Registered substances
Registered substances
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The new ECHA CHEM database has been released by ECHA. At first this system will contain only substances and data from REACH registration dossiers. For new and updated REACH registration data please check ECHA CHEM. See for more information on the transition to ECHA CHEM. More
Please be aware that REACH registration data here on the current Dissemination Platform is no longer maintained; it remains frozen as of 19th May 2023.
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Registered Substances Factsheets
Substances which have been registered and can be placed on the EEA market by those companies with a valid registration
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Registrant/Supplier | Address | Country | Registration Status | Name | EC / List no. | CAS no. | Last update year | Details |
---|---|---|---|---|---|---|---|---|
Syngenta Ltd | Jealott’s Hill International Research Centre RG42 6EY Bracknell Berkshire United Kingdom | United Kingdom | No longer Valid | (2R)-2-(4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoic acid | 617-435-2 | 83066-88-0 | 2021 | View substance registered dossier |
Deretil S.A.U. | Villaricos, s/n 04618 Cuevas del Almanzora Almeria Spain | Spain | Active | (2R)-2-amino-2-phenylacetamide | 420-370-0 | 6485-67-2 | 2011; 2012; 2014 | View substance registered dossier |
Former NONS notifier unknown to ECHA - Contact the relevant Dutch competent national authority. | - | - | Active | (2R)-2-amino-2-phenylacetamide | 420-370-0 | 6485-67-2 | - | View substance registered dossier |
Reuter Chemische Apparatebau e.K. | Engesserstrasse 4b 79108 Freiburg Germany | Germany | Active | (2R)-2-amino-3-(1H-indol-3-yl)propanoic acid hydrochloride | 609-287-2 | 36760-44-8 | - | View substance registered dossier |
PROCOS SpA | via Matteotti 249 28062 Cameri Piemonte Italy | Italy | Active | (2R)-2-amino-3-phenylpropanoic acid compound with (R)-2-hydroxy-2-phenylacetic acid (1:1) | 955-710-1 | 97251-01-9 | - | View substance registered dossier |
ZaCh System | ZI La Croix Cadeaux 49242 Avrillè France | France | Active | (2R)-2-amino-3-sulfanylpropanoic acid hydrate hydrochloride | 615-117-8 | 7048-04-6 | - | View substance registered dossier |
Barentz Service S.p.A. | via Privata Goito, 8 20037 Paderno Dugnano Italy | Italy | Active | (2R)-2-amino-3-sulfanylpropanoic acid hydrate hydrochloride | 615-117-8 | 7048-04-6 | - | View substance registered dossier |
MOEHS CANTABRA | P.I.Requejada Z-23 39313 Polanco Cantabria Spain | Spain | Active | (2R)-2-amino-3-sulfanylpropanoic acid hydrate hydrochloride | 615-117-8 | 7048-04-6 | - | View substance registered dossier |
MOEHS CATALANA | Cesar Martinell i Brunet 12 A 08191 Rubi Barcelona Spain | Spain | Active | (2R)-2-amino-3-sulfanylpropanoic acid hydrate hydrochloride | 615-117-8 | 7048-04-6 | - | View substance registered dossier |
MOEHS BCN, S.L. | C/ Zenc, 12 08755 Castellbisbal Barcelona Spain | Spain | Active | (2R)-2-amino-3-sulfanylpropanoic acid hydrate hydrochloride | 615-117-8 | 7048-04-6 | - | View substance registered dossier |
F.I.S. Fabbrica Italiana Sintetici S.p.a. | Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy | Italy | Active | (2R)-2-amino-3-sulfanylpropanoic acid hydrate hydrochloride | 615-117-8 | 7048-04-6 | 2013 | View substance registered dossier |
Arran Chemical Company Ltd | Monksland Industrial Estate N37DN24 Athlone Co. Roscommon Ireland | Ireland | Active | (2R)-2-aminobutan-1-ol L-tartrate monohydrate | 814-787-0 | 153078-05-8 | - | View substance registered dossier |
Labcorp Development SA 169 | Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 – 5 Planta 28050 Madrid Spain | Spain | Active | (2R)-2-methyloxirane | 604-958-6 | 15448-47-2 | - | View substance registered dossier |
OLON Spa | Strada Rivoltana Km 6/7 20090 RODANO Milano Italy | Italy | No longer Valid | (2R)-3-(acetyloxy)-2-[(2-amino-6-oxo-6,9-dihydro-3H-purin-9-yl)methoxy]propyl (2S)-2-amino-3-methylbutanoate hydrochloride | 691-736-7 | 960495-42-5 | - | View substance registered dossier |
OLON Spa | Strada Rivoltana Km 6/7 20053 RODANO Milano Italy | Italy | Active | (2R)-3-(acetyloxy)-2-[(2-amino-6-oxo-6,9-dihydro-3H-purin-9-yl)methoxy]propyl (2S)-2-amino-3-methylbutanoate hydrochloride | 691-736-7 | 960495-42-5 | 2012; 2014; 2016 | View substance registered dossier |
Clarochem Ireland Ltd | damastown mulhuddart dn 15 dublin Ireland | Ireland | Active | (2R)-3-chloropropane-1,2-diol | 611-463-9 | 57090-45-6 | - | View substance registered dossier |
Barentz Service S.p.A. | via Privata Goito, 8 20037 Paderno Dugnano Italy | Italy | Active | (2R)-3-cyano-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride | 700-669-5 | 2788-28-5 | - | View substance registered dossier |
Biosint S.p.A. | Via Murillo 16 04013 Sermoneta Italy | Italy | Active | (2R)-3-cyano-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride | 700-669-5 | 2788-28-5 | 2019 | View substance registered dossier |
Janssen Pharmaceutica N.V. | Turnhoutseweg 30 2340 Beerse Belgium | Belgium | Active | (2R)-6-fluoro-2-[(2R)-oxiran-2-yl]-3,4-dihydro-2H-1-benzopyran | 606-373-1 | 197706-50-6 | 2019 | View substance registered dossier |
F.I.S. Fabbrica Italiana Sintetici S.p.a. | Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy | Italy | Active | (2R)-6-fluoro-2-[(2R)-oxiran-2-yl]-3,4-dihydro-2H-1-benzopyran | 606-373-1 | 197706-50-6 | - | View substance registered dossier |
Janssen Pharmaceutica N.V. | Turnhoutseweg 30 2340 Beerse Belgium | Belgium | Active | (2R)-6-fluoro-2-[(2S)-oxiran-2-yl]-3,4-dihydro-2H-1-benzopyran | 603-315-7 | 129050-26-6 | 2019 | View substance registered dossier |
F.I.S. Fabbrica Italiana Sintetici S.p.a. | Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy | Italy | Active | (2R)-6-fluoro-2-[(2S)-oxiran-2-yl]-3,4-dihydro-2H-1-benzopyran | 603-315-7 | 129050-26-6 | - | View substance registered dossier |
cordenpharma chenove | 47, rue de Longvic 21300 Chenôve France | France | Active | (2R)-6-fluorochromane-2-carboxylic acid | 810-841-2 | 129101-37-7 | - | View substance registered dossier |
Flamma S.p.a. | via Bedeschi, 22 24040 Chignolo d'Isola Bergamo Italy | Italy | Active | (2R)-[(methoxycarbonyl)amino](phenyl)acetic acid | 694-843-7 | 50890-96-5 | - | View substance registered dossier |
Excella GmbH & Co. KG | Nuernberger Str. 12 90537 Feucht Germany | Germany | Active | (2R)-N-(2,6-Dimethylphenyl)-1-propylpiperidine-2-carboxamide - (2R,3R)-2,3-dihydroxysuccinic acid - propan-2-ol (2:1:1) | 947-841-8 | - | - | View substance registered dossier |
Selectchemie Italia Srl | Via Messina, 47 20154 Milano Italy | Italy | Active | (2R*)-1-[4-(benzyloxy)phenyl]-1-oxo-N-[(2R*)-1-phenoxypropan-2-yl]propan-2-aminium chloride | 867-647-6 | 1179802-09-5 | - | View substance registered dossier |
ERREGIERRE SPA | Via Francesco Baracca, 19 24060 SAN PAOLO D'ARGON BERGAMO Italy | Italy | Active | (2R*)-1-[4-(benzyloxy)phenyl]-1-oxo-N-[(2R*)-1-phenoxypropan-2-yl]propan-2-aminium chloride | 867-647-6 | 1179802-09-5 | - | View substance registered dossier |
Pfizer Ltd | Ramsgate Road (IPC 979) CT13 9NJ Sandwich Kent United Kingdom | United Kingdom | No longer Valid | (2R*,3S*)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol (1R)-10-camphorsulfonate | 427-100-0 | - | 2021 | View substance registered dossier |
Evonik Operations GmbH | Rellinghauser Straße 1-11 45128 Essen Germany | Germany | Active | (2R,2'R)-3,3'-disulfanediylbis(2-((S)-2-aminopropanamido)propanoic acid) | 850-779-3 | 115888-13-6 | 2022 | View substance registered dossier |
EUROAPI FRANCE | 15 rue Traversière 75012 Paris France | France | Active | (2R,3R)-2,3-bis(acetyloxy)butanedioic acid - 3-(2-methoxy-10H-phenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine (1:1) | 920-610-9 | - | 2021; 2022 | View substance registered dossier |
MINAKEM Beuvry Production SAS | 145, Chemin des Lilas 59310 Beuvry-la-Forêt France | France | Active | (2R,3R)-2,3-bis[(4-methoxybenzoyl)oxy]butanedioic acid | 672-585-6 | 50583-51-2 | - | View substance registered dossier |
Excella GmbH & Co. KG | Nuernberger Str. 12 90537 Feucht Germany | Germany | Active | (2R,3R)-2,3-Dihydroxybutanedioic acid-(2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide (1/1) | 947-840-2 | - | - | View substance registered dossier |
PROCOS SpA | via Matteotti 249 28062 Cameri Piemonte Italy | Italy | Active | (2R,3R)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butane-2,3-diol methanesulfonate | 815-196-0 | 1175536-50-1 | - | View substance registered dossier |
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. | - | - | Active | (2R,3R)-3-((R)-1-(tert-butyldimethylsiloxy)ethyl)-4-oxoazetidin-2-yl acetate | 408-050-9 | 76855-69-1 | - | View substance registered dossier |
ACS DOBFAR S.p.A | Viale Addetta 4/12 20067 Tribiano Milano Italy | Italy | Active | (2R,3R)-3-((R)-1-(tert-butyldimethylsiloxy)ethyl)-4-oxoazetidin-2-yl acetate | 408-050-9 | 76855-69-1 | 2023 | View substance registered dossier |
L.C.M. TRADING SPA | via Mazzini 33 20099 Sesto San Giovanni Lombardia Italy | Italy | Active | (2R,3R)-3-((R)-1-(tert-butyldimethylsiloxy)ethyl)-4-oxoazetidin-2-yl acetate | 408-050-9 | 76855-69-1 | - | View substance registered dossier |
[Confidential] | - | - | - | (2R,3R)-3-(2,5-difluorophenyl)-3-hydroxy-2-methyl-4-[1,2,4]triazol-1-yl-thiobutyramide | 609-299-8 | 368421-58-3 | - | View substance registered dossier |
Krka, d. d., Novo mesto | Smarjeska cesta 6 SI-8501 Novo mesto Slovenia | Slovenia | Active | (2R,3R)-3-(3-(Benzyloxy)phenyl-2-methylpentanoic acid | 805-624-4 | 1367878-84-9 | - | View substance registered dossier |
Krka, d. d., Novo mesto | Smarjeska cesta 6 SI-8501 Novo mesto Slovenia | Slovenia | Active | (2R,3R)-3-(3-Methoxyphenyl)-N,N,2-trimethylpentan-1-amine hydrochloride | 837-046-3 | 175591-17-0 | - | View substance registered dossier |
Former NONS notifier unknown to ECHA - Contact the relevant German competent national authority. | - | - | Active | (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate | 479-560-7 | 989-51-5 | - | View substance registered dossier |
DSM Nutritional Products GmbH | Emil-Barell-Str. 3 79639 Grenzach-Wyhlen Germany | Germany | Cease Manufacture | (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate | 479-560-7 | 989-51-5 | 2019 | View substance registered dossier |
F.I.S. Fabbrica Italiana Sintetici S.p.a. | Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy | Italy | Active | (2R,3R,11bR)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol [(1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid | 948-743-8 | - | - | View substance registered dossier |
F.I.S. Fabbrica Italiana Sintetici S.p.a. | Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy | Italy | Active | (2R,3R,11bR)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-yl L-valinate dihydrochloride | 948-534-1 | 1639208-51-7 | - | View substance registered dossier |
