Registered substances

Registered substances

Registered substances

Please note:

We have successfully adapted to the latest IUCLID format, and have resumed processing dossiers since 3 March 2022. Over the coming weeks we will catch up with the backlog of submissions since 14 October 2021, and expect to have all outstanding data online in approximately one month’s time. Please be aware that any new submissions will be at the back of the processing queue, and will be correspondingly delayed before publication. We appreciate your understanding in this matter.

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REACH - Registration, Evaluation, Authorisation and Restriction of Chemicals Regulation

Registered Substances Factsheets

Substances which have been registered and can be placed on the EEA market by those companies with a valid registration



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Details
(4R)-Tetrahydro-4-hydroxy-4-methyl-2H-Pyran-2-one
433-160-9 - Active Full Joint ≥ 1 to < 10 tonnes 18-08-2020 View substance registered dossier
(4R,4'S)-[4,4'-bi-1,3-dioxolane]-2,2'-dione
636-728-6 24690-44-6 Active Full Joint ≥ 1 to < 10 tonnes 22-12-2021 View substance registered dossier
(4R,4aS,7aR,12bS)-3-(ethoxycarbonyl)-7-oxo-1,2,3,4,7,7a-hexahydro-4aH-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diyl diacetate
955-282-6 2387639-94-1 Active Intermediate Joint Intermediate use only 15-12-2021 View substance registered dossier
(4R,4aS,7aR,12bS)-3-methyl-7-oxo-2,3,4,4a,7,7a-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diyl diacetate
875-213-2 50798-31-7 Active Intermediate Joint Intermediate use only 03-11-2021 View substance registered dossier
(4R,6S)-6-methyl-7,7-dioxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-ol
604-572-8 147128-77-6 Active Intermediate Joint Intermediate use only 06-09-2018 View substance registered dossier
(4S)-3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino][4-[(trimethylsilyl)oxy]phenyl]methyl]-1-oxo-5-[(trimethylsilyl)oxy]pentyl]-4-phenyl-2-oxazolidinone
848-798-7 272778-12-8 Active Intermediate Joint Intermediate use only 15-06-2020 View substance registered dossier
(4S)-4-(2-Chlorophenyl)-2-hydroxy-5,5-dimethyl-1,3,2-dioxaphosphinane 2-oxide
623-314-5 98674-86-3 Active Intermediate Joint Intermediate use only 26-03-2018 View substance registered dossier
(4S)-4-hydroxy-2-(3-methoxypropyl)-1,1-dioxo-3,4,4a,7a-tetrahydrothieno[3,2-e]thiazine-6-sulfonamide
807-123-6 154127-42-1 Active Intermediate Joint Intermediate use only 23-03-2022 View substance registered dossier
(4S,4aR,5aR,6R,6aR,6bS,7S,9aS,11aS,11bR)-6-hydroxy-9a,11b-dimethyl-9-oxohexadeca hydrocyclopenta[1,2]phenanthro[8a,9-b]oxirene-4,7-diyl bis(2,2-dimethylpropanoate)
825-705-8 1235460-56-6 Active Intermediate Joint Intermediate use only 17-07-2018 View substance registered dossier
(4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide 4-methylbenzenesulfonate (1:1)
940-053-5 - Active Intermediate Joint Intermediate use only 19-01-2017 View substance registered dossier
(4S,4aS,5aR,12aR)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide
617-177-0 808-26-4 Active Intermediate Joint Intermediate use only 13-09-2018 View substance registered dossier
(4S,4aS,5aR,12aR)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-7-[[methoxy(methyl)amino]methyl]-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide
811-441-0 1035654-66-0 Active Intermediate Joint Intermediate use only 27-11-2019 View substance registered dossier
(4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide; 4-chlorobenzene-1-sulfonic acid
618-775-4 916439-93-5 Active Intermediate Joint Intermediate use only 22-12-2017 View substance registered dossier
(4S,5S)-5-hydroxy-2-methyl-3,4,5,6-tetrahydropyrimidine-4-carboxylic acid
HYDROXYECTOIN
442-870-8 165542-15-4 Active NONS Joint Tonnage data confidential 10-11-2008 View substance registered dossier
(4S,6S)-4H-Thieno[2,3-b]thiopyran-2-sulfonyl chloride, 4-(acetylethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide,
824-717-0 403848-30-6 Active Intermediate Joint Intermediate use only 05-06-2018 View substance registered dossier
(4S,6S)-5,6-dihydro-4-[ethylamin-N-(2-nitrobenzenesulfonic)]-6-methyl-4H-thieno(2,3-b)thiopyran-7,7-dioxide
