Registration Dossier
Registration Dossier
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EC number: 242-637-9 | CAS number: 18868-43-4
Endpoint summary
Administrative data
Description of key information
The registered substance is not considered as causing skin-, eye- or respiratory irritation/corrosivity, based on substance specific test data or based on a category/read-across approach.
For molybdenum dioxide:
Not irritating/corrosive to skin, based on study data with this substance.
Not irritating/corrosive to the eye, based on study data with this substance.
Not irritating to the respiratory tract, based on read-across from worst-case surrogate substance MoO3.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Studies on skin and eye irritation in laboratory animals are available, covering the entire range if soluble, moderately soluble and poorly soluble molybdenum substances and also all relevant valencies (i.e. molybdenum trioxide, molybdenum dioxide, molybdenum disulfide, sodium molybdate, ammonium dimolybdate and roasted molybdenite concentrate. None of the tested chemicals require classification as a skin or eye irritant, and to avoid further unnecessary testing, read-across is applied to other molybdenum substances, which are also assumed to be non-irritant/non-corrosive to skin and eyes.
Regarding respiratory irritation, read across from the substance MoO3to other molybdenum substances is applied. MoO3is considered