Registered substances

Registered substances

Registered substances

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We have successfully adapted to the latest IUCLID format, and have resumed processing dossiers since 3 March 2022. Over the coming weeks we will catch up with the backlog of submissions since 14 October 2021, and expect to have all outstanding data online in approximately one month’s time. Please be aware that any new submissions will be at the back of the processing queue, and will be correspondingly delayed before publication. We appreciate your understanding in this matter.

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REACH - Registration, Evaluation, Authorisation and Restriction of Chemicals Regulation

Registered Substances Factsheets

Substances which have been registered and can be placed on the EEA market by those companies with a valid registration



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Details
(2S,3S)-di-tert-butyl 3-ethyl-4-oxopyrrolidine-1,2-dicarboxylate
942-044-1 - Active Intermediate Joint Intermediate use only 27-02-2017 View substance registered dossier
(2S,3S,4R)-2-aminooctadecane-1,3,4-triol
439-210-6 554-62-1 Active Full Joint ≥ 1 to < 10 tonnes 01-12-2020 View substance registered dossier
(2S,3S,4R)-2-aminooctadecane-1,3,4-triol
439-210-6 554-62-1 Active NONS Individual Tonnage data confidential 02-09-2011 View substance registered dossier
(2S,3S,4R)-3-ethyl-4-hydroxy-2-(methoxycarbonyl)pyrrolidinium 4-methylbenzenesulfonate
813-641-3 1799733-43-9 Active Intermediate Joint Intermediate use only 18-04-2018 View substance registered dossier
(2S,3S,5S)-5-amino-2-(dibenzylamino)-1,6-diphenylhexan-3-ol succinate
938-481-2 - Active Intermediate Joint Intermediate use only 31-10-2018 View substance registered dossier
(2S,4aR)-1,1,5,5-tetramethyl-1,3,4,5,6,7-hexahydro-2H-2,4a-methanonaphthalen-7-ol
942-036-8 645413-57-6 Active Intermediate Joint Intermediate use only 01-07-2020 View substance registered dossier
(2S,4Z)-5-amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one;5-amino-[2S-di(methylphenyl)amino]-1,6-diphenyl-4Z-hexen-3-one
423-090-7 156732-13-7 Active Intermediate Joint Intermediate use only 12-06-2018 View substance registered dossier
(2S,4Z)-5-amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one;5-amino-[2S-di(methylphenyl)amino]-1,6-diphenyl-4Z-hexen-3-one
423-090-7 156732-13-7 Active NONS Joint Tonnage data confidential 10-11-2008 View substance registered dossier
(2S,5R)-6,6-dibromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide
427-200-4 76646-91-8 Active NONS Joint Tonnage data confidential 15-12-2008 View substance registered dossier
(2S,5S,32S)-5-{[(5S,8S,11S,14S,17S)-11-[(2R)-BUTAN-2-YL]-8-{4-[(TERT-BUTOXYCARBONYL)AMINO]BUTYL}-5-(2-TERT-BUTOXY-2-OXOETHYL)-1-(9H-FLUOREN-9-YL)-14-METHYL-3,6,9,12,15,18-HEXAOXO-17-{3-OXO-3-[(TRIPHENYLMETHYL)AMINO]PROPYL}-2-OXA-4,7,10,13,16-PENTAAZAOCTADECAN-18-YL]AMINO}-32-(TERT-BUTOXYCARBONYL)-2,55,55-TRIMETHYL-4,11,20,29,34,53-HEXAOXO-13,16,22,25,54-PENTAOXA-3,10,19,28,33-PENTAAZAHEXAPENTACONTAN-1-OIC ACID
954-943-6 - Active Intermediate Individual Intermediate use only 02-09-2021 View substance registered dossier
(2S-cis)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
255-799-0 42399-49-5 Active Intermediate Joint Intermediate use only 19-10-2018 View substance registered dossier
(2S-cis)-2-(diphenylmethyl)-N-(phenylmethyl)-1-azabicyclo[2.2.2]octan-3-amine7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonic acid
444-810-6 - Active Full Joint ≥ 10 to < 100 tonnes 11-05-2021 View substance registered dossier
