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Registered substances

Registered substances

In this table, you will find all public data submitted to ECHA in REACH registration dossiers by substance manufacturers, importers, or their representatives, as laid out by the REACH Regulation (see Understanding REACH regulation).

ECHA makes available this information as REACH registered substance factsheets, which contain the full set of non-confidential information from related registration dossiers for a substance. Depending on the number of registrations that have been made for a substance, one factsheet can thus represent data from anything between hundreds of registration dossiers in a joint submission, to data from just one registration dossier.

As noted in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission. Please also note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).

In the portal results table are presented:

  • Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
  • Registration status – indicating the calculated registration status: Active - being actively manufactured or imported to the EEA; Cease manufacture - is no longer being manufactured or imported, but still considered to have a valid registration under REACH, and capable of resuming manufacture or import at any time; or No longer valid - no longer considered registered under REACH and not currently permitted to be manufactured or imported to the EEA unless and until properly registered again.
  • Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
  • Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
  • Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
  • Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
  • Link to the full factsheet.

A subset of the key chemical properties (physico-chemical, environmental fate, ecotoxicological and toxicological data) of registered substances can be searched and accessed via the OECD eChemPortal.

Please note:
  • The REACH Registered substance portal was updated on 9th November 2020; the REACH registered factsheets were further updated on 21st December 2020. Details of the improvements can be found at Dissemination Platform Updates. Reprocessing the entire dataset is ongoing since 21 December 2020. ECHA is making all possible efforts to make the improvements and additional data visible with the shortest delay.
  • The ‘Substance has nanoform’ search filter returns all factsheets containing any data related to nanomaterials. NB: This does not mean that a registration covering nanoforms has been submitted in line with the revised annexes of REACH. Since 1 January 2020, before manufacturing or importing a nanoform of a substance, the operators concerned must submit the required nano-specific information to ECHA in a new or updated registration dossier.
Last updated 22 June 2021. Database contains 23314 unique substances and contains information from 103850 dossiers.
Substance identity
Administrative data
Submission type:
First published date:
Last update date:
Substance data
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Uses and exposure
Life cycle:
  • Consumer Uses
  • Article service life
  • Widespread uses by professional workers
  • Formulation or re-packing
  • Uses at industrial sites
  • Manufacture
Category:
Details
(3R,4S,5S,6R,7R,9R,10Z,11S,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione 10-oxime
603-883-6 134931-01-4 Cease Manufacture Intermediate Individual Cease manufacture 25-10-2012 View substance registered dossier
(3R,4S,5S,6R,7R,9R,10Z,11S,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione 10-oxime
603-883-6 134931-01-4 Active Intermediate Joint Intermediate use only 23-08-2016 View substance registered dossier
(3R,4S,6R,7R,9R,11S,12R,13S,14R)-6-{[4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-14-ethyl-12,13-dihydroxy-4-[(5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl)oxy]-10-(hydroxyimino)-7-methoxy-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecan-2-one
918-279-0 - Active Intermediate Joint Intermediate use only 26-04-2017 View substance registered dossier
(3R,5aS,6R,8aS,9R,12S,12aR)-3,6,9-trimethyloctahydro-3,12-epoxypyrano[4,3-j][1,2]benzodioxepin-10(3H)-one
700-290-5 63968-64-9 Active Intermediate Individual Intermediate use only 15-11-2012 View substance registered dossier
(3R,5R)-tert-Butyl 7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate
603-817-6 134395-00-9 Active Intermediate Joint Intermediate use only 28-09-2017 View substance registered dossier
(3R,5Z)-3-METHYL-5-CYCLOPENTADECEN-1-ONE
851-742-4 464207-51-0 Active Full Joint ≥ 1 to < 10 tonnes 28-05-2020 View substance registered dossier
(3R,6R)-3,6-dimethyl-1,4-dioxane-2,5-dione
603-436-5 13076-17-0 Active Full Joint ≥ 1 000 to < 10 000 tonnes 26-07-2018 View substance registered dossier
(3R,7aR)-3-tert-butyl-1,5-dioxodihydro-1H-pyrrolo[1,2-c][1,3]oxazole-7a(5H)-carbaldehyde
812-036-1 1214741-19-1 Cease Manufacture Intermediate Individual Cease manufacture 28-04-2016 View substance registered dossier
(3R,7aR)-3-tert-butyl-7a-{methoxy[(trimethylsilyl)oxy]methyl}dihydro-1H-pyrrolo[1,2-c][1,3]oxazole-1,5(6H)-dione
942-823-6 - Cease Manufacture Intermediate Individual Cease manufacture 03-11-2015 View substance registered dossier
(3R,7aS)-3-tert-butyldihydro-1H-pyrrolo[1,2-c][1,3]oxazole-1,5(6H)-dione
810-392-2 171284-84-7 Cease Manufacture Intermediate Individual Cease manufacture 07-09-2015 View substance registered dossier
(3R-trans)-dihydro-2,5-dioxofuran-3,4-diyl diacetate
228-502-7 6283-74-5 Active Intermediate Joint Intermediate use only 31-08-2018 View substance registered dossier
(3RS,3aRS,6SR,7aSR)-hexahydro-3,6-dimethyl-2(3H)-benzofuranone and (3RS,3aSR,6RS,7aRS)-hexahydro-3,6-dimethyl-2(3H)-benzofuranone
429-980-1 - Active NONS Joint Tonnage data confidential 15-12-2008 View substance registered dossier
(3S)-2-{N-[1-ethoxy-1-oxo-4-phenylbutan-2-yl]-substituted}-heteropolycyclic-3-carboxylic acid hydrochloride
919-408-3 - Active Intermediate Individual Intermediate use only 14-01-2020 View substance registered dossier
(3S)-3,7-Dimethyl-1-octanol
814-059-2 68680-98-8 Active Full Joint ≥ 1 to < 10 tonnes 30-05-2018 View substance registered dossier
(3S)-3,7-dimethylocta-1,6-dien-1-yl acetate
946-529-9 1439355-19-7 Active Intermediate Joint Intermediate use only 24-01-2018 View substance registered dossier
