Registration Dossier
Registration Dossier
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EC number: 425-430-1 | CAS number: 6746-94-7
Endpoint summary
Administrative data
Description of key information
oral
rat (EU method B.7) NOAEL (m/f): 1000 mg/kg bw/day (DuPont Merck, 1997)
dermal
Actually, there is no information available.
inhalation
Actually, there is no information available.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
Additional information
oral
A 28-day subacute study was conducted with rats which received 15, 150 or 1000 mg/kg/d Ethynyl cyclopropane by gavage. The animal’s state of health was checked each day, examinations of blood, urine and clinical chemistry parameters were performed. Gross and histopathology were done at the end of the study period. There were no deaths attributable to the administration of SD957 during the study. There were no treatment-related clinical signs and no effect on the rates of bodyweight gain or food consumption parameters. No meaningful effects were observed in haematological or clinical chemistry parameters or on organ weights, with the possible exception of slight increased kidney weight in the male test groups. Similarly, except for an increased incidence of eosinophilic inclusions in renal cortical tubular epithelium, confined to male rats in the Ethynyl cyclopropane treated groups, there were no Ethynyl cyclopropane histopathological findings observed in the study. Based on these results the NOAEL of the test substance was defined at the highest dose level tested.
dermal
Actually, there is no information available.
inhalation
Actually, there is no information available.Justification for classification or non-classification
Regarding the results of these studies in rats, the subacute NOAEL of Ethynyl cyclopropane is 1000 mg/kg bw/day due to the overall no effects observed. Based on the GHS and the EU criteria for classification and labeling there is currently no need for classification of effects due to repeated oral exposure to the test substance.
There are no data available given to classify Ethynyl cyclopropane for repeated dermal or inhalative toxicity.
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