Registered substances

Registered substances

Registered substances

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We have successfully adapted to the latest IUCLID format, and have resumed processing dossiers since 3 March 2022. Over the coming weeks we will catch up with the backlog of submissions since 14 October 2021, and expect to have all outstanding data online in approximately one month’s time. Please be aware that any new submissions will be at the back of the processing queue, and will be correspondingly delayed before publication. We appreciate your understanding in this matter.

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REACH - Registration, Evaluation, Authorisation and Restriction of Chemicals Regulation

Registered Substances Factsheets

Substances which have been registered and can be placed on the EEA market by those companies with a valid registration



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Details
(3AS,4S,6AR)-4-METHOXYTETRAHYDROFURO[3,4- B]FURAN-2(3H)-ONE
443-930-6 - Active Full Joint ≥ 10 to < 100 tonnes 03-05-2018 View substance registered dossier
(3AS,4S,6AR)-4-METHOXYTETRAHYDROFURO[3,4- B]FURAN-2(3H)-ONE
443-930-6 - Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
(3beta)-17-(3-pyridinyl)androsta-5,16-dien-3-yl acetate compound with (2R,3R)-tartaric acid and methanol (1 : 1 : 1.5)
931-336-4 - Cease Manufacture Intermediate Individual Cease manufacture 13-09-2012 View substance registered dossier
(3R)-2,3-dihydro-1,1,3-trimethyl-1H-Inden-4-amine-(2S,3S)-2,3-dihydroxybutanedioate
701-382-8 - Active Intermediate Joint Intermediate use only 09-04-2021 View substance registered dossier
(3R)-4[(2.4-Methoxyphenyl)methyl]-3-methylpiperazine-2-one
- - Active Intermediate Individual Intermediate use only 02-07-2021 View substance registered dossier
(3R,4S,6R,7R,9R,11S,12R,13S,14R)-6-{[4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-14-ethyl-12,13-dihydroxy-4-[(5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl)oxy]-10-(hydroxyimino)-7-methoxy-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecan-2-one
918-279-0 - Active Intermediate Joint Intermediate use only 26-04-2017 View substance registered dossier
(3RS,3aRS,6SR,7aSR)-hexahydro-3,6-dimethyl-2(3H)-benzofuranone and (3RS,3aSR,6RS,7aRS)-hexahydro-3,6-dimethyl-2(3H)-benzofuranone
429-980-1 - Active NONS Joint Tonnage data confidential 15-12-2008 View substance registered dossier
(3S)-3-{4-[8-(2,4-dichlorophenyl)-3-(methoxycarbonyl)-6,7-dihydro-5H-benzocyclohepten-9-yl]phenoxy}-1-(3-fluoropropyl)pyrrolidinium hydrogen oxalate
950-060-5 - Active Intermediate Joint Intermediate use only 15-01-2020 View substance registered dossier
(3S,3S’)-Dineopentyl 4,4’-disulfanediylbis(3-(benzyloxycarbonylamino)butane-1-sulfonate
954-955-1 - Active Intermediate Joint Intermediate use only 27-09-2021 View substance registered dossier
(3S,4R)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-1-benzyl-4-(4-fluorophenyl)piperidine
929-011-7 - Active Intermediate Joint Intermediate use only 20-04-2018 View substance registered dossier
(3S,5R)-4-chloro-[5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)furan-3-yl]methylbenzenesulfonate
436-150-2 - Active Intermediate Joint Intermediate use only 16-05-2018 View substance registered dossier
(3S,5R)-4-chloro-[5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)furan-3-yl]methylbenzenesulfonate
436-150-2 - Active Intermediate Joint Intermediate use only 12-07-2013 View substance registered dossier
(3S,6E)- 3,7,11-trimethyldodeca-6,10-dien-1-ol
450-320-3 - Active Full Joint ≥ 0 to < 10 tonnes 16-04-2018 View substance registered dossier
(3S,6E)- 3,7,11-trimethyldodeca-6,10-dien-1-ol
450-320-3 - Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
(4-(3,4-dichloro-phenyl)-3,4-dihydro-2H-naphthalen-1-ylidene)-methyl-amide
455-240-2 - Active Intermediate Joint Intermediate use only 03-03-2022 View substance registered dossier
(4-(3,4-dichloro-phenyl)-3,4-dihydro-2H-naphthalen-1-ylidene)-methyl-amide
455-240-2 - Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
(4-6) PEPTIDE
427-550-8 - Active NONS Joint Tonnage data confidential 10-11-2008 View substance registered dossier
(4-nitrophenyl)methyl [6R,(6α,7β)]-[3-hydroxy-5,8-dioxo-7-(phenoxyacetylamino)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate]
ENOL SULFOXIDE ESTER
411-820-7 - Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
(4-vinylphenyl)methyl-2-[(1Z)-1-aza-3-methyl-2-(4-methylthiophenyl)-3-morpholin-4-ylbut-1-enyloxy]acetate
453-050-4 - Active NONS Individual Tonnage data confidential 04-02-2011 View substance registered dossier
