Registered substances

Registered substances

Registered substances

Please note:

We have successfully adapted to the latest IUCLID format, and have resumed processing dossiers since 3 March 2022. Over the coming weeks we will catch up with the backlog of submissions since 14 October 2021, and expect to have all outstanding data online in approximately one month’s time. Please be aware that any new submissions will be at the back of the processing queue, and will be correspondingly delayed before publication. We appreciate your understanding in this matter.

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REACH - Registration, Evaluation, Authorisation and Restriction of Chemicals Regulation

Registered Substances Factsheets

Substances which have been registered and can be placed on the EEA market by those companies with a valid registration



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Details
4-phenylbut-1-ene
4-PHENYL-1-BUTENE; SQ 31,175; SQ31175
405-980-7 768-56-9 Active NONS Joint Tonnage data confidential 15-12-2008 View substance registered dossier
4-phenylbutan-1-ol
222-128-8 3360-41-6 Active Intermediate Joint Intermediate use only 03-07-2018 View substance registered dossier
4-phenylbutan-2-one
219-847-4 2550-26-7 Active Full Joint ≥ 100 to < 1 000 tonnes 08-07-2020 View substance registered dossier
4-phenylbutan-2-one
219-847-4 2550-26-7 Active Intermediate Joint Intermediate use only 12-09-2017 View substance registered dossier
4-phenylbutenone
204-555-1 122-57-6 Active Full Joint ≥ 100 to < 1 000 tonnes 15-01-2021 View substance registered dossier
4-phenylbutyric acid
217-341-8 1821-12-1 Active Intermediate Joint Intermediate use only 15-05-2018 View substance registered dossier
4-phenylbutyronitrile
218-068-7 2046-18-6 Active Intermediate Joint Intermediate use only 05-08-2015 View substance registered dossier
4-Phenylfluoren-9-one
- - Active Intermediate Joint Intermediate use only 04-03-2022 View substance registered dossier
4-phenylpiperidine-4-carboxylic acid, compound with toluene-p-sulphonic acid
281-391-7 83949-32-0 Active Intermediate Joint Intermediate use only 21-03-2022 View substance registered dossier
4-phytase
629-845-9 9001-89-2 Active Full Joint ≥ 10 to < 100 tonnes 22-09-2021 View substance registered dossier
4-Piperidinecarbonitrile, 3-methyl-1-[(4-methylphenyl)sulfonyl]-4-phenyl-, (3R,4S)-rel-
607-821-9 25858-24-6 Cease Manufacture Intermediate Joint Cease manufacture 23-10-2012 View substance registered dossier
4-piperidinecarboxylic acid
207-872-3 498-94-2 Active Intermediate Joint Intermediate use only 18-08-2020 View substance registered dossier
4-Piperidinecarboxylic acid, 1-methyl-, hydrochloride (1:1)
815-057-4 71985-80-3 Active Intermediate Joint Intermediate use only 04-07-2017 View substance registered dossier
4-Piperidinecarboxylic acid, hydrochloride (1:1)
611-901-9 5984-56-5 Active Full Joint ≥ 1 to < 10 tonnes 31-05-2018 View substance registered dossier
4-Piperidinol, 4-(nitromethyl)-1-(2-phenylethyl)-, hydrochloride (1:1)
928-867-9 56561-90-1 Active Intermediate Joint Intermediate use only 14-02-2017 View substance registered dossier
4-Piperidinone, 2,6-diethyl-2,3,6-trimethyl-1-(1-phenylethoxy)-
440-550-2 244021-01-0 Active NONS Joint Tonnage data confidential 24-06-2009 View substance registered dossier
4-piperidylmethylamine
230-446-3 7144-05-0 Active Intermediate Joint Intermediate use only 06-03-2018 View substance registered dossier
4-Propylbenzen-1,2-diol
688-464-6 2525-02-2 Active Intermediate Joint Intermediate use only 18-01-2021 View substance registered dossier
4-propylcyclohexanone
BICH-3 STUFE 3
