Registered substances
Registered substances
In this table, you will find all public data submitted to ECHA in REACH registration dossiers by substance manufacturers, importers, or their representatives, as laid out by the REACH Regulation (see Understanding REACH regulation).
ECHA makes available this information as REACH registered substance factsheets, which contain the full set of non-confidential information from related registration dossiers for a substance. Depending on the number of registrations that have been made for a substance, one factsheet can thus represent data from anything between hundreds of registration dossiers in a joint submission, to data from just one registration dossier.
As noted in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission. Please also note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).
In the portal results table are presented:
- Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
- Registration status – indicating the calculated registration status: Active - being actively manufactured or imported to the EEA; Cease manufacture - is no longer being manufactured or imported, but still considered to have a valid registration under REACH, and capable of resuming manufacture or import at any time; or No longer valid - no longer considered registered under REACH and not currently permitted to be manufactured or imported to the EEA unless and until properly registered again.
- Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
- Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
- Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
- Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
- Link to the full factsheet.
A subset of the key chemical properties (physico-chemical, environmental fate, ecotoxicological and toxicological data) of registered substances can be searched and accessed via the OECD eChemPortal.
Please note:
- The REACH Registered substance portal was updated on 9th November 2020; the REACH registered factsheets were further updated on 21st December 2020. Details of the improvements can be found at Dissemination Platform Updates. Reprocessing the entire dataset is ongoing since 21 December 2020. ECHA is making all possible efforts to make the improvements and additional data visible with the shortest delay.
- The ‘Substance has nanoform’ search filter returns all factsheets containing any data related to nanomaterials. NB: This does not mean that a registration covering nanoforms has been submitted in line with the revised annexes of REACH. Since 1 January 2020, before manufacturing or importing a nanoform of a substance, the operators concerned must submit the required nano-specific information to ECHA in a new or updated registration dossier.
Further information
- Registered substances information
- How to determine what will be published (Data Submission Manual 15)
- Understanding REACH Regulation
- Q&A on registered substances
- What is an Infocard? [PDF]
- What is a Registered substance Factsheet? [PDF]
- eChemPortal
- REACH study results download
- REACH Regulation
- ECHA Legal notice
Last updated 31 March 2021. Database contains 25847 unique substances and contains information from 99441 dossiers.
| Registrant/Supplier | Address | Country | Registration Status | Name | EC / List no. | CAS no. | Last update year | Details |
|---|---|---|---|---|---|---|---|---|
| Former NONS notifier unknown to ECHA - Contact the relevant German competent national authority. | - | - | Active | (S)-3-benzyloxycarbonyl-1,2,3,4-tetrahydro-isoquinolinium 4-methylbenzenesulfonate | 406-960-0 | 77497-97-3 | - | View substance registered dossier |