(3S)-3-[4-(2-chloro-5-iodobenzyl)phenoxy]tetrahydrofuran
619-599-0 915095-94-2 Active Intermediate Joint Intermediate use only 15-04-2020 View substance registered dossier
(3S)-3-hydroxy-4,4-dimethyldihydrofuran-2(3H)-one
626-470-2 5405-40-3 Cease Manufacture Full Individual Cease manufacture 05-07-2011 View substance registered dossier
(3S)-3-hydroxypyrrolidin-2-one
676-349-3 34368-52-0 Active Intermediate Individual Intermediate use only 12-11-2019 View substance registered dossier
(3S)-3-thiophen-2-ylsulfanylbutanoic acid
948-811-7 133359-80-5 Active Intermediate Joint Intermediate use only 23-10-2018 View substance registered dossier
(3S)-3-{4-[8-(2,4-dichlorophenyl)-3-(methoxycarbonyl)-6,7-dihydro-5H-benzocyclohepten-9-yl]phenoxy}-1-(3-fluoropropyl)pyrrolidinium hydrogen oxalate
950-060-5 - Active Intermediate Joint Intermediate use only 15-01-2020 View substance registered dossier
(3S)-N,N-dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine ethanedioate
603-567-8 132335-47-8 Active Intermediate Individual Intermediate use only 08-10-2009 View substance registered dossier
(3S, 4R)-4-(4’-Fluorophenyl)-3-(3’, 4’-methylenedioxyphenyl)-Nmethylpiperidine
924-787-3 110429-36-2 Active Intermediate Joint Intermediate use only 08-03-2021 View substance registered dossier
(3S,4aS,8aS)-2-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N-tert-butyldecahydroisoquinoline-3-carboxamide
430-230-0 136522-17-3 Cease Manufacture NONS Individual Cease manufacture 13-09-2010 View substance registered dossier
(3S,4aS,8aS)-N-tert-butyldecahydro-3-isoquinolinecarboxamide
420-380-5 136465-81-1 Cease Manufacture Intermediate Individual Cease manufacture 29-10-2012 View substance registered dossier
(3S,4aS,8aS)-N-tert-butyldecahydro-3-isoquinolinecarboxamide
420-380-5 136465-81-1 Active NONS Joint Tonnage data confidential 10-11-2008 View substance registered dossier
(3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-1-benzyl-4-(4-fluorophenyl)piperidine
929-011-7 - Active Intermediate Joint Intermediate use only 20-04-2018 View substance registered dossier
(3S,4S)-3-hexyl-4-[(R)-2-hydroxytridecyl]-2-oxetanone
418-650-2 104872-06-2 Active NONS Joint Tonnage data confidential 10-11-2008 View substance registered dossier
(3S,5R)-4-chloro-[5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)furan-3-yl]methylbenzenesulfonate
436-150-2 - Active Intermediate Joint Intermediate use only 12-07-2013 View substance registered dossier
(3S,5R)-4-chloro-[5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)furan-3-yl]methylbenzenesulfonate
436-150-2 - Active Intermediate Joint Intermediate use only 16-05-2018 View substance registered dossier
(3S,5S)-5-[(1S,3S)-1-azido-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl]-3-(propan-2-yl)oxolan-2-one
608-748-5 324763-46-4 Active Intermediate Joint Intermediate use only 13-08-2014 View substance registered dossier
(3S,5S,6S,9R)-6-isopropyl-3,9-dimethyl-1,4- and (3S,5R,6S,9R)-6-isopropyl-3,9-dimethyl-1,4-
457-410-1 831213-72-0 Active NONS Joint Tonnage data confidential 10-11-2008 View substance registered dossier
(3S,6E)- 3,7,11-trimethyldodeca-6,10-dien-1-ol
450-320-3 - Active Full Joint ≥ 0 to < 10 tonnes 16-04-2018 View substance registered dossier
(3S,6E)- 3,7,11-trimethyldodeca-6,10-dien-1-ol
450-320-3 - Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
(3S,6E)-3,7,11-trimethyldodeca-6,10-dienal
810-298-1 194934-66-2 Active Full Joint ≥ 1 to < 10 tonnes 07-09-2020 View substance registered dossier
(3S,6R,9S,12R,15S,18R,21S,24R)-6,18-dibenzyl-3,9,15,21-tetraisobutyl-4,10,12,16,22,24-hexamethyl-1,7,13,19-tetraoxa-4,10,16,22-tetraazacyclo-tetracosane-2,5,8,11,14,17,20,23-octaone
444-350-6 133413-70-4 Active Intermediate Joint Intermediate use only 24-09-2019 View substance registered dossier
(3S-cis)-3,6-dimethyl-1,4-dioxane-2,5-dione
224-832-0 4511-42-6 Active Full Joint ≥ 1 000 to < 10 000 tonnes 26-07-2018 View substance registered dossier
(3S-cis)-3,6-dimethyl-1,4-dioxane-2,5-dione
224-832-0 4511-42-6 Cease Manufacture Full Individual Cease manufacture 17-08-2015 View substance registered dossier
(3S-trans)-phenyl-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-1-piperidinecarboxylate
430-510-2 - Active NONS Joint Tonnage data confidential 10-11-2008 View substance registered dossier
(3Z)-hex-3-en-1-yl 2-methylprop-2-en-1-yl ether
439-790-0 292605-05-1 Active Full Individual ≥ 0 to < 10 tonnes 18-01-2013 View substance registered dossier
(3α,5β,7β)-3,7-Dihydroxy-24-norcholane-23-nitrile
828-107-5 118316-12-4 Active Intermediate Joint Intermediate use only 05-09-2018 View substance registered dossier
(3β)-17-(1,1,1-trifluoromethanesulfonate)-Androsta-5,16-diene-3,17-diol, 3-(2,2,2-trifluoroacetate)
840-627-4 1802323-89-2 Active Intermediate Joint Intermediate use only 26-06-2019 View substance registered dossier
(3β)-3-[(2,2,2-trifluoroacetyl)oxy]-Androst-5-en-17-one
840-626-9 3798-17-2 Active Intermediate Joint Intermediate use only 26-06-2019 View substance registered dossier
(3β,20β)-3-acetoxy-11-oxoolean-12-en-29-oic acid
228-475-1 6277-14-1 Active Full Joint ≥ 0 to < 10 tonnes 27-06-2019 View substance registered dossier
(3β,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-yl butyrate
250-567-5 31316-20-8 Active Intermediate Joint Intermediate use only 06-05-2015 View substance registered dossier
(4'-methyl-3-fluoro[1,1'-biphenyl]-4-yl)-boronic acid
813-651-8 1698890-39-9 Active Full Joint ≥ 1 to < 10 tonnes 14-05-2018 View substance registered dossier
(4,5-dibromo-1H-pyrrol-2-yl)(phenyl)methanone
700-338-5 50372-61-7 Active Intermediate Joint Intermediate use only 05-10-2016 View substance registered dossier
(4-(1-methylethyl)phenyl)-(4-methylphenyl)iodonium tetrakis(pentafluorophenyl)borate (1-) 422-960-3 178233-72-2 Active NONS Joint Tonnage data confidential 10-11-2008 View substance registered dossier
(4-(3,4-dichloro-phenyl)-3,4-dihydro-2H-naphthalen-1-ylidene)-methyl-amide
455-240-2 - Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
(4-(4-(4-dimethylaminobenzyliden-1-yl)-3-methyl-5-oxo-2-pyrazolin-1-yl)benzoic acid
410-430-4 117573-89-4 Active NONS Joint Tonnage data confidential 10-11-2008 View substance registered dossier
(4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(tetrahydrofuran-2-yl)methanone
613-265-8 63590-64-7 Active Intermediate Joint Intermediate use only 25-07-2018 View substance registered dossier