(4aR*, 8aR*)-1-bromo-4a,5,9,10,11,12-hexahydro-3-methoxy-6H-benzofuro[3a,3,2-ef] [2]benzazepin-6-one hydrochloride (1:1)
700-867-1 - Active Full Joint ≥ 1 to < 10 tonnes 11-06-2020 View substance registered dossier
(4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid;N,N-diethylethanamine
926-346-0 - Active Intermediate Joint Intermediate use only 10-11-2017 View substance registered dossier
(4R)-Tetrahydro-4-hydroxy-4-methyl-2H-Pyran-2-one
433-160-9 - Active Full Joint ≥ 1 to < 10 tonnes 18-08-2020 View substance registered dossier
(4R)-Tetrahydro-4-hydroxy-4-methyl-2H-Pyran-2-one
433-160-9 - Cease Manufacture NONS Individual Cease manufacture 10-11-2008 View substance registered dossier
(4S)-3-carbamoyl-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-1-ium (2S,3S)-2,3-bis(benzoyloxy)-3-carboxypropanoate
947-346-7 - Active Intermediate Individual Intermediate use only 22-10-2021 View substance registered dossier
(4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide 4-methylbenzenesulfonate (1:1)
940-053-5 - Active Intermediate Joint Intermediate use only 19-01-2017 View substance registered dossier
Registrant/Supplier Address Country Registration Status Name EC / List no. CAS no. Last update year Details
Janssen Pharmaceutica N.V. Turnhoutseweg 30 2340 Beerse Belgium Belgium Active (3AS,4S,6AR)-4-METHOXYTETRAHYDROFURO[3,4- B]FURAN-2(3H)-ONE 443-930-6 - 2010; 2018 View substance registered dossier
DSM Pharma Chemicals Venlo B.V. Grubbenvorsterweg 8 Postbox 81 5900 AB Venlo Netherlands Netherlands Active (3AS,4S,6AR)-4-METHOXYTETRAHYDROFURO[3,4- B]FURAN-2(3H)-ONE 443-930-6 - - View substance registered dossier
Janssen Pharmaceutica N.V. Turnhoutseweg 30 2340 Beerse Belgium Belgium Cease Manufacture (3beta)-17-(3-pyridinyl)androsta-5,16-dien-3-yl acetate compound with (2R,3R)-tartaric acid and methanol (1 : 1 : 1.5) 931-336-4 - 2019 View substance registered dossier
Saltigo GmbH HSEQ-RA Kaiser-Wilhelm-Allee 40 51373 Leverkusen Germany Germany Active (3R)-2,3-dihydro-1,1,3-trimethyl-1H-Inden-4-amine-(2S,3S)-2,3-dihydroxybutanedioate 701-382-8 - - View substance registered dossier
SONEAS Chemicals Ltd. Banyaleg Str. 47-59. H-1225 Budapest Hungary Hungary Active (3R)-4[(2.4-Methoxyphenyl)methyl]-3-methylpiperazine-2-one - - - View substance registered dossier
Ercros SA Avenida Diagonal 593-595 08014 Barcelona Spain Spain Active (3R,4S,6R,7R,9R,11S,12R,13S,14R)-6-{[4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-14-ethyl-12,13-dihydroxy-4-[(5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl)oxy]-10-(hydroxyimino)-7-methoxy-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecan-2-one 918-279-0 - - View substance registered dossier
- - - - (3RS,3aRS,6SR,7aSR)-hexahydro-3,6-dimethyl-2(3H)-benzofuranone and (3RS,3aSR,6RS,7aRS)-hexahydro-3,6-dimethyl-2(3H)-benzofuranone 429-980-1 - - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active (3RS,3aRS,6SR,7aSR)-hexahydro-3,6-dimethyl-2(3H)-benzofuranone and (3RS,3aSR,6RS,7aRS)-hexahydro-3,6-dimethyl-2(3H)-benzofuranone 429-980-1 - - View substance registered dossier
sanofi chimie 82 avenue Raspail 94250 Gentilly France France Active (3S)-3-{4-[8-(2,4-dichlorophenyl)-3-(methoxycarbonyl)-6,7-dihydro-5H-benzocyclohepten-9-yl]phenoxy}-1-(3-fluoropropyl)pyrrolidinium hydrogen oxalate 950-060-5 - - View substance registered dossier
ORGAPHARM Rue du Moulin de la Canne 45300 PITHIVIERS France France Active (3S,3S’)-Dineopentyl 4,4’-disulfanediylbis(3-(benzyloxycarbonylamino)butane-1-sulfonate 954-955-1 - - View substance registered dossier
Gedeon Richter Plc. Gyomroi ut 19-21 1103 Budapest Hungary Hungary Active (3S,4R)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-1-benzyl-4-(4-fluorophenyl)piperidine 929-011-7 - - View substance registered dossier
MINAKEM Beuvry Production SAS 145, Chemin des Lilas 59310 Beuvry-la-Forêt France France Active (3S,5R)-4-chloro-[5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)furan-3-yl]methylbenzenesulfonate 436-150-2 - - View substance registered dossier
MSD International GmbH Ballydine - Kilsheelan 0 Clonmel Ireland Ireland Active (3S,5R)-4-chloro-[5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)furan-3-yl]methylbenzenesulfonate 436-150-2 - 2011; 2015 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Irish competent national authority. - - Active (3S,5R)-4-chloro-[5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)furan-3-yl]methylbenzenesulfonate 436-150-2 - - View substance registered dossier
[Confidential] - - - (3S,5R)-4-chloro-[5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)furan-3-yl]methylbenzenesulfonate 436-150-2 - - View substance registered dossier
