Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Studies of the acute and chronic toxicity of undecylenic acid
Author:
Newell GW et al.
Year:
1949
Bibliographic source:
J. Invest. Dermatol. 1949 ; 13 : 145-14

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
Undec-10-enoic acid
EC Number:
203-965-8
EC Name:
Undec-10-enoic acid
Cas Number:
112-38-9
Molecular formula:
C11H20O2
IUPAC Name:
undec-10-enoic acid
Details on test material:
no data on source and purity

Test animals

Species:
mouse
Strain:
other: Carworth CF1
Sex:
male/female
Details on test animals or test system and environmental conditions:
no data on source and age;
weight at sudy initiation: 18- 22g

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: sesame oil
Doses:
11, 16, 20, 24 and 36 mg
No. of animals per sex per dose:
30
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
953 - 967 mg/kg bw
Mortality:
see table 1
Clinical signs:
no data
Gross pathology:
No obvious target organ

Any other information on results incl. tables

Table 1: Number of animals dead [and with evident toxicity] [and time range within which mortality occurred]

 

Dose
(mg/mouse)

Mortality (# dead/total)

Time range of deaths (hours)

Number with evident toxicity (#/total)

Male

Female

Combined

Male

Female

Combined

Control

 

 

 

 

 

 

 

11

 

 

 1/6

 

 

 

 

16

 

 

0/6 

 

 

 

 

20

 

 

5/6 

 

 

 

 

24

 

 

6/6 

 

 

 

 

 36      6/6        

Applicant's summary and conclusion

Conclusions:
The calculated LD50 was 960 mg/kg bw for intraperitoneal administration.
Executive summary:

The acute toxicologic potential of Undecylenic Acid was evaluated in the mouse in a procedure similar to OECD guideline 401. The test substance was applied intraperitoneally. The calculated LD50 was 960 mg/kg bw for intraperitoneal administration.

First results of an ongoing chronic toxicity are reported, but the study was not finished at the timepoint of reporting.