406-810-4 40649-36-3 Active Intermediate Joint Intermediate use only 13-09-2019 View substance registered dossier
4-Propylphenylboronium acid
603-797-9 134150-01-9 Active Intermediate Joint Intermediate use only 08-12-2017 View substance registered dossier
4-Pyridinamine, 2-chloro-5-methyl-
813-201-0 79055-62-2 Active Intermediate Joint Intermediate use only 25-11-2016 View substance registered dossier
4-Pyridinamine, 5-methyl-2-(phenylmethoxy)-
813-194-4 1552820-82-2 Active Intermediate Joint Intermediate use only 05-12-2016 View substance registered dossier
4-pyridylamine
207-987-9 504-24-5 Active Full Joint ≥ 0 to < 10 tonnes 25-09-2018 View substance registered dossier
4-pyridylamine
207-987-9 504-24-5 Active Intermediate Joint Intermediate use only 02-11-2018 View substance registered dossier
4-Pyrimidinecarboxamide, 2-(1-amino-1-methylethyl)-N-[(4-fluorophenyl)methyl]-1,6-dihydro-5-hydroxy-1-methyl-6-oxo-
465-070-0 518048-03-8 Active Intermediate Joint Intermediate use only 29-05-2019 View substance registered dossier
Registrant/Supplier Address Country Registration Status Name EC / List no. CAS no. Last update year Details
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active 4-phenylbut-1-ene 405-980-7 768-56-9 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Irish competent national authority. - - Active 4-phenylbut-1-ene 405-980-7 768-56-9 - View substance registered dossier
Corden Pharma Latina S.p.A. Via del Murillo Km 2, 800 IT04013 Sermoneta (LT) Lazio Italy Italy Cease Manufacture 4-phenylbut-1-ene 405-980-7 768-56-9 2017 View substance registered dossier
Zach System ZI La Croix Cadeau 49242 Avrillé France France Active 4-phenylbutan-1-ol 222-128-8 3360-41-6 - View substance registered dossier
Intertek Deutschland GmbH IBVC Stangenstr. 1 70771 Leinfelden-Echterdingen Germany Germany Active 4-phenylbutan-2-one 219-847-4 2550-26-7 - View substance registered dossier
ERNESTO VENTOS, S.A. Carretera Reial 120B 08960 Sant Just Desvern Spain Spain Active 4-phenylbutan-2-one 219-847-4 2550-26-7 - View substance registered dossier
CHEMICAL INSPECTION & REGULATION SERVICE LIMITED Regus Harcourt Centre D02 HW77 Dublin Ireland Ireland Active 4-phenylbutan-2-one 219-847-4 2550-26-7 2016; 2017; 2019; 2020 View substance registered dossier
Symrise AG Mühlenfeldstraße 1 37603 Holzminden Germany Germany Active 4-phenylbutan-2-one 219-847-4 2550-26-7 - View substance registered dossier
PROCOS SpA via Matteotti 249 28062 Cameri Piemonte Italy Italy Active 4-phenylbutan-2-one 219-847-4 2550-26-7 - View substance registered dossier
Symrise AG Mühlenfeldstraße 1 37603 Holzminden Germany Germany Cease Manufacture 4-phenylbutenone 204-555-1 122-57-6 2019 View substance registered dossier
PICCADILLY Internationaler Handel GmbH Wipperauer Str. 117 42699 Solingen NRW Germany Germany Active 4-phenylbutenone 204-555-1 122-57-6 - View substance registered dossier
Galata Chemicals GmbH Chemiestrasse 22 68623 Lampertheim 06 Germany Germany Active 4-phenylbutenone 204-555-1 122-57-6 - View substance registered dossier
Avison Chemical GmbH Elisabethstr. 40 40217 Düsseldorf Germany Germany Active 4-phenylbutenone 204-555-1 122-57-6 - View substance registered dossier
Raschig GmbH Mundenheimerstraße 100 D-67061 Ludwigshafen Germany Germany Active 4-phenylbutenone 204-555-1 122-57-6 2014; 2019; 2020 View substance registered dossier
REACHLaw Ltd. (acting as OR for Grauer & Weil (India) Limited) Vänrikinkuja 3JK 21 02600 Espoo Helsinki Finland Finland Active 4-phenylbutenone 204-555-1 122-57-6 2021 View substance registered dossier