PCAS | 21 Chemin de la Sauvegarde 21 Ecully Parc - CS33167 69134 ECULLY France | France | Active | (2R,3R,4R)-3,4-Bis(benzyloxy)-2-((benzyloxy)methyl)-5-methoxytetrahydrofuran | 857-987-3 | 64363-77-5 | - | View substance registered dossier |
Gilead Sciences Ireland UC | IDA Business &Technology Park Carrigtohill Cork Cork Ireland | Ireland | Active | (2R,3R,4R,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-bis(phenylmethoxy)-5-(phenylmethoxymethyl)oxolane-2-carbonitrile | 856-564-0 | 1355357-49-1 | - | View substance registered dossier |
F.I.S. Fabbrica Italiana Sintetici S.p.a. | Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy | Italy | Active | (2R,3R,4R,5R)-5-(2-Amino-6-chloro-9h-purin-9-yl)-2-[(4-chlorobenzoyloxy)methyl]-4-fluoro-4-methyloxolan-3-yl 4-chlorobenzoate | 875-019-8 | 1294481-82-5 | - | View substance registered dossier |
[Confidential] | - | - | - | (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-(benzoyloxymethyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate | 807-677-9 | 817204-32-3 | - | View substance registered dossier |
F.I.S. Fabbrica Italiana Sintetici S.p.a. | Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy | Italy | Active | (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-(benzoyloxymethyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate | 807-677-9 | 817204-32-3 | - | View substance registered dossier |
Bayer AG | Kaiser-Wilhelm-Allee 1 51373 Leverkusen Germany | Germany | Active | (2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol | 606-239-2 | 19130-96-2 | 2011; 2012 | View substance registered dossier |
Gilead Sciences Ireland UC | IDA Business &Technology Park Carrigtohill Cork Cork Ireland | Ireland | Active | (2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carbonitrile | 857-885-9 | 1191237-69-0 | - | View substance registered dossier |
Janssen Pharmaceutica N.V. | Turnhoutseweg 30 2340 Beerse Belgium | Belgium | Active | (2R,3R,4S,5R)-2-(acetoxymethyl)-6-oxotetrahydro-2H-pyran-3,4,5-triyl triacetate | 612-107-5 | 61259-48-1 | - | View substance registered dossier |
N.V. Ajinomoto OmniChem S.A. | Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium | Belgium | Cease Manufacture | (2R,3R,4S,5R)-2-(acetoxymethyl)-6-oxotetrahydro-2H-pyran-3,4,5-triyl triacetate | 612-107-5 | 61259-48-1 | 2019 | View substance registered dossier |
Pfizer Ireland Pharmaceuticals | n/a P43 X336 Ringaskiddy Cork Ireland | Ireland | Active | (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-12,4-triazol-1-yl)-2-butanol (1R)-10-camphorsulfonate | 927-721-1 | - | 2013 | View substance registered dossier |
Upjohn Manufacturing Ireland Unlimited | Little Island T45 F627 Co. Cork Ireland | Ireland | Active | (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-12,4-triazol-1-yl)-2-butanol (1R)-10-camphorsulfonate | 927-721-1 | - | - | View substance registered dossier |
SCC Scientific Consulting Company GmbH | Am Grenzgraben 11 55545 Bad Kreuznach Germany | Germany | Active | (2R,3S)-butane-2,3-diol | 823-920-1 | 5341-95-7 | 2023 | View substance registered dossier |
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. | - | - | Active | (2R,3S)-N-(3-amino-2-hydroxy-4-phenylbutyl)-N-isobutyl-4-nitrobenzenesulfonamide hydrochloride | 425-260-6 | 244634-31-9 | - | View substance registered dossier |
N.V. Ajinomoto OmniChem S.A. | Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium | Belgium | Cease Manufacture | (2R,3S)-N-(3-amino-2-hydroxy-4-phenylbutyl)-N-isobutyl-4-nitrobenzenesulfonamide hydrochloride | 425-260-6 | 244634-31-9 | 2020 | View substance registered dossier |
PCAS | 21 Chemin de la Sauvegarde 21 Ecully Parc - CS33167 69134 ECULLY France | France | Active | (2R,3S,4R)-2-(Hydroxymethyl)-5-methoxytetrahydrofuran-3,4-diol | 857-672-0 | 13039-63-9 | - | View substance registered dossier |
Curia France SAS | ZI de Laville 47240 BON-ENCONTRE France | France | Active | (2R,3S,4R,5R)-2,3,4,6-tetrakis(benzyloxy)-5-hydroxy-1-(4-methylpiperazin-1-yl) hexan-1-one | 829-550-7 | 1431329-04-2 | - | View substance registered dossier |
Curia Italy S.r.l. | VIA DEL VECCHIO POLITECNICO, n. 9 20121 Milano Italy | Italy | Active | (2R,3S,4R,5R)-2,3,4,6-tetrakis(benzyloxy)-5-hydroxy-1-(4-methylpiperazin-1-yl) hexan-1-one | 829-550-7 | 1431329-04-2 | - | View substance registered dossier |
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. | - | - | Active | (2R,3S,4R,5R,7R,9R,10R,11S,12S,13R)-10-((4-Dimethylamino-3-hydroxy-6-methyltetrahydropyran-2-yl)oxy)-2-ethyl-3,4,12-trihydroxy-9-methoxy-3,5,7,9,11,13-hexamethyl-6,14-dioxo-1-oxacyclotetradecane | 433-820-6 | 118058-74-5 | - | View substance registered dossier |
Sanofi Aventis Deutschland GmbH | Industriepark Höchst H 831 (Room A0472) z.Hd. Hr. Dr. Schwind 65926 Frankfurt am Main Germany | Germany | Active | (2R,3S,4R,5R,7R,9R,10R,11S,12S,13R)-10-((4-Dimethylamino-3-hydroxy-6-methyltetrahydropyran-2-yl)oxy)-2-ethyl-3,4,12-trihydroxy-9-methoxy-3,5,7,9,11,13-hexamethyl-6,14-dioxo-1-oxacyclotetradecane | 433-820-6 | 118058-74-5 | - | View substance registered dossier |
Former NONS notifier unknown to ECHA - Contact the relevant French competent national authority. | - | - | Active | (2R,3S,4R,5R,7R,9R,10R,11S,12S,13R)-10-((4-Dimethylamino-3-hydroxy-6-methyltetrahydropyran-2-yl)oxy)-2-ethyl-3,4,12-trihydroxy-9-methoxy-3,5,7,9,11,13-hexamethyl-6,14-dioxo-1-oxacyclotetradecane | 433-820-6 | 118058-74-5 | - | View substance registered dossier |
QUIMICA SINTETICA, S.A. | C/ Dulcinea, s/n 28805 Alcalá de Henares Madrid Spain | Spain | Active | (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(4-Dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2-ethyl-3,4,10-trihydroxy-13-(5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydropyran-2-yloxy)-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one | 616-385-9 | 76801-85-9 | - | View substance registered dossier |
Midas Pharma GmbH | Rheinstrasse 49 55218 Ingelheim Germany | Germany | Active | (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(4-Dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2-ethyl-3,4,10-trihydroxy-13-(5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydropyran-2-yloxy)-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one | 616-385-9 | 76801-85-9 | - | View substance registered dossier |
Ercros SA | Avenida Diagonal 593-595 08014 Barcelona Spain | Spain | Active | (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(4-Dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2-ethyl-3,4,10-trihydroxy-13-(5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydropyran-2-yloxy)-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one | 616-385-9 | 76801-85-9 | - | View substance registered dossier |
Pliva Hrvatska doo | Prilaz baruna Filipovića 25 10000 Zagreb Croatia | Croatia | Active | (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(4-Dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2-ethyl-3,4,10-trihydroxy-13-(5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydropyran-2-yloxy)-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one | 616-385-9 | 76801-85-9 | - | View substance registered dossier |
F.I.S. Fabbrica Italiana Sintetici S.p.a. | Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy | Italy | Active | (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-erythro-hexopyranosyl-4-ulose)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-15-oxo-1-oxa-6-azacyclopentadecan-11-yl 2-O-[(benzyloxy)carbonyl]-3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranoside trifluoroacetate (1:2) | 953-335-8 | 1210740-88-7 | 2021 | View substance registered dossier |
F.I.S. Fabbrica Italiana Sintetici S.p.a. | Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy | Italy | Active | (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-13-{[(3S,4S,6R,8R)-8-methoxy-4,8-dimethyl-1,5-dioxaspiro[2.5]oct-6-yl]oxy}-3,5,8,10,12,14-hexamethyl-15-oxo-1-oxa-6-azacyclopentadecan-11-yl 3,4,6-trideoxy-3-(dimethylamino)--D-xylo-hexopyranoside | 953-425-7 | 217500-75-9 | - | View substance registered dossier |
Pfizer Ireland Pharmaceuticals | n/a P43 X336 Ringaskiddy Cork Ireland | Ireland | Active | (2R,3S,4S)-2,3,4-tris(benzyloxy)-4-((R)-4-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxotan-4-yl)-1-(4-methylpiperazin-1-yl)butan-1-one | 809-911-5 | 1431329-07-5 | - | View substance registered dossier |
Derivados Químicos S.A. | Camino de Pliego, 150 30820 Alcantarilla Murcia Spain | Spain | Active | (2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl) -4,5-dimethyl-5-(trifluoromethyl) tetrahydrofuran-2-carboxylic acid: (R )-alfa- methylbenzylamine salt (1:1) | 893-589-6 | 2649470-89-1 | - | View substance registered dossier |
SUANFARMA Italia SpA | Corso Verona, 165 38068 Rovereto Trentino Alto Adige Italy | Italy | Active | (2R-(2α,3Z,5α))-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 1:1 salt with 2,4,4-Trimethylpentan-2-amine | 613-879-6 | 66069-32-7 | - | View substance registered dossier |
Pfizer Ireland Pharmaceuticals | n/a P43 X336 Ringaskiddy Cork Ireland | Ireland | Active | (2RS, 3SR)-3-(6-chloro-5-fluoro-4-pyrimidinyl)-2-(2,4- difluorphenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol hydrochloride | 928-729-8 | - | 2013 | View substance registered dossier |
Pfizer Ireland Pharmaceuticals | n/a P43 X336 Ringaskiddy Cork Ireland | Ireland | Active | (2RS,3SR)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (1R)-10-camphorsulphonate | 917-473-2 | - | 2011; 2013 | View substance registered dossier |
BASF Schwarzheide GmbH | Schipkauer Str. 1 01987 Schwarzheide Brandenburg Germany | Germany | Active | (2RS,3SR)-3-(2-chlorophenyl)-2-(4-fluorophenyl)-[( 1H-1,2,4-triazol-1-yl)methyl]oxirane | 406-850-2 | 133855-98-8 | 2022 | View substance registered dossier |
Fine Organics Limited | Seal Sands TS2 1UB Middlesbrough Teesside United Kingdom | United Kingdom | No longer Valid | (2RS,3SR)-3-(2-chlorophenyl)-2-(4-fluorophenyl)-[( 1H-1,2,4-triazol-1-yl)methyl]oxirane | 406-850-2 | 133855-98-8 | 2021 | View substance registered dossier |
Macfarlan Smith Limited | Wheatfield Road EH11 2QA Edinburgh United Kingdom | United Kingdom | No longer Valid | (2S)-(5α,7α)-7-(2-hydroxy-3,3-dimethylbutan-2-yl)-6-methoxy-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol | 682-862-3 | 78715-23-8 | 2021 | View substance registered dossier |
Indivior UK Ltd | Henry Boot Way HU4 7DY Hull United Kingdom | United Kingdom | No longer Valid | (2S)-(5α,7α)-7-(2-hydroxy-3,3-dimethylbutan-2-yl)-6-methoxy-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol | 682-862-3 | 78715-23-8 | 2021 | View substance registered dossier |
UNION QUIMICO FARMACÉUTICA S.A. | Mallorca 262 08008 Barcelona Barcelona Spain | Spain | Active | (2S)-1,1,2-triphenylethane-1,2-diol | 624-788-6 | 108998-83-0 | - | View substance registered dossier |