(2S-cis)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
255-795-9 42399-40-6 Active Intermediate Joint Intermediate use only 09-04-2018 View substance registered dossier
(2S-trans)-3-amino-2-methyl-4-oxoazetidine-1-sulphonic acid
279-393-8 80082-65-1 Active Intermediate Joint Intermediate use only 23-02-2018 View substance registered dossier
(2Z)-2-phenylhex-2-enenitrile
482-160-5 130786-09-3 Active Full Joint ≥ 10 to < 100 tonnes 27-08-2020 View substance registered dossier
(2Z)-2-phenylhex-2-enenitrile
482-160-5 130786-09-3 Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
(2Z)-4,8-dimethylnona-2,7-dien-4-ol
807-754-7 89929-57-7 Active Full Joint ≥ 1 to < 10 tonnes 27-05-2019 View substance registered dossier
(2Z)-7-chloro-2-({[(1S)-2,2-dimethylcyclopropyl]carbonyl}amino)hept-2-enoic acid
618-065-4 877674-77-6 Active Intermediate Joint Intermediate use only 13-09-2017 View substance registered dossier
(2α,4aα,8α)-hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalen-8(5H)-one
249-649-3 29461-14-1 Active Full Joint ≥ 0 to < 10 tonnes 07-11-2017 View substance registered dossier
(2α,4aα,8β)-hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalen-8(5H)-one
249-648-8 29461-13-0 Cease Manufacture Full Joint Cease manufacture 24-12-2019 View substance registered dossier
Registrant/Supplier Address Country Registration Status Name EC / List no. CAS no. Last update year Details
OLON Spa Strada Rivoltana Km 6/7 20053 RODANO Milano Italy Italy Active (2S,3S)-di-tert-butyl 3-ethyl-4-oxopyrrolidine-1,2-dicarboxylate 942-044-1 - 2017 View substance registered dossier
[Confidential] - - - (2S,3S,4R)-2-aminooctadecane-1,3,4-triol 439-210-6 554-62-1 - View substance registered dossier
SCC Scientific Consulting Company GmbH Am Grenzgraben 11 55545 Bad Kreuznach Germany Germany Active (2S,3S,4R)-2-aminooctadecane-1,3,4-triol 439-210-6 554-62-1 - View substance registered dossier
N.V. Ajinomoto OmniChem S.A. Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium Belgium Active (2S,3S,4R)-2-aminooctadecane-1,3,4-triol 439-210-6 554-62-1 2011 View substance registered dossier
Gilead Sciences Ireland UC IDA Business &Technology Park Carrigtohill Cork Cork Ireland Ireland Active (2S,3S,4R)-3-ethyl-4-hydroxy-2-(methoxycarbonyl)pyrrolidinium 4-methylbenzenesulfonate 813-641-3 1799733-43-9 - View substance registered dossier
AbbVie Srl S.R. 148 Pontina Km 52 snc 04011 Campoverde di Aprilia (LT) Italy Italy Active (2S,3S,5S)-5-amino-2-(dibenzylamino)-1,6-diphenylhexan-3-ol succinate 938-481-2 - - View substance registered dossier
Symrise AG Mühlenfeldstraße 1 37603 Holzminden Germany Germany Active (2S,4aR)-1,1,5,5-tetramethyl-1,3,4,5,6,7-hexahydro-2H-2,4a-methanonaphthalen-7-ol 942-036-8 645413-57-6 2020 View substance registered dossier
AbbVie Srl S.R. 148 Pontina Km 52 snc 04011 Campoverde di Aprilia (LT) Italy Italy Active (2S,4Z)-5-amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one;5-amino-[2S-di(methylphenyl)amino]-1,6-diphenyl-4Z-hexen-3-one 423-090-7 156732-13-7 2011; 2018 View substance registered dossier
ITELYUM Purification S.P.A. Via S. Intini n. 2 27015 Landriano (PV) Italy Italy Active (2S,4Z)-5-amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one;5-amino-[2S-di(methylphenyl)amino]-1,6-diphenyl-4Z-hexen-3-one 423-090-7 156732-13-7 2014 View substance registered dossier
