Registered substances

Registered substances

Registered substances

Please note:

We have successfully adapted to the latest IUCLID format, and have resumed processing dossiers since 3 March 2022. Over the coming weeks we will catch up with the backlog of submissions since 14 October 2021, and expect to have all outstanding data online in approximately one month’s time. Please be aware that any new submissions will be at the back of the processing queue, and will be correspondingly delayed before publication. We appreciate your understanding in this matter.

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REACH - Registration, Evaluation, Authorisation and Restriction of Chemicals Regulation

Registered Substances Factsheets

Substances which have been registered and can be placed on the EEA market by those companies with a valid registration



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Details
1,3-Dioxane-4-acetic acid, 6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R,6R)-
700-258-0 125971-95-1 Active Intermediate Joint Intermediate use only 23-07-2020 View substance registered dossier
1,3-Dioxane-4-acetic acid, 6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R,6R)-
700-258-0 125971-95-1 Active Intermediate Individual Intermediate use only 29-09-2010 View substance registered dossier
1,3-Dioxane-4-acetic acid, 6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R,6R)-
700-258-0 125971-95-1 Active Intermediate Individual Intermediate use only 27-10-2010 View substance registered dossier
11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one, 8-chloro-5,6-dihydro-
700-257-5 31251-41-9 Active Intermediate Individual Intermediate use only 27-01-2011 View substance registered dossier
11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one, 8-chloro-5,6-dihydro-
700-257-5 31251-41-9 Active Intermediate Joint Intermediate use only 31-05-2018 View substance registered dossier
3-[(3-sulfanylbutanoyl)oxy]-2,2-bis{[(3-sulfanylbutanoyl)oxy]methyl}propyl 3-sulfanylbutanoate
700-255-4 31775-89-0 Active Full Individual ≥ 1 to < 10 tonnes 07-06-2018 View substance registered dossier
1-[(3,3-diphenylpropyl)(methyl)amino]-2-methyl-2-propanol
700-254-9 100442-33-9 Active Intermediate Individual Intermediate use only 29-09-2015 View substance registered dossier
N-(3-{1,1,1,5,5,5-hexamethyl-3-[(trimethylsilyl)oxy]trisiloxan-3-yl}propyl)prop-2-enamide
700-253-3 115258-10-1 Active Full Individual ≥ 1 to < 10 tonnes 15-11-2010 View substance registered dossier
2-Thiophenesulfonamide, 5-chloro-
700-252-8 53595-66-7 Cease Manufacture Intermediate Individual Cease manufacture 29-09-2009 View substance registered dossier
4-hydroxy-3,5-dimethoxybenzonitrile
700-251-2 72684-95-8 Active Full Joint ≥ 1 to < 10 tonnes 28-03-2019 View substance registered dossier
Registrant/Supplier Address Country Registration Status Name EC / List no. CAS no. Last update year Details
Krka, d. d., Novo mesto Smarjeska cesta 6 SI-8501 Novo mesto Slovenia Slovenia Active 1,3-Dioxane-4-acetic acid, 6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R,6R)- 700-258-0 125971-95-1 2018 View substance registered dossier
DKSH France S.A. 1475 Quai du Rhone 01702 Miribel France France Active 1,3-Dioxane-4-acetic acid, 6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R,6R)- 700-258-0 125971-95-1 - View substance registered dossier
Gedeon Richter Plc. Gyomroi ut 19-21 1103 Budapest Hungary Hungary Active 1,3-Dioxane-4-acetic acid, 6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R,6R)- 700-258-0 125971-95-1 - View substance registered dossier
ORIL INDUSTRIE 13 rue Auguste Desgenétais 76210 BOLBEC France France Active 1,3-Dioxane-4-acetic acid, 6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R,6R)- 700-258-0 125971-95-1 2019; 2020 View substance registered dossier
EGIS Pharmaceuticals PLC Keresztúri út 30-38 H-1106 Budapest Hungary Hungary Active 1,3-Dioxane-4-acetic acid, 6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R,6R)- 700-258-0 125971-95-1 - View substance registered dossier