Corteva Agriscience Spain, S.L.U | Valle de Tamón s/n 33469 Carreño (Asturias) Spain 33469 Carreño (Asturias) Spain | Spain | Active | (2S)-1,1-bis(4-fluorophenyl)propan-2-yl L-alaninate hydrochloride | 953-783-4 | 2171323-89-8 | - | View substance registered dossier |
DSM Nutritional Products GmbH | Emil-Barell-Str. 3 79639 Grenzach-Wyhlen Germany | Germany | Cease Manufacture | (2S)-1,1-diphenylpropane-1,2-diol | 443-220-6 | 46755-94-6 | 2019 | View substance registered dossier |
EcoGreen Fine Chemicals B.V. | Lichtenauerlaan 102-120 3062ME Rotterdam Netherlands | Netherlands | Active | (2S)-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalene | 214-494-2 | 1135-66-6 | 2018 | View substance registered dossier |
Global Product Compliance (Europe) AB | IDEON, Beta 5, Scheelevägen 17 22363 Lund Sweden | Sweden | Active | (2S)-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalene | 214-494-2 | 1135-66-6 | 2019 | View substance registered dossier |
REACH24H CONSULTING GROUP | Paramount Court, Corrig Road, Sandyford Dublin18 Dublin Ireland | Ireland | Active | (2S)-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalene | 214-494-2 | 1135-66-6 | - | View substance registered dossier |
Symrise AG | Mühlenfeldstraße 1 37603 Holzminden Germany | Germany | Active | (2S)-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalene | 214-494-2 | 1135-66-6 | 2020 | View substance registered dossier |
IFF Benicarlo, S.L. | Avda. Felipe Klein 2 12580 Benicarlo Castellon Spain | Spain | Active | (2S)-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalene | 214-494-2 | 1135-66-6 | - | View substance registered dossier |
[Confidential] | - | - | - | (2S)-1-(2-aminoacetyl)-N-[(1S)-1-(tert-butoxymethyl)-2-oxo-2-[[(1S)-1-(tert-butoxymethyl)-2-oxo-2-[[2-oxo-2-[[(1S)-1-methyl-2-oxo-2-[(2S)-2-[(2S)-2-[(2S)-2-[[(1S)-2-amino-1-(tert-butoxymethyl)-2-oxo-ethyl]carbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carbonyl]pyrrolidin-1-yl]ethyl]amino]ethyl]amino]ethyl]amino]ethyl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid | 955-960-1 | 2656383-23-0 | - | View substance registered dossier |
JSC "Olainfarm" | Rupnicu str. 5 LV-2114 Olaine Latvia | Latvia | Active | (2S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile | 807-388-8 | 207557-35-5 | 2019 | View substance registered dossier |
Krka, d. d., Novo mesto | Smarjeska cesta 6 SI-8501 Novo mesto Slovenia | Slovenia | Active | (2S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile | 807-388-8 | 207557-35-5 | - | View substance registered dossier |
MOEHS BCN, S.L. | C/ Zenc, 12 08755 Castellbisbal Barcelona Spain | Spain | Active | (2S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile | 807-388-8 | 207557-35-5 | - | View substance registered dossier |
ERREGIERRE SPA | Via Francesco Baracca, 19 24060 SAN PAOLO D'ARGON BERGAMO Italy | Italy | Active | (2S)-1-(2-phenylacetyl)pyrrolidine-2-carboxylic acid | 928-037-6 | 2752-38-7 | - | View substance registered dossier |
Evonik Operations GmbH | Rellinghauser Straße 1-11 45128 Essen Germany | Germany | Active | (2S)-1-(tert-butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid | 617-556-0 | 84348-37-8 | 2020; 2022 | View substance registered dossier |
Curia Italy S.r.l. | VIA DEL VECCHIO POLITECNICO, n. 9 20121 Milano Italy | Italy | Active | (2S)-1-(tert-butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid | 617-556-0 | 84348-37-8 | - | View substance registered dossier |
Corden Pharma Bergamo S.p.A. | Via Bergamo, 121 IT-24047 Treviglio BG Italy | Italy | Active | (2S)-1-({[(benzyloxy)carbonyl]amino}acetyl)-2-methylpyrrolidine-2-carboxylic acid | 832-934-7 | 869001-86-5 | - | View substance registered dossier |
F.I.S. Fabbrica Italiana Sintetici S.p.a. | Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy | Italy | Active | (2S)-1-({[(benzyloxy)carbonyl]amino}acetyl)-2-methylpyrrolidine-2-carboxylic acid | 832-934-7 | 869001-86-5 | - | View substance registered dossier |
Arran Chemical Company Ltd | Monksland Industrial Estate N37DN24 Athlone Co. Roscommon Ireland | Ireland | Active | (2S)-1-[(tert-butyl)oxycarbonyl]-2-methylpyrrolidine-2-carboxylic acid | 813-635-0 | 103336-06-7 | - | View substance registered dossier |
Patheon Austria GmbH & Co KG | St. Peterstrasse 25 A-4020 Linz Austria | Austria | Active | (2S)-1-[(tert-butyl)oxycarbonyl]-2-methylpyrrolidine-2-carboxylic acid | 813-635-0 | 103336-06-7 | - | View substance registered dossier |
[Confidential] | - | - | - | (2S)-1-amino-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-aminium chloride | 954-882-5 | 2628280-48-6 | - | View substance registered dossier |
[Confidential] | - | - | - | (2S)-1-tert-butoxycarbonyl-2,3-dihydropyrrole-2-carboxylic acid;N-cyclohexylcyclohexanamine | 618-453-3 | 90104-21-5 | - | View substance registered dossier |
Roche Diagnostics GmbH | Sandhoferstrasse 116 68305 Mannheim Germany | Germany | Active | (2S)-2-(1,3-DIOXO-2,3-DIHYDRO-1H-ISOINDOL-2-YL)PENTANEDIOIC ACID | 608-945-6 | 340-90-9 | 2019; 2022 | View substance registered dossier |
SIGMA-ALDRICH CHEMIE GMBH | Riedstrasse 2 89555 Steinheim Germany | Germany | Active | (2S)-2-(1,3-DIOXO-2,3-DIHYDRO-1H-ISOINDOL-2-YL)PENTANEDIOIC ACID | 608-945-6 | 340-90-9 | - | View substance registered dossier |
ISOCHEM | 32 rue Lavoisier 91710 VERT LE PETIT France | France | Active | (2S)-2-(1,3-dioxoisoindol-2-yl)-5-oxo-5-phenylmethoxypentanoic acid | 443-560-5 | 88784-33-2 | - | View substance registered dossier |
Former NONS notifier unknown to ECHA - Contact the relevant Italian competent national authority. | - | - | No longer Valid | (2S)-2-(1,3-dioxoisoindol-2-yl)-5-oxo-5-phenylmethoxypentanoic acid | 443-560-5 | 88784-33-2 | 2022 | View substance registered dossier |
Indivior UK Ltd | Henry Boot Way HU4 7DY Hull United Kingdom | United Kingdom | No longer Valid | (2S)-2-(17-carbonitrile-3,6-dimethoxy-4,5α-epoxy-6α,14-ethano-14α-morphinan-7α-yl)-3,3-dimethylbutan-2-ol | 605-429-2 | 16614-60-1 | 2021 | View substance registered dossier |
Siegfried PharmaChemikalien Minden GmbH | Karlstr. 15-39, 42-44 32423 Minden Nordrhein-Westphalen Germany | Germany | Active | (2S)-2-(17-carbonitrile-3,6-dimethoxy-4,5α-epoxy-6α,14-ethano-14α-morphinan-7α-yl)-3,3-dimethylbutan-2-ol | 605-429-2 | 16614-60-1 | 2019 | View substance registered dossier |
Macfarlan Smith Limited | Wheatfield Road EH11 2QA Edinburgh United Kingdom | United Kingdom | No longer Valid | (2S)-2-(17-carbonitrile-3,6-dimethoxy-4,5α-epoxy-6α,14-ethano-14α-morphinan-7α-yl)-3,3-dimethylbutan-2-ol | 605-429-2 | 16614-60-1 | 2021 | View substance registered dossier |
Siegfried St. Vulbas SAS | 530, allée de la Luye 01150 SAINT VULBAS France | France | Active | (2S)-2-(2-AMINO-5-CHLOROPHENYL)-4-CYCLOPROPYL-1,1, 1-TRIFLUOROBUT-3-YN-2-OL METHANESULFONATE (1:1.5) | 610-316-6 | 467426-34-2 | - | View substance registered dossier |
F.I.S. Fabbrica Italiana Sintetici S.p.a. | Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy | Italy | Active | (2S)-2-(2-AMINO-5-CHLOROPHENYL)-4-CYCLOPROPYL-1,1, 1-TRIFLUOROBUT-3-YN-2-OL METHANESULFONATE (1:1.5) | 610-316-6 | 467426-34-2 | 2017 | View substance registered dossier |
F.I.S. Fabbrica Italiana Sintetici S.p.a. | Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy | Italy | Active | (2S)-2-(3-benzoylphenyl)propanoic acid | 606-944-5 | 22161-81-5 | 2019 | View substance registered dossier |
LusoChimica S.p.A. | Via Giotto, 9 23871 Lomagna (Lecco) Italy | Italy | Active | (2S)-2-(3-benzoylphenyl)propanoic acid | 606-944-5 | 22161-81-5 | - | View substance registered dossier |
Lodichem S.r.l. | Via delle Rimembranze, 1 26582 Mairano di Casaletto Lodigiano (Lodi) Italy | Italy | Active | (2S)-2-(3-benzoylphenyl)propanoic acid | 606-944-5 | 22161-81-5 | - | View substance registered dossier |
Indivior UK Ltd | Henry Boot Way HU4 7DY Hull United Kingdom | United Kingdom | No longer Valid | (2S)-2-(4,5α-epoxy-3,6-dimethoxy-17-methyl-6α,14-ethano-14α-morphinan-7α-yl)-3,3-dimethylbutan-2-ol | 605-274-0 | 16196-70-6 | 2021 | View substance registered dossier |
Macfarlan Smith Limited | Wheatfield Road EH11 2QA Edinburgh United Kingdom | United Kingdom | No longer Valid | (2S)-2-(4,5α-epoxy-3,6-dimethoxy-17-methyl-6α,14-ethano-14α-morphinan-7α-yl)-3,3-dimethylbutan-2-ol | 605-274-0 | 16196-70-6 | 2021 | View substance registered dossier |
Alkaloida Chemical Company Zrt. | Kabay Janos 29 H-4440 Tiszavasvari Hungary | Hungary | Active | (2S)-2-(4,5α-epoxy-3,6-dimethoxy-17-methyl-6α,14-ethano-14α-morphinan-7α-yl)-3,3-dimethylbutan-2-ol | 605-274-0 | 16196-70-6 | 2018 | View substance registered dossier |
Siegfried PharmaChemikalien Minden GmbH | Karlstr. 15-39, 42-44 32423 Minden Nordrhein-Westphalen Germany | Germany | Active | (2S)-2-(4,5α-epoxy-3,6-dimethoxy-17-methyl-6α,14-ethano-14α-morphinan-7α-yl)-3,3-dimethylbutan-2-ol | 605-274-0 | 16196-70-6 | - | View substance registered dossier |
MinAscent Leuna Production GmbH | Am Haupttor Gebäude 4208 06237 Leuna Germany | Germany | Active | (2S)-2-(benzyloxy)propanal | 617-235-5 | 81445-44-5 | - | View substance registered dossier |
Labcorp Development SA 169 | Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 – 5 Planta 28050 Madrid Spain | Spain | Active | (2S)-2-(chloromethyl)oxirane | 482-080-0 | 67843-74-7 | 2011 | View substance registered dossier |
Swords Laboratories Unlimited Company | Cruiserath Road Mulhuddart D15H6EF Dublin 15 Co Dublin Ireland | Ireland | Active | (2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoic acid | 431-620-3 | - | 2009; 2010; 2017 | View substance registered dossier |
Patheon Austria GmbH & Co KG | St. Peterstrasse 25 A-4020 Linz Austria | Austria | Cease Manufacture | (2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoic acid | 431-620-3 | - | 2022 | View substance registered dossier |
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. | - | - | Active | (2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoic acid | 431-620-3 | - | - | View substance registered dossier |
Evonik Rexim S.A.S. | 33, Rue de Verdun 80400 Ham France | France | Active | (2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoic acid | 431-620-3 | - | 2011 | View substance registered dossier |
Former NONS notifier unknown to ECHA - Contact the relevant Dutch competent national authority. | - | - | Active | (2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoic acid | 431-620-3 | - | - | View substance registered dossier |
Former NONS notifier unknown to ECHA - Contact the relevant Irish competent national authority. | - | - | Active | (2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoic acid | 431-620-3 | - | - | View substance registered dossier |
