Registration Dossier
Registration Dossier
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EC number: 264-202-2 | CAS number: 63451-47-8
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
The substance exhibits an ErC50 for freshwater algae of 0.24 mg/L and a NOEC of 0.078 mg/L.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 0.24 mg/L
- EC10 or NOEC for freshwater algae:
- 0.078 mg/L
Additional information
The submission substance is poorly water-soluble and traditional methods of preparation of test solutions are inappropriate. The substance meets the criterion of a "difficult substance". One reliable toxicity study to aquatic algae is available. The toxicity to freshwater alage was studied by following to OECD TG No. 201 and OECD Guidance document No. 23 on aquatic toxicity testing of difficult substances and mixtures, under GLP. Algae cultures (Pseudokirchneriella subcapitata) were exposed to concentrations of 0, 0.10, 0.32, 1.0, 3.2 and 10 % v/v saturated solution of substance over a test period of 72 hours (static test). The substance present in test medium was monitored at 0 and 72 hours of the 0.10, 0.32, 1.0, 3.2 and 10% v/v saturated solution. The measured concentrations were < LOQ, 0.065, 0.22, 0.76 and 2.2 mg/L (0 hours) and 0.058, 0.090, 0.22, 0.68 and 2.2 mg/L (72 hours). Therefore, the endpoints were based on mean measured test concentrations. The 72h-EC50 was determined to 0.24 mg/L and the NOEC to 0.078 mg/L.
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