Lek Pharmaceuticals d.d. Verovskova 57 1526 Ljubljana Slovenia Slovenia Active 1,3-Dioxane-4-acetic acid, 6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R,6R)- 700-258-0 125971-95-1 2008; 2010 View substance registered dossier
QUIMICA SINTETICA, S.A. C/ Dulcinea, s/n 28805 Alcalá de Henares Madrid Spain Spain Active 11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one, 8-chloro-5,6-dihydro- 700-257-5 31251-41-9 2009; 2011 View substance registered dossier
ROLABO OUTSOURCING, S.L. Polígono Industrial Malpica. Calle J, nº 3-4 50016 Zaragoza Zaragoza Spain Spain Active 11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one, 8-chloro-5,6-dihydro- 700-257-5 31251-41-9 2018 View substance registered dossier
AUROCHEM Aribau 123, 2-3 08036 Barcelona Spain Spain Active 11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one, 8-chloro-5,6-dihydro- 700-257-5 31251-41-9 2018 View substance registered dossier
Showa Denko Europe GmbH (SDK) Daimlerstrasse 19 86368 Gersthofen Germany Germany Active 3-[(3-sulfanylbutanoyl)oxy]-2,2-bis{[(3-sulfanylbutanoyl)oxy]methyl}propyl 3-sulfanylbutanoate 700-255-4 31775-89-0 2018 View substance registered dossier
RECORDATI SPA Via Mediana Cisterna, 4 04011 Campoverde di Aprilia lazio Italy Italy Active 1-[(3,3-diphenylpropyl)(methyl)amino]-2-methyl-2-propanol 700-254-9 100442-33-9 2010; 2015 View substance registered dossier
CIBA VISION GmbH Industriering1 63868 Großwallstadt Bavaria Germany Germany Active N-(3-{1,1,1,5,5,5-hexamethyl-3-[(trimethylsilyl)oxy]trisiloxan-3-yl}propyl)prop-2-enamide 700-253-3 115258-10-1 - View substance registered dossier
MINAKEM Beuvry Production SAS 145, Chemin des Lilas 59310 Beuvry-la-Forêt France France Cease Manufacture 2-Thiophenesulfonamide, 5-chloro- 700-252-8 53595-66-7 2015 View substance registered dossier
Genencor International B.V. - OR-US Willem Einthovenstraat 4 2342 BH Oegstgeest Netherlands Netherlands Active 4-hydroxy-3,5-dimethoxybenzonitrile 700-251-2 72684-95-8 - View substance registered dossier
Genencor International Oy Tiilikantie 15 FI-42300 Jämsänkoski Finland Finland Active 4-hydroxy-3,5-dimethoxybenzonitrile 700-251-2 72684-95-8 2012; 2019 View substance registered dossier

In this table, you will find all public data submitted to ECHA in REACH registration dossiers by substance manufacturers, importers, or their representatives, as laid out by the REACH Regulation (see Understanding REACH regulation).

ECHA makes available this information as REACH registered substance factsheets, which contain the full set of non-confidential information from related registration dossiers for a substance. Depending on the number of registrations that have been made for a substance, one factsheet can thus represent data from anything between hundreds of registration dossiers in a joint submission, to data from just one registration dossier.

As noted in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission. Please also note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).

In the portal results table are presented:

  • Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
  • Registration status – indicating the calculated registration status for the whole factsheet: Active – is being manufactured or imported to the EEA by one or more registrants; Cease Manufacture - is no longer being manufactured or imported above 1 tone per calendar year. All registrants of the substance have reported a cease of manufacture or import; or No longer valid - no longer considered registered under REACH and not currently allowed to be manufactured or imported to the EEA, until the substance is registered again.
  • Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
  • Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
  • Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
  • Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
  • Link to the full factsheet.

A subset of the key chemical properties (physico-chemical, environmental fate, ecotoxicological and toxicological data) of registered substances can be searched and accessed via the OECD eChemPortal.

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