Registered substances

Registered substances

Registered substances

Please note:

We have successfully adapted to the latest IUCLID format, and have resumed processing dossiers since 3 March 2022. Over the coming weeks we will catch up with the backlog of submissions since 14 October 2021, and expect to have all outstanding data online in approximately one month’s time. Please be aware that any new submissions will be at the back of the processing queue, and will be correspondingly delayed before publication. We appreciate your understanding in this matter.

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REACH - Registration, Evaluation, Authorisation and Restriction of Chemicals Regulation

Registered Substances Factsheets

Substances which have been registered and can be placed on the EEA market by those companies with a valid registration



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Details
1-Pyrrolidinecarboxylic acid, 2-[5-[4'-[2-[(2S)-1-[(1,1-dimethylethoxy)carbonyl]-2-pyrrolidinyl]-1H-imidazol-5-yl][1,1'-biphenyl]-4-yl]-1H-pyrazol-3-yl]-, 1,1-dimethylethyl ester, (2S)-
941-432-8 1085706-46-2 Active Intermediate Individual Intermediate use only 26-09-2014 View substance registered dossier
1-Pyrrolidinehexanoic acid, 2,5-dioxo-3-(pentapropenyl)-, sodium salt, compd. with 2,2',2''-nitrilotris[ethanol] (1:?:?)
800-766-3 1424148-97-9 Cease Manufacture Full Individual Cease manufacture 14-12-2016 View substance registered dossier
1-Pyrrolidinepropanoic acid, 2-carboxy-.alpha.-(1,1-dimethylethyl)-4-hydroxy-.beta.-oxo-, 1-(1,1-dimethylethyl) ester, (.alpha.S,2S,4R)-, compd. with tetrahydrofuran (1:1)
941-817-0 1690340-81-8 Active Intermediate Individual Intermediate use only 10-02-2015 View substance registered dossier
1-tert-butoxycarbonylpiperidine-4-carboxylic acid
700-076-1 84358-13-4 Active Intermediate Individual Intermediate use only 27-10-2020 View substance registered dossier
1-Tetradecanaminium, N,N,N-trimethyl-, methyl carbonate (1:1)
807-015-9 126437-91-0 Active Intermediate Individual Intermediate use only 01-06-2016 View substance registered dossier
1-tetradecanoylbenzotriazole
MYRISTINBENZOTRIAZOL
437-790-5 85642-15-5 Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
1-{benzyl[2-(2-methoxyphenoxy)ethyl]amino}-3-(9H-carbazol-4-yloxy)propan-2-ol
BM 96.0254
432-890-5 72955-94-3 Cease Manufacture NONS Individual Cease manufacture 27-08-2010 View substance registered dossier
10,11-dihydro-5H-dibenz[b,f]azepine
207-787-1 494-19-9 Active Intermediate Individual Intermediate use only 29-07-2010 View substance registered dossier
10-[3-(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine
201-578-9 84-97-9 Active Intermediate Individual Intermediate use only 23-05-2018 View substance registered dossier
10-hydroxy-1-(2-hydroxy-3,4-dimethoxy-6-methylphenyl) decan-1-one
700-045-2 104966-97-4 Active Intermediate Individual Intermediate use only 15-04-2011 View substance registered dossier
10-Undecenoic acid, trimethylsilyl ester
607-358-2 24338-09-8 Active Intermediate Individual Intermediate use only 04-11-2013 View substance registered dossier
10-undecenyl 2-cyano-3,3-diphenylpropenoate
700-604-0 947701-81-7 Active Full Individual ≥ 1 to < 10 tonnes 16-05-2012 View substance registered dossier
10H-Pyrido[3,2-b][1,4]benzothiazine-10-propanamine, N,N-dimethyl-
608-469-9 303-69-5 Active Intermediate Individual Intermediate use only 04-02-2015 View substance registered dossier
11-piperazin-1-yldibenzo[b,f][1,4]thiazepine dihydrochloride
700-276-9 111974-74-4 Active Intermediate Individual Intermediate use only 26-02-2010 View substance registered dossier
11-piperazin-1-yldibenzo[b,f][1,4]thiazepine dihydrochloride
700-276-9 111974-74-4 Active Intermediate Individual Intermediate use only 07-04-2010 View substance registered dossier
11a-Chloro-6-demethyl-6-deoxytetracycline hydrochloride
917-355-0 - Active Intermediate Individual Intermediate use only 21-05-2018 View substance registered dossier
11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one, 8-chloro-5,6-dihydro-
