Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 210-484-7 | CAS number: 616-47-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Not readily biodegradable (according to OECD criteria) but inherently biodegradable after a prolonged test duration.
Key value for chemical safety assessment
Additional information
QSAR-disclaimer
In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met.
According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.
The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and, therefore, the endpoint(s) sufficiently covered and suitable for risk assessment.
Assessment:
The biodegradability of 1-methylimidazole (CAS 616-47-7) is assessed based on experimental and estimated data.
Experimental data:
- In a GLP compliant CO2/DOC-combination test performed according to International Standard ISO 9439 (Annex D) the biodegradation was studied under enhanced test conditions applying a prolonged test duration of 60 days (BASF SE, 2011; report no. 29G0492/11G077). Non-adapted domestic activated sludge was used as inoculum. Based on CO2-production, an elimination of 18% was observed after 28 d of exposure. The substance revealed a long lag-phase within the test up to approx. 24 days. After 35 d, degradation was > 60%. The final degradation value was 79% after 60 d. However, elimination based on DOC was higher than based on CO2 evolution. After 28 d the DOC removal was 46% (35 d: 98%). Therefore, 1-methylimidazole was found to be not readily biodegradable according to OECD criteria but inherently biodegradable after prolonged test duration.
- Furthermore, the substance turned out to be not readily biodegradable (according to OECD criteria) in a GLP guideline study according to OECD 301 F. The oxygen consumption was measured to be in the range of 0 to 10 % after 28 days (BASF AG, 2000; report no. 00/0336/26/1). The inoculum was a mixture of municipal and industrial activated sludge (1:1).
- Additionally, in a GLP study conducted according to OECD Guideline 310 the required pass level for ready biodegradability was not reached. 2 ±2% TIC/TOC (mean ±SD) based on the mean value of the maximum level of degradation observed at the end of the test. No ten-day window was observed during the study. Therefore, 1 -methylimidazole was not readily biodegradable under the conditions of this test over the
28-day exposure to domestic non-adapted activated sludge.
(Q)SAR data:
To support the experimaental data the (Q)SAR model of OASIS CATALOGIC v5.14.1.5, 301C v11.16 was applied; the substance was within the parametric and the metabolic domain of the model, but not entirely within the structural domain (the substance is to 67% within the structural fragments domain, 33% of fragments are not present in the set of training chemicals).
- CATALOGIC 301C v11.16 predicted a degradation of 10% after 28 d, based on O2 consumption.
Predicted metabolites:
Table: QSAR prediction for CAS 616-47-7 (1-methylimidazole) using CATALOGIC 301C v11.16 (OASIS CATALOGIC v5.14.1.5; metabolites with a quantity > 0.001 mol/mol parent after 28 d are highlighted by grey background and bold type; metabolite no: according to (Q)SAR model Catalogic v11.16)
# | Metabolite (No) |
Smiles | CAS-# | Name | Quantity (mol/mol parent) |
LogKow | BOD prediction (% after 28 d) |
PBT-Assessment (ECHA (disseminated substances) |
parent | 1 | CN1C=CN=C1 | 616-47-7 | 1-Methylimidazole | 0.6153 | 0.6059 | 10 | not PBT / vPvB |
1 | 3 | CN1C=NCC1=O | 184590-87-2 | 1H-Imidazol-5-ol, 1-methyl- | 0.1689 | -0.7281 | 3 | not listed |
2 | 9 | CN(CO)C=N | - | - | 0.1055 | -1.6131 | 26 | not listed |
3 | 7 | CN1CC(=O)N=C1 | 184590-85-0 | 1H-Imidazol-4-ol, 1-methyl- | 0.02631 | -1.3631 | 37 | not listed |
4 | 23 | OCN1C=CN=C1 | 51505-76-1 | 1H-Imidazol-1-ylmethanol | 0.0259 | -0.3095 | 10 | not listed |
5 | 4 | OCN1C=NCC1=O | - | - | 0.01283 | -2.1929 | 2 | not listed |
6 | 16 | CN | 74-89-5 | Methanamine | 0.004689 | -0.6385 | 64 | not PBT / vPvB |
7 | 22 | N=CNCO | - | N-(Hydroxymethyl)imidoformamid | 0.002048 | -1.8243 | 86 | not listed |
8 | 19 | CNC=N | 57500-38-6 | Methanimidamide, N-methyl- | 0.002048 | -0.3595 | 78 | not listed |
9 | 13 | CNCO | 3400-38-2 | (Methylamino)methanol | 0.002048 | -1.6374 | 77 | not listed |
10 | 25 | CN1CNC=C1 | - | - | 0.0007803 | -1.2939 | 71 | n.a. |
11 | 26 | CN(C=C=O)C=N | - | - | 0.0007803 | -1.582 | 86 | n.a. |
12 | 5 | OCNC=NCC(O)=O | - | - | 0.0001228 | -3.2227 | 77 | n.a. |
13 | 2 | CN1C=NC=C1O | - | - | 0 | 0.8757 | 3 | n.a. |
14 | 6 | CN1C=C(O)N=C1 | - | - | 0 | 0.8757 | 37 | n.a. |
15 | 18 | NCO | - | - | 0 | -2.1033 | 100 | n.a. |
16 | 21 | C=N | - | - | 0 | 0.7191 | 100 | n.a. |
17 | 20 | NC=N | - | - | 0 | -0.8254 | 100 | n.a. |
18 | 14 | OC=O | - | - | 0 | -0.4605 | 100 | n.a. |
19 | 10 | N=C=O | - | - | 0 | 0.239 | 100 | n.a. |
20 | 17 | C=O | - | - | 0 | 0.35 | 100 | n.a. |
21 | 24 | OCN1C=NC=C1O | - | - | 0 | -0.0397 | 2 | n.a. |
22 | 8 | CN(CO)C=NC(O)=O | - | - | 0 | -2.3026 | 26 | n.a. |
n.a.– not assessed. Metabolites with a quantity < 0.001 mol/mol parent after 28 d are not considered being relevant for the PBT/vPvB assessment and, therefore their PBT/vPvB status was not assessed.
Overall predicted metabolites: 22 metabolites
9 metabolites: quantity > 0.001; thereof: 4 readily biodegradable (BOD > 60%). 9 metabolites have a log Kow < 3 indicating no significant accumulation in organisms.
Conclusion:
Based on the available experimental and estimated results, 1-methylimidazole (CAS 616-47-7) is assessed to be not readily biodegradable (according to OECD criteria) but inherently biodegradable after a prolonged test duration.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
This website uses cookies to ensure you get the best experience on our websites.