(4-(4-aminophenyl)(4-iminocyclohexa-2,5-dienylidene)methyl)-2-methylaniline hydrochloride
211-189-6 632-99-5 Active Full Joint ≥ 1 to < 10 tonnes 25-03-2018 View substance registered dossier
(4-(5-Oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-phenylamino)-acetic acid ethyl ester
927-587-4 872728-83-1 Active Intermediate Joint Intermediate use only 28-07-2016 View substance registered dossier
(4-(5-Oxo-4,5-dihydro-1,2,4-oxadiazole-3-yl)phenylamino)acetic acid
460-450-2 872728-82-0 Active Intermediate Joint Intermediate use only 17-05-2019 View substance registered dossier
(4-(6-diethylamino-2-methylpyridin-3-yl)imino-4,5-dihydro-3-methyl-1-(4-methylphenyl)-1H-pyrazol-5-one
427-070-9 - Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
(4-6) PEPTIDE
427-550-8 - Active NONS Joint Tonnage data confidential 10-11-2008 View substance registered dossier
(4-acetamido-2,2,6,6-tetramethyl-1-piperidinyl)oxidanyl; N-(2,2,6,6-tetramethyl-1-oxylpiperidin-4-yl)acetamide
423-840-3 14691-89-5 Active NONS Joint Tonnage data confidential 17-02-2012 View substance registered dossier
(4-amino-1-hydroxy-1-phosphonobutyl)phosphonic acid;hydrate
680-378-7 138624-11-0 Active Full Joint ≥ 1 to < 10 tonnes 02-02-2018 View substance registered dossier
(4-amino-2-chloro-5-methylphenyl)(4-chlorophenyl)acetonitrile
262-792-6 61437-85-2 Active Intermediate Joint Intermediate use only 09-03-2018 View substance registered dossier
(4-aminophenyl)-N-methylmethylenesulfonamide hydrochloride
406-010-5 88918-84-7 Active NONS Joint Tonnage data confidential 10-11-2008 View substance registered dossier
(4-butoxy-2,3-difluorophenyl)boronic acid
692-793-0 156487-12-6 Active Full Joint ≥ 1 to < 10 tonnes 16-05-2018 View substance registered dossier
(4-carboxybutyl)triphenylphosphonium bromide
241-782-5 17814-85-6 Active Intermediate Joint Intermediate use only 15-12-2015 View substance registered dossier
(4-Chloro-3-(4-ethoxybenzyl)phenyl)((3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methanone
695-300-7 1103738-30-2 Active Intermediate Joint Intermediate use only 24-11-2020 View substance registered dossier
(4-chlorophenyl)(2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol
814-124-5 133545-64-9 Active Intermediate Joint Intermediate use only 10-05-2017 View substance registered dossier
(4-chlorophenyl)hydrazine
214-029-3 1073-69-4 Active Intermediate Individual Intermediate use only 28-09-2010 View substance registered dossier
(4-chlorophenyl)hydrazine
214-029-3 1073-69-4 No longer Valid Intermediate Individual No longer valid 13-11-2013 View substance registered dossier
(4-cyclopropyl-6-methyl-pyrimidin-5-yl)boronic acid
826-639-2 1817776-86-5 Active Intermediate Joint Intermediate use only 20-07-2020 View substance registered dossier
(4-ethoxyphenyl)(3-(4-fluoro-3-phenoxyphenyl)propyl)dimethylsilane
405-020-7 105024-66-6 Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
(4-hydrazinophenyl)-N-methylmethanesulfonamide hydrochloride
406-090-1 81880-96-8 No longer Valid NONS Individual No longer valid 10-11-2008 View substance registered dossier
(4-methoxybiphenyl-3-yl)hydrazine hydrochloride
924-885-6 - Active Intermediate Joint Intermediate use only 22-10-2012 View substance registered dossier
(4-Methoxyphenyl)diphenylsulfoniumnonaflate
435-570-3 - Active NONS Joint Tonnage data confidential 24-06-2009 View substance registered dossier
(4-methylphenyl)mesitylene sulfonate
407-530-5 67811-06-7 Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
(4-nitrophenyl)methanesulfonyl chloride
609-806-2 4025-75-6 Active Intermediate Individual Intermediate use only 18-12-2019 View substance registered dossier
(4-nitrophenyl)methyl [6R,(6α,7β)]-[3-hydroxy-5,8-dioxo-7-(phenoxyacetylamino)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate]
411-820-7 - Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
(4-nonylphenoxy)acetic acid
221-486-2 3115-49-9 Active Full Joint ≥ 100 to < 1 000 tonnes 04-07-2014 View substance registered dossier
(4-phenylbutyl)phosphinic acid
420-450-5 86552-32-1 Active Intermediate Joint Intermediate use only 09-12-2013 View substance registered dossier
(4-pyridylmethyl)amine
223-092-6 3731-53-1 Active Intermediate Joint Intermediate use only 19-02-2018 View substance registered dossier
(4-pyridylthio)acetyl chloride hydrochloride
248-348-4 27230-51-9 Active Intermediate Joint Intermediate use only 01-07-2020 View substance registered dossier
(4-Sulfamoylpheny)hydrazine monohydrochloride
479-480-2 17852-52-7 Active Full Joint ≥ 10 to < 100 tonnes 18-09-2017 View substance registered dossier
(4-Sulfamoylpheny)hydrazine monohydrochloride
479-480-2 17852-52-7 Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
(4-Sulfamoylpheny)hydrazine monohydrochloride
479-480-2 17852-52-7 Active Intermediate Joint Intermediate use only 15-05-2018 View substance registered dossier
(4-tert-butyl-2,6-dimethylphenyl)acetonitrile
284-183-4 84803-57-6 Active Intermediate Joint Intermediate use only 30-07-2015 View substance registered dossier
(4-vinylphenyl)methyl-2-[(1Z)-1-aza-3-methyl-2-(4-methylthiophenyl)-3-morpholin-4-ylbut-1-enyloxy]acetate
453-050-4 - Active NONS Individual Tonnage data confidential 04-02-2011 View substance registered dossier
(4aR*, 8aR*)-1-bromo-4a,5,9,10,11,12-hexahydro-3-methoxy-6H-benzofuro[3a,3,2-ef] [2]benzazepin-6-one hydrochloride (1:1)
700-867-1 - Active Full Joint ≥ 1 to < 10 tonnes 02-07-2020 View substance registered dossier
(4aR*,8aR*)-1-bromo-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-one hydrochloride
439-750-2 183487-56-1 Active Full Joint ≥ 1 to < 10 tonnes 23-05-2018 View substance registered dossier
(4aR*,8aR*)-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-one
428-690-2 1668-86-6 Cease Manufacture NONS Individual Cease manufacture 23-11-2010 View substance registered dossier
(4aR,4bS,6aS,7aS,8aS,8bR,8cR)-2-methoxy-4a,6a-dimethyl-4,4a,4b,5,6,6a,7a,8,8a,8b,8c,9-dodecahydrocyclopropa[4,5]cyclopenta[1,2-a]phenanthren-7(3H)-one
607-934-3 26441-40-7 Active Intermediate Joint Intermediate use only 29-04-2020 View substance registered dossier
(4aR,4bS,6aS,7S,7aS,8aS,8bR,8cR)-7-[2-(1,3-dioxolan-2-yl)ethyl]-2-methoxy-4a,6a-dimethyl-3,4,4a,4b,5,6,6a,7,7a,8,8a,8b,8c,9-tetradecahydrocyclopropa[4,5]cyclopenta[1,2-a]phenanthren-7-ol
618-226-9 889652-22-6 Active Intermediate Joint Intermediate use only 05-05-2020 View substance registered dossier