947-800-4 - Active Intermediate Joint Intermediate use only 21-06-2018 View substance registered dossier
(4S-trans)-N-(5,6-diidro-6-metil-7,7-diossido-4Htieno[2,3-b]tiopiran-4-il)-acetammide
604-558-1 147086-83-7 Active Intermediate Joint Intermediate use only 09-03-2018 View substance registered dossier
(5-bromothiophen-2-yl)-phenylmethanone
608-584-4 31161-46-3 Active Intermediate Joint Intermediate use only 14-02-2018 View substance registered dossier
(5-ethyl-1,3-dioxan-5-yl)methyl acrylate
266-380-7 66492-51-1 Active Full Joint ≥ 1 000 to < 10 000 tonnes 02-12-2021 View substance registered dossier
(5E)-3,5-dimethyloct-5-en-4-ol
947-581-5 2209852-19-5 Active Full Joint ≥ 1 to < 10 tonnes 13-03-2020 View substance registered dossier
(5or8)-aminonaphthalene-2-sulphonic acid
257-269-4 51548-48-2 Active Full Joint ≥ 1 to < 10 tonnes 06-04-2018 View substance registered dossier
(5R,6S)-allyl 6-((R)-1-(tert-butyldimethylsilyloxy)ethyl)-7-oxo-3-(propylthio)-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
820-260-6 93603-76-0 Active Intermediate Joint Intermediate use only 28-06-2018 View substance registered dossier
(5S)-1,2,3,4-tetra-O-acetyl-5-[4-chloro-3-(4-ethoxybenzyl)phenyl]-beta-L-xylopyranose
815-962-4 1384242-56-1 Active Intermediate Joint Intermediate use only 04-12-2019 View substance registered dossier
(5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-ol
879-204-4 1373116-05-2 Active Intermediate Joint Intermediate use only 04-02-2022 View substance registered dossier
(5S,6S,9R)-6-(2,3-difluorophenyl)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-aminedihydrochloride
874-683-6 1373116-04-1 Active Intermediate Joint Intermediate use only 15-10-2021 View substance registered dossier
Registrant/Supplier Address Country Registration Status Name EC / List no. CAS no. Last update year Details
Visolis, B.V. Urmonderbaan 22 6167 RD Geleen Netherlands Netherlands Active (4R)-Tetrahydro-4-hydroxy-4-methyl-2H-Pyran-2-one 433-160-9 - - View substance registered dossier
CHEMICAL INSPECTION & REGULATION SERVICE LIMITED Regus Harcourt Centre D02 HW77 Dublin Ireland Ireland Active (4R,4'S)-[4,4'-bi-1,3-dioxolane]-2,2'-dione 636-728-6 24690-44-6 - View substance registered dossier
Cambrex Karlskoga AB Bjorkborns Industriomrade 69185 Karlskoga Sweden Sweden Active (4R,4aS,7aR,12bS)-3-(ethoxycarbonyl)-7-oxo-1,2,3,4,7,7a-hexahydro-4aH-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diyl diacetate 955-282-6 2387639-94-1 - View substance registered dossier
Cambrex Karlskoga AB Bjorkborns Industriomrade 69185 Karlskoga Sweden Sweden Active (4R,4aS,7aR,12bS)-3-methyl-7-oxo-2,3,4,4a,7,7a-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diyl diacetate 875-213-2 50798-31-7 - View substance registered dossier
DUKE CHEM, S.A. Avgda. Mare de Déu de Montserrat, 93 - 99 Pol. Ind. Sant Pere Molanta 08799 Olèrdola Barcelona Spain Spain Active (4R,6S)-6-methyl-7,7-dioxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-ol 604-572-8 147128-77-6 - View substance registered dossier
Krka, d. d., Novo mesto Smarjeska cesta 6 SI-8501 Novo mesto Slovenia Slovenia Active (4S)-3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino][4-[(trimethylsilyl)oxy]phenyl]methyl]-1-oxo-5-[(trimethylsilyl)oxy]pentyl]-4-phenyl-2-oxazolidinone 848-798-7 272778-12-8 2020 View substance registered dossier
Arran Chemical Company Ltd Monksland Industrial Estate N37DN24 Athlone Co. Roscommon Ireland Ireland Active (4S)-4-(2-Chlorophenyl)-2-hydroxy-5,5-dimethyl-1,3,2-dioxaphosphinane 2-oxide 623-314-5 98674-86-3 - View substance registered dossier
ChemLeader 11 Fine & Performance Chemicals Ltd Długosza 67 43-188 Orzesze Poland Poland Active (4S)-4-hydroxy-2-(3-methoxypropyl)-1,1-dioxo-3,4,4a,7a-tetrahydrothieno[3,2-e]thiazine-6-sulfonamide 807-123-6 154127-42-1 - View substance registered dossier
ICROM S.r.l Via delle arti, 33 20863 Concorezzo Italy Italy Active (4S)-4-hydroxy-2-(3-methoxypropyl)-1,1-dioxo-3,4,4a,7a-tetrahydrothieno[3,2-e]thiazine-6-sulfonamide 807-123-6 154127-42-1 - View substance registered dossier
CHEMO BIOSYNTHESIS SRL VIALE ISONZO, 8 20135 MILANO Italy Italy Active (4S,4aR,5aR,6R,6aR,6bS,7S,9aS,11aS,11bR)-6-hydroxy-9a,11b-dimethyl-9-oxohexadeca hydrocyclopenta[1,2]phenanthro[8a,9-b]oxirene-4,7-diyl bis(2,2-dimethylpropanoate) 825-705-8 1235460-56-6 - View substance registered dossier