| Pfizer Ireland Pharmaceuticals | n/a P43 X3336 Ringaskiddy Cork Ireland | Ireland | Active | (S)-3-benzyloxycarbonyl-1,2,3,4-tetrahydro-isoquinolinium 4-methylbenzenesulfonate | 406-960-0 | 77497-97-3 | - | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. | - | - | Active | (S)-3-benzyloxycarbonyl-1,2,3,4-tetrahydro-isoquinolinium 4-methylbenzenesulfonate | 406-960-0 | 77497-97-3 | - | View substance registered dossier |
| MAPIC Europe NV | EXCELSIORLAAN 83 1930 ZAVENTEM Belgium | Belgium | Cease Manufacture | (S)-3-benzyloxycarbonyl-1,2,3,4-tetrahydro-isoquinolinium 4-methylbenzenesulfonate | 406-960-0 | 77497-97-3 | 2019 | View substance registered dossier |
| Fine Organics Limited | Seal Sands TS2 1UB Middlesbrough Teesside United Kingdom | United Kingdom | No longer Valid | (S)-3-benzyloxycarbonyl-1,2,3,4-tetrahydro-isoquinolinium 4-methylbenzenesulfonate | 406-960-0 | 77497-97-3 | 2021 | View substance registered dossier |
| Esteve Quimica, S.A. | Torre Esteve Passeig de la Zona Franca, 109, 4ª Planta 08038 Barcelona Barcelona Spain | Spain | Cease Manufacture | (S)-3-benzyloxycarbonyl-1,2,3,4-tetrahydro-isoquinolinium 4-methylbenzenesulfonate | 406-960-0 | 77497-97-3 | 2017 | View substance registered dossier |
| ROLABO OUTSOURCING, S.L. | Polígono Industrial Malpica. Calle J, nº 3-4 50016 Zaragoza Zaragoza Spain | Spain | Active | (S)-3-benzyloxycarbonyl-1,2,3,4-tetrahydro-isoquinolinium 4-methylbenzenesulfonate | 406-960-0 | 77497-97-3 | 2020 | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. | - | - | Active | (S)-3-hydroxy-γ-butyrolactone | 434-990-4 | 7331-52-4 | - | View substance registered dossier |
| Boehringer Ingelheim Pharma GmbH & Co. KG | Binger Strasse 173 55216 Ingelheim am Rhein Germany | Germany | Active | (S)-3-Methyl-1-(2-piperidine-1-phenyl)butylamine compound with N-Acetyl-L-glutamic acid | 606-883-4 | 219921-94-5 | - | View substance registered dossier |
| Boehringer Ingelheim Pharma GmbH & Co. KG | Binger Strasse 173 55216 Ingelheim am Rhein Germany | Germany | Active | (S)-3-Methyl-1-(2-piperidinophenyl)-1-butylamine | 604-603-5 | 147769-93-5 | - | View substance registered dossier |
| AbbVie Srl | S.R. 148 Pontina Km 52 snc 04011 Campoverde di Aprilia (LT) Italy | Italy | Active | (S)-3-methyl-2-(2-oxotetrahydropyrimidine-1-yl)butyric acid | 430-900-2 | 192725-50-1 | 2011; 2018 | View substance registered dossier |
| Amri Italy S.r.l. | VIA DEL VECCHIO POLITECNICO, n. 9 20121 Milano Italy | Italy | Active | (S)-3-methyl-2-(2-oxotetrahydropyrimidine-1-yl)butyric acid | 430-900-2 | 192725-50-1 | - | View substance registered dossier |
| Fermion Oy | Koivu-Mankkaan tie 6 A FI-02101 Espoo Finland | Finland | Active | (S)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-chlorobenzonitrile | 941-762-2 | 1297537-41-7 | - | View substance registered dossier |
| FINORGA SAS | 497 route de Givors 38670 CHASSE SUR RHONE France | France | Active | (S)-4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-one | 444-830-5 | 124379-29-9 | 2010; 2020 | View substance registered dossier |
| MOEHS BCN, S.L. | C/ Zenc, 12 08755 Castellbisbal Barcelona Spain | Spain | Active | (S)-4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-one | 444-830-5 | 124379-29-9 | - | View substance registered dossier |
| H. Lundbeck A/S | Ottiliavej 7-9 2500 Copenhagen Denmark | Denmark | Active | (S)-4-(4-dimethylamino-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile | 430-770-7 | 128173-52-4 | - | View substance registered dossier |
| Lundbeck Pharmaceuticals Italy S.p.A | via quarta strada 2 35129 padova Italy | Italy | Active | (S)-4-[4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-hydroxymethylbenzonitrile hemi(+)-di-toluoyltartrate | 603-261-4 | 128173-53-5 | 2018 | View substance registered dossier |
