1-methylimidazole

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Remarks:

Low attainable concentration due to the low vapour pressure, when the test substance is evaporated at 20°C, which is below cut off values for classification / any limit concentration.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1966

Report date:

1966

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Principles of method if other than guideline:

BASF-test: Test was performed in principle as described in OECD Guideline 403. The test demonstrates the toxicity of an atmosphere saturated with vapours of the volatile components of a test substance at the temperature chosen for vapour generation (20°C). 3 rats per sex were exposed sequentially to the vapours, generated by bubbling 200 l/h air through a substance column of about 5 cm above a fritted glassdisc in a glass cylinder for 8 h. The documentation of clinical signs was performed over a period of 7 days. In order to verify the results, the test was repeated once. Calculatted saturated vapour concentration for 1-methylimidazole: 0.0412*MW*VP = 0.0412 * 82.1038 g/mol * 0.3514 hPa = 1.2 mg/L)

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

1-methylimidazole

EC Number:

210-484-7

EC Name:

1-methylimidazole

Cas Number:

616-47-7

Molecular formula:

C4H6N2

IUPAC Name:

1-methyl-1H-imidazole

Test material form:

liquid

Details on test material:

Substance name: 1-Methylimidazol (flüssig)
Substance number: XVI/41

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

not specified

Vehicle:

other: unchanged (no vehicle)

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

8 h

Concentrations:

saturated vapour at 20 ºC (calculated saturated vapour concentration: 1.2 mg/L)

No. of animals per sex per dose:

3

Control animals:

yes

Details on study design:

- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: days 1 and 7
- Necropsy of survivors performed: yes

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC0

Effect level:

other: saturated vapour at 20 ºC (calculated saturated vapour concentration: 1.2 mg/L)

Based on:

test mat.

Exp. duration:

8 h

Mortality:

None of the animals died.

Clinical signs:

other: Signs of escape behaviour and distinct irritation of mucous membranes.

Body weight:

Normal body weight growth.

Gross pathology:

No effects.

Applicant's summary and conclusion

Interpretation of results:

other: The inhalation of a saturated vapour-air-mixture represents an unlikely acute hazard.