Address Country Registration Status Name EC / List no. CAS no. Last update year Details
PROCOS SpA via Matteotti 249 28062 Cameri Piemonte Italy Italy Active (1R, 3r, 5S)-3-hydroxyspiro[8-azoniabicyclo[3.2.1]octane-8,1’-pyrrolidinium]chloride 609-015-2 3464-71-9 - View substance registered dossier
CURIA SPAIN, S.A.U. Parque Tecnológico de Boecillo, parcela 105 47151 Boecillo Valladolid Spain Spain Active (1R,11aS)-1-acetyl-11a-methyl-2,3,3a,3b,4,5,6,8,9,11-decahydrospiro[cyclopenta[a]phenanthrene-7,2'-[1,3]dioxolan]-1-yl acetate 607-316-3 240806-31-9 2018 View substance registered dossier
CURIA SPAIN, S.A.U. Parque Tecnológico de Boecillo, parcela 105 47151 Boecillo Valladolid Spain Spain Active (1R,11aS)-1-hydroxy-11a-methyl-2,3,3a,5,6,8,9,11-octahydrospiro[cyclopenta[a]phenanthrene-7,2'-[1,3]dioxolane]-1-carbonitrile 608-856-2 33300-19-5 2018 View substance registered dossier
Pliva Hrvatska doo Prilaz baruna Filipovića 25 10000 Zagreb Croatia Croatia Active (1R,2R)-1,2-Cyclohexanedimethanol 692-053-7 65376-05-8 - View substance registered dossier
Hovione FarmaCiencia SA Sete Casas 2674-506 Loures Portugal Portugal Active (1R,2R)-1,3-Dihydroxy-1-(4-nitrophenyl)propyl-2-ammonium (1R, 5S)-5-(dimethylphenylsilyl)-2-(hydroxymethyl)cyclopent-2-ene-1-carboxylate 445-910-2 649761-22-8 2010; 2011; 2012; 2014 View substance registered dossier
Swords Laboratories Unlimited Company Cruiserath Road Mulhuddart D15H6EF Dublin 15 Co Dublin Ireland Ireland Active (1R,2R)-1,3-Dihydroxy-1-(4-nitrophenyl)propyl-2-ammonium (1R, 5S)-5-(dimethylphenylsilyl)-2-(hydroxymethyl)cyclopent-2-ene-1-carboxylate 445-910-2 649761-22-8 2010; 2012; 2014; 2016 View substance registered dossier
AbbVie Srl S.R. 148 Pontina Km 52 snc 04011 Campoverde di Aprilia (LT) Italy Italy Active (1R,2R)-1-Amino-2-(difluoromethyl)-N-(1-methylcyclopropylsulfonyl)cyclopropanecarboxamide hydrochloride 943-460-6 1360828-80-3 2020 View substance registered dossier
AbbVie Ireland NL B.V. Manorhamilton Road none Sligo Ireland Ireland Active (1R,2R)-1-Amino-2-(difluoromethyl)-N-(1-methylcyclopropylsulfonyl)cyclopropanecarboxamide hydrochloride 943-460-6 1360828-80-3 - View substance registered dossier
AbbVie Logistics B.V. Zuiderzeelaan 53 8017 JV Zwolle Netherlands Netherlands Active (1R,2R)-1-Amino-2-(difluoromethyl)-N-(1-methylcyclopropylsulfonyl)cyclopropanecarboxamide hydrochloride 943-460-6 1360828-80-3 - View substance registered dossier
N.V. Ajinomoto OmniChem S.A. Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium Belgium Active (1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carboxamide 600-115-1 1006376-62-0 - View substance registered dossier
Arran Chemical Company Ltd Monksland Industrial Estate N37DN24 Athlone Co. Roscommon Ireland Ireland Active (1R,2R)-cyclohexane-1,2-diamine (2R,3R)-2,3-dihydroxybutanedioic acid 609-759-8 39961-95-0 - View substance registered dossier
DIPHARMA FRANCIS srl Bissone, 5 20021 Baranzate Milano Italy Italy Active (1R,2R,3S,4S)-1-(1,1,3,3-tetraoxido-1,3-dithian-2-yl)pentane-1,2,3,4-tetrol 936-126-6 1352707-53-9 - View substance registered dossier
DIPHARMA FRANCIS srl Bissone, 5 20021 Baranzate Milano Italy Italy Active (1R,2R,3S,4S)-1-(1,3-dithian-2-yl)pentane-1,2,3,4-tetrol 936-125-0 1352707-52-8 - View substance registered dossier

In this table, you will find all public data submitted to ECHA in REACH registration dossiers by substance manufacturers, importers, or their representatives, as laid out by the REACH Regulation (see Understanding REACH regulation).

ECHA makes available this information as REACH registered substance factsheets, which contain the full set of non-confidential information from related registration dossiers for a substance. Depending on the number of registrations that have been made for a substance, one factsheet can thus represent data from anything between hundreds of registration dossiers in a joint submission, to data from just one registration dossier.

As noted in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission. Please also note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).

In the portal results table are presented:

  • Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
  • Registration status – indicating the calculated registration status for the whole factsheet: Active – is being manufactured or imported to the EEA by one or more registrants; Cease Manufacture - is no longer being manufactured or imported above 1 tone per calendar year. All registrants of the substance have reported a cease of manufacture or import; or No longer valid - no longer considered registered under REACH and not currently allowed to be manufactured or imported to the EEA, until the substance is registered again.
  • Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
  • Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
  • Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
  • Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
  • Link to the full factsheet.

A subset of the key chemical properties (physico-chemical, environmental fate, ecotoxicological and toxicological data) of registered substances can be searched and accessed via the OECD eChemPortal.

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