| - | - | - | - | (S)-4-amino-5-[(2-(1H-imidazol-4-yl)ethyl)amino]-5-oxopentanoic acid | 421-900-3 | - | - | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant Spanish competent national authority. | - | - | Active | (S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione | 444-280-6 | 7689-03-4 | - | View substance registered dossier |
| PMC ISOCHEM | 32 rue Lavoisier 91710 VERT LE PETIT France | France | Active | (S)-4-methyloxazolidine-2,5-dione | 218-750-4 | 2224-52-4 | - | View substance registered dossier |
| Corden Pharma Bergamo S.p.A. | Via Bergamo, 121 IT-24047 Treviglio BG Italy | Italy | Active | (S)-4-{[1-(2-Benzyloxycarbonylamino-acetyl)-(S)-2-methyl-pyrrolidine-2-carbonyl]-amino}-5-oxo-hexanoic acid | 949-609-1 | - | - | View substance registered dossier |
| bracco imaging | Via Folli 50 20134 milan Italy | Italy | Active | (S)-5-[2-(acetyloxy)propanamido]-2,4,6-triiodo-1,3-di(chloroformyl)benzene | 410-940-7 | - | - | View substance registered dossier |
| Fermion Oy | Koivu-Mankkaan tie 6 A FI-02101 Espoo Finland | Finland | Active | (S)-5-acetyl-N-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1H-pyrazole-3-carboxamide | 941-760-1 | 1297537-33-7 | - | View substance registered dossier |
| Patheon Austria GmbH & Co KG | St. Peterstrasse 25 A-4020 Linz Austria | Austria | Active | (S)-5-chloro-4-methyl-2-(2-methylpyrrolidin-2-yl)-1H-benzo[d]imidazole dihydrochloride | 948-271-2 | - | - | View substance registered dossier |
| Pfizer Ireland Pharmaceuticals | n/a P43 X3336 Ringaskiddy Cork Ireland | Ireland | Active | (S)-5-fluoro-3-methylisobenzofuran-1(3H)-one | 943-180-4 | 1803573-19-4 | 2019 | View substance registered dossier |
| Cambrex Karlskoga AB | Bjorkborns Industriomrade 69185 Karlskoga Sweden | Sweden | Active | (S)-5-Methoxy-2-propionamidotetralin | 607-376-0 | 244239-67-6 | - | View substance registered dossier |
| Patheon Austria GmbH & Co KG | St. Peterstrasse 25 A-4020 Linz Austria | Austria | Active | (S)-5-tert-butoxy-3-(tert-butyldimethylsilyloxy)-5-oxopentylboronic acid (+)-pinanediol ester | 811-219-3 | 1681053-95-1 | - | View substance registered dossier |
| [Confidential] | - | - | - | (S)-7-[[2-O-6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one | 236-216-9 | 13241-33-3 | - | View substance registered dossier |
| TAKASAGO TEPL-OR(1) | 12 rue Torricelli 75017 Paris France | France | Active | (S)-7-hydroxy-3,7-dimethyloctanal | 829-246-4 | 34212-53-8 | - | View substance registered dossier |
| MinAscent Leuna Production GmbH | Am Haupttor Gebäude 4208 06237 Leuna Germany | Germany | Active | (S)-[2-(phenylmethoxy)propylidene]hydrazinecarboxylate, tert-butyle | 439-220-0 | - | - | View substance registered dossier |
| - | - | - | - | (S)-[2-(phenylmethoxy)propylidene]hydrazinecarboxylate, tert-butyle | 439-220-0 | - | - | View substance registered dossier |
| Eli Lilly Kinsale Limited | Dunderrow Kinsale P17 NY71 Cork Co. Cork Ireland | Ireland | Active | (S)-alpha-hydroxy-benzeneacetic acid compd. With (R)-N-methyl-gamma-(2-methylphenoxy)benzenepropanamine (1:1) | 617-437-3 | 83113-55-7 | - | View substance registered dossier |
| Sicor - Società Italiana Corticosteroidi S.r.l. | Piazzale Luigi Cadorna 4 20123 Milano (MI) Italy | Italy | Active | (S)-alpha-hydroxy-benzeneacetic acid compd. With (R)-N-methyl-gamma-(2-methylphenoxy)benzenepropanamine (1:1) | 617-437-3 | 83113-55-7 | - | View substance registered dossier |
| AstraZeneca | B313:5 AZ GlobalSHE- Chem.Reg. SE-15185 Södertälje Sweden | Sweden | Cease Manufacture | (S)-azetidine-2-carboxylic acid 4-cyanobenzylamide hydrochloride | 433-010-2 | - | 2012 | View substance registered dossier |
| Fine Organics Limited | Seal Sands TS2 1UB Middlesbrough Teesside United Kingdom | United Kingdom | No longer Valid | (S)-ethyl 3-(4,4-difluorocyclohexanecarboxamido)-3-phenylpropanoate | 445-820-3 | - | 2021 | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. | - | - | Active | (S)-ethyl 3-(4,4-difluorocyclohexanecarboxamido)-3-phenylpropanoate | 445-820-3 | - | - | View substance registered dossier |