Hovione FarmaCiencia SA Sete Casas 2674-506 Loures Portugal Portugal Active (4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide 4-methylbenzenesulfonate (1:1) 940-053-5 - 2017 View substance registered dossier
Hovione Limited Loughbeg not available Ringaskiddy County Cork Ireland Ireland Active (4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide 4-methylbenzenesulfonate (1:1) 940-053-5 - 2017 View substance registered dossier
Cipan - Companhia Industrial Produtora de Antibióticos Rua da Estação, 42 Vala do Carregado 2600-726 Castanheira do Ribatejo Lisboa Portugal Portugal Active (4S,4aS,5aR,12aR)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide 617-177-0 808-26-4 - View substance registered dossier
Hovione FarmaCiencia SA Sete Casas 2674-506 Loures Portugal Portugal Active (4S,4aS,5aR,12aR)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide 617-177-0 808-26-4 - View substance registered dossier
Curia Italy S.r.l. VIA DEL VECCHIO POLITECNICO, n. 9 20121 Milano Italy Italy Active (4S,4aS,5aR,12aR)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide 617-177-0 808-26-4 - View substance registered dossier
Curia Italy S.r.l. VIA DEL VECCHIO POLITECNICO, n. 9 20121 Milano Italy Italy Active (4S,4aS,5aR,12aR)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-7-[[methoxy(methyl)amino]methyl]-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide 811-441-0 1035654-66-0 - View substance registered dossier
Curia Italy S.r.l. VIA DEL VECCHIO POLITECNICO, n. 9 20121 Milano Italy Italy Active (4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide; 4-chlorobenzene-1-sulfonic acid 618-775-4 916439-93-5 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant German competent national authority. - - Active (4S,5S)-5-hydroxy-2-methyl-3,4,5,6-tetrahydropyrimidine-4-carboxylic acid 442-870-8 165542-15-4 - View substance registered dossier
- - - - (4S,5S)-5-hydroxy-2-methyl-3,4,5,6-tetrahydropyrimidine-4-carboxylic acid 442-870-8 165542-15-4 - View substance registered dossier
DUKE CHEM, S.A. Avgda. Mare de Déu de Montserrat, 93 - 99 Pol. Ind. Sant Pere Molanta 08799 Olèrdola Barcelona Spain Spain Active (4S,6S)-4H-Thieno[2,3-b]thiopyran-2-sulfonyl chloride, 4-(acetylethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, 824-717-0 403848-30-6 - View substance registered dossier
DUKE CHEM, S.A. Avgda. Mare de Déu de Montserrat, 93 - 99 Pol. Ind. Sant Pere Molanta 08799 Olèrdola Barcelona Spain Spain Active (4S,6S)-5,6-dihydro-4-[ethylamin-N-(2-nitrobenzenesulfonic)]-6-methyl-4H-thieno(2,3-b)thiopyran-7,7-dioxide 947-800-4 - - View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active (4S-trans)-N-(5,6-diidro-6-metil-7,7-diossido-4Htieno[2,3-b]tiopiran-4-il)-acetammide 604-558-1 147086-83-7 - View substance registered dossier
ERREGIERRE SPA Via Francesco Baracca, 19 24060 SAN PAOLO D'ARGON BERGAMO Italy Italy Active (5-bromothiophen-2-yl)-phenylmethanone 608-584-4 31161-46-3 - View substance registered dossier
Jobachem GmbH Am Burgberg 13 37586 Dassel Lower Saxony Germany Germany Active (5-ethyl-1,3-dioxan-5-yl)methyl acrylate 266-380-7 66492-51-1 2019 View substance registered dossier
IGM Resins B.V. Gompenstraat 49 5145 RA Waalwijk Netherlands Netherlands Active (5-ethyl-1,3-dioxan-5-yl)methyl acrylate 266-380-7 66492-51-1 2020 View substance registered dossier
BASF SE Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany Germany Active (5-ethyl-1,3-dioxan-5-yl)methyl acrylate 266-380-7 66492-51-1 2015 View substance registered dossier
ARKEMA PHOTOCURES 420 rue d'Estienne d'Orves 92700 Colombes France France Active (5-ethyl-1,3-dioxan-5-yl)methyl acrylate 266-380-7 66492-51-1 - View substance registered dossier
Lankwitzer Lackfabrik GmbH Haynauer Str. 61-63 12249 Berlin Germany Germany Active (5-ethyl-1,3-dioxan-5-yl)methyl acrylate 266-380-7 66492-51-1 - View substance registered dossier
RAHN NL B.V. (30) Westplein 11 3016BM Rotterdam Netherlands Netherlands Active (5-ethyl-1,3-dioxan-5-yl)methyl acrylate 266-380-7 66492-51-1 - View substance registered dossier
