Registration Dossier
Registration Dossier
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EC number: 210-484-7 | CAS number: 616-47-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- pre-GLP, pre-OECD guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- BASF-test (application on intact skin, for 24 hours, under occlusion)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1-methylimidazole
- EC Number:
- 210-484-7
- EC Name:
- 1-methylimidazole
- Cas Number:
- 616-47-7
- Molecular formula:
- C4H6N2
- IUPAC Name:
- 1-methyl-1H-imidazole
- Test material form:
- liquid
- Details on test material:
- Substance name: 1-methylimidazol
Substance number: 79/527
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: M .GAUKLER, 6050 Offenbach
- Weight at study initiation: males 3.1 kg, femalses 3.0 kg
- Diet: Ssniff K, standard diet for rabbits and guinea pigs (Fa. INTERMAST GMBH, Soe) and Ovator Solikanin (Fa. Muskator-Werke, Düsseldorf) ad libitum
- Water: ad libitum
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 110 cm2 (clipped skin)
- Type of wrap if used: inert foil fixed with a adhesive bandage
REMOVAL OF TEST SUBSTANCE
- Washing: with warm water or a water/Lutrol solution
- Time after start of exposure: 24 h - Duration of exposure:
- 24 h
- Doses:
- 250, 400 and 640 mg/kg bw
- No. of animals per sex per dose:
- 3 (250 and 640 mg/kg bw) and 6 (400 mg/kg bw)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 15 days
- Frequency of observations and weighing: 1 h and 1, 2, 7 and 15 days
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 400 - 640 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 250 mg/kg bw: no mortality occurred
400 mg/kg bw: 2/6 males and 0/6 females
640 mg/kg bw: 1/3 males and 3/3 females - Clinical signs:
- other: Resorptive intoxications symptoms: apathy, accelerated breathing, spasms, salivation, excess lacrimation, narrowed pupils Local irritation symptoms: Besides obvious redness of the skin and edema at the end of the observation period necrotic changes in th
- Gross pathology:
- Animals which died during the study: dilatation of the heart and hyperemia in the lungs. In the animals which were sacrified at the end of the study no effects were observed.
- Other findings:
- Skin findings: firstly, erythema and edema. During the observation period necrosis was observed.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
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