| Pfizer Ireland Pharmaceuticals | n/a P43 X3336 Ringaskiddy Cork Ireland | Ireland | Active | (S)-ethyl 3-(4,4-difluorocyclohexanecarboxamido)-3-phenylpropanoate | 445-820-3 | - | - | View substance registered dossier |
| N.V. Ajinomoto OmniChem S.A. | Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium | Belgium | Active | (S)-ethyl 3-(4,4-difluorocyclohexanecarboxamido)-3-phenylpropanoate | 445-820-3 | - | - | View substance registered dossier |
| CABB Oy (OR of CABB AG) | Kemirantie 1 P.O.Box 566 Kokkola Finland | Finland | Active | (S)-methyl-2-chloropropionate | 412-470-8 | 73246-45-4 | - | View substance registered dossier |
| Ajinomoto OmniChem (OR) | Cooppallaan 91 9230 Wetteren Belgium | Belgium | Active | (S)-N,N'-dibutyl-2-[(1-oxododecyl)amino]glutaramide | 264-391-1 | 63663-21-8 | - | View substance registered dossier |
| ORIL INDUSTRIE | 13 rue Auguste Desgenétais 76210 BOLBEC France | France | Active | (S)-N-(Ethoxycarbonyl)-butyl-(S)-alanine | 617-393-5 | 82834-12-6 | 2019; 2020 | View substance registered dossier |
| Esteve Quimica, S.A. | Torre Esteve Passeig de la Zona Franca, 109, 4ª Planta 08038 Barcelona Barcelona Spain | Spain | Active | (S)-N-[(Diethylamino)methyl]-.alpha.-ethyl-2-oxo-1-pyrrolidineacetamide L-(+)-tartrate | 700-272-7 | 754186-36-2 | 2008; 2010; 2012; 2015 | View substance registered dossier |
| Pliva Hrvatska doo | Prilaz baruna Filipovića 25 10000 Zagreb Croatia | Croatia | Active | (S)-N-[[3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-amine | 942-077-1 | - | - | View substance registered dossier |
| - | - | - | - | (S)-N-tert-butyl-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide | 414-600-9 | 149182-72-9 | - | View substance registered dossier |
| ISOCHEM | 32 rue Lavoisier 91710 VERT LE PETIT France | France | Active | (S)-N-tert-butyl-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide | 414-600-9 | 149182-72-9 | - | View substance registered dossier |
| Bayer AG | Kaiser-Wilhelm-Allee 51373 Leverkusen Germany | Germany | Active | (S)-Oxamin Hydrochlorid | 618-311-0 | 898543-06-1 | 2012; 2018; 2020 | View substance registered dossier |
| Destilerías Muñoz Gálvez, S.A. | Avda. Ciudad de Almería, 162 E30010 Murcia Murcia Spain | Spain | Active | (S)-p-mentha-1,8-diene | 227-815-6 | 5989-54-8 | 2017 | View substance registered dossier |
| TAKASAGO TICSA-Producer/Importer | Avenida de Mazarrón, 49 30120 El Palmar Murcia Spain | Spain | Active | (S)-p-mentha-1,8-diene | 227-815-6 | 5989-54-8 | - | View substance registered dossier |
| DESTILACIONES BORDAS CHINCHURRETA, S.A. | C/ Acueducto, 4-6 Pol. Ind. Ctra la Isla 41703 Dos Hermanas (Sevilla) Spain | Spain | Active | (S)-p-mentha-1,8-diene | 227-815-6 | 5989-54-8 | 2019 | View substance registered dossier |
| Arran Chemical Company Ltd | Monksland Industrial Estate N37DN24 Athlone Co. Roscommon Ireland | Ireland | Active | (S)-propane-1,2-diamine bis((2S,3S)-2,3-dihydroxysuccinate) dihydrate | 924-425-4 | - | - | View substance registered dossier |
| CU Chemie Uetikon GmbH | Raiffeisenstrasse 4 77933 Lahr Baden-Württemberg Germany | Germany | Active | (S)-propane-1,2-diamine bis((2S,3S)-2,3-dihydroxysuccinate) dihydrate | 924-425-4 | - | - | View substance registered dossier |
| F.I.S. Fabbrica Italiana Sintetici S.p.a. | Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy | Italy | Active | (S)-pyrrolidine-2-carboxamide | 231-397-0 | 7531-52-4 | - | View substance registered dossier |
| Novartis Integrated Services Limited | Ringaskiddy IE Ringaskiddy Cork Ireland | Ireland | Active | (S)-pyrrolidine-2-carboxamide | 231-397-0 | 7531-52-4 | 2018 | View substance registered dossier |