(4aR,4bS,6aS,7S,7aS,8aS,8bS,8cR)-5`-methoxy-4a,6a-dimethyl-4,4`,4a,4b,5`,6,6a,7a,8,8a,8b,8c-dodecahydro-3H,3`H-spiro[cyclopropa[4,5]cyclopenta[1,2-a]phenathrene-7,2`-furan]-2(5H)-one
695-294-6 71136-60-2 Active Intermediate Joint Intermediate use only 30-04-2020 View substance registered dossier
(4aR,4bS,6aS,9aS,9bR,11aR)-4a,6a-Dimethyltetradecahydro-1H-indeno[5,4-f]quinoline-2,7-dione
616-323-0 76318-69-9 Active Intermediate Joint Intermediate use only 14-06-2016 View substance registered dossier
(4aR,5S,8R,8aS)-1,2,3,4,4a,5,8,8a-octahydro-1,4:5,8-dimethanonaphthalene
700-678-4 - Active Full Individual ≥ 100 to < 1 000 tonnes 05-05-2020 View substance registered dossier
(4aS-cis-)-6-benzyl-octahydropyrrolo[3.4-b]pyridine
425-930-8 151213-39-7 Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
(4E)-4-(3,3,4-trimethylcyclopentylidene)butanal
- - Active Full Joint ≥ 0 to < 10 tonnes 05-03-2021 View substance registered dossier
(4E)-4-(C13-C17)alkylidene-3-(C12-C16)alkyloxetan-2-one
939-401-9 - Active Full Joint ≥ 100 to < 1 000 tonnes 03-11-2020 View substance registered dossier
(4E)-4-[3-(2,5-dichloro-4,6-dimethylpyridin-3-yl)-2H-1,2,4-oxadiazol-5-ylidene]-2-methoxy-6-nitrocyclohexa-2,5-dien-1-one
941-406-6 1391712-50-7 Active Intermediate Joint Intermediate use only 08-01-2019 View substance registered dossier
(4E)-4-methyl-5-(4-methylphenyl)pent-4-enal
700-748-4 1226911-69-8 Active Full Joint ≥ 0 to < 10 tonnes 20-12-2017 View substance registered dossier
(4E)-5-cyclohexyl-2,4-dimethylpent-4-enal
947-579-4 1449104-34-0 Active Full Joint ≥ 1 to < 10 tonnes 08-12-2020 View substance registered dossier
(4E)-N-hydroxy-1,2-benzoxathiin-4(3H)-imine 2,2-dioxide
611-875-9 597563-86-5 Active Intermediate Joint Intermediate use only 28-10-2016 View substance registered dossier
(4R)-2-(1-butoxyethoxy)-4-isopropyl-1-methylenecyclohexane
944-221-9 1429469-15-7 Active Intermediate Joint Intermediate use only 24-02-2017 View substance registered dossier
(4R)-2-oxo-1,3-oxazolidine-4-carboxylic acid
849-166-3 83841-00-3 Active Intermediate Joint Intermediate use only 18-05-2021 View substance registered dossier
(4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid;N,N-diethylethanamine
926-346-0 - Active Intermediate Joint Intermediate use only 10-11-2017 View substance registered dossier
Registrant/Supplier Address Country Registration Status Name EC / List no. CAS no. Last update year Details
[Confidential] - - - (3R,4S,5S,6R,7R,9R,10Z,11S,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione 10-oxime 603-883-6 134931-01-4 - View substance registered dossier
[Confidential] - - - (3R,4S,5S,6R,7R,9R,10Z,11S,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione 10-oxime 603-883-6 134931-01-4 - View substance registered dossier
Ercros SA Avenida Diagonal 593-595 08014 Barcelona Spain Spain Active (3R,4S,6R,7R,9R,11S,12R,13S,14R)-6-{[4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-14-ethyl-12,13-dihydroxy-4-[(5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl)oxy]-10-(hydroxyimino)-7-methoxy-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecan-2-one 918-279-0 - - View substance registered dossier
Huvepharma Italia s.r.l. Via Roberto Lepetit, 142 12075 GARESSIO (CN) Italy Italy Active (3R,5aS,6R,8aS,9R,12S,12aR)-3,6,9-trimethyloctahydro-3,12-epoxypyrano[4,3-j][1,2]benzodioxepin-10(3H)-one 700-290-5 63968-64-9 2009; 2010; 2012 View substance registered dossier
Krka, d. d., Novo mesto Smarjeska cesta 6 SI-8501 Novo mesto Slovenia Slovenia Active (3R,5R)-tert-Butyl 7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate 603-817-6 134395-00-9 - View substance registered dossier
FIRMENICH GRASSE SAS OR 1 Parc Industriel Les Bois de Grasse 06130 Grasse France France Active (3R,5Z)-3-METHYL-5-CYCLOPENTADECEN-1-ONE 851-742-4 464207-51-0 - View substance registered dossier
Evonik Operations GmbH Rellinghauser Straße 1-11 45128 Essen Germany Germany Active (3R,6R)-3,6-dimethyl-1,4-dioxane-2,5-dione 603-436-5 13076-17-0 - View substance registered dossier
PURAC Biochem Arkelsedijk 46 4206AC Gorinchem Netherlands Netherlands Active (3R,6R)-3,6-dimethyl-1,4-dioxane-2,5-dione 603-436-5 13076-17-0 2011; 2015 View substance registered dossier
Total Corbion PLA bv Arkelsedijk 46 4206AC Gorinchem Netherlands Netherlands Active (3R,6R)-3,6-dimethyl-1,4-dioxane-2,5-dione 603-436-5 13076-17-0 - View substance registered dossier
MINAKEM Beuvry Production SAS 145, Chemin des Lilas 59310 Beuvry-la-Forêt France France Cease Manufacture (3R,7aR)-3-tert-butyl-1,5-dioxodihydro-1H-pyrrolo[1,2-c][1,3]oxazole-7a(5H)-carbaldehyde 812-036-1 1214741-19-1 2019 View substance registered dossier
MINAKEM Beuvry Production SAS 145, Chemin des Lilas 59310 Beuvry-la-Forêt France France Cease Manufacture (3R,7aR)-3-tert-butyl-7a-{methoxy[(trimethylsilyl)oxy]methyl}dihydro-1H-pyrrolo[1,2-c][1,3]oxazole-1,5(6H)-dione 942-823-6 - 2019 View substance registered dossier
MINAKEM Beuvry Production SAS 145, Chemin des Lilas 59310 Beuvry-la-Forêt France France Cease Manufacture (3R,7aS)-3-tert-butyldihydro-1H-pyrrolo[1,2-c][1,3]oxazole-1,5(6H)-dione 810-392-2 171284-84-7 2019 View substance registered dossier
sanofi chimie 82 avenue Raspail 94250 Gentilly France France Active (3R-trans)-dihydro-2,5-dioxofuran-3,4-diyl diacetate 228-502-7 6283-74-5 - View substance registered dossier
All'Chem rue Marceau 03108 MONTLUCON CEDEX France France Active (3R-trans)-dihydro-2,5-dioxofuran-3,4-diyl diacetate 228-502-7 6283-74-5 2018 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active (3RS,3aRS,6SR,7aSR)-hexahydro-3,6-dimethyl-2(3H)-benzofuranone and (3RS,3aSR,6RS,7aRS)-hexahydro-3,6-dimethyl-2(3H)-benzofuranone 429-980-1 - - View substance registered dossier
- - - - (3RS,3aRS,6SR,7aSR)-hexahydro-3,6-dimethyl-2(3H)-benzofuranone and (3RS,3aSR,6RS,7aRS)-hexahydro-3,6-dimethyl-2(3H)-benzofuranone 429-980-1 - - View substance registered dossier
[Confidential] - - - (3S)-2-{N-[1-ethoxy-1-oxo-4-phenylbutan-2-yl]-substituted}-heteropolycyclic-3-carboxylic acid hydrochloride 919-408-3 - - View substance registered dossier
TAKASAGO TEPL-OR(1) 12 rue Torricelli 75017 Paris France France Active (3S)-3,7-Dimethyl-1-octanol 814-059-2 68680-98-8 - View substance registered dossier
TAKASAGO TICSA-Producer/Importer Avenida de Mazarrón, 49 30120 El Palmar Murcia Spain Spain Active (3S)-3,7-dimethylocta-1,6-dien-1-yl acetate 946-529-9 1439355-19-7 - View substance registered dossier
