Registered substances

Registered substances

Registered substances

Please note:

We have successfully adapted to the latest IUCLID format, and have resumed processing dossiers since 3 March 2022. Over the coming weeks we will catch up with the backlog of submissions since 14 October 2021, and expect to have all outstanding data online in approximately one month’s time. Please be aware that any new submissions will be at the back of the processing queue, and will be correspondingly delayed before publication. We appreciate your understanding in this matter.

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REACH - Registration, Evaluation, Authorisation and Restriction of Chemicals Regulation

Registered Substances Factsheets

Substances which have been registered and can be placed on the EEA market by those companies with a valid registration



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Details
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-, 4,4-dioxide, (2S,3S,5R)-
618-303-7 89786-04-9 Active Intermediate Joint Intermediate use only 12-03-2018 View substance registered dossier
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-, diphenylmethyl ester, 4,4-dioxide, (2S,3S,5R)-
618-304-2 89789-07-1 Active Intermediate Joint Intermediate use only 13-03-2018 View substance registered dossier
4-Thiazoleacetic acid, 2-(formylamino)-α-oxo-
613-733-1 64987-06-0 Active Intermediate Individual Intermediate use only 27-10-2017 View substance registered dossier
4-Thiazolemethanamine, N-methyl-2-(1-methylethyl)-, hydrochloride (1:2)
937-695-3 1185167-55-8 Active Intermediate Individual Intermediate use only 31-07-2012 View substance registered dossier
4-THIAZOLIDINE CARBOXYLIC ETHYL ESTER HCl
613-908-2 66223-38-9 Active Intermediate Individual Intermediate use only 18-01-2018 View substance registered dossier
4-trans-[4-trans-(3,4-Difluorphenyl)-cyclohexyl]-cyclohexancarbaldehyd
604-491-8 145767-92-6 Active Intermediate Joint Intermediate use only 19-02-2018 View substance registered dossier
4-vinylcyclohexene
202-848-9 100-40-3 Active Intermediate Joint Intermediate use only 11-07-2017 View substance registered dossier
4-{[4-(3-amino-4-sulfoanilino)-6-chloro-1,3,5-triazin-2-yl]amino}-6-[(5-carbamoyl-1-ethyl-2-hydroxy-4-methyl-6-oxo-1,6-dihydropyridin-3-yl)diazenyl]benzene-1,3-disulfonic acid
926-027-6 - Active Intermediate Joint Intermediate use only 08-07-2019 View substance registered dossier
4-{[4-amino-5-bromo-6-(methoxymethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]methyl}piperazin-2-one
828-315-6 1443532-21-5 Active Intermediate Individual Intermediate use only 22-11-2019 View substance registered dossier
4H-1,2,4-triazol-4-ylamine
209-533-5 584-13-4 Active Intermediate Individual Intermediate use only 31-05-2016 View substance registered dossier
Registrant/Supplier Address Country Registration Status Name EC / List no. CAS no. Last update year Details
IBI - Istituto Biochimico Italiano Giovanni Lorenzini Spa Via Fossignano, 2 04011 Aprilia (LT) Italy Italy Active 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-, 4,4-dioxide, (2S,3S,5R)- 618-303-7 89786-04-9 - View substance registered dossier
FRESENIUS KABI iPSUM s.r.l. Via Roma, 108 20060 Cassina de' Pecchi (MI) Italy Italy Active 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-, 4,4-dioxide, (2S,3S,5R)- 618-303-7 89786-04-9 - View substance registered dossier
FRESENIUS KABI iPSUM s.r.l. Via Roma, 108 20060 Cassina de' Pecchi (MI) Italy Italy Active 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-, diphenylmethyl ester, 4,4-dioxide, (2S,3S,5R)- 618-304-2 89789-07-1 - View substance registered dossier
Curia Italy S.r.l. VIA DEL VECCHIO POLITECNICO, n. 9 20121 Milano Italy Italy Active 4-Thiazoleacetic acid, 2-(formylamino)-α-oxo- 613-733-1 64987-06-0 - View substance registered dossier
Flamma S.p.a. via Bedeschi, 22 24040 Chignolo d'Isola Bergamo Italy Italy Active 4-Thiazolemethanamine, N-methyl-2-(1-methylethyl)-, hydrochloride (1:2) 937-695-3 1185167-55-8 - View substance registered dossier
Curia France SAS ZI de Laville 47240 BON-ENCONTRE France France Active 4-THIAZOLIDINE CARBOXYLIC ETHYL ESTER HCl 613-908-2 66223-38-9 - View substance registered dossier
Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany Germany Active 4-trans-[4-trans-(3,4-Difluorphenyl)-cyclohexyl]-cyclohexancarbaldehyd 604-491-8 145767-92-6 - View substance registered dossier
Evonik Operations GmbH Rellinghauser Straße 1-11 45128 Essen Germany Germany Active 4-vinylcyclohexene 202-848-9 100-40-3 2016; 2017 View substance registered dossier
Synthesia, a.s. Semtín103 53002 Pardubice Czech Republic Czech Republic Active 4-{[4-(3-amino-4-sulfoanilino)-6-chloro-1,3,5-triazin-2-yl]amino}-6-[(5-carbamoyl-1-ethyl-2-hydroxy-4-methyl-6-oxo-1,6-dihydropyridin-3-yl)diazenyl]benzene-1,3-disulfonic acid 926-027-6 - - View substance registered dossier
Bayer AG Kaiser-Wilhelm-Allee 51373 Leverkusen Germany Germany Active 4-{[4-amino-5-bromo-6-(methoxymethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]methyl}piperazin-2-one 828-315-6 1443532-21-5 - View substance registered dossier
QUIMICA SINTETICA, S.A. C/ Dulcinea, s/n 28805 Alcalá de Henares Madrid Spain Spain Active 4H-1,2,4-triazol-4-ylamine 209-533-5 584-13-4 - View substance registered dossier

In this table, you will find all public data submitted to ECHA in REACH registration dossiers by substance manufacturers, importers, or their representatives, as laid out by the REACH Regulation (see Understanding REACH regulation).

ECHA makes available this information as REACH registered substance factsheets, which contain the full set of non-confidential information from related registration dossiers for a substance. Depending on the number of registrations that have been made for a substance, one factsheet can thus represent data from anything between hundreds of registration dossiers in a joint submission, to data from just one registration dossier.

As noted in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission. Please also note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).

In the portal results table are presented:

  • Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
  • Registration status – indicating the calculated registration status for the whole factsheet: Active – is being manufactured or imported to the EEA by one or more registrants; Cease Manufacture - is no longer being manufactured or imported above 1 tone per calendar year. All registrants of the substance have reported a cease of manufacture or import; or No longer valid - no longer considered registered under REACH and not currently allowed to be manufactured or imported to the EEA, until the substance is registered again.
  • Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
  • Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
  • Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
  • Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
  • Link to the full factsheet.

A subset of the key chemical properties (physico-chemical, environmental fate, ecotoxicological and toxicological data) of registered substances can be searched and accessed via the OECD eChemPortal.

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