| Patheon Austria GmbH & Co KG | St. Peterstrasse 25 A-4020 Linz Austria | Austria | Active | (S)-pyrrolidine-2-carboxamide | 231-397-0 | 7531-52-4 | - | View substance registered dossier |
| Cambrex Karlskoga AB | Bjorkborns Industriomrade 69185 Karlskoga Sweden | Sweden | Cease Manufacture | (S)-tert-butyl(1-((3-fluoro-2-(phenylcarbamoyl)phenyl)amino)-1-oxobutan-2 yl)carbamate | 942-159-7 | - | 2017 | View substance registered dossier |
| Patheon Austria GmbH & Co KG | St. Peterstrasse 25 A-4020 Linz Austria | Austria | Active | (S)-tert.-Butyl-[2-(aminoethoxy)-[1,2]oxaborolan-4-yl]acetate | 942-682-0 | - | - | View substance registered dossier |
| F.I.S. Fabbrica Italiana Sintetici S.p.a. | Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy | Italy | Active | (S)-α-(acetylthio)benzenepropanoic acid | 430-300-0 | 76932-17-7 | - | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant German competent national authority. | - | - | Active | (S)-α-(acetylthio)benzenepropanoic acid | 430-300-0 | 76932-17-7 | - | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant Irish competent national authority. | - | - | Active | (S)-α-(acetylthio)benzenepropanoic acid | 430-300-0 | 76932-17-7 | - | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant Italian competent national authority. | - | - | Active | (S)-α-(acetylthio)benzenepropanoic acid | 430-300-0 | 76932-17-7 | - | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant Dutch competent national authority. | - | - | Active | (S)-α-(acetylthio)benzenepropanoic acid | 430-300-0 | 76932-17-7 | - | View substance registered dossier |
| ESIM Chemicals GmbH | St.-Peter-Strasse 25 4020 Linz Austria | Austria | Active | (S)-α-hydroxy-3-phenoxy-benzeneacetonitrile | 441-070-6 | 61826-76-4 | 2013; 2019 | View substance registered dossier |
| [Confidential] | - | - | - | (S)-α-hydroxy-3-phenoxy-benzeneacetonitrile | 441-070-6 | 61826-76-4 | - | View substance registered dossier |
| DOW CHEMICAL COMPANY LTD | Diamond House, Lotus Park Kingsbury Crescent Middx UB7 0DQ Staines Middx United Kingdom | United Kingdom | No longer Valid | (S)-α-hydroxy-3-phenoxy-benzeneacetonitrile | 441-070-6 | 61826-76-4 | 2021 | View substance registered dossier |
| Bábolna Bioenvironmental Centre Ltd. | Szállás u. 6. H-1107 Budapest Hungary | Hungary | Active | (S)Ammonium-(2E,4E)-11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate | 926-381-1 | - | - | View substance registered dossier |
| Chemours Netherlands B.V. | Baanhoekweg 22 3313 LA Dordrecht Netherlands | Netherlands | Cease Manufacture | (S,S)-1,1,1,2,2,3,4,5,5,5-decafluoropentane;reaction mass of: (R,R)-1,1,1,2,2,3,4,5,5,5-decafluoropentane | 420-640-8 | 138495-42-8 | 2016 | View substance registered dossier |
| Chemours Netherlands B.V._1 | Baanhoekweg 22 3313 LA Dordrecht Netherlands | Netherlands | Active | (S,S)-1,1,1,2,2,3,4,5,5,5-decafluoropentane;reaction mass of: (R,R)-1,1,1,2,2,3,4,5,5,5-decafluoropentane | 420-640-8 | 138495-42-8 | 2011; 2020 | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant Dutch competent national authority. | - | - | Active | (S,S)-1,1,1,2,2,3,4,5,5,5-decafluoropentane;reaction mass of: (R,R)-1,1,1,2,2,3,4,5,5,5-decafluoropentane | 420-640-8 | 138495-42-8 | - | View substance registered dossier |
| F.I.S. Fabbrica Italiana Sintetici S.p.a. | Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy | Italy | Active | (S,S)-trans-4-(acetylamino)-5,6-dihydro-6-methyl-7,7-dioxo-4H-thieno[2,3-b]thiopyran-2-sulfonamide | 415-030-3 | 120298-38-6 | - | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant Irish competent national authority. | - | - | Active | (S,S)-trans-4-(acetylamino)-5,6-dihydro-6-methyl-7,7-dioxo-4H-thieno[2,3-b]thiopyran-2-sulfonamide | 415-030-3 | 120298-38-6 | - | View substance registered dossier |
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