Boehringer Ingelheim Pharma GmbH & Co. KG Binger Strasse 173 55216 Ingelheim am Rhein Germany Germany Active (3S)-3-[4-(2-chloro-5-iodobenzyl)phenoxy]tetrahydrofuran 619-599-0 915095-94-2 2019 View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active (3S)-3-[4-(2-chloro-5-iodobenzyl)phenoxy]tetrahydrofuran 619-599-0 915095-94-2 - View substance registered dossier
Bidachem S.p.A. S.S. 11 Padana Superiore No. 8 24040 Fornovo San Giovanni BG Italy Italy Active (3S)-3-[4-(2-chloro-5-iodobenzyl)phenoxy]tetrahydrofuran 619-599-0 915095-94-2 2019 View substance registered dossier
TÜV SÜD Industrie Service GmbH IS-USR-MUC Westendstr. 199 80686 Munich Germany Germany Cease Manufacture (3S)-3-hydroxy-4,4-dimethyldihydrofuran-2(3H)-one 626-470-2 5405-40-3 2015 View substance registered dossier
Bayer AG Kaiser-Wilhelm-Allee 51373 Leverkusen Germany Germany Active (3S)-3-hydroxypyrrolidin-2-one 676-349-3 34368-52-0 - View substance registered dossier
DUKE CHEM, S.A. Avgda. Mare de Déu de Montserrat, 93 - 99 Pol. Ind. Sant Pere Molanta 08799 Olèrdola Barcelona Spain Spain Active (3S)-3-thiophen-2-ylsulfanylbutanoic acid 948-811-7 133359-80-5 - View substance registered dossier
sanofi chimie 82 avenue Raspail 94250 Gentilly France France Active (3S)-3-{4-[8-(2,4-dichlorophenyl)-3-(methoxycarbonyl)-6,7-dihydro-5H-benzocyclohepten-9-yl]phenoxy}-1-(3-fluoropropyl)pyrrolidinium hydrogen oxalate 950-060-5 - - View substance registered dossier
Saneca Pharmaceuticals a.s. Nitrianska 100 92027 Hlohovec Slovakia Slovakia Active (3S)-N,N-dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine ethanedioate 603-567-8 132335-47-8 2009 View substance registered dossier
Thermofisher Scientific Cork Ltd. Currabinny P43 AY66 Carrigaline Co. Cork Ireland Ireland Active (3S, 4R)-4-(4’-Fluorophenyl)-3-(3’, 4’-methylenedioxyphenyl)-Nmethylpiperidine 924-787-3 110429-36-2 2021 View substance registered dossier
CHEMI S.p.A. Via dei lavoratori, 54 20092 Cinisello balsamo Lombardia Italy Italy Active (3S, 4R)-4-(4’-Fluorophenyl)-3-(3’, 4’-methylenedioxyphenyl)-Nmethylpiperidine 924-787-3 110429-36-2 - View substance registered dossier
Roche Ireland Limited Clarehill . Clarecastle Ireland Ireland Cease Manufacture (3S,4aS,8aS)-2-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N-tert-butyldecahydroisoquinoline-3-carboxamide 430-230-0 136522-17-3 2020 View substance registered dossier
Roche Ireland Limited Clarehill . Clarecastle Ireland Ireland Cease Manufacture (3S,4aS,8aS)-N-tert-butyldecahydro-3-isoquinolinecarboxamide 420-380-5 136465-81-1 2020 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Dutch competent national authority. - - Active (3S,4aS,8aS)-N-tert-butyldecahydro-3-isoquinolinecarboxamide 420-380-5 136465-81-1 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active (3S,4aS,8aS)-N-tert-butyldecahydro-3-isoquinolinecarboxamide 420-380-5 136465-81-1 - View substance registered dossier
Gedeon Richter Plc. Gyomroi ut 19-21 1103 Budapest Hungary Hungary Active (3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-1-benzyl-4-(4-fluorophenyl)piperidine 929-011-7 - - View substance registered dossier
Patheon Austria GmbH & Co KG St. Peterstrasse 25 A-4020 Linz Austria Austria Active (3S,4S)-3-hexyl-4-[(R)-2-hydroxytridecyl]-2-oxetanone 418-650-2 104872-06-2 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Austrian competent national authority. - - Active (3S,4S)-3-hexyl-4-[(R)-2-hydroxytridecyl]-2-oxetanone 418-650-2 104872-06-2 - View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active (3S,4S)-3-hexyl-4-[(R)-2-hydroxytridecyl]-2-oxetanone 418-650-2 104872-06-2 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Irish competent national authority. - - Active (3S,5R)-4-chloro-[5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)furan-3-yl]methylbenzenesulfonate 436-150-2 - - View substance registered dossier
[Confidential] - - - (3S,5R)-4-chloro-[5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)furan-3-yl]methylbenzenesulfonate 436-150-2 - - View substance registered dossier
MINAKEM Beuvry Production SAS 145, Chemin des Lilas 59310 Beuvry-la-Forêt France France Active (3S,5R)-4-chloro-[5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)furan-3-yl]methylbenzenesulfonate 436-150-2 - - View substance registered dossier
MSD International GmbH Ballydine - Kilsheelan 0 Clonmel Ireland Ireland Active (3S,5R)-4-chloro-[5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)furan-3-yl]methylbenzenesulfonate 436-150-2 - 2011; 2015 View substance registered dossier
Novartis Integrated Services Limited Ringaskiddy P43 FR63 Ringaskiddy Co. Cork Ireland Ireland Active (3S,5S)-5-[(1S,3S)-1-azido-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl]-3-(propan-2-yl)oxolan-2-one 608-748-5 324763-46-4 2014 View substance registered dossier
Novartis Grimsby Limited Moody Lane, Pyewipe DN31 2SR Grimsby N.E. Lincolnshire United Kingdom United Kingdom No longer Valid (3S,5S)-5-[(1S,3S)-1-azido-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl]-3-(propan-2-yl)oxolan-2-one 608-748-5 324763-46-4 2021 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active (3S,5S,6S,9R)-6-isopropyl-3,9-dimethyl-1,4- and (3S,5R,6S,9R)-6-isopropyl-3,9-dimethyl-1,4- 457-410-1 831213-72-0 - View substance registered dossier
- - - - (3S,5S,6S,9R)-6-isopropyl-3,9-dimethyl-1,4- and (3S,5R,6S,9R)-6-isopropyl-3,9-dimethyl-1,4- 457-410-1 831213-72-0 - View substance registered dossier
TAKASAGO TEPL-OR(1) 12 rue Torricelli 75017 Paris France France Active (3S,6E)- 3,7,11-trimethyldodeca-6,10-dien-1-ol 450-320-3 - 2018 View substance registered dossier
- - - - (3S,6E)- 3,7,11-trimethyldodeca-6,10-dien-1-ol 450-320-3 - - View substance registered dossier
TAKASAGO TEPL-Importer 12 rue Torricelli 75017 Paris France France Active (3S,6E)-3,7,11-trimethyldodeca-6,10-dienal 810-298-1 194934-66-2 2020 View substance registered dossier
TAKASAGO TEPL-OR(1) 12 rue Torricelli 75017 Paris France France Active (3S,6E)-3,7,11-trimethyldodeca-6,10-dienal 810-298-1 194934-66-2 - View substance registered dossier
Bayer AG Kaiser-Wilhelm-Allee 51373 Leverkusen Germany Germany Active (3S,6R,9S,12R,15S,18R,21S,24R)-6,18-dibenzyl-3,9,15,21-tetraisobutyl-4,10,12,16,22,24-hexamethyl-1,7,13,19-tetraoxa-4,10,16,22-tetraazacyclo-tetracosane-2,5,8,11,14,17,20,23-octaone 444-350-6 133413-70-4 2010; 2018 View substance registered dossier
