Registration Dossier
Registration Dossier
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EC number: 210-959-9 | CAS number: 626-67-5
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Method not validated.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Teratogenic Effects in Cattle of Conium maculatum and Conium Alkaloids and Analogs
- Author:
- Keeler RF and Dell Balls L
- Year:
- 1 978
- Bibliographic source:
- Clin. Toxicol. 12, 49-64
- Reference Type:
- publication
- Title:
- ALKALOID TERATOGENS FROM LUPINUS, CONIUM, VERATRUM, AND RELATED GENERA
- Author:
- Keeler RF
- Year:
- 1 978
- Bibliographic source:
- in: Keeler RF et al. (eds.): Effects of poisonous plants in Livestock
- Reference Type:
- publication
- Title:
- Toxins and Teratogens of the Solanaceae and Liliaceae
- Author:
- Keeler RF
- Year:
- 1 979
- Bibliographic source:
- in: Kinghorn AD (ed.): Toxic Plants, Vol. 3, pp. 59-82
Materials and methods
- Principles of method if other than guideline:
- Two cows were treated with N-Methylpiperidine. Maternal toxicity and teratogenicity were examined.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- N-Methylpiperidine
- IUPAC Name:
- N-Methylpiperidine
Constituent 1
Test animals
- Species:
- other: cattle
- Strain:
- other: Hereford
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 425 ± 100 kg
- Diet: hay with salt, ad libitum
- Water: ad libitum
Administration / exposure
- Route of administration:
- other: capsule
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Details on mating procedure:
- Impregnation procedure: artificial insemination (day of insemination was considered day 0 of gestation)
- Duration of treatment / exposure:
- day 45 through 75 of pregnancy
- Frequency of treatment:
- daily
- Duration of test:
- Until day 10 post partum.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
ca. 23.5 mg/kg bw/d (10000 mg/animal/d)
Basis:
actual ingested
- No. of animals per sex per dose:
- 2 females
- Control animals:
- yes, plain diet
- Details on study design:
- Control animals: During the experiments approximately 75 cows on the premises maintained a similar diet served as controls.
Examinations
- Maternal examinations:
- Dams were examined for signs of toxicity.
- Fetal examinations:
- Offspring were examined for deformities characteristic of field outbreaks (deformities of limbs, spine, and palate).
Results and discussion
Results: maternal animals
Maternal developmental toxicity
- Details on maternal toxic effects:
- Maternal toxic effects:no effects
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Embryotoxic / teratogenic effects:no effects
Details on embryotoxic / teratogenic effects:
Normal condition of calfs after 10 days. No congenital deformations / teratogenicity were observed in the calfs.
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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