POLPHARMA 19 Pelplińska 83-200 Starogard Gdański Poland Poland Active (2S,4Z)-5-amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one;5-amino-[2S-di(methylphenyl)amino]-1,6-diphenyl-4Z-hexen-3-one 423-090-7 156732-13-7 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Italian competent national authority. - - Active (2S,4Z)-5-amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one;5-amino-[2S-di(methylphenyl)amino]-1,6-diphenyl-4Z-hexen-3-one 423-090-7 156732-13-7 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant German competent national authority. - - Active (2S,4Z)-5-amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one;5-amino-[2S-di(methylphenyl)amino]-1,6-diphenyl-4Z-hexen-3-one 423-090-7 156732-13-7 - View substance registered dossier
Curia Italy S.r.l. VIA DEL VECCHIO POLITECNICO, n. 9 20121 Milano Italy Italy Active (2S,4Z)-5-amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one;5-amino-[2S-di(methylphenyl)amino]-1,6-diphenyl-4Z-hexen-3-one 423-090-7 156732-13-7 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Irish competent national authority. - - Active (2S,5R)-6,6-dibromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide 427-200-4 76646-91-8 - View substance registered dossier
Pfizer Ireland Pharmaceuticals n/a P43 X3336 Ringaskiddy Cork Ireland Ireland Active (2S,5R)-6,6-dibromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide 427-200-4 76646-91-8 - View substance registered dossier
ACS DOBFAR S.p.A Viale Addetta 4/12 20067 Tribiano Milano Italy Italy Active (2S,5R)-6,6-dibromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide 427-200-4 76646-91-8 - View substance registered dossier
[Confidential] - - - (2S,5S,32S)-5-{[(5S,8S,11S,14S,17S)-11-[(2R)-BUTAN-2-YL]-8-{4-[(TERT-BUTOXYCARBONYL)AMINO]BUTYL}-5-(2-TERT-BUTOXY-2-OXOETHYL)-1-(9H-FLUOREN-9-YL)-14-METHYL-3,6,9,12,15,18-HEXAOXO-17-{3-OXO-3-[(TRIPHENYLMETHYL)AMINO]PROPYL}-2-OXA-4,7,10,13,16-PENTAAZAOCTADECAN-18-YL]AMINO}-32-(TERT-BUTOXYCARBONYL)-2,55,55-TRIMETHYL-4,11,20,29,34,53-HEXAOXO-13,16,22,25,54-PENTAOXA-3,10,19,28,33-PENTAAZAHEXAPENTACONTAN-1-OIC ACID 954-943-6 - - View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active (2S-cis)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one 255-799-0 42399-49-5 2018 View substance registered dossier
Cambrex Profarmaco Milano Srl via Curiel, 34 20067 Paullo MI Italy Italy Active (2S-cis)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one 255-799-0 42399-49-5 - View substance registered dossier
LusoChimica S.p.A. Via Giotto, 9 23871 Lomagna (Lecco) Italy Italy Active (2S-cis)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one 255-799-0 42399-49-5 - View substance registered dossier
Fermion Oy Koivu-Mankkaan tie 6 A FI-02101 Espoo Finland Finland Active (2S-cis)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one 255-799-0 42399-49-5 2018 View substance registered dossier
INTEROR 49, rue d'Ostende F-62100 CALAIS France France Active (2S-cis)-2-(diphenylmethyl)-N-(phenylmethyl)-1-azabicyclo[2.2.2]octan-3-amine7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonic acid 444-810-6 - 2014; 2021 View substance registered dossier
Zoetis Belgium S.A. Rue Laid Burniat, 1 1348 Louvain-La-Neuve Belgium Belgium Active (2S-cis)-2-(diphenylmethyl)-N-(phenylmethyl)-1-azabicyclo[2.2.2]octan-3-amine7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonic acid 444-810-6 - - View substance registered dossier
FINORGA - MOURENX avenue du lac 64150 MOURENX France France Active (2S-cis)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one 255-795-9 42399-40-6 - View substance registered dossier
Corden Pharma Latina S.p.A. Via del Murillo Km 2, 800 IT04013 Sermoneta (LT) Lazio Italy Italy Active (2S-trans)-3-amino-2-methyl-4-oxoazetidine-1-sulphonic acid 279-393-8 80082-65-1 - View substance registered dossier
