Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
other information
Study period:
June 2000
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2000

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Qualifier:
according to guideline
Guideline:
EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Reaction mass 2-methylpenta-1,3-diene and 4-methylpenta-1,3-diene
EC Number:
909-068-4
Molecular formula:
C6H10
IUPAC Name:
Reaction mass 2-methylpenta-1,3-diene and 4-methylpenta-1,3-diene
Test material form:
other: liquid

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
semiocclusive
Preparation of test site:
other: intact skin
Vehicle:
unchanged (no vehicle)
Duration of treatment / exposure:
4 hours, 0,5 mL
Observation period:
1, 14, 48, 72 hours and 7 and 14 days.
Number of animals:
3 rabbits

Results and discussion

In vivo

Results
Irritation parameter:
primary dermal irritation index (PDII)
Score:
3.2

Applicant's summary and conclusion

Interpretation of results:
moderately irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The test material did not meet the criteria for classification as irritant or corrosive according to EU labelling regulations Cimmission Directive 93/21/EEC.