Evonik Operations GmbH | Rellinghauser Straße 1-11 45128 Essen Germany | Germany | Active | (2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoic acid | 431-620-3 | - | 2012 | View substance registered dossier |
OLON Spa | Strada Rivoltana Km 6/7 20053 RODANO Milano Italy | Italy | Active | (2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoic acid | 431-620-3 | - | - | View substance registered dossier |
A.C.R.A.F. Spa | Via Amelia 70 00181 Roma Italy | Italy | Active | (2S)-2-[(4-Chlorobenzoyl)oxy]propanoic acid | 817-559-9 | 1047975-16-5 | - | View substance registered dossier |
CHEMO BIOSYNTHESIS SRL | VIALE ISONZO, 8 20135 MILANO Italy | Italy | Active | (2S)-2-[(8S,9S,10R,13S,14S,17R)-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]propanal | 861-038-9 | 3986-89-8 | - | View substance registered dossier |
Flamma S.p.a. | via Bedeschi, 22 24040 Chignolo d'Isola Bergamo Italy | Italy | Active | (2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoic acid | 616-135-9 | 74761-42-5 | 2019 | View substance registered dossier |
Gilead Sciences Ireland UC | IDA Business &Technology Park Carrigtohill Cork Cork Ireland | Ireland | Active | (2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoic acid | 616-135-9 | 74761-42-5 | - | View substance registered dossier |
MSD International GmbH (Ballydine Branch) | Ballydine - Kilsheelan 0 Clonmel Ireland | Ireland | Active | (2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoic acid | 616-135-9 | 74761-42-5 | - | View substance registered dossier |
Innospec Performance Chemicals France SAS (Only Rep 2) | Zone Industrielle de Han Sur Meuse BP19 55300 Saint-Mihiel France | France | Active | (2S)-2-[2-[[(1S)-1,2-dicarboxyethyl]amino]ethylamino]butanedioic acid | 439-840-1 | 161233-89-2 | 2012; 2013 | View substance registered dossier |
Huvepharma Italia s.r.l. | Via Roberto Lepetit, 142 12075 GARESSIO (CN) Italy | Italy | Active | (2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoic acid | 406-310-6 | - | 2010; 2012 | View substance registered dossier |
Former NONS notifier unknown to ECHA - Contact the relevant Irish competent national authority. | - | - | Active | (2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoic acid | 406-310-6 | - | - | View substance registered dossier |
MAPIC Europe NV | EXCELSIORLAAN 83 1930 ZAVENTEM Belgium | Belgium | Active | (2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoic acid | 406-310-6 | - | - | View substance registered dossier |
Former NONS notifier unknown to ECHA - Contact the relevant Dutch competent national authority. | - | - | Active | (2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoic acid | 406-310-6 | - | - | View substance registered dossier |
B.I.G. - OR634 | Technische Schoolstraat 43A 2440 Geel Belgium | Belgium | Active | (2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoic acid | 406-310-6 | - | 2011; 2012; 2014; 2020 | View substance registered dossier |
EUROAPI Germany GmbH | Brüningstraße 50 65926 Frankfurt am Main Germany | Germany | Active | (2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoic acid | 406-310-6 | - | 2010; 2012 | View substance registered dossier |
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. | - | - | Active | (2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoic acid | 406-310-6 | - | - | View substance registered dossier |
Saltigo GmbH | HSEQ-RA Kaiser-Wilhelm-Allee 40 51373 Leverkusen Germany | Germany | Cease Manufacture | (2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoic acid | 406-310-6 | - | 2014 | View substance registered dossier |
EGIS Pharmaceuticals PLC | Keresztúri út 30-38 H-1106 Budapest Hungary | Hungary | Active | (2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoic acid | 406-310-6 | - | - | View substance registered dossier |
Medichem S.A. | Polígon Industrial de Celrà 17460 Celrà Girona Spain | Spain | Active | (2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoic acid | 406-310-6 | - | 2018 | View substance registered dossier |
FARMHISPANIA S.A. | Passeig del Riu Besós, 9-10 08160 Montmeló Barcelona Spain | Spain | Active | (2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoic acid | 406-310-6 | - | - | View substance registered dossier |
ROLABO OUTSOURCING, S.L. | Polígono Industrial Malpica. Calle J, nº 3-4 50016 Zaragoza Zaragoza Spain | Spain | Active | (2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoic acid | 406-310-6 | - | - | View substance registered dossier |
TAMARANG, S.A. | Balmes, 84, 4-2 08008 Barcelona Barcelona Spain | Spain | Cease Manufacture | (2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoic acid | 406-310-6 | - | 2012 | View substance registered dossier |
ROLABO OUTSOURCING, S.L. | Polígono Industrial Malpica. Calle J, nº 3-4 50016 Zaragoza Zaragoza Spain | Spain | Active | (2S)-2-[[(2S)-1-ethoxy-1-oxopentan-2-yl]amino]propanoic acid | 617-393-5 | 82834-12-6 | - | View substance registered dossier |
LABORATORIOS SERVIER S.L. | RIO JARAMA 59 45007 TOLEDO Spain | Spain | Active | (2S)-2-[[(2S)-1-ethoxy-1-oxopentan-2-yl]amino]propanoic acid | 617-393-5 | 82834-12-6 | - | View substance registered dossier |
ORIL INDUSTRIE | 13 rue Auguste Desgenétais 76210 BOLBEC France | France | Active | (2S)-2-[[(2S)-1-ethoxy-1-oxopentan-2-yl]amino]propanoic acid | 617-393-5 | 82834-12-6 | 2019; 2020; 2021 | View substance registered dossier |
[Confidential] | - | - | - | (2S)-2-[[(2S)-6-[[2-[2-[2-[[2-[2-[2-[[(4S)-5-tert-butoxy-4-[(20-tert-butoxy-20-oxo-icosanoyl)amino]-5-oxo-pentanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-6-(tert-butoxycarbonylamino)-2-[[(2S)-4-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-butanoyl]amino]hexanoyl]amino]-3-methyl-pentanoyl]amino]propanoyl]amino]-5-oxo-5-(tritylamino)pentanoyl]amino]hexanoyl]amino]propanoic acid | 954-943-6 | - | - | View substance registered dossier |
Midas Pharma Polska Sp. z o.o. | Ul. Hankiewicza 2 02-103 Warszawa Poland | Poland | Active | (2S)-2-amino-3-(3,4-dimethoxyphenyl)-2-methylpropanoic acid;hydrochloride | 611-205-5 | 5486-79-3 | - | View substance registered dossier |
EGIS Pharmaceuticals PLC | Keresztúri út 30-38 H-1106 Budapest Hungary | Hungary | Active | (2S)-2-amino-3-(3,4-dimethoxyphenyl)-2-methylpropanoic acid;hydrochloride | 611-205-5 | 5486-79-3 | - | View substance registered dossier |
Arevipharma GmbH | Meißner Straße 35 01445 Radebeul Saxony Germany | Germany | Active | (2S)-2-amino-3-(4-phosphonooxyphenyl)propanoic acid | 891-585-9 | 21820-51-9 | - | View substance registered dossier |
Sigma-Aldrich Ireland Ltd | Vale Road . Arklow Co. Wicklow Ireland | Ireland | Active | (2S)-2-amino-3-(4-{[bis(sodiooxy)phosphoryl]oxy}phenyl)propanoic acid | 860-352-3 | 1610350-91-8 | - | View substance registered dossier |
Arevipharma GmbH | Meißner Straße 35 01445 Radebeul Saxony Germany | Germany | Active | (2S)-2-amino-3-(4-{[bis(sodiooxy)phosphoryl]oxy}phenyl)propanoic acid | 860-352-3 | 1610350-91-8 | - | View substance registered dossier |
Sandoz GmbH | Biochemiestr. 10 6250 Kundl Austria | Austria | Active | (2S)-2-amino-3-[3,5-diiodo-4-(4-methoxyphenoxy)phenyl]propanoic acid | 619-013-3 | 94345-95-6 | 2021 | View substance registered dossier |
N.V. Ajinomoto OmniChem S.A. | Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium | Belgium | Active | (2S)-2-Aminobutyramide Hydrochloride | 471-490-5 | 7682-20-4 | - | View substance registered dossier |
UCB Pharma S.A.(Belgium) | Allée de la recherche, 60 1070 Brussels Belgium | Belgium | Active | (2S)-2-Aminobutyramide Hydrochloride | 471-490-5 | 7682-20-4 | 2013; 2017; 2019; 2020 | View substance registered dossier |
Sterling Pharma Solutions Ltd | Dudley NE23 7QG Cramlington Northumberland United Kingdom | United Kingdom | No longer Valid | (2S)-2-Aminobutyramide Hydrochloride | 471-490-5 | 7682-20-4 | 2021 | View substance registered dossier |
MITSUBISHI GAS CHEMICAL EUROPE GMBH | Immermannstr.13 40210 Duesseldorf Germany | Germany | Cease Manufacture | (2S)-2-Aminobutyramide Hydrochloride | 471-490-5 | 7682-20-4 | 2013 | View substance registered dossier |
Flamma S.p.a. | via Bedeschi, 22 24040 Chignolo d'Isola Bergamo Italy | Italy | Active | (2S)-2-benzyl-N,N-dimethylaziridine-1-sulfonamide | 620-285-0 | 902146-43-4 | - | View substance registered dossier |
[Confidential] | - | - | - | (2S)-2-hydrazinyl-3-[4-hydroxy-3-(substituted)phenyl]-2-alkylpropanoic acid | - | - | - | View substance registered dossier |
[Confidential] | - | - | - | (2S)-2-hydrazinyl-3-[4-hyrdoxy-3-(substituted)phenyl]-2-alkylpropanoic acid — tert-alkylamine (1/1) | - | - | - | View substance registered dossier |
MinAscent Leuna Production GmbH | Am Haupttor Gebäude 4208 06237 Leuna Germany | Germany | Active | (2S)-2-hydroxy-1-(1-pyrrolidinyl)-1-propanone | 601-833-8 | 122151-38-6 | - | View substance registered dossier |
[Confidential] | - | - | - | (2S)-2-hydroxy-2-(3-phenoxyphenyl)acetonitrile | 441-070-6 | 61826-76-4 | - | View substance registered dossier |
ESIM Chemicals GmbH | St.-Peter-Strasse 25 4020 Linz Austria | Austria | Cease Manufacture | (2S)-2-hydroxy-2-(3-phenoxyphenyl)acetonitrile | 441-070-6 | 61826-76-4 | 2023 | View substance registered dossier |
DOW CHEMICAL COMPANY LTD | Diamond House, Lotus Park Kingsbury Crescent Middx UB7 0DQ Staines Middx United Kingdom | United Kingdom | No longer Valid | (2S)-2-hydroxy-2-(3-phenoxyphenyl)acetonitrile | 441-070-6 | 61826-76-4 | 2021 | View substance registered dossier |
OLON Spa | Strada Rivoltana Km 6/7 20053 RODANO Milano Italy | Italy | Cease Manufacture | (2S)-2-{[(1E)-(5-chloro-2-hydroxyphenyl)(phenyl)methylene]amino}-3-methylbutanoic acid | 609-516-6 | 38075-43-3 | 2022 | View substance registered dossier |
Első Vegyi Industria ZRt. | Kartács utca 6. H-1139 BUDAPEST Hungary | Hungary | Active | (2S)-3-(dimethylamino)-1-(3-methoxyphenyl)-2-methyl-1-propanonone | 477-290-4 | - | - | View substance registered dossier |
Janssen Pharmaceutica N.V. | Turnhoutseweg 30 2340 Beerse Belgium | Belgium | Cease Manufacture | (2S)-3-(dimethylamino)-1-(3-methoxyphenyl)-2-methyl-1-propanonone | 477-290-4 | - | 2019 | View substance registered dossier |
Gruenenthal GmbH | Zieglerstrasse 6 52078 Aachen Germany | Germany | Active | (2S)-3-(dimethylamino)-1-(3-methoxyphenyl)-2-methyl-1-propanonone | 477-290-4 | - | - | View substance registered dossier |
AbbVie Srl | S.R. 148 Pontina Km 52 snc 04011 Campoverde di Aprilia (LT) Italy | Italy | Active | (2S)-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanoic acid | 430-900-2 | 192725-50-1 | 2011; 2018 | View substance registered dossier |
Curia Italy S.r.l. | VIA DEL VECCHIO POLITECNICO, n. 9 20121 Milano Italy | Italy | Active | (2S)-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanoic acid | 430-900-2 | 192725-50-1 | - | View substance registered dossier |
