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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1975
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Number of animals low, purity not specified.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975

Materials and methods

Principles of method if other than guideline:
Adipic acid was tested as a 40% solution in corn oil. Minimum lethal dose was determined using 1-2 rabbits per group (5010 mg/kg bw one animal, 7940 mg/kg bw two animals). A 24- hour dermal exposure under occlusive conditions was conducted. Necropsy was conducted after a 14-day observation period.
GLP compliance:
no
Test type:
other:

Test material

Constituent 1
Chemical structure
Reference substance name:
Adipic acid
EC Number:
204-673-3
EC Name:
Adipic acid
Cas Number:
124-04-9
Molecular formula:
C6H10O4
IUPAC Name:
Hexanedioic acid
Test material form:
not specified
Details on test material:
Test substance purity not specified

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female

Administration / exposure

Type of coverage:
occlusive
Vehicle:
corn oil
Duration of exposure:
24 hours
Doses:
5010 and 7940 mg/kg
No. of animals per sex per dose:
5010 mg/kg bw one animal, 7940 mg/kg bw two animals
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD0
Effect level:
7 940 mL/kg bw

Any other information on results incl. tables

No deaths occurred at 5010 mg/kg bw (0/1) or 7940 mg/kg bw
(0/2). Observations included reduced appetite and activity.
Reduced appetite and activity ( one or two days).

Applicant's summary and conclusion

Executive summary:

No lethality was reported in rabbits following occlusive dermal administration of up to 7940 mg/kg bw of 40 % adipic acid in corn oil for 24 hours. Animals showed reduced appetite and activity and the viscera were normal at necropsy after 14 days observation period (Solutia Inc. 1975).