Bayer Animal Health GmbH Alfred Nobel Straße 50 40789 Monheim Germany Germany Active (3S,6R,9S,12R,15S,18R,21S,24R)-6,18-dibenzyl-3,9,15,21-tetraisobutyl-4,10,12,16,22,24-hexamethyl-1,7,13,19-tetraoxa-4,10,16,22-tetraazacyclo-tetracosane-2,5,8,11,14,17,20,23-octaone 444-350-6 133413-70-4 - View substance registered dossier
Total Corbion PLA bv Arkelsedijk 46 4206AC Gorinchem Netherlands Netherlands Active (3S-cis)-3,6-dimethyl-1,4-dioxane-2,5-dione 224-832-0 4511-42-6 - View substance registered dossier
Evonik Operations GmbH Rellinghauser Straße 1-11 45128 Essen Germany Germany Active (3S-cis)-3,6-dimethyl-1,4-dioxane-2,5-dione 224-832-0 4511-42-6 - View substance registered dossier
PURAC Biochem Arkelsedijk 46 4206AC Gorinchem Netherlands Netherlands Active (3S-cis)-3,6-dimethyl-1,4-dioxane-2,5-dione 224-832-0 4511-42-6 2011; 2015 View substance registered dossier
Santrol Europe ApS Aagade 103 Pjedsted 7000 Fredericia Denmark Denmark Cease Manufacture (3S-cis)-3,6-dimethyl-1,4-dioxane-2,5-dione 224-832-0 4511-42-6 2016 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active (3S-trans)-phenyl-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-1-piperidinecarboxylate 430-510-2 - - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Irish competent national authority. - - Active (3S-trans)-phenyl-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-1-piperidinecarboxylate 430-510-2 - - View substance registered dossier
IFF Benicarlo, S.L. Avda. Felipe Klein 2 12580 Benicarlo Castellon Spain Spain Active (3Z)-hex-3-en-1-yl 2-methylprop-2-en-1-yl ether 439-790-0 292605-05-1 2013 View substance registered dossier
Farmabios Spa Via Pavia, 1 27027 Gropello Cairoli PV Italy Italy Active (3α,5β,7β)-3,7-Dihydroxy-24-norcholane-23-nitrile 828-107-5 118316-12-4 - View substance registered dossier
OLON Spa Strada Rivoltana Km 6/7 20053 RODANO Milano Italy Italy Active (3β)-17-(1,1,1-trifluoromethanesulfonate)-Androsta-5,16-diene-3,17-diol, 3-(2,2,2-trifluoroacetate) 840-627-4 1802323-89-2 - View substance registered dossier
OLON Spa Strada Rivoltana Km 6/7 20053 RODANO Milano Italy Italy Active (3β)-3-[(2,2,2-trifluoroacetyl)oxy]-Androst-5-en-17-one 840-626-9 3798-17-2 - View substance registered dossier
Indena S.p.A. Viale Ortles, 12 20139 Milan Italy Italy Active (3β,20β)-3-acetoxy-11-oxoolean-12-en-29-oic acid 228-475-1 6277-14-1 2019 View substance registered dossier
DSM Nutritional Products France SAS 1 boulevard d'Alsace F-68128 Village-Neuf France France Active (3β,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-yl butyrate 250-567-5 31316-20-8 - View substance registered dossier
Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany Germany Active (4'-methyl-3-fluoro[1,1'-biphenyl]-4-yl)-boronic acid 813-651-8 1698890-39-9 - View substance registered dossier
UNION QUIMICO FARMACÉUTICA S.A. Mallorca 262 08008 Barcelona Barcelona Spain Spain Active (4,5-dibromo-1H-pyrrol-2-yl)(phenyl)methanone 700-338-5 50372-61-7 2016 View substance registered dossier
QUIMICA SINTETICA, S.A. C/ Dulcinea, s/n 28805 Alcalá de Henares Madrid Spain Spain Active (4,5-dibromo-1H-pyrrol-2-yl)(phenyl)methanone 700-338-5 50372-61-7 2016 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant French competent national authority. - - Active (4-(1-methylethyl)phenyl)-(4-methylphenyl)iodonium tetrakis(pentafluorophenyl)borate (1-) 422-960-3 178233-72-2 - View substance registered dossier
ELKEM SILICONES FRANCE S.A.S. Immeuble DANICA 21, Avenue Georges Pompidou 69003 Lyon France France Active (4-(1-methylethyl)phenyl)-(4-methylphenyl)iodonium tetrakis(pentafluorophenyl)borate (1-) 422-960-3 178233-72-2 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active (4-(1-methylethyl)phenyl)-(4-methylphenyl)iodonium tetrakis(pentafluorophenyl)borate (1-) 422-960-3 178233-72-2 - View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active (4-(3,4-dichloro-phenyl)-3,4-dihydro-2H-naphthalen-1-ylidene)-methyl-amide 455-240-2 - - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active (4-(4-(4-dimethylaminobenzyliden-1-yl)-3-methyl-5-oxo-2-pyrazolin-1-yl)benzoic acid 410-430-4 117573-89-4 - View substance registered dossier
CU Chemie Uetikon GmbH Raiffeisenstrasse 4 77933 Lahr Baden-Württemberg Germany Germany Active (4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(tetrahydrofuran-2-yl)methanone 613-265-8 63590-64-7 2018 View substance registered dossier
Global Product Compliance (Europe) AB IDEON, Beta 5, Scheelevägen 17 22363 Lund Sweden Sweden Active (4-(4-aminophenyl)(4-iminocyclohexa-2,5-dienylidene)methyl)-2-methylaniline hydrochloride 211-189-6 632-99-5 - View substance registered dossier
AllessaProduktion GmbH Alt-Fechenheim 34 60386 Frankfurt am Main Germany Germany Active (4-(5-Oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-phenylamino)-acetic acid ethyl ester 927-587-4 872728-83-1 2016 View substance registered dossier
Bidachem S.p.A. S.S. 11 Padana Superiore No. 8 24040 Fornovo San Giovanni BG Italy Italy Active (4-(5-Oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-phenylamino)-acetic acid ethyl ester 927-587-4 872728-83-1 - View substance registered dossier
AllessaProduktion GmbH Alt-Fechenheim 34 60386 Frankfurt am Main Germany Germany Active (4-(5-Oxo-4,5-dihydro-1,2,4-oxadiazole-3-yl)phenylamino)acetic acid 460-450-2 872728-82-0 2012; 2019 View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active (4-(5-Oxo-4,5-dihydro-1,2,4-oxadiazole-3-yl)phenylamino)acetic acid 460-450-2 872728-82-0 - View substance registered dossier
Bidachem S.p.A. S.S. 11 Padana Superiore No. 8 24040 Fornovo San Giovanni BG Italy Italy Active (4-(5-Oxo-4,5-dihydro-1,2,4-oxadiazole-3-yl)phenylamino)acetic acid 460-450-2 872728-82-0 2013; 2016 View substance registered dossier
Boehringer Ingelheim Pharma GmbH & Co. KG Binger Strasse 173 55216 Ingelheim am Rhein Germany Germany Active (4-(5-Oxo-4,5-dihydro-1,2,4-oxadiazole-3-yl)phenylamino)acetic acid 460-450-2 872728-82-0 2012; 2014; 2016 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active (4-(6-diethylamino-2-methylpyridin-3-yl)imino-4,5-dihydro-3-methyl-1-(4-methylphenyl)-1H-pyrazol-5-one 427-070-9 - - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Belgian competent national authority. - - Active (4-6) PEPTIDE 427-550-8 - - View substance registered dossier