Novartis Grimsby Limited | Moody Lane, Pyewipe DN31 2SR Grimsby N.E. Lincolnshire United Kingdom | United Kingdom | No longer Valid | (2S)-3-methyl-2-(N-{[2'-(1H-1,2,3,4-tetrazol-5-yl)-[1,1-biphenyl]-4-yl]methyl}pentanamido)butanoic acid | 604-045-2 | 137862-53-4 | 2021 | View substance registered dossier |
Novartis Ringaskiddy Limited | . . Ringaskiddy County Cork Ireland | Ireland | Active | (2S)-3-methyl-2-(N-{[2'-(1H-1,2,3,4-tetrazol-5-yl)-[1,1-biphenyl]-4-yl]methyl}pentanamido)butanoic acid | 604-045-2 | 137862-53-4 | 2014 | View substance registered dossier |
Novartis Integrated Services Limited | Ringaskiddy IE Ringaskiddy Cork Ireland | Ireland | Active | (2S)-3-methyl-2-(N-{[2'-(1H-1,2,3,4-tetrazol-5-yl)-[1,1-biphenyl]-4-yl]methyl}pentanamido)butanoic acid | 604-045-2 | 137862-53-4 | 2014 | View substance registered dossier |
Bayer AG | Kaiser-Wilhelm-Allee 1 51373 Leverkusen Germany | Germany | Active | (2S)-4-amino-2-hydroxy-butanoic acid | 670-305-7 | 40371-51-5 | - | View substance registered dossier |
Evonik Rexim S.A.S. | 33, Rue de Verdun 80400 Ham France | France | Active | (2S)-5-amino-2-[(aminoacetyl)amino]-5-oxopentanoic acid | 700-144-0 | 13115-71-4 | 2023 | View substance registered dossier |
Evonik Rexim S.A.S. | 33, Rue de Verdun 80400 Ham France | France | Active | (2S)-5-amino-2-{[(2S)-2-aminopropanoyl]amino}-5-oxopentanoic acid | 475-290-9 | - | 2022 | View substance registered dossier |
- | - | - | - | (2S)-5-amino-2-{[(2S)-2-aminopropanoyl]amino}-5-oxopentanoic acid | 475-290-9 | - | - | View substance registered dossier |
Former NONS notifier unknown to ECHA - Contact the relevant German competent national authority. | - | - | Active | (2S)-5-amino-2-{[(2S)-2-aminopropanoyl]amino}-5-oxopentanoic acid | 475-290-9 | - | - | View substance registered dossier |
Avara Shannon Pharmaceutical Services Limited | Shannon Industrial Estate V14 FX09 Shannon Clare Ireland | Ireland | Cease Manufacture | (2S)-5-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride (1:1) | 695-797-0 | 93601-86-6 | 2021 | View substance registered dossier |
[Confidential] | - | - | - | (2S)-5-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride (1:1) | 695-797-0 | 93601-86-6 | - | View substance registered dossier |
Avara Shannon Pharmaceutical Services Limited | Shannon Industrial Estate V14 FX09 Shannon Clare Ireland | Ireland | Cease Manufacture | (2S)-5-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-aminium (2R)-(2-chlorophenyl)(hydroxy)acetate | 814-350-4 | 1352917-66-8 | 2021 | View substance registered dossier |
Janssen Pharmaceutica N.V. | Turnhoutseweg 30 2340 Beerse Belgium | Belgium | Active | (2S)-6-fluoro-2-[(2S)-oxiran-2-yl]chromane [S-(R*,R*)] | 603-314-1 | 129050-23-3 | 2019 | View substance registered dossier |
F.I.S. Fabbrica Italiana Sintetici S.p.a. | Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy | Italy | Active | (2S)-6-fluoro-2-[(2S)-oxiran-2-yl]chromane [S-(R*,R*)] | 603-314-1 | 129050-23-3 | 2022 | View substance registered dossier |
cordenpharma chenove | 47, rue de Longvic 21300 Chenôve France | France | Active | (2S)-6-fluoro-3,4-dihydro-2H-1-Benzopyran-2-carboxylic acid | 810-842-8 | 129101-36-6 | - | View substance registered dossier |
Patheon Austria GmbH & Co KG | St. Peterstrasse 25 A-4020 Linz Austria | Austria | Cease Manufacture | (2S)-[(tert-butoxycarbonyl)amino](3-hydroxytricyclo[3.3.1.1 3,7]dec-1-yl)acetic acid | 700-361-0 | 361442-00-4 | 2021 | View substance registered dossier |
Piramal Healthcare UK Ltd | Whalton Road NE61 3YA Morpeth Northumberland United Kingdom | United Kingdom | No longer Valid | (2S)-[(tert-butoxycarbonyl)amino](3-hydroxytricyclo[3.3.1.1 3,7]dec-1-yl)acetic acid | 700-361-0 | 361442-00-4 | 2021 | View substance registered dossier |
SK BIOTEK IRELAND LIMITED | Watery Lane Swords K67 AY91 Swords Co. Dublin Ireland | Ireland | Active | (2S)-[(tert-butoxycarbonyl)amino](3-hydroxytricyclo[3.3.1.1 3,7]dec-1-yl)acetic acid | 700-361-0 | 361442-00-4 | 2010; 2014 | View substance registered dossier |
MINAKEM Beuvry Production SAS | 145, Chemin des Lilas 59310 Beuvry-la-Forêt France | France | Active | (2S)-but-3-yn-2-yl methanesulfonate | 857-677-8 | 73647-37-7 | - | View substance registered dossier |
Ajinomoto OmniChem (OR) | Cooppallaan 91 9230 Wetteren Belgium | Belgium | Active | (2S)-N, N’-dibutyl-2-(2-ethylhexanamido)pentanediamide | 700-664-8 | 486455-65-6 | 2019 | View substance registered dossier |
Excella GmbH & Co. KG | Nuernberger Str. 12 90537 Feucht Germany | Germany | Active | (2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide | 617-525-1 | 84057-95-4 | - | View substance registered dossier |
FINORGA SAS | 497 route de Givors 38670 CHASSE SUR RHONE France | France | Active | (2S)-propane-1,2-diamine dihydrochloride | 606-377-3 | 19777-66-3 | - | View substance registered dossier |
Esteve Quimica, S.A. | Torre Esteve Passeig de la Zona Franca, 109, 4ª Planta 08038 Barcelona Barcelona Spain | Spain | Active | (2S)-propane-1,2-diamine dihydrochloride | 606-377-3 | 19777-66-3 | - | View substance registered dossier |
Arran Chemical Company Ltd | Monksland Industrial Estate N37DN24 Athlone Co. Roscommon Ireland | Ireland | Active | (2S)-propane-1,2-diamine dihydrochloride | 606-377-3 | 19777-66-3 | - | View substance registered dossier |
CU Chemie Uetikon GmbH | Raiffeisenstrasse 4 77933 Lahr Baden-Württemberg Germany | Germany | Active | (2S)-propane-1,2-diamine dihydrochloride | 606-377-3 | 19777-66-3 | - | View substance registered dossier |
Janssen Pharmaceutica N.V. | Turnhoutseweg 30 2340 Beerse Belgium | Belgium | Cease Manufacture | (2S)-{[(benzyloxy)carbonyl]amino}(cyclohexyl)acetic acid | 478-210-0 | 69901-75-3 | 2019 | View substance registered dossier |
Envigo Consulting Limited | Woolley Road Alconbury PE28 4HS Huntingdon Cambridgeshire United Kingdom | United Kingdom | No longer Valid | (2S)-{[(benzyloxy)carbonyl]amino}(cyclohexyl)acetic acid | 478-210-0 | 69901-75-3 | 2021 | View substance registered dossier |
Envigo Consulting Limited | Woolley Road Alconbury PE28 4HS Huntingdon Cambridgeshire United Kingdom | United Kingdom | No longer Valid | (2S)-{[(benzyloxy)carbonyl]amino}(cyclohexyl)acetic acid | 478-210-0 | 69901-75-3 | 2021 | View substance registered dossier |
Corden Pharma Bergamo S.p.A. | Via Bergamo, 121 IT-24047 Treviglio BG Italy | Italy | Active | (2S)‐2‐{[(2S)‐1‐(2‐{[(benzyloxy)carbonyl]amino}acetyl)‐2‐methylpyrrolidin‐2‐yl]formamido}pentanedioic acid | 949-609-1 | - | 2022 | View substance registered dossier |
F.I.S. Fabbrica Italiana Sintetici S.p.a. | Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy | Italy | Active | (2S)‐2‐{[(2S)‐1‐(2‐{[(benzyloxy)carbonyl]amino}acetyl)‐2‐methylpyrrolidin‐2‐yl]formamido}pentanedioic acid | 949-609-1 | - | - | View substance registered dossier |
[Confidential] | - | - | - | (2S, 4R)-1-((S)-2-(tert-butoxycarbonylamino)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxylic acid compound with tetrahydrofuran | 941-817-0 | - | - | View substance registered dossier |
ORIL INDUSTRIE | 13 rue Auguste Desgenétais 76210 BOLBEC France | France | Active | (2S,3aS,7aS)-Octahydro-1H-indole-2-carboxylic acid | 617-180-7 | 80875-98-5 | 2019; 2020; 2021; 2022 | View substance registered dossier |
Krka, d. d., Novo mesto | Smarjeska cesta 6 SI-8501 Novo mesto Slovenia | Slovenia | Active | (2S,3aS,7aS)-Octahydro-1H-indole-2-carboxylic acid | 617-180-7 | 80875-98-5 | 2019 | View substance registered dossier |
DKSH France S.A. | 1475 Quai du Rhone 01702 Miribel France | France | Active | (2S,3aS,7aS)-Octahydro-1H-indole-2-carboxylic acid | 617-180-7 | 80875-98-5 | - | View substance registered dossier |
ROLABO OUTSOURCING, S.L. | Polígono Industrial Malpica. Calle J, nº 3-4 50016 Zaragoza Zaragoza Spain | Spain | Active | (2S,3aS,7aS)-Octahydro-1H-indole-2-carboxylic acid | 617-180-7 | 80875-98-5 | - | View substance registered dossier |
LABORATORIOS SERVIER S.L. | RIO JARAMA 59 45007 TOLEDO Spain | Spain | Active | (2S,3aS,7aS)-Octahydro-1H-indole-2-carboxylic acid | 617-180-7 | 80875-98-5 | - | View substance registered dossier |
Flamma S.p.a. | via Bedeschi, 22 24040 Chignolo d'Isola Bergamo Italy | Italy | Active | (2S,3R)-3-methoxy-2-(methoxycarbonylamino)butanoic acid | 800-213-6 | 1007881-21-1 | - | View substance registered dossier |
Roche Ireland Limited | Clarehill . Clarecastle Ireland | Ireland | Active | (2S,3R,4R,5R)-2,4-bis(acetyloxy)-5-methyloxolan-3-yl acetate | 612-957-7 | 62211-93-2 | 2012; 2020 | View substance registered dossier |
F.I.S. Fabbrica Italiana Sintetici S.p.a. | Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy | Italy | Active | (2S,3R,4R,5R)-2,4-bis(acetyloxy)-5-methyloxolan-3-yl acetate | 612-957-7 | 62211-93-2 | 2020 | View substance registered dossier |
Patheon Austria GmbH & Co KG | St. Peter Strasse 25 4020 Linz Austria | Austria | Cease Manufacture | (2S,3R,4R,5R)-2,4-bis(acetyloxy)-5-methyloxolan-3-yl acetate | 612-957-7 | 62211-93-2 | 2020 | View substance registered dossier |
N.V. Ajinomoto OmniChem S.A. | Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium | Belgium | Cease Manufacture | (2S,3R,4R,5S,6R)-3,4,5-tris(benzyloxy)-2-methyl-6-(p-tolylthio)tetrahydro-2H-pyran | 835-228-7 | 211801-54-6 | 2021 | View substance registered dossier |
REACH24H CONSULTING GROUP | Suite 1E, Paramount Court, Corrig Road, Sandyford Dublin 18 Dublin Ireland | Ireland | Active | (2S,3R,4S,5R,6R)-3,4,5-tris(phenylmethoxy)-6-(phenylmethoxymethyl)oxan-2-ol | 667-304-9 | 6564-72-3 | 2020 | View substance registered dossier |
CHEMICAL INSPECTION & REGULATION SERVICE LIMITED | Regus Harcourt Centre D02 HW77 Dublin Ireland | Ireland | Active | (2S,3R,4S,5R,6R)-3,4,5-tris(phenylmethoxy)-6-(phenylmethoxymethyl)oxan-2-ol | 667-304-9 | 6564-72-3 | 2019 | View substance registered dossier |
N.V. Ajinomoto OmniChem S.A. | Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium | Belgium | Cease Manufacture | (2S,3R,4S,5R,6R)-6-(acetoxymethyl)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-2-hydroxytetrahydro-2H-pyran-3,4,5-triyl triacetate | 921-285-6 | 1071929-02-6 | 2019 | View substance registered dossier |
Janssen Pharmaceutica N.V. | Turnhoutseweg 30 2340 Beerse Belgium | Belgium | Active | (2S,3R,4S,5R,6R)-6-(acetoxymethyl)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-2-hydroxytetrahydro-2H-pyran-3,4,5-triyl triacetate | 921-285-6 | 1071929-02-6 | - | View substance registered dossier |
REACHLaw Ltd. | Aleksanterinkatu 19 00100 Helsinki Finland | Finland | Active | (2S,3R,4S,5S,6R)-2-(1,3-dihydroxypropan-2-yloxy)-6-(hydroxymethyl)oxane-3,4,5-triol | 824-773-6 | 22160-26-5 | - | View substance registered dossier |
bitop AG | Carlo-Schmid-Allee 5 44263 Dortmund Germany | Germany | Active | (2S,3R,4S,5S,6R)-2-(1,3-dihydroxypropan-2-yloxy)-6-(hydroxymethyl)oxane-3,4,5-triol | 824-773-6 | 22160-26-5 | 2018; 2021 | View substance registered dossier |