Curia Italy S.r.l. VIA DEL VECCHIO POLITECNICO, n. 9 20121 Milano Italy Italy Active (2S-trans)-3-amino-2-methyl-4-oxoazetidine-1-sulphonic acid 279-393-8 80082-65-1 - View substance registered dossier
FIRMENICH GRASSE SAS OR 1 Parc Industriel Les Bois de Grasse 06130 Grasse France France Active (2Z)-2-phenylhex-2-enenitrile 482-160-5 130786-09-3 2020 View substance registered dossier
FIRMENICH GRASSE SAS OR 2 Parc Industriel Les Bois de Grasse 06130 Grasse France France Active (2Z)-2-phenylhex-2-enenitrile 482-160-5 130786-09-3 2020 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active (2Z)-2-phenylhex-2-enenitrile 482-160-5 130786-09-3 - View substance registered dossier
FIRMENICH GRASSE SAS OR 1 Parc Industriel Les Bois de Grasse 06130 Grasse France France Active (2Z)-4,8-dimethylnona-2,7-dien-4-ol 807-754-7 89929-57-7 - View substance registered dossier
ACS DOBFAR S.p.A Viale Addetta 4/12 20067 Tribiano Milano Italy Italy Active (2Z)-7-chloro-2-({[(1S)-2,2-dimethylcyclopropyl]carbonyl}amino)hept-2-enoic acid 618-065-4 877674-77-6 - View substance registered dossier
Symrise AG Mühlenfeldstraße 1 37603 Holzminden Germany Germany Active (2α,4aα,8α)-hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalen-8(5H)-one 249-649-3 29461-14-1 2017 View substance registered dossier
Global Product Compliance (Europe) AB IDEON, Beta 5, Scheelevägen 17 22363 Lund Sweden Sweden Cease Manufacture (2α,4aα,8β)-hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalen-8(5H)-one 249-648-8 29461-13-0 2020 View substance registered dossier

In this table, you will find all public data submitted to ECHA in REACH registration dossiers by substance manufacturers, importers, or their representatives, as laid out by the REACH Regulation (see Understanding REACH regulation).

ECHA makes available this information as REACH registered substance factsheets, which contain the full set of non-confidential information from related registration dossiers for a substance. Depending on the number of registrations that have been made for a substance, one factsheet can thus represent data from anything between hundreds of registration dossiers in a joint submission, to data from just one registration dossier.

As noted in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission. Please also note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).

In the portal results table are presented:

  • Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
  • Registration status – indicating the calculated registration status: Active - being actively manufactured or imported to the EEA; Cease manufacture - is no longer being manufactured or imported, but still considered to have a valid registration under REACH, and capable of resuming manufacture or import at any time; or No longer valid - no longer considered registered under REACH and not currently permitted to be manufactured or imported to the EEA unless and until properly registered again.
  • Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
  • Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
  • Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
  • Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
  • Link to the full factsheet.

A subset of the key chemical properties (physico-chemical, environmental fate, ecotoxicological and toxicological data) of registered substances can be searched and accessed via the OECD eChemPortal.

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