United Initiators GmbH Dr. Gustav-Adolph-Str. 3 D-82049 Pullach Bavaria Germany Germany Active (4-acetamido-2,2,6,6-tetramethyl-1-piperidinyl)oxidanyl; N-(2,2,6,6-tetramethyl-1-oxylpiperidin-4-yl)acetamide 423-840-3 14691-89-5 - View substance registered dossier
Evonik Operations GmbH Rellinghauser Straße 1-11 45128 Essen Germany Germany Active (4-acetamido-2,2,6,6-tetramethyl-1-piperidinyl)oxidanyl; N-(2,2,6,6-tetramethyl-1-oxylpiperidin-4-yl)acetamide 423-840-3 14691-89-5 2012 View substance registered dossier
MSD International GmbH Ballydine - Kilsheelan 0 Clonmel Ireland Ireland Active (4-amino-1-hydroxy-1-phosphonobutyl)phosphonic acid;hydrate 680-378-7 138624-11-0 - View substance registered dossier
Globalquimia, S.L.U. Avenida Diagonal, 519, 1º 1ª 08029 Barcelona Spain Spain Spain Active (4-amino-2-chloro-5-methylphenyl)(4-chlorophenyl)acetonitrile 262-792-6 61437-85-2 - View substance registered dossier
Menadiona SL Pol Ind Mas Puigvert, Ctra Nacional II Km 680, 5 08389 Palafolls Barcelona Spain Spain Active (4-amino-2-chloro-5-methylphenyl)(4-chlorophenyl)acetonitrile 262-792-6 61437-85-2 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Irish competent national authority. - - Active (4-aminophenyl)-N-methylmethylenesulfonamide hydrochloride 406-010-5 88918-84-7 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active (4-aminophenyl)-N-methylmethylenesulfonamide hydrochloride 406-010-5 88918-84-7 - View substance registered dossier
Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany Germany Active (4-butoxy-2,3-difluorophenyl)boronic acid 692-793-0 156487-12-6 - View substance registered dossier
Evonik Operations GmbH Rellinghauser Straße 1-11 45128 Essen Germany Germany Active (4-carboxybutyl)triphenylphosphonium bromide 241-782-5 17814-85-6 - View substance registered dossier
sanofi chimie 82 avenue Raspail 94250 Gentilly France France Active (4-Chloro-3-(4-ethoxybenzyl)phenyl)((3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methanone 695-300-7 1103738-30-2 2020 View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active (4-Chloro-3-(4-ethoxybenzyl)phenyl)((3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methanone 695-300-7 1103738-30-2 - View substance registered dossier
Derivados Químicos S.A. Camino Viejo del Pliego s/n 30820 Alcantarilla Murcia Spain Spain Active (4-chlorophenyl)(2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol 814-124-5 133545-64-9 - View substance registered dossier
BASF SE Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany Germany Active (4-chlorophenyl)hydrazine 214-029-3 1073-69-4 2010 View substance registered dossier
Fine Organics Limited Seal Sands TS2 1UB Middlesbrough Teesside United Kingdom United Kingdom No longer Valid (4-chlorophenyl)hydrazine 214-029-3 1073-69-4 2018 View substance registered dossier
Boehringer Ingelheim Pharma GmbH & Co. KG Binger Strasse 173 55216 Ingelheim am Rhein Germany Germany Active (4-cyclopropyl-6-methyl-pyrimidin-5-yl)boronic acid 826-639-2 1817776-86-5 - View substance registered dossier
Bidachem S.p.A. S.S. 11 Padana Superiore No. 8 24040 Fornovo San Giovanni BG Italy Italy Active (4-cyclopropyl-6-methyl-pyrimidin-5-yl)boronic acid 826-639-2 1817776-86-5 - View substance registered dossier
INTEROR 49, rue d'Ostende F-62100 CALAIS France France Active (4-ethoxyphenyl)(3-(4-fluoro-3-phenoxyphenyl)propyl)dimethylsilane 405-020-7 105024-66-6 - View substance registered dossier
Fine Organics Limited Seal Sands TS2 1UB Middlesbrough Teesside United Kingdom United Kingdom No longer Valid (4-hydrazinophenyl)-N-methylmethanesulfonamide hydrochloride 406-090-1 81880-96-8 2021 View substance registered dossier
Synthesia, a.s. Semtín103 53002 Pardubice Czech Republic Czech Republic Active (4-methoxybiphenyl-3-yl)hydrazine hydrochloride 924-885-6 - - View substance registered dossier
- - - - (4-Methoxyphenyl)diphenylsulfoniumnonaflate 435-570-3 - - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active (4-Methoxyphenyl)diphenylsulfoniumnonaflate 435-570-3 - - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active (4-methylphenyl)mesitylene sulfonate 407-530-5 67811-06-7 - View substance registered dossier
MINAKEM Beuvry Production SAS 145, Chemin des Lilas 59310 Beuvry-la-Forêt France France Active (4-nitrophenyl)methanesulfonyl chloride 609-806-2 4025-75-6 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Irish competent national authority. - - Active (4-nitrophenyl)methyl [6R,(6α,7β)]-[3-hydroxy-5,8-dioxo-7-(phenoxyacetylamino)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate] 411-820-7 - - View substance registered dossier
BASF Lampertheim GmbH Chemiestrasse 22 68619 Lampertheim Germany Germany Active (4-nonylphenoxy)acetic acid 221-486-2 3115-49-9 2014 View substance registered dossier
BASF Performance Products France SA 49, Avenue Georges Pompidou 92593 Levallois-Perret Cedex France France Cease Manufacture (4-nonylphenoxy)acetic acid 221-486-2 3115-49-9 2015 View substance registered dossier
BASF SE Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany Germany Active (4-nonylphenoxy)acetic acid 221-486-2 3115-49-9 - View substance registered dossier
Corden Pharma Latina S.p.A. Via del Murillo Km 2, 800 IT04013 Sermoneta (LT) Lazio Italy Italy Cease Manufacture (4-phenylbutyl)phosphinic acid 420-450-5 86552-32-1 2017 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Irish competent national authority. - - Active (4-phenylbutyl)phosphinic acid 420-450-5 86552-32-1 - View substance registered dossier
INTEROR 49, rue d'Ostende F-62100 CALAIS France France Active (4-pyridylmethyl)amine 223-092-6 3731-53-1 - View substance registered dossier
Intertek Italia SpA_ITAzo Via Miglioli 2/A 20063 CERNUSCO SUL NAVIGLIO Milano Italy Italy Active (4-pyridylthio)acetyl chloride hydrochloride 248-348-4 27230-51-9 - View substance registered dossier
Fine and Performance Chemicals Ltd Skutterskelfe TS15 0JR Hutton Rudby North Yorkshire United Kingdom United Kingdom No longer Valid (4-pyridylthio)acetyl chloride hydrochloride 248-348-4 27230-51-9 2021 View substance registered dossier
Corden Pharma Latina S.p.A. Via del Murillo Km 2, 800 IT04013 Sermoneta (LT) Lazio Italy Italy Active (4-pyridylthio)acetyl chloride hydrochloride 248-348-4 27230-51-9 - View substance registered dossier
[Confidential] - - - (4-Sulfamoylpheny)hydrazine monohydrochloride 479-480-2 17852-52-7 - View substance registered dossier