SK BIOTEK IRELAND LIMITED | Watery Lane Swords K67 AY91 Swords Co. Dublin Ireland | Ireland | Active | (2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol with 2-butyne-1, 4-diol (1:1) | 619-496-0 | 960404-59-5 | 2014; 2017; 2022 | View substance registered dossier |
AstraZeneca | B 313:5 AZ GlobalSHE- Chem.Reg. 15185 Södertälje Sweden | Sweden | Active | (2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol with 2-butyne-1, 4-diol (1:1) | 619-496-0 | 960404-59-5 | - | View substance registered dossier |
FINORGA SAS | 497 route de Givors 38670 CHASSE SUR RHONE France | France | Active | (2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol with 2-butyne-1, 4-diol (1:1) | 619-496-0 | 960404-59-5 | 2021 | View substance registered dossier |
Warsaw University of Technology, Faculty of Chemistry, Laboratory of Technological Processes | Noakowskiego 3 00-664 Warszawa Poland | Poland | Cease Manufacture | (2S,3S)-2,3-Bis((4-methoxybenzoyl)oxy)succinic acid | 606-247-6 | 191605-10-4 | 2014 | View substance registered dossier |
MSD International GmbH (Ballydine Branch) | Ballydine - Kilsheelan 0 Clonmel Ireland | Ireland | Active | (2S,3S)-2,3-Bis[(4-methylbenzoyl)oxy]butanedioic acid — methyl {(4S)-8-fluoro-2-[4-(3methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydroquinazolin-4yl}acetate — ethyl acetate (1:1:1) | 947-432-4 | - | 2018; 2020 | View substance registered dossier |
Excella GmbH & Co. KG | Nuernberger Str. 12 90537 Feucht Germany | Germany | Active | (2S,3S)-2,3-Dihydroxysuccinic acid - (2S)-N-(2,6-dimethylphenyl)-1-propyl-2-piperidinecarboxamide (1:2) | 954-871-5 | - | - | View substance registered dossier |
Bidachem S.p.A. | S.S. 11 Padana Superiore No. 8 24040 Fornovo San Giovanni BG Italy | Italy | Active | (2S,3S)-2,3-dihydroxysuccinic acid - 2-[(3R)-piperidin-3-yl]-1H-isoindole-1,3(2H)-dione (1:1) | 692-713-4 | 886588-62-1 | 2019 | View substance registered dossier |
Boehringer Ingelheim Pharma GmbH & Co. KG | Binger Strasse 173 55216 Ingelheim am Rhein Germany | Germany | Active | (2S,3S)-2,3-dihydroxysuccinic acid - 2-[(3R)-piperidin-3-yl]-1H-isoindole-1,3(2H)-dione (1:1) | 692-713-4 | 886588-62-1 | 2016; 2019 | View substance registered dossier |
AGC Pharma Chemicals Europe, S.L.U. | Camí de la Pomereda, 13 08380 Malgrat de Mar (Barcelona) Spain | Spain | Active | (2S,3S)-2,3-dihydroxysuccinic acid - 2-[(3R)-piperidin-3-yl]-1H-isoindole-1,3(2H)-dione (1:1) | 692-713-4 | 886588-62-1 | - | View substance registered dossier |
Zoetis Belgium S.A. | Rue Laid Burniat, 1 1348 Louvain-La-Neuve Belgium | Belgium | Active | (2S,3S)-2-benzhydryl-N-[(5-tert-butyl-2-methoxy-phenyl)methyl]quinuclidin-3-amine | 831-973-7 | 147116-67-4 | - | View substance registered dossier |
Former NONS notifier unknown to ECHA - Contact the relevant French competent national authority. | - | - | Active | (2S,3S)-3-(2-Ethoxyphenoxy)-2-hydroxy-3-phenylpropylammonium methanesulfonate | 425-530-3 | 98769-75-6 | - | View substance registered dossier |
Sterling Pharma Solutions Ltd | Dudley NE23 7QG Cramlington Northumberland United Kingdom | United Kingdom | No longer Valid | (2S,3S)-3-(2-Ethoxyphenoxy)-2-hydroxy-3-phenylpropylammonium methanesulfonate | 425-530-3 | 98769-75-6 | 2021 | View substance registered dossier |
Envigo Consulting Limited | Woolley Road Alconbury PE28 4HS Huntingdon Cambridgeshire United Kingdom | United Kingdom | No longer Valid | (2S,3S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride | 478-270-8 | - | 2021 | View substance registered dossier |
Janssen Pharmaceutica N.V. | Turnhoutseweg 30 2340 Beerse Belgium | Belgium | Cease Manufacture | (2S,3S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride | 478-270-8 | - | 2019 | View substance registered dossier |
Envigo Consulting Limited | Woolley Road Alconbury PE28 4HS Huntingdon Cambridgeshire United Kingdom | United Kingdom | No longer Valid | (2S,3S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride | 478-270-8 | - | 2021 | View substance registered dossier |
OLON Spa | Strada Rivoltana Km 6/7 20053 RODANO Milano Italy | Italy | Active | (2S,3S)-di-tert-butyl 3-ethyl-4-oxopyrrolidine-1,2-dicarboxylate | 942-044-1 | - | 2017 | View substance registered dossier |
Novartis Integrated Services Limited | Ringaskiddy P43 FR63 Ringaskiddy Co. Cork Ireland | Ireland | Active | (2S,3S,3aR,9aS)-3-hydroxy-2-(hydroxymethyl)-7-methyl-2,3,3a,9a-tertryhydro-6H-furo[2’,3’:4,5][1,3]oxazolo [3,2-a]pyrimidin-6-one | 700-330-1 | 433733-92-7 | 2008; 2010; 2019 | View substance registered dossier |
Evonik Operations GmbH | Rellinghauser Straße 1-11 45128 Essen Germany | Germany | Active | (2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-aminium sulfate | 917-270-9 | 29790-50-9 | - | View substance registered dossier |
[Confidential] | - | - | - | (2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-aminium sulfate | 917-270-9 | 29790-50-9 | - | View substance registered dossier |
N.V. Ajinomoto OmniChem S.A. | Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium | Belgium | Active | (2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-aminium sulfate | 917-270-9 | 29790-50-9 | 2020 | View substance registered dossier |
Evonik Operations GmbH | Rellinghauser Straße 1-11 45128 Essen Germany | Germany | Active | (2S,3S,4R)-2-aminooctadecane-1,3,4-triol | 439-210-6 | 554-62-1 | - | View substance registered dossier |
[Confidential] | - | - | - | (2S,3S,4R)-2-aminooctadecane-1,3,4-triol | 439-210-6 | 554-62-1 | - | View substance registered dossier |
SCC Scientific Consulting Company GmbH | Am Grenzgraben 11 55545 Bad Kreuznach Germany | Germany | Active | (2S,3S,4R)-2-aminooctadecane-1,3,4-triol | 439-210-6 | 554-62-1 | 2022 | View substance registered dossier |
N.V. Ajinomoto OmniChem S.A. | Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium | Belgium | Active | (2S,3S,4R)-2-aminooctadecane-1,3,4-triol | 439-210-6 | 554-62-1 | 2011 | View substance registered dossier |
Gilead Sciences Ireland UC | IDA Business &Technology Park Carrigtohill Cork Cork Ireland | Ireland | Active | (2S,3S,4R)-3-ethyl-4-hydroxy-2-(methoxycarbonyl)pyrrolidinium 4-methylbenzenesulfonate | 813-641-3 | 1799733-43-9 | - | View substance registered dossier |
OLON Spa | Strada Rivoltana Km 6/7 20053 RODANO Milano Italy | Italy | Active | (2S,3S,4R)-methyl 4-((3-(1,1-difluorobut-3-en-1-yl)-7-methoxyquinoxalin-2-yl)oxy)-3-ethylpyrrolidine-2-carboxylate 4-methylbenzenesulfonate | 942-021-6 | 1799733-71-3 | - | View substance registered dossier |
Gilead Sciences Ireland UC | IDA Business &Technology Park Carrigtohill Cork Cork Ireland | Ireland | Active | (2S,3S,4R)-methyl 4-((3-(1,1-difluorobut-3-en-1-yl)-7-methoxyquinoxalin-2-yl)oxy)-3-ethylpyrrolidine-2-carboxylate 4-methylbenzenesulfonate | 942-021-6 | 1799733-71-3 | - | View substance registered dossier |
Esteve Quimica, S.A. | Torre Esteve Passeig de la Zona Franca, 109, 4ª Planta 08038 Barcelona Barcelona Spain | Spain | Active | (2S,3S,4R)-methyl 4-((3-(1,1-difluorobut-3-en-1-yl)-7-methoxyquinoxalin-2-yl)oxy)-3-ethylpyrrolidine-2-carboxylate 4-methylbenzenesulfonate | 942-021-6 | 1799733-71-3 | - | View substance registered dossier |
F.I.S. Fabbrica Italiana Sintetici S.p.a. | Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy | Italy | Cease Manufacture | (2S,3S,5R)-2-hexyl-3-hydroxy-5-(phenylmethoxy)-Hexadecanoic acid compd. with (S)-α-methylbenzenemethanamine (1:1) | 604-018-5 | 137433-01-3 | 2015 | View substance registered dossier |
Patheon Austria GmbH & Co KG | St. Peter Strasse 25 4020 Linz Austria | Austria | Cease Manufacture | (2S,3S,5R)-2-hexyl-3-hydroxy-5-(phenylmethoxy)-Hexadecanoic acid compd. with (S)-α-methylbenzenemethanamine (1:1) | 604-018-5 | 137433-01-3 | 2020 | View substance registered dossier |
FRESENIUS KABI iPSUM s.r.l. | Via Roma, 108 20060 Cassina de' Pecchi (MI) Italy | Italy | Active | (2S,3S,5R)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide | 618-303-7 | 89786-04-9 | - | View substance registered dossier |
IBI - Istituto Biochimico Italiano Giovanni Lorenzini Spa | Via Fossignano, 2 04011 Aprilia (LT) Italy | Italy | Active | (2S,3S,5R)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide | 618-303-7 | 89786-04-9 | - | View substance registered dossier |
AbbVie Srl | S.R. 148 Pontina Km 52 snc 04011 Campoverde di Aprilia (LT) Italy | Italy | Active | (2S,3S,5S)-5-amino-2-(dibenzylamino)-1,6-diphenylhexan-3-ol succinate | 938-481-2 | - | - | View substance registered dossier |
Symrise AG | Mühlenfeldstraße 1 37603 Holzminden Germany | Germany | Active | (2S,4aR)-1,1,5,5-tetramethyl-1,3,4,5,6,7-hexahydro-2H-2,4a-methanonaphthalen-7-ol | 942-036-8 | 645413-57-6 | 2020 | View substance registered dossier |
Corden Pharma Latina S.p.A. | Via Murillo, 7 IT04013 Sermoneta (LT) Lazio Italy | Italy | Cease Manufacture | (2S,4R)-1-benzoyl-4-hydroxy-pyrrolydin-2-carboxylic acid methyl ester | 411-020-8 | - | 2017 | View substance registered dossier |
Former NONS notifier unknown to ECHA - Contact the relevant Italian competent national authority. | - | - | Active | (2S,4R)-1-benzoyl-4-hydroxy-pyrrolydin-2-carboxylic acid methyl ester | 411-020-8 | - | - | View substance registered dossier |
Former NONS notifier unknown to ECHA - Contact the relevant German competent national authority. | - | - | Active | (2S,4R)-1-benzoyl-4-hydroxy-pyrrolydin-2-carboxylic acid methyl ester | 411-020-8 | - | - | View substance registered dossier |
Former NONS notifier unknown to ECHA - Contact the relevant Irish competent national authority. | - | - | Active | (2S,4R)-1-benzoyl-4-hydroxy-pyrrolydin-2-carboxylic acid methyl ester | 411-020-8 | - | - | View substance registered dossier |
Symrise AG | Mühlenfeldstraße 1 37603 Holzminden Germany | Germany | Active | (2S,4R)-1-hexadecanoyl-4-hydroxy-pyrrolidine-2-carboxylic acid | 944-347-4 | - | - | View substance registered dossier |
Flamma S.p.a. | via Bedeschi, 22 24040 Chignolo d'Isola Bergamo Italy | Italy | Active | (2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid | 604-011-7 | 13726-69-7 | - | View substance registered dossier |
Evonik Operations GmbH | Rellinghauser Straße 1-11 45128 Essen Germany | Germany | Active | (2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid | 604-011-7 | 13726-69-7 | 2019; 2022 | View substance registered dossier |
Lundbeck Pharmaceuticals Italy S.p.A | via quarta strada 2 35129 padova Italy | Italy | Active | (2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid | 604-011-7 | 13726-69-7 | - | View substance registered dossier |
F.I.S. Fabbrica Italiana Sintetici S.p.a. | Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy | Italy | Active | (2S,4S) 4-Hydroxymethyl-pyrrolidine-1,2-dicarboxylic acid 1-butyl ester 2-methyl ester | 807-618-7 | 1194059-42-1 | - | View substance registered dossier |
F.I.S. Fabbrica Italiana Sintetici S.p.a. | Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy | Italy | Active | (2S,4S)-1-(tert-butoxycarbonyl)-4-(hydroxymethyl)pyrrolidine-2-carboxylic acid | 812-482-7 | 1643468-66-9 | - | View substance registered dossier |
