Registered substances

Registered substances

Registered substances

Please note:

We have successfully adapted to the latest IUCLID format, and have resumed processing dossiers since 3 March 2022. Over the coming weeks we will catch up with the backlog of submissions since 14 October 2021, and expect to have all outstanding data online in approximately one month’s time. Please be aware that any new submissions will be at the back of the processing queue, and will be correspondingly delayed before publication. We appreciate your understanding in this matter.


REACH - Registration, Evaluation, Authorisation and Restriction of Chemicals Regulation

Registered Substances Factsheets

Substances which have been registered and can be placed on the EEA market by those companies with a valid registration

No results were found
203-184-2 104-20-1 Active Intermediate Joint Intermediate use only 27-02-2017 View substance registered dossier
4-(4-methoxyphenyl)butyric acid
224-849-3 4521-28-2 Active Intermediate Joint Intermediate use only 31-10-2017 View substance registered dossier
4-(4-Methylpiperazin-1-yl)-2-[(tetrahydropyran-4-yl)(2,2,2-trifluoroacetyl)amino]benzoic acid tert-butyl ester
840-712-6 1034975-53-5 Active Intermediate Individual Intermediate use only 26-06-2019 View substance registered dossier
440-740-5 81936-33-6 Active Intermediate Joint Intermediate use only 20-12-2019 View substance registered dossier
448-010-8 - Active Intermediate Joint Intermediate use only 20-08-2018 View substance registered dossier
4-(6-(3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile bis sulphate
951-814-6 - Active Intermediate Individual Intermediate use only 03-01-2020 View substance registered dossier
617-498-6 83883-25-4 Active Intermediate Joint Intermediate use only 31-05-2018 View substance registered dossier
856-352-8 937263-71-3 Active Intermediate Joint Intermediate use only 16-07-2020 View substance registered dossier
4-(aminomethyl)-1-phenethylpiperidin-4-ol dihydrochloride
245-892-4 23804-64-0 Active Intermediate Joint Intermediate use only 23-07-2020 View substance registered dossier
809-933-5 95306-62-0 Active Intermediate Individual Intermediate use only 21-08-2018 View substance registered dossier
Registrant/Supplier Address Country Registration Status Name EC / List no. CAS no. Last update year Details
RECORDATI SPA Via Mediana Cisterna, 4 04011 Campoverde di Aprilia lazio Italy Italy Active 4-(4-methoxyphenyl)butan-2-one 203-184-2 104-20-1 - View substance registered dossier
INTEROR 49, rue d'Ostende F-62100 CALAIS France France Active 4-(4-methoxyphenyl)butyric acid 224-849-3 4521-28-2 - View substance registered dossier
Flamma S.p.a. via Bedeschi, 22 24040 Chignolo d'Isola Bergamo Italy Italy Active 4-(4-Methylpiperazin-1-yl)-2-[(tetrahydropyran-4-yl)(2,2,2-trifluoroacetyl)amino]benzoic acid tert-butyl ester 840-712-6 1034975-53-5 - View substance registered dossier
Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany Germany Active 4-(4-trans-propylcylohexyl)phenol 440-740-5 81936-33-6 2009; 2010; 2013; 2017; 2019 View substance registered dossier
Pfizer Ireland Pharmaceuticals n/a P43 X3336 Ringaskiddy Cork Ireland Ireland Active 4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide 448-010-8 - 2016 View substance registered dossier
Piramal Healthcare UK Ltd Whalton Road NE61 3YA Morpeth Northumberland United Kingdom United Kingdom No longer Valid 4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide 448-010-8 - 2021 View substance registered dossier
Eli Lilly Kinsale Limited Dunderrow Kinsale P17 NY71 Cork Co. Cork Ireland Ireland Active 4-(6-(3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile bis sulphate 951-814-6 - - View substance registered dossier
SYNTHEXIM 1 Quai d'Amérique 62 100 calais France France Active 4-(6-HYDROXYHEXYLOXY)BENZOIC ACID 617-498-6 83883-25-4 - View substance registered dossier
Esteve Quimica, S.A. Torre Esteve Passeig de la Zona Franca, 109, 4ª Planta 08038 Barcelona Barcelona Spain Spain Active 4-([1,2,4]triazolo[1,5-a]pyrid-7-yloxy)-3-methylaniline 856-352-8 937263-71-3 - View substance registered dossier
ERREGIERRE SPA Via Francesco Baracca, 19 24060 SAN PAOLO D'ARGON BERGAMO Italy Italy Active 4-(aminomethyl)-1-phenethylpiperidin-4-ol dihydrochloride 245-892-4 23804-64-0 - View substance registered dossier
ORIL INDUSTRIE 13 rue Auguste Desgenétais 76210 BOLBEC France France Active 4-(aminomethyl)-1-phenethylpiperidin-4-ol dihydrochloride 245-892-4 23804-64-0 2019; 2020 View substance registered dossier
CU Chemie Uetikon GmbH Raiffeisenstrasse 4 77933 Lahr Baden-Württemberg Germany Germany Active 4-(aminomethyl)-1-phenethylpiperidin-4-ol dihydrochloride 245-892-4 23804-64-0 - View substance registered dossier
MinAscent Leuna Production GmbH Am Haupttor Gebäude 4208 06237 Leuna Germany Germany Active 4-(benzylamino)-5-methyl-2(1H)-pyridinon 809-933-5 95306-62-0 - View substance registered dossier

In this table, you will find all public data submitted to ECHA in REACH registration dossiers by substance manufacturers, importers, or their representatives, as laid out by the REACH Regulation (see Understanding REACH regulation).

ECHA makes available this information as REACH registered substance factsheets, which contain the full set of non-confidential information from related registration dossiers for a substance. Depending on the number of registrations that have been made for a substance, one factsheet can thus represent data from anything between hundreds of registration dossiers in a joint submission, to data from just one registration dossier.

As noted in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission. Please also note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).

In the portal results table are presented:

  • Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
  • Registration status – indicating the calculated registration status for the whole factsheet: Active – is being manufactured or imported to the EEA by one or more registrants; Cease Manufacture - is no longer being manufactured or imported above 1 tone per calendar year. All registrants of the substance have reported a cease of manufacture or import; or No longer valid - no longer considered registered under REACH and not currently allowed to be manufactured or imported to the EEA, until the substance is registered again.
  • Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
  • Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
  • Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
  • Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
  • Link to the full factsheet.

A subset of the key chemical properties (physico-chemical, environmental fate, ecotoxicological and toxicological data) of registered substances can be searched and accessed via the OECD eChemPortal.

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