Octyl (R)-2-(4-chloro-2-methylphenoxy)propionate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: original study report not available, but secondary source contains sufficient data to assess study at least as rel. 2

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1992

Report date:

1993

Reference 2

Reference Type:

secondary source

Title:

Unnamed

Year:

2006

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: US.EPA Pesticide Assessment Guidelines, Sub division. F. Human and Domestic Animals 81-5 (Revised November 1984)

GLP compliance:

yes

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

861229-15-4

Cas Number:

861229-15-4

IUPAC Name:

861229-15-4

Constituent 2

Reference substance name:

Mecoprop-P 2-ethylhexyl ester

IUPAC Name:

Mecoprop-P 2-ethylhexyl ester

Constituent 3

Reference substance name:

MCPP-P 2-EHE

IUPAC Name:

MCPP-P 2-EHE

Constituent 4

Reference substance name:

R-(+)-2-(4-chloro-2-methylphenoxy)-propionic acid, 2-ethylhexyl ester

IUPAC Name:

R-(+)-2-(4-chloro-2-methylphenoxy)-propionic acid, 2-ethylhexyl ester

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Administration / exposure

Route of administration:

inhalation: aerosol

Type of inhalation exposure:

whole body

Vehicle:

not specified

Details on inhalation exposure:

Inhalation of a test atmosphere containing liquid droplet aerosol generated from the test substance.

Duration of exposure:

4 h

Concentrations:

0 and 4.66 mg/L (highest achieved concentration)

No. of animals per sex per dose:

5

Control animals:

yes

Details on study design:

- Duration of observation period following administration: 14 days

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 4.66 other: mg/L air (highest attainable concentration)

Exp. duration:

4 h

Mortality:

One exposed female died overnight following exposure.

Clinical signs:

other: CLINICAL SIGNS. During exposure : signs consistent with exposure to an irritant aerosol, including partial closing of the eyes, wetness around the mouth and snout, and exaggerated respiratory movements. During observation period: signs seen in rats includ

Body weight:

Reduced bodyweight or reduced rate of bodyweight gain was evident for up to 5 days following exposure. Subsequently weight gain was similar to that for control rats.

Gross pathology:

The lung weight to bodyweight ratio for the rat that died was higher than for the surviving rats.
Macroscopic pathology: the lungs of the rat that died following exposure the substance were congested and the stomach was gas-filled.