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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Additional information

Two in vitro studies were performed on Methyl-10-undecenoate in the years 1995 and 2002, respectively. Both the bacterial reverse mutation rate test (Ames Test) and a mammalian chromosomal aberration test revealed negative results. Concerning the mammalian cell gene mutation tests a read across with undecylenic acid is being proposed (also negative study outcome). No in-vivo studies needed to be carried out yet for methyl 10-undecenoate.
The Ames test was achieved on Salmonella typhimurium strains: TA 1535, TA 1537, TA 98, TA 100 and TA 102, with and without metabolic activation. Test item concentrations up to 5000 µg/plate were tested. Methyl undecylenate did not reveal any mutagenic activity, despite its toxicity to bacteria.
This lack of mutagenic properties was confirmed by a chromosomal aberrations test carried out on human lymphocytes. Those cells were exposed with and without metabolic activation at the following doses : 1.25, 2.5, 5 and 10 mM. No significant chromosomal aberrations were noticed. In-vivo studies were not required for this substance.

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

As indicated above, the available in vitro studies on genetic toxicity gave negative results, thus no classification of methyl 10 -undecenoate is warranted for genotoxicity according to EU regulation (EC) No. 1272/2008 (CLP) and to EU 67/548/ECC classification system.