Registration Dossier

Administrative data

Key value for chemical safety assessment

Additional information

The UVCB substance to be registered is a mixture of the two Guerbet alcohols 2 -hexyldecan-1-ol & 2-octyldodecan-1 -ol and their corresponding esters with C12 and C14 fatty acids. Genetic toxicity studies are available for the two Guerbet alcohols and for the UVCB substance as such.

Experimental data on in vitro mutagenicity on bacteria are furthermore available nearly all representatives of the category of Guerbet alcohols, as evaluated by the REACH consortium in charge of this substance group. All tests are negative. Studies on mammalian cells are only available for the C16 Guerbet alcohol (2 -hexyldecan-1-ol , CAS-No. 2425-77-6). Both a cytogenetic assay (chromosome aberration test) and a gene mutation study (HPRT test) are negative. Due to the similar structure with no additional functional groups, these data can be cross-read to 2-octyldodecan-1 -ol , the second Guerbet alcohol present in the UVCB.

A gene mutation study (HPRT test) was conducted with the UVCB substance to be registered to support the data set for genetic toxicity. In the HPRT test, the UVCB did not induce mutations.

Altogether, no indication exists for a mutagenic potential of the UVCB substance to be registered.

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

Avalaible data are conclusive but not sufficient for classification of 2-hexyldecan-1-ol with regard to mutagenicity / genotoxicity.