Gilead Sciences Ireland UC | IDA Business &Technology Park Carrigtohill Cork Cork Ireland | Ireland | Active | (2S,4S)-1-(tert-butoxycarbonyl)-4-(methoxymethyl)pyrrolidine-2-carboxylic acid | 807-416-9 | 1378388-16-9 | - | View substance registered dossier |
Derivados Químicos S.A. | Camino de Pliego, 150 30820 Alcantarilla Murcia Spain | Spain | Active | (2S,4S)-1-(tert-butoxycarbonyl)-4-(methoxymethyl)pyrrolidine-2-carboxylic acid | 807-416-9 | 1378388-16-9 | - | View substance registered dossier |
F.I.S. Fabbrica Italiana Sintetici S.p.a. | Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy | Italy | Active | (2S,4S)-1-(tert-butoxycarbonyl)-4-(methoxymethyl)pyrrolidine-2-carboxylic acid | 807-416-9 | 1378388-16-9 | - | View substance registered dossier |
AbbVie Srl | S.R. 148 Pontina Km 52 snc 04011 Campoverde di Aprilia (LT) Italy | Italy | Active | (2S,4Z)-5-Amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one | 423-090-7 | 156732-13-7 | 2011; 2018 | View substance registered dossier |
ITELYUM Purification S.P.A. | Via S. Intini n. 2 27015 Landriano (PV) Italy | Italy | Active | (2S,4Z)-5-Amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one | 423-090-7 | 156732-13-7 | 2014 | View substance registered dossier |
Former NONS notifier unknown to ECHA - Contact the relevant German competent national authority. | - | - | Active | (2S,4Z)-5-Amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one | 423-090-7 | 156732-13-7 | - | View substance registered dossier |
POLPHARMA | 19 Pelplińska 83-200 Starogard Gdański Poland | Poland | Cease Manufacture | (2S,4Z)-5-Amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one | 423-090-7 | 156732-13-7 | 2022 | View substance registered dossier |
Curia Italy S.r.l. | VIA DEL VECCHIO POLITECNICO, n. 9 20121 Milano Italy | Italy | Active | (2S,4Z)-5-Amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one | 423-090-7 | 156732-13-7 | - | View substance registered dossier |
Former NONS notifier unknown to ECHA - Contact the relevant Italian competent national authority. | - | - | Active | (2S,4Z)-5-Amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one | 423-090-7 | 156732-13-7 | - | View substance registered dossier |
N.V. Ajinomoto OmniChem S.A. | Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium | Belgium | Active | (2S,5R)-5-((benzyloxy)amino)piperidine-2-carboxamide | 812-263-6 | 1416134-49-0 | - | View substance registered dossier |
Former NONS notifier unknown to ECHA - Contact the relevant Irish competent national authority. | - | - | Active | (2S,5R)-6,6-Dibromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid 4,4-dioxide | 427-200-4 | 76646-91-8 | - | View substance registered dossier |
Pfizer Ireland Pharmaceuticals | n/a P43 X3336 Ringaskiddy Cork Ireland | Ireland | Active | (2S,5R)-6,6-Dibromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid 4,4-dioxide | 427-200-4 | 76646-91-8 | - | View substance registered dossier |
ACS DOBFAR S.p.A | Viale Addetta 4/12 20067 Tribiano Milano Italy | Italy | Active | (2S,5R)-6,6-Dibromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid 4,4-dioxide | 427-200-4 | 76646-91-8 | - | View substance registered dossier |
N.V. Ajinomoto OmniChem S.A. | Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium | Belgium | Active | (2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide | 812-287-7 | 1192651-49-2 | - | View substance registered dossier |
Gilead Sciences Ireland UC | IDA Business &Technology Park Carrigtohill Cork Cork Ireland | Ireland | Active | (2S,5S)-1-((S)-2-((Methoxycarbonyl)amino)-3-methylbutanoyl)-5-methylpyrrolidine-2-carboxylic acid | 811-415-9 | 1335316-40-9 | - | View substance registered dossier |
Flamma S.p.a. | via Bedeschi, 22 24040 Chignolo d'Isola Bergamo Italy | Italy | Active | (2S,5S)-1-((S)-2-((Methoxycarbonyl)amino)-3-methylbutanoyl)-5-methylpyrrolidine-2-carboxylic acid | 811-415-9 | 1335316-40-9 | 2018 | View substance registered dossier |
F.I.S. Fabbrica Italiana Sintetici S.p.a. | Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy | Italy | Active | (2S-cis)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one | 255-799-0 | 42399-49-5 | 2018 | View substance registered dossier |
Cambrex Profarmaco Milano Srl | via Curiel, 34 20067 Paullo MI Italy | Italy | Active | (2S-cis)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one | 255-799-0 | 42399-49-5 | - | View substance registered dossier |
LusoChimica S.p.A. | Via Giotto, 9 23871 Lomagna (Lecco) Italy | Italy | Active | (2S-cis)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one | 255-799-0 | 42399-49-5 | - | View substance registered dossier |
Fermion Oy | Koivu-Mankkaan tie 6 A FI-02101 Espoo Finland | Finland | Active | (2S-cis)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one | 255-799-0 | 42399-49-5 | 2018 | View substance registered dossier |
INTEROR | 49, rue d'Ostende F-62100 CALAIS France | France | Active | (2S-cis)-2-(diphenylmethyl)-N-(phenylmethyl)-1-azabicyclo[2.2.2]octan-3-amine7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonic acid | 444-810-6 | - | 2014; 2021 | View substance registered dossier |
Zoetis Belgium S.A. | Rue Laid Burniat, 1 1348 Louvain-La-Neuve Belgium | Belgium | Active | (2S-cis)-2-(diphenylmethyl)-N-(phenylmethyl)-1-azabicyclo[2.2.2]octan-3-amine7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonic acid | 444-810-6 | - | - | View substance registered dossier |
FINORGA - MOURENX | avenue du lac 64150 MOURENX France | France | Active | (2S-cis)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one | 255-795-9 | 42399-40-6 | - | View substance registered dossier |
Curia France SAS | ZI de Laville 47240 BON-ENCONTRE France | France | Active | (2S-trans)-3-amino-2-methyl-4-oxoazetidine-1-sulphonic acid | 279-393-8 | 80082-65-1 | - | View substance registered dossier |
Curia Italy S.r.l. | VIA DEL VECCHIO POLITECNICO, n. 9 20121 Milano Italy | Italy | Active | (2S-trans)-3-amino-2-methyl-4-oxoazetidine-1-sulphonic acid | 279-393-8 | 80082-65-1 | - | View substance registered dossier |
Corden Pharma Latina S.p.A. | Via Murillo, 7 IT04013 Sermoneta (LT) Lazio Italy | Italy | Active | (2S-trans)-3-amino-2-methyl-4-oxoazetidine-1-sulphonic acid | 279-393-8 | 80082-65-1 | - | View substance registered dossier |
CHEMSAFE srl on behalf of AZO INTERNATIONAL CHEMICAL ltd | Via Ribes, 5 10010 Colleretto Giacosa TO Italy | Italy | Active | (2Z)-(5-amino-1,2,4-thiadiazol-3-yl)(ethoxyimino)acetic acid | 616-178-3 | 75028-24-9 | - | View substance registered dossier |
Fine and Performance Chemicals Ltd | Skutterskelfe TS15 0JR Hutton Rudby North Yorkshire United Kingdom | United Kingdom | No longer Valid | (2Z)-(5-amino-1,2,4-thiadiazol-3-yl)(ethoxyimino)acetic acid | 616-178-3 | 75028-24-9 | 2021 | View substance registered dossier |
Chemours Netherlands B.V._3 | Baanhoekweg 22 3313 LA Dordrecht Netherlands | Netherlands | Cease Manufacture | (2Z)-1,1,1,4,4,4-hexafluorobut-2-ene | 700-651-7 | 692-49-9 | 2021 | View substance registered dossier |
Chemours Netherlands B.V. | Baanhoekweg 22 3313 LA Dordrecht Netherlands | Netherlands | Active | (2Z)-1,1,1,4,4,4-hexafluorobut-2-ene | 700-651-7 | 692-49-9 | 2014; 2015; 2019 | View substance registered dossier |
ACS DOBFAR S.p.A | Viale Addetta 4/12 20067 Tribiano Milano Italy | Italy | Active | (2Z)-2-(2-{[(benzyloxy)carbonyl]amino}-1,3-thiazol-4-yl)-5-[(3-methylbut-2-en-1-yl)oxy]-5-oxopent-2-enoic acid | 889-755-2 | 102199-30-4 | - | View substance registered dossier |
ACS DOBFAR S.p.A | Viale Addetta 4/12 20067 Tribiano Milano Italy | Italy | Active | (2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-[2-methyl-1-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]oxyiminoacetic acid | 616-285-5 | 76028-96-1 | - | View substance registered dossier |
ChemLeader 11 Fine & Performance Chemicals Ltd | Długosza 67 43-188 Orzesze Poland | Poland | Active | (2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-[2-methyl-1-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]oxyiminoacetic acid | 616-285-5 | 76028-96-1 | - | View substance registered dossier |
Corden Pharma Latina S.p.A. | Via Murillo, 7 IT04013 Sermoneta (LT) Lazio Italy | Italy | Active | (2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-[2-methyl-1-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]oxyiminoacetic acid | 616-285-5 | 76028-96-1 | - | View substance registered dossier |
F.I.S. Fabbrica Italiana Sintetici S.p.a. | Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy | Italy | Active | (2Z)-2-chloro-3-(dimethylamino)-N,N-dimethylprop-2-en-1-iminium hexafluorophosphate | 619-785-1 | 249561-98-6 | - | View substance registered dossier |
Bayer AG | Kaiser-Wilhelm-Allee 1 51373 Leverkusen Germany | Germany | Active | (2Z)-2-fluoro-3-(morpholin-4-yl)prop-2-enal | 813-789-9 | 152873-67-1 | 2020 | View substance registered dossier |
Minakem Dunkerque Production | 224 avenue de la Dordogne Zone d'entreprises du Nord Gracht 59640 DUNKERQUE France | France | Active | (2Z)-2-fluoro-3-(morpholin-4-yl)prop-2-enal | 813-789-9 | 152873-67-1 | - | View substance registered dossier |
MINAKEM Beuvry Production SAS | 145, Chemin des Lilas 59310 Beuvry-la-Forêt France | France | Active | (2Z)-2-fluoro-3-(morpholin-4-yl)prop-2-enal | 813-789-9 | 152873-67-1 | - | View substance registered dossier |
PMC ISOCHEM | 32 rue Lavoisier 91710 VERT LE PETIT France | France | Active | (2Z)-2-fluoro-3-(morpholin-4-yl)prop-2-enal | 813-789-9 | 152873-67-1 | - | View substance registered dossier |
Evotec DS Germany GmbH | Kantstrasse 2 33790 Halle/ Westf. Germany | Germany | Active | (2Z)-2-fluoro-3-(morpholin-4-yl)prop-2-enal | 813-789-9 | 152873-67-1 | - | View substance registered dossier |
FIRMENICH GRASSE SAS OR 2 | Parc Industriel Les Bois de Grasse 06130 Grasse France | France | Active | (2Z)-2-phenylhex-2-enenitrile | 482-160-5 | 130786-09-3 | 2020; 2022 | View substance registered dossier |
FIRMENICH GRASSE SAS OR 1 | Parc Industriel Les Bois de Grasse 06130 Grasse France | France | Active | (2Z)-2-phenylhex-2-enenitrile | 482-160-5 | 130786-09-3 | 2020 | View substance registered dossier |
IFF Benicarlo, S.L. | Avda. Felipe Klein 2 12580 Benicarlo Castellon Spain | Spain | Active | (2Z)-2-phenylhex-2-enenitrile | 482-160-5 | 130786-09-3 | - | View substance registered dossier |
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. | - | - | Active | (2Z)-2-phenylhex-2-enenitrile | 482-160-5 | 130786-09-3 | - | View substance registered dossier |
F.I.S. Fabbrica Italiana Sintetici S.p.a. | Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy | Italy | Active | (2Z)-3-amino-1-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)but-2-en-1-one | 616-378-0 | 767340-03-4 | - | View substance registered dossier |