ARKEMA FRANCE 420 rue d'Estienne d'Orves 92700 COLOMBES France France Active (5-ethyl-1,3-dioxan-5-yl)methyl acrylate 266-380-7 66492-51-1 2018 View substance registered dossier
IGM Resins Ltd c/o Baldwins, Wynyard Park House Wynyard Avenue TS22 5TB Wynyard Durham United Kingdom United Kingdom No longer Valid (5-ethyl-1,3-dioxan-5-yl)methyl acrylate 266-380-7 66492-51-1 2021 View substance registered dossier
Labcorp DEVELOPMENT SA 119 Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5-5 Planta 28050 Madrid Spain Spain Active (5-ethyl-1,3-dioxan-5-yl)methyl acrylate 266-380-7 66492-51-1 - View substance registered dossier
Miwon Europe GmbH Zeppelinstraße 26 D-47638 Straelen Germany Germany Active (5-ethyl-1,3-dioxan-5-yl)methyl acrylate 266-380-7 66492-51-1 - View substance registered dossier
FIRMENICH GRASSE SAS OR 1 Parc Industriel Les Bois de Grasse 06130 Grasse France France Active (5E)-3,5-dimethyloct-5-en-4-ol 947-581-5 2209852-19-5 - View substance registered dossier
Synthesia, a.s. Semtín103 53002 Pardubice Czech Republic Czech Republic Active (5or8)-aminonaphthalene-2-sulphonic acid 257-269-4 51548-48-2 - View substance registered dossier
Global Product Compliance (Europe) AB IDEON, Beta 5, Scheelevägen 17 22363 Lund Sweden Sweden Active (5or8)-aminonaphthalene-2-sulphonic acid 257-269-4 51548-48-2 - View substance registered dossier
ACS DOBFAR S.p.A Viale Addetta 4/12 20067 Tribiano Milano Italy Italy Active (5R,6S)-allyl 6-((R)-1-(tert-butyldimethylsilyloxy)ethyl)-7-oxo-3-(propylthio)-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate 820-260-6 93603-76-0 - View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active (5S)-1,2,3,4-tetra-O-acetyl-5-[4-chloro-3-(4-ethoxybenzyl)phenyl]-beta-L-xylopyranose 815-962-4 1384242-56-1 - View substance registered dossier
sanofi chimie 82 avenue Raspail 94250 Gentilly France France Active (5S)-1,2,3,4-tetra-O-acetyl-5-[4-chloro-3-(4-ethoxybenzyl)phenyl]-beta-L-xylopyranose 815-962-4 1384242-56-1 - View substance registered dossier
[Confidential] - - - (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-ol 879-204-4 1373116-05-2 - View substance registered dossier
[Confidential] - - - (5S,6S,9R)-6-(2,3-difluorophenyl)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-aminedihydrochloride 874-683-6 1373116-04-1 - View substance registered dossier

In this table, you will find all public data submitted to ECHA in REACH registration dossiers by substance manufacturers, importers, or their representatives, as laid out by the REACH Regulation (see Understanding REACH regulation).

ECHA makes available this information as REACH registered substance factsheets, which contain the full set of non-confidential information from related registration dossiers for a substance. Depending on the number of registrations that have been made for a substance, one factsheet can thus represent data from anything between hundreds of registration dossiers in a joint submission, to data from just one registration dossier.

As noted in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission. Please also note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).

In the portal results table are presented:

  • Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
  • Registration status – indicating the calculated registration status for the whole factsheet: Active – is being manufactured or imported to the EEA by one or more registrants; Cease Manufacture - is no longer being manufactured or imported above 1 tone per calendar year. All registrants of the substance have reported a cease of manufacture or import; or No longer valid - no longer considered registered under REACH and not currently allowed to be manufactured or imported to the EEA, until the substance is registered again.
  • Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
  • Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
  • Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
  • Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
  • Link to the full factsheet.

A subset of the key chemical properties (physico-chemical, environmental fate, ecotoxicological and toxicological data) of registered substances can be searched and accessed via the OECD eChemPortal.

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