Horizon Pharma Ireland Limited Connaught House, 1st Floor 1 Burlington Road D04 C5Y6 Dublin Ireland Ireland Active 4-phenylbutyric acid 217-341-8 1821-12-1 - View substance registered dossier
CU Chemie Uetikon GmbH Raiffeisenstrasse 4 77933 Lahr Baden-Württemberg Germany Germany Active 4-phenylbutyric acid 217-341-8 1821-12-1 - View substance registered dossier
CU Chemie Uetikon GmbH Raiffeisenstrasse 4 77933 Lahr Baden-Württemberg Germany Germany Active 4-phenylbutyronitrile 218-068-7 2046-18-6 - View substance registered dossier
Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany Germany Active 4-Phenylfluoren-9-one - - 2022 View substance registered dossier
Esteve Quimica, S.A. Torre Esteve Passeig de la Zona Franca, 109, 4ª Planta 08038 Barcelona Barcelona Spain Spain Active 4-phenylpiperidine-4-carboxylic acid, compound with toluene-p-sulphonic acid 281-391-7 83949-32-0 - View substance registered dossier
UNION QUIMICO FARMACÉUTICA S.A. Mallorca 262 08008 Barcelona Barcelona Spain Spain Active 4-phenylpiperidine-4-carboxylic acid, compound with toluene-p-sulphonic acid 281-391-7 83949-32-0 2022 View substance registered dossier
Genencor International B.V. - OR-CN Willem Einthovenstraat 4 2342 BH Oegstgeest​ Netherlands Netherlands Active 4-phytase 629-845-9 9001-89-2 - View substance registered dossier
Genencor International B.V. - OR-US Willem Einthovenstraat 4 2342 BH Oegstgeest Netherlands Netherlands Active 4-phytase 629-845-9 9001-89-2 - View substance registered dossier
Genencor International BV - Belgium Komvest 43 8000 Brugge Belgium Belgium Active 4-phytase 629-845-9 9001-89-2 2021 View substance registered dossier
Genencor International Oy Tiilikantie 15 FI-42300 Jämsänkoski Finland Finland Active 4-phytase 629-845-9 9001-89-2 2021 View substance registered dossier
Janssen Pharmaceutica N.V. Turnhoutseweg 30 2340 Beerse Belgium Belgium Cease Manufacture 4-Piperidinecarbonitrile, 3-methyl-1-[(4-methylphenyl)sulfonyl]-4-phenyl-, (3R,4S)-rel- 607-821-9 25858-24-6 2020 View substance registered dossier
Aceto France SAS 3 Place Giovanni da Verrazzano 69009 Lyon France France Active 4-piperidinecarboxylic acid 207-872-3 498-94-2 - View substance registered dossier
SONEAS Chemicals Ltd. Banyaleg Str. 47-59. H-1225 Budapest Hungary Hungary Active 4-piperidinecarboxylic acid 207-872-3 498-94-2 - View substance registered dossier
INTEROR 49, rue d'Ostende F-62100 CALAIS France France Active 4-piperidinecarboxylic acid 207-872-3 498-94-2 - View substance registered dossier
PCAS 21 Chemin de la Sauvegarde 21 Ecully Parc - CS33167 69134 ECULLY France France Active 4-Piperidinecarboxylic acid, 1-methyl-, hydrochloride (1:1) 815-057-4 71985-80-3 - View substance registered dossier
Janssen Pharmaceutica N.V. Turnhoutseweg 30 2340 Beerse Belgium Belgium Active 4-Piperidinecarboxylic acid, hydrochloride (1:1) 611-901-9 5984-56-5 - View substance registered dossier
JSC "Olainfarm" Rupnicu str. 5 LV-2114 Olaine Latvia Latvia Active 4-Piperidinecarboxylic acid, hydrochloride (1:1) 611-901-9 5984-56-5 - View substance registered dossier
ERREGIERRE SPA Via Francesco Baracca, 19 24060 SAN PAOLO D'ARGON BERGAMO Italy Italy Active 4-Piperidinol, 4-(nitromethyl)-1-(2-phenylethyl)-, hydrochloride (1:1) 928-867-9 56561-90-1 - View substance registered dossier
- - - - 4-Piperidinone, 2,6-diethyl-2,3,6-trimethyl-1-(1-phenylethoxy)- 440-550-2 244021-01-0 - View substance registered dossier
INTEROR 49, rue d'Ostende F-62100 CALAIS France France Active 4-piperidylmethylamine 230-446-3 7144-05-0 - View substance registered dossier
Arran Chemical Company Ltd Monksland Industrial Estate N37DN24 Athlone Co. Roscommon Ireland Ireland Active 4-Propylbenzen-1,2-diol 688-464-6 2525-02-2 2021 View substance registered dossier
Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany Germany Active 4-propylcyclohexanone 406-810-4 40649-36-3 2011; 2013; 2019 View substance registered dossier
Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany Germany Active 4-Propylphenylboronium acid 603-797-9 134150-01-9 - View substance registered dossier
Saltigo GmbH HSEQ-RA Kaiser-Wilhelm-Allee 40 51373 Leverkusen Germany Germany Active 4-Pyridinamine, 2-chloro-5-methyl- 813-201-0 79055-62-2 - View substance registered dossier
Saltigo GmbH HSEQ-RA Kaiser-Wilhelm-Allee 40 51373 Leverkusen Germany Germany Active 4-Pyridinamine, 5-methyl-2-(phenylmethoxy)- 813-194-4 1552820-82-2 - View substance registered dossier
Schuelke & Mayr GmbH Robert-Koch-Str. 2 22851 Norderstedt Germany Germany Active 4-pyridylamine 207-987-9 504-24-5 2018 View substance registered dossier
Sterling Pharma Solutions Ltd Dudley NE23 7QG Cramlington Northumberland United Kingdom United Kingdom No longer Valid 4-pyridylamine 207-987-9 504-24-5 2021 View substance registered dossier
Derivados Químicos S.A. Camino de Pliego, 150 30820 Alcantarilla Murcia Spain Spain Active 4-pyridylamine 207-987-9 504-24-5 - View substance registered dossier
Biesterfeld Spezialchemie GmbH Ferdinandstr. 41 20095 Hamburg Germany Germany Active 4-pyridylamine 207-987-9 504-24-5 2018 View substance registered dossier
MSD International GmbH Ballydine - Kilsheelan 0 Clonmel Ireland Ireland Active 4-Pyrimidinecarboxamide, 2-(1-amino-1-methylethyl)-N-[(4-fluorophenyl)methyl]-1,6-dihydro-5-hydroxy-1-methyl-6-oxo- 465-070-0 518048-03-8 2011; 2012; 2018; 2019 View substance registered dossier

In this table, you will find all public data submitted to ECHA in REACH registration dossiers by substance manufacturers, importers, or their representatives, as laid out by the REACH Regulation (see Understanding REACH regulation).

ECHA makes available this information as REACH registered substance factsheets, which contain the full set of non-confidential information from related registration dossiers for a substance. Depending on the number of registrations that have been made for a substance, one factsheet can thus represent data from anything between hundreds of registration dossiers in a joint submission, to data from just one registration dossier.

As noted in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission. Please also note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).

In the portal results table are presented:

  • Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
  • Registration status – indicating the calculated registration status for the whole factsheet: Active – is being manufactured or imported to the EEA by one or more registrants; Cease Manufacture - is no longer being manufactured or imported above 1 tone per calendar year. All registrants of the substance have reported a cease of manufacture or import; or No longer valid - no longer considered registered under REACH and not currently allowed to be manufactured or imported to the EEA, until the substance is registered again.
  • Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
  • Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
  • Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
  • Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
  • Link to the full factsheet.

A subset of the key chemical properties (physico-chemical, environmental fate, ecotoxicological and toxicological data) of registered substances can be searched and accessed via the OECD eChemPortal.

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