FIRMENICH GRASSE SAS OR 1 | Parc Industriel Les Bois de Grasse 06130 Grasse France | France | Active | (2Z)-4,8-dimethylnona-2,7-dien-4-ol | 807-754-7 | 89929-57-7 | 2022 | View substance registered dossier |
ACS DOBFAR S.p.A | Viale Addetta 4/12 20067 Tribiano Milano Italy | Italy | Active | (2Z)-7-chloro-2-({[(1S)-2,2-dimethylcyclopropyl]carbonyl}amino)hept-2-enoic acid | 618-065-4 | 877674-77-6 | - | View substance registered dossier |
Merck KGaA | Frankfurter Strasse 250 64293 Darmstadt Germany | Germany | Active | (2Z)-but-2-ene-1,4-diyl diacetate | 607-674-0 | 25260-60-0 | 2012; 2019 | View substance registered dossier |
Evonik Operations GmbH | Rellinghauser Straße 1-11 45128 Essen Germany | Germany | Cease Manufacture | (2Z)-but-2-ene-1,4-diyl diacetate | 607-674-0 | 25260-60-0 | 2020 | View substance registered dossier |
In this table, you will find all public data submitted to ECHA in REACH registration dossiers by substance manufacturers, importers, or their representatives, as laid out by the REACH Regulation (see Understanding REACH regulation).
ECHA makes available this information as REACH registered substance factsheets, which contain the full set of non-confidential information from related registration dossiers for a substance. Depending on the number of registrations that have been made for a substance, one factsheet can thus represent data from anything between hundreds of registration dossiers in a joint submission, to data from just one registration dossier.
As noted in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission. Please also note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).
In the portal results table are presented:
- Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
- Registration status – indicating the calculated registration status for the whole factsheet: Active – is being manufactured or imported to the EEA by one or more registrants; Cease Manufacture - is no longer being manufactured or imported above 1 tone per calendar year. All registrants of the substance have reported a cease of manufacture or import; or No longer valid - no longer considered registered under REACH and not currently allowed to be manufactured or imported to the EEA, until the substance is registered again.
- Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
- Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
- Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
- Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
- Link to the full factsheet.
A subset of the key chemical properties (physico-chemical, environmental fate, ecotoxicological and toxicological data) of registered substances can be searched and accessed via the OECD eChemPortal.
RELATED INFORMATION
- Registered substances information
- How to determine what will be published (Data Submission Manual 15)
- Understanding REACH Regulation
- Q&A on registered substances
- What is an Infocard? [PDF]
- What is a Registered substance Factsheet? [PDF]
- eChemPortal
- REACH study results download
- REACH Regulation
- ECHA Legal notice
Welcome to the REACH Registered Substance Factsheets
Here you will find details from REACH registrations submitted to ECHA. Registrations under REACH can be submitted either jointly – where a group of legal entities pool their data – or individually. The set of details from each published joint or individual submission is presented as a row in the results table. For each row there is also an ‘eye’ icon leading to the detailed factsheet which contains the entire public dataset, following the IUCLID format.
Note that there can be more than one joint or individual submission for the same substance, thus there can be cases where one substance is covered by many REACH registered substance factsheets.
Note too, that as mentioned in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission.
Finally, please note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).
All substances table
The “All substances” table gives an overview of all the REACH registered substance factsheets on file at ECHA. Since this covers all data ever submitted since the entry into force of the REACH Regulation, there are some substances which are no longer considered registered under REACH in the EU / EEA. These can be for example substances that were registered only in the UK; since Brexit they are no longer registered in the EU / EEA.
The following columns are presented in the “All substances” table:
- Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
- Registration status – indicating the calculated registration status for the whole factsheet: Active – is being manufactured or imported to the EEA by one or more registrants; Cease Manufacture - is no longer being manufactured or imported above 1 tone per calendar year. All registrants of the substance have reported a cease of manufacture or import; or No longer valid - no longer considered registered under REACH and not currently allowed to be manufactured or imported to the EEA, until the substance is registered again.
- Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
- Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
- Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
- Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
- ‘Eye’ icon linking to the full factsheet.
Searching
The search for REACH registered substance factsheets is divided into logically separated blocks of related search filters. Note that the search works so that if you provide filters in different blocks, then the results returned must match the filters in block 1 AND those in block 2 etc. Searches are conducted on all the public data included in all published REACH registrations.
Substance identity
In this block you can search by substance identifiers, under filters for Name, EC / List number, and CAS number. Full or partial identifiers can be used. And under the Name filter you can search by any substance name of any kind from any source. Other numerical identifiers such as Harmonised C&L Index number, or PIC CN code can also optionally be used.
Administrative data
In this block you can search by administrative information relating to REACH registered substance factsheets:
- Registration type – picklist of Full, Intermediate, NONS
- Registration status – picklist of Active, Cease Manufacture, No longer valid
- Submission type – Individual or Joint
- Country in which registered – picklist of current and former EU / EEA member states from which REACH registrations were received
- First published date – the date when a REACH registration factsheet was first published
- Last update date – the last date when any registrant / supplier submission contributing to a given REACH registration factsheet was submitted
- Last update year – the year in which any registrant / supplier last made an update submission included in a given REACH registration factsheet
- Registrant / supplier name – where available and not claimed confidential
- Registration number – where available and not claimed confidential
- Registrant address – where available and not claimed confidential
Substance data
In this block you can search by substance related data from REACH registered substance factsheets:
- Tonnage band – picklist of Tonnage range, Tonnage Confidential, Intermediate use only
- Selected total tonnage band range – available only if Tonnage range is selected, and allows to filter REACH registered substance factsheets within any selected min and max value
- Substance has nanoform – picklist of Yes, No
- PBT assessment outcome – picklist of all possible PBT assessment outcomes
- CSA performed – picklist of Yes, No
Use and exposure
In this block you can search by elements relating to how use and exposure are encoded in REACH registrations.
Under the Life cycle option you can select one or more life cycle stages. The search results returned will include only factsheets containing uses reported under the selected life cycle stages.
Under the Category option there are modal popups for each of the use descriptor categories – Product, Sector of use, Process, Environmental release, and Article categories. In each of these are multi select picklists for all the related descriptor codes. The search results returned will include only factsheets containing uses which include the selected descriptor codes.
Note that the Life cycle and Category options work together, so that if a life cycle stage and Category options are both selected the search results will include factsheets containing specific uses in the selected life cycle stage, and where the use includes the selected descriptor codes.
With the search operator option you can select to refine how the search works. AND refines results and returns only those factsheets where ALL the search filter criteria are met. OR broadens the results and returns factsheets where ANY of the selected search filter criteria are met.
The factsheets
There is always a detailed factsheet per joint or individual submission, and it is generated based primarily on the IUCLID format.
The factsheet header begins with the identity of the substance in question, to which the factsheet is linked. The substance identity should always be aligned with that shown in the related substance Infocard. Note that since the Infocard refreshes daily, whereas the factsheet sometimes refreshes on a slower pace, sometimes the data may be out of alignment. In such cases it will always realign as quickly as possible.
The substance identification is enriched with the data provided in the relevant IUCLID section of the primary submitted dossier – either the joint submission lead, or the single individual submission.
In this section are also provided the type of substance, all other identifiers such as trade names, common names, other names etc, as well as all distinct submitted compositions for the substance.
Next is a page covering administrative type information from the data submitted, including:
Registration details, on the total tonnage band informed to ECHA, the registration type, first published and last updated dates, and whether a chemical safety assessment has been performed.
Registrant / supplier details, giving the identity and status of registrants / suppliers, except where the identity has been claimed confidential.
Registration numbers, giving again the identity and status of registration numbers, except where claimed confidential.
Contact persons responsible for the SDS, giving the non-confidential SDS contacts provided to ECHA.
The remainder of the factsheet faithfully follows the IUCLID structure, covering the C&L and PBT, Manufacture, use, and exposure, Physical and chemical properties, Environmental fate and pathways, Ecotoxicological information, Toxicological information, Analytical methods (if available), Guidance on safe use, Assessment reports, and Reference substances.