Siemsgluss Ibérica, S.A. Pol. Ind. Sant Antoni, parcela 6, nave 2 08620 Sant Vicenç dels Horts Barcelona Spain Spain Active (4-Sulfamoylpheny)hydrazine monohydrochloride 479-480-2 17852-52-7 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant German competent national authority. - - Active (4-Sulfamoylpheny)hydrazine monohydrochloride 479-480-2 17852-52-7 - View substance registered dossier
Biesterfeld Spezialchemie GmbH Ferdinandstr. 41 20095 Hamburg Germany Germany Active (4-Sulfamoylpheny)hydrazine monohydrochloride 479-480-2 17852-52-7 - View substance registered dossier
Excella GmbH & Co. KG Nuernberger Str. 12 90537 Feucht Germany Germany Active (4-Sulfamoylpheny)hydrazine monohydrochloride 479-480-2 17852-52-7 2018 View substance registered dossier
Siegfried PharmaChemikalien Minden GmbH Karlstr. 15-39, 42-44 32423 Minden Nordrhein-Westphalen Germany Germany Active (4-tert-butyl-2,6-dimethylphenyl)acetonitrile 284-183-4 84803-57-6 - View substance registered dossier
FujiFilm Manufacturing Europe BV Oudenstaart 1 5047 TK Tilburg Netherlands Netherlands Active (4-vinylphenyl)methyl-2-[(1Z)-1-aza-3-methyl-2-(4-methylthiophenyl)-3-morpholin-4-ylbut-1-enyloxy]acetate 453-050-4 - 2011 View substance registered dossier
Janssen Pharmaceutica N.V. Turnhoutseweg 30 2340 Beerse Belgium Belgium Active (4aR*, 8aR*)-1-bromo-4a,5,9,10,11,12-hexahydro-3-methoxy-6H-benzofuro[3a,3,2-ef] [2]benzazepin-6-one hydrochloride (1:1) 700-867-1 - 2020 View substance registered dossier
N.V. Ajinomoto OmniChem S.A. Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium Belgium Active (4aR*, 8aR*)-1-bromo-4a,5,9,10,11,12-hexahydro-3-methoxy-6H-benzofuro[3a,3,2-ef] [2]benzazepin-6-one hydrochloride (1:1) 700-867-1 - 2020 View substance registered dossier
Janssen Pharmaceutica N.V. Turnhoutseweg 30 2340 Beerse Belgium Belgium Active (4aR*,8aR*)-1-bromo-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-one hydrochloride 439-750-2 183487-56-1 2010; 2012; 2018 View substance registered dossier
Janssen Pharmaceutica N.V. Turnhoutseweg 30 2340 Beerse Belgium Belgium Cease Manufacture (4aR*,8aR*)-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-one 428-690-2 1668-86-6 2019 View substance registered dossier
Gedeon Richter Plc. Gyomroi ut 19-21 1103 Budapest Hungary Hungary Active (4aR,4bS,6aS,7aS,8aS,8bR,8cR)-2-methoxy-4a,6a-dimethyl-4,4a,4b,5,6,6a,7a,8,8a,8b,8c,9-dodecahydrocyclopropa[4,5]cyclopenta[1,2-a]phenanthren-7(3H)-one 607-934-3 26441-40-7 2020 View substance registered dossier
Gedeon Richter Plc. Gyomroi ut 19-21 1103 Budapest Hungary Hungary Active (4aR,4bS,6aS,7S,7aS,8aS,8bR,8cR)-7-[2-(1,3-dioxolan-2-yl)ethyl]-2-methoxy-4a,6a-dimethyl-3,4,4a,4b,5,6,6a,7,7a,8,8a,8b,8c,9-tetradecahydrocyclopropa[4,5]cyclopenta[1,2-a]phenanthren-7-ol 618-226-9 889652-22-6 2020 View substance registered dossier
Gedeon Richter Plc. Gyomroi ut 19-21 1103 Budapest Hungary Hungary Active (4aR,4bS,6aS,7S,7aS,8aS,8bS,8cR)-5`-methoxy-4a,6a-dimethyl-4,4`,4a,4b,5`,6,6a,7a,8,8a,8b,8c-dodecahydro-3H,3`H-spiro[cyclopropa[4,5]cyclopenta[1,2-a]phenathrene-7,2`-furan]-2(5H)-one 695-294-6 71136-60-2 2020 View substance registered dossier
Gedeon Richter Plc. Gyomroi ut 19-21 1103 Budapest Hungary Hungary Active (4aR,4bS,6aS,9aS,9bR,11aR)-4a,6a-Dimethyltetradecahydro-1H-indeno[5,4-f]quinoline-2,7-dione 616-323-0 76318-69-9 - View substance registered dossier
Covance Clinical Development SA 163 Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 -5 Planta 28050 Madrid Spain Spain Active (4aR,5S,8R,8aS)-1,2,3,4,4a,5,8,8a-octahydro-1,4:5,8-dimethanonaphthalene 700-678-4 - 2019; 2020 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Belgian competent national authority. - - Active (4aS-cis-)-6-benzyl-octahydropyrrolo[3.4-b]pyridine 425-930-8 151213-39-7 - View substance registered dossier
V. MANE FILS 620 route de Grasse 06620 Le Bar sur Loup France France Active (4E)-4-(3,3,4-trimethylcyclopentylidene)butanal - - - View substance registered dossier
Solenis Belgium B.V.B.A. Industrieweg 15 3583 Beringen Belgium Belgium Cease Manufacture (4E)-4-(C13-C17)alkylidene-3-(C12-C16)alkyloxetan-2-one 939-401-9 - 2016 View substance registered dossier
Mare S.p.A. Via Verdi No. 3 20002 Ossona Fraz. Asmonte Italy Italy Active (4E)-4-(C13-C17)alkylidene-3-(C12-C16)alkyloxetan-2-one 939-401-9 - 2020 View substance registered dossier
Solenis Netherlands B.V. Pesetastraat 62 2991 XT Barendrecht Netherlands Netherlands Active (4E)-4-(C13-C17)alkylidene-3-(C12-C16)alkyloxetan-2-one 939-401-9 - - View substance registered dossier
Derivados Químicos S.A. Camino Viejo del Pliego s/n 30820 Alcantarilla Murcia Spain Spain Active (4E)-4-[3-(2,5-dichloro-4,6-dimethylpyridin-3-yl)-2H-1,2,4-oxadiazol-5-ylidene]-2-methoxy-6-nitrocyclohexa-2,5-dien-1-one 941-406-6 1391712-50-7 - View substance registered dossier
Patheon Austria GmbH & Co KG St. Peterstrasse 25 A-4020 Linz Austria Austria Active (4E)-4-[3-(2,5-dichloro-4,6-dimethylpyridin-3-yl)-2H-1,2,4-oxadiazol-5-ylidene]-2-methoxy-6-nitrocyclohexa-2,5-dien-1-one 941-406-6 1391712-50-7 - View substance registered dossier
FIRMENICH GRASSE SAS OR 1 Parc Industriel Les Bois de Grasse 06130 Grasse France France Active (4E)-4-methyl-5-(4-methylphenyl)pent-4-enal 700-748-4 1226911-69-8 - View substance registered dossier
FIRMENICH GRASSE SAS OR 1 Parc Industriel Les Bois de Grasse 06130 Grasse France France Active (4E)-5-cyclohexyl-2,4-dimethylpent-4-enal 947-579-4 1449104-34-0 2020 View substance registered dossier
DIPHARMA FRANCIS srl Bissone, 5 20021 Baranzate Milano Italy Italy Active (4E)-N-hydroxy-1,2-benzoxathiin-4(3H)-imine 2,2-dioxide 611-875-9 597563-86-5 - View substance registered dossier
Symrise AG Mühlenfeldstraße 1 37603 Holzminden Germany Germany Active (4R)-2-(1-butoxyethoxy)-4-isopropyl-1-methylenecyclohexane 944-221-9 1429469-15-7 - View substance registered dossier
Syngenta Hellas Single Member S.A.C.I. Anthousas Avenue 153 49 Anthousa - Attiki Greece Greece Active (4R)-2-oxo-1,3-oxazolidine-4-carboxylic acid 849-166-3 83841-00-3 2021 View substance registered dossier
CABB Oy Kemirantie 1 FI-67701 Kokkola Finland Finland Active (4R)-2-oxo-1,3-oxazolidine-4-carboxylic acid 849-166-3 83841-00-3 2020 View substance registered dossier
DIPHARMA FRANCIS srl Bissone, 5 20021 Baranzate Milano Italy Italy Active (4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid;N,N-diethylethanamine 926-346-0 - - View substance registered dossier

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