1-methylpiperidine

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Comparable to guideline study with acceptable restrictions (limited documentation).

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1970

Report date:

1970

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Version / remarks:

adopted in 1981

Deviations:

no

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

1-methylpiperidine

EC Number:

210-959-9

EC Name:

1-methylpiperidine

Cas Number:

626-67-5

Molecular formula:

C6H13N

IUPAC Name:

1-methylpiperidine

Details on test material:

- Name of test material (as cited in study report): Methylpiperidine
- Physical state: liquid
- Analytical purity: no data

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: breeder, Gassner
- Weight at study initiation: males: 215 ± 21 g; females: 185 ± 13 g

ENVIRONMENTAL CONDITIONS
- No data

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Details on oral exposure:

VEHICLE
- Concentration in vehicle: The doses were applied as 2 % , 4 %, 8 % or 20 % v/v preparations of the test substance in aqua dest.
- Justification for choice of vehicle: soluble in water

MAXIMUM DOSE VOLUME APPLIED: 12.5 mL/kg

Doses:

200, 400, 500, 640, 800 and 1600 µL/kg bw (corresponding to approx. 163, 327, 408, 523, 653 and 1306 mg/kg bw; calculation based on density of 0.8165 g/cm³)

No. of animals per sex per dose:

10

Control animals:

no

Details on study design:

- Duration of observation period following administration: 13 days
- Frequency of observations and weighing: Body weight was determined before the beginning of the study for dose calculation. Observation of clinical signs was determined several times on the day of administration and once daily afterwards with the exception of weekends and on holidays.
- Necropsy of survivors performed: yes

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

ca. 490 mg/kg bw

Based on:

test mat.

Remarks on result:

other: The original value 0.6 mL/kg was converted to mg/kg body weight using the density of 0.8165 g/cm³

Mortality:

Results are given as dead animals/total number of animals:
163 mg/kg bw: 0/10 males and 0/10 females
327 mg/kg bw: 0/10 males and 0/10 females
408 mg/kg bw: 0/10 males; 1/10 females within 24 hours
523 mg/kg bw: 3/10 males within 24 hours and 8/10 females within 24 hours and 9/10 females within 48 hours
653 mg/kg bw: 8/10 males and 10/10 females within 24 hours, respectively
1306 mg/kg bw: 10/10 males and 10/10 females within 24 hours

Clinical signs:

other: 163 mg/kg bw: immediately after gavage sedate behaviour, accelerated respiration, convulsion; one day after treatment: sedate behaviour, accelerated respiration, scrubby fur; day 2 to 6 sedate behaviour and on day 7 scrubby fur. From day 8 nothing abnorma

Gross pathology:

Deceased animals:
once bloody erosion at the stomach; twice oedema at the stomach wall; no other abnormalities detected.

Sacrifized animals:
no abnormalities detected.