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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

One acute freshwater fish study. 

Key value for chemical safety assessment

LC50 for freshwater fish:
7.9 mg/L

Additional information

The purpose of this study was to assess the effects of Paraformaldehyde, oligomeric reaction products with 4-tert-butylphenol, m-phenylenebis(methylamine), referred to as Mannich Base PTBP-MXDA, to the freshwater fish, the rainbow trout (Oncorhynchus mykiss), over a 96-hour static exposure period. Mannich Base PTBP-MXDA has low aqueous solubility and therefore test solutions were prepared as water accomodated fractions (WAFs). The definitive test was conducted with one replicate vessels with seven fish per test level exposed to nominal loading rates of 0 (water control), 1.9, 3.8, 7.5, 15, and 30 mg Mannich Base PTBP-MXDA/L. Dosing was confirmed by dissolved organic carbon analysis. The acute toxicity values for Mannich Base PTBP-MXDA were determined based on nominal loading rates. The results were as follows: The 24-hour LL50 value was 10.6 mg Mannich Base PTBP-MXDA/L. The 95% confidence limits were not calculable. The 48 -hour LL50 value was 9.62 mg Mannich Base PTBP-MXDA/L with 95% confidence limits of 8.02 – 11.5 mg/L. The 72 -hour LL50 value was 7.90 mg Mannich Base PTBP-MXDA/L with 95% confidence limits of 6.11 – 10.2 mg/L. The 96 -hour LL50 value was 7.90 mg Mannich Base PTBP-MXDA/L with 95% confidence limits of 6.11 – 10.2 mg/L. The 96-hour NOELR was 3.8 mg Mannich Base PTBP-MXDA/L