700-257-5 31251-41-9 Active Intermediate Individual Intermediate use only 27-01-2011 View substance registered dossier
11H-Dibenzo[b,e][1,4]diazepin-11-one, 8-chloro-5,10-dihydro-
700-018-5 50892-62-1 Active Intermediate Individual Intermediate use only 05-11-2010 View substance registered dossier
12-Oxa-3,6,9-triazatridecanoic acid, 10-carboxy-3,6,9-tris(carboxymethyl)-13-phenyl-
426-360-2 113786-33-7 Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
1265F
416-480-3 - Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
13-β-ethyl-3-methoxygona-2,5(10)-dien-17-one
219-034-4 2322-77-2 Active Full Individual ≥ 1 to < 10 tonnes 29-07-2021 View substance registered dossier
14,14',15,15'-tetradehydro-7,7'-spirobi[dibenzo[b,g][1,9,4,6]dioxadiazacyclododecine]
700-609-8 1231148-36-9 Active Full Individual ≥ 1 to < 10 tonnes 29-01-2013 View substance registered dossier
14-α-hydroxyandrost-4-ene-3,17-dione
VAD
427-340-6 564-63-6 Active Intermediate Individual Intermediate use only 12-11-2010 View substance registered dossier
15CPT TOLUENE SOLVATE
443-550-0 - Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
17,17-(2,2-Dimethyltrimethylenedioxy)androst-5-en-3 beta-ol
617-864-5 864672-26-4 Active Intermediate Individual Intermediate use only 27-08-2018 View substance registered dossier
Registrant/Supplier Address Country Registration Status Name EC / List no. CAS no. Last update year Details
Swords Laboratories Unlimited Company Cruiserath Road Mulhuddart D15H6EF Dublin 15 Co Dublin Ireland Ireland Active 1-Pyrrolidinecarboxylic acid, 2-[5-[4'-[2-[(2S)-1-[(1,1-dimethylethoxy)carbonyl]-2-pyrrolidinyl]-1H-imidazol-5-yl][1,1'-biphenyl]-4-yl]-1H-pyrazol-3-yl]-, 1,1-dimethylethyl ester, (2S)- 941-432-8 1085706-46-2 - View substance registered dossier
Clariant Ibérica Producción S.A. Avda. Baix Llobregat, 3-5 08970 Sant Joan Despí Barcelona Spain Spain Cease Manufacture 1-Pyrrolidinehexanoic acid, 2,5-dioxo-3-(pentapropenyl)-, sodium salt, compd. with 2,2',2''-nitrilotris[ethanol] (1:?:?) 800-766-3 1424148-97-9 2017 View substance registered dossier
[Confidential] - - - 1-Pyrrolidinepropanoic acid, 2-carboxy-.alpha.-(1,1-dimethylethyl)-4-hydroxy-.beta.-oxo-, 1-(1,1-dimethylethyl) ester, (.alpha.S,2S,4R)-, compd. with tetrahydrofuran (1:1) 941-817-0 1690340-81-8 - View substance registered dossier
Siegfried St. Vulbas SAS 530, allée de la Luye 01150 SAINT VULBAS France France Active 1-tert-butoxycarbonylpiperidine-4-carboxylic acid 700-076-1 84358-13-4 - View substance registered dossier
Clariant Produkte (Deutschland) GmbH Am Unisys-Park 1 65843 Sulzbach am Taunus Germany Germany Active 1-Tetradecanaminium, N,N,N-trimethyl-, methyl carbonate (1:1) 807-015-9 126437-91-0 - View substance registered dossier
- - - - 1-tetradecanoylbenzotriazole 437-790-5 85642-15-5 - View substance registered dossier
Roche Diagnostics GmbH Sandhoferstrasse 116 68305 Mannheim Germany Germany Cease Manufacture 1-{benzyl[2-(2-methoxyphenoxy)ethyl]amino}-3-(9H-carbazol-4-yloxy)propan-2-ol 432-890-5 72955-94-3 2019 View substance registered dossier
Novartis Integrated Services Limited Ringaskiddy P43 FR63 Ringaskiddy Co. Cork Ireland Ireland Active 10,11-dihydro-5H-dibenz[b,f]azepine 207-787-1 494-19-9 - View substance registered dossier
Trifarma S.p.A. Via G. Guarini Matteucci 1 20162 Milan (MI) Italy Italy Active 10-[3-(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine 201-578-9 84-97-9 - View substance registered dossier
Industriale Chimica s.r.l. via E.H. Grieg, 13 21074 Saronno (VA) Italy Italy Active 10-hydroxy-1-(2-hydroxy-3,4-dimethoxy-6-methylphenyl) decan-1-one 700-045-2 104966-97-4 - View substance registered dossier
Wacker Chemie AG Hanns-Seidel-Platz 4 81737 Muenchen Germany Germany Active 10-Undecenoic acid, trimethylsilyl ester 607-358-2 24338-09-8 - View substance registered dossier
Hallstar Italia Srl con socio unico Piazza Meda, 3 20121 Milano Lombardia Italy Italy Active 10-undecenyl 2-cyano-3,3-diphenylpropenoate 700-604-0 947701-81-7 - View substance registered dossier
Sigma-Aldrich Ireland Ltd Vale Road . Arklow Co. Wicklow Ireland Ireland Active 10H-Pyrido[3,2-b][1,4]benzothiazine-10-propanamine, N,N-dimethyl- 608-469-9 303-69-5 - View substance registered dossier