TAKASAGO TEPL-OR(1) 12 rue Torricelli 75017 Paris France France Active (3S,6E)- 3,7,11-trimethyldodeca-6,10-dien-1-ol 450-320-3 - 2018 View substance registered dossier
- - - - (3S,6E)- 3,7,11-trimethyldodeca-6,10-dien-1-ol 450-320-3 - - View substance registered dossier
Alkaloida Chemical Company Zrt. Kabay Janos 29 H-4440 Tiszavasvari Hungary Hungary Active (4-(3,4-dichloro-phenyl)-3,4-dihydro-2H-naphthalen-1-ylidene)-methyl-amide 455-240-2 - - View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active (4-(3,4-dichloro-phenyl)-3,4-dihydro-2H-naphthalen-1-ylidene)-methyl-amide 455-240-2 - - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Belgian competent national authority. - - Active (4-6) PEPTIDE 427-550-8 - - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Irish competent national authority. - - Active (4-nitrophenyl)methyl [6R,(6α,7β)]-[3-hydroxy-5,8-dioxo-7-(phenoxyacetylamino)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate] 411-820-7 - - View substance registered dossier
FujiFilm Manufacturing Europe BV Oudenstaart 1 5047 TK Tilburg Netherlands Netherlands Active (4-vinylphenyl)methyl-2-[(1Z)-1-aza-3-methyl-2-(4-methylthiophenyl)-3-morpholin-4-ylbut-1-enyloxy]acetate 453-050-4 - 2011 View substance registered dossier
Janssen Pharmaceutica N.V. Turnhoutseweg 30 2340 Beerse Belgium Belgium Active (4aR*, 8aR*)-1-bromo-4a,5,9,10,11,12-hexahydro-3-methoxy-6H-benzofuro[3a,3,2-ef] [2]benzazepin-6-one hydrochloride (1:1) 700-867-1 - 2020 View substance registered dossier
DIPHARMA FRANCIS srl Bissone, 5 20021 Baranzate Milano Italy Italy Active (4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid;N,N-diethylethanamine 926-346-0 - - View substance registered dossier
Visolis, B.V. Urmonderbaan 22 6167 RD Geleen Netherlands Netherlands Active (4R)-Tetrahydro-4-hydroxy-4-methyl-2H-Pyran-2-one 433-160-9 - - View substance registered dossier
- - - - (4R)-Tetrahydro-4-hydroxy-4-methyl-2H-Pyran-2-one 433-160-9 - - View substance registered dossier
Bayer AG Kaiser-Wilhelm-Allee 51373 Leverkusen Germany Germany Active (4S)-3-carbamoyl-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-1-ium (2S,3S)-2,3-bis(benzoyloxy)-3-carboxypropanoate 947-346-7 - 2020; 2021 View substance registered dossier
Hovione FarmaCiencia SA Sete Casas 2674-506 Loures Portugal Portugal Active (4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide 4-methylbenzenesulfonate (1:1) 940-053-5 - 2017 View substance registered dossier
Hovione Limited Loughbeg not available Ringaskiddy County Cork Ireland Ireland Active (4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide 4-methylbenzenesulfonate (1:1) 940-053-5 - 2017 View substance registered dossier

In this table, you will find all public data submitted to ECHA in REACH registration dossiers by substance manufacturers, importers, or their representatives, as laid out by the REACH Regulation (see Understanding REACH regulation).

ECHA makes available this information as REACH registered substance factsheets, which contain the full set of non-confidential information from related registration dossiers for a substance. Depending on the number of registrations that have been made for a substance, one factsheet can thus represent data from anything between hundreds of registration dossiers in a joint submission, to data from just one registration dossier.

As noted in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission. Please also note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).

In the portal results table are presented:

  • Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
  • Registration status – indicating the calculated registration status for the whole factsheet: Active – is being manufactured or imported to the EEA by one or more registrants; Cease Manufacture - is no longer being manufactured or imported above 1 tone per calendar year. All registrants of the substance have reported a cease of manufacture or import; or No longer valid - no longer considered registered under REACH and not currently allowed to be manufactured or imported to the EEA, until the substance is registered again.
  • Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
  • Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
  • Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
  • Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
  • Link to the full factsheet.

A subset of the key chemical properties (physico-chemical, environmental fate, ecotoxicological and toxicological data) of registered substances can be searched and accessed via the OECD eChemPortal.

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