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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Description of key information

One daphnia acute immobilization test. 

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
8.98 mg/L

Additional information

The purpose of this study was to evaluate the effects of Paraformaldehyde oligomeric reaction products with 4-tert-butylphenol, m-phenylenebis(methylamine), hereafter referred to as Mannich Base PTBP-MXDA, to the freshwater cladoceran, Daphnia magna, over a 48 - hour static exposure period. Mannich Base PTBP-MXDA has low aqueous solubility and therefore test solutions were prepared as water accomodated fractions (WAFs). The definitive test was conducted with 4 replicate vessels per test level with five daphnids in each exposed to the WAF prepared with nominal loading rates of 0 (laboratory dilution control), 1.9, 3.8, 7.5, 15, and 30 mg Mannich Base PTBP-MXDA/L. The acute toxicity values for Mannich Base PTBP-MXDA with Daphnia magna were determined based on nominal loading rates. The results were as follows: The 24-hour EL50 (effective loading rate) = 10.5 mg Mannich Base PTBPMXDA/

L ( 95% confidence limits not calculable); The 48-hour EL50 = 8.98 mg Mannich Base PTBP-MXDA/L ( 95% confidence

limits of 7.55 – 10.7 mg/L); The 48-hour NOELR (no-observed-effect loading rate) = 3.8 mg/ Mannich Base PTBP-MXDA/L.