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EC number: 210-484-7 | CAS number: 616-47-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Short-term toxicity to fish:
The LC50 value of 1-methyl-1H-imidazole (CAS 616-47-7) on Leuciscus idus was determined to be >= 100 mg/L to <= 215 mg/L (nominal, no analytics) in a guideline study according to DIN 38 412 (BASF AG 10F0073/885186, 1989).
Therefore, the substance is considered to be with high probability acutely not harmful to fish.
Long-term toxicity to fish:
No experimental data available.
In Annex IX of Regulation (EC) No 1907/2006, it is laid down that chronic tests shall be proposed by the registrant if the chemical safety assessment indicates the need to investigate further the effects on fish. According to Annex I of this regulation, the chemical safety assessment triggers further action when the substance or the preparation meets the criteria for classification as dangerous according to Directive 67/548/EEC or Directive 1272/2008 or is assessed to be a PBT or vPvB. The hazard assessment of the substance reveals neither a need to classify the substance as dangerous to the environment, nor is it a PBT or vPvB substance, nor are there any further indications that the substance may be hazardous to the environment. Therefore, and for reasons of animal welfare a chronic test on fish is not provided.
Short-term toxicity to aquatic invertebrates:
The acute toxicity of 1-methyl-1H-imidazole (CAS 616-47-7) to Daphnia magna was tested in a guideline study according to EU method C2. The EC0 value was determined to be 125 mg/L; the EC50 value was found to be about 267.94 mg/L after 48 h, based on nominal test concentrations (BASF AG, 1989; report no.: 1/0243/2/89-0243/89).
In conclusion, 1-methyl-1H-imidazole (CAS 616-47-7) is considered to be with high probability acutely not harmful to aquatic invertebrates.
Long-term toxicity to aquatic invertebrates:
A long-term toxicity study is available for aquatic invertebrates. This study was conducted according to OECD Guideline 211 and Daphnia magna was used as a test specie. The following nominal test concentrations were analytically verified: 0 (control), 1.2, 2.5, 5, 7.5 and 10 mg/L. The 21-d EC10 value was determined to be 2.24 mg/L (for reproduction). The NOEC was determined to be >= 1.2 mg/L (BASF SE, 2023).
Overall, it can be concluded that no significant and relevant long-term effects on aquatic invertebrates are to be expected (NOEC > 1 mg/L).
Toxicity to aquatic algae and cyanobacteria:
The acute toxicity of 1-methyl-1H-imidazole (CAS 616-47-7) on the aquatic green algae Desmodesmus subspicatus was investigated in a study conducted according to OECD 201 (BASF AG, 1990; report no.: 2/204389/t72). The results were recalculated using ToxRatPro v3.3.0 (BASF SE, 2021). After 72 h, the ErC10 was found to be 119.4 mg/L based on nominal concentrations; the 72-h ErC50 was determined to be 202.5 mg/L.
1-methyl-1H-imidazole (CAS 616-47-7) is considered to be with high probability acutely not harmful to aquatic algae.
Toxicity to microorganisms:
The of 1-methyl-1H-imidazole (CAS 616-47-7) to microorganisms was investigated in a growth inhibition guideline study performed according to DIN 38412-8, using Pseudomonas putida as test organism. After 7 h of incubation, the EC10 was determined to be 589.6 mg/L (7h EC50 = 1050 mg/L), based on nominal test concentrations.
The inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriate low concentrations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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