Registration Dossier
Registration Dossier
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EC number: 701-017-2 | CAS number: -
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Full GLP report guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: ASTM method E981-84, Standard Method for Estimating Sensory Irritation of Airborne Chemicals, 1984
- GLP compliance:
- yes
- Type of method:
- in vivo
Test material
- Reference substance name:
- m-tolylidene diisocyanate
- EC Number:
- 247-722-4
- EC Name:
- m-tolylidene diisocyanate
- Cas Number:
- 26471-62-5
- IUPAC Name:
- 2,4-diisocyanato-1-methylbenzene
- Details on test material:
- - Name of test material (as cited in study report): Mondur TD 80
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: vapour
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- The test substance was generated as a vapor in a glass bubbler, immersed in a water bath at 25 degree C, and concentrations achieved by varying the rate of airflow.
- Analytical verification of doses or concentrations:
- yes
- Details on analytical verification of doses or concentrations:
- Concentrations of Mondur TD-80 in the exposure chamber were determined at 0.5, 1.5, and 2.5 hours of exposure.
- Duration of treatment / exposure:
- 3h
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.10 to 1.45 ppm
Basis:
analytical conc.
- No. of animals per sex per dose:
- 4
- Details on study design:
- Statistics
The RD 50 value with 95% confidence limits were calculated by probit analysis using computer programs of SAS (SAS Institute Inc. Cary, North Carolina, US)
Results and discussion
- Details on results:
- Effect levels
Sex male
Endpoint other: RD50
Effect level 2.12 ppm
95% CL 1.61 — 3.4
Exp. duration 3 h
Remarks
Any other information on results incl. tables
Remarks on results including tables and figures
95% confidence interval = 1.61 - 3.40 ppm
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Applicant's summary and conclusion
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