Menadiona SL Pol Ind Mas Puigvert, Ctra Nacional II Km 680, 5 08389 Palafolls Barcelona Spain Spain Active 11-piperazin-1-yldibenzo[b,f][1,4]thiazepine dihydrochloride 700-276-9 111974-74-4 2010 View substance registered dossier
MOEHS CANTABRA P.I.Requejada Z-23 39313 Polanco Cantabria Spain Spain Active 11-piperazin-1-yldibenzo[b,f][1,4]thiazepine dihydrochloride 700-276-9 111974-74-4 - View substance registered dossier
[Confidential] - - - 11a-Chloro-6-demethyl-6-deoxytetracycline hydrochloride 917-355-0 - - View substance registered dossier
QUIMICA SINTETICA, S.A. C/ Dulcinea, s/n 28805 Alcalá de Henares Madrid Spain Spain Active 11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one, 8-chloro-5,6-dihydro- 700-257-5 31251-41-9 2009; 2011 View substance registered dossier
Cambrex Profarmaco Milano Srl via Curiel, 34 20067 Paullo MI Italy Italy Active 11H-Dibenzo[b,e][1,4]diazepin-11-one, 8-chloro-5,10-dihydro- 700-018-5 50892-62-1 2010 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Italian competent national authority. - - Active 12-Oxa-3,6,9-triazatridecanoic acid, 10-carboxy-3,6,9-tris(carboxymethyl)-13-phenyl- 426-360-2 113786-33-7 - View substance registered dossier
- - - - 1265F 416-480-3 - - View substance registered dossier
Bayer AG Kaiser-Wilhelm-Allee 51373 Leverkusen Germany Germany Active 13-β-ethyl-3-methoxygona-2,5(10)-dien-17-one 219-034-4 2322-77-2 2021 View substance registered dossier
[Confidential] - - - 14,14',15,15'-tetradehydro-7,7'-spirobi[dibenzo[b,g][1,9,4,6]dioxadiazacyclododecine] 700-609-8 1231148-36-9 - View substance registered dossier
Bayer AG Kaiser-Wilhelm-Allee 51373 Leverkusen Germany Germany Active 14-α-hydroxyandrost-4-ene-3,17-dione 427-340-6 564-63-6 2010 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Irish competent national authority. - - Active 15CPT TOLUENE SOLVATE 443-550-0 - - View substance registered dossier
Bayer AG Kaiser-Wilhelm-Allee 51373 Leverkusen Germany Germany Active 17,17-(2,2-Dimethyltrimethylenedioxy)androst-5-en-3 beta-ol 617-864-5 864672-26-4 2018 View substance registered dossier

In this table, you will find all public data submitted to ECHA in REACH registration dossiers by substance manufacturers, importers, or their representatives, as laid out by the REACH Regulation (see Understanding REACH regulation).

ECHA makes available this information as REACH registered substance factsheets, which contain the full set of non-confidential information from related registration dossiers for a substance. Depending on the number of registrations that have been made for a substance, one factsheet can thus represent data from anything between hundreds of registration dossiers in a joint submission, to data from just one registration dossier.

As noted in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission. Please also note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).

In the portal results table are presented:

  • Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
  • Registration status – indicating the calculated registration status for the whole factsheet: Active – is being manufactured or imported to the EEA by one or more registrants; Cease Manufacture - is no longer being manufactured or imported above 1 tone per calendar year. All registrants of the substance have reported a cease of manufacture or import; or No longer valid - no longer considered registered under REACH and not currently allowed to be manufactured or imported to the EEA, until the substance is registered again.
  • Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
  • Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
  • Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
  • Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
  • Link to the full factsheet.

A subset of the key chemical properties (physico-chemical, environmental fate, ecotoxicological and toxicological data) of registered substances can be searched and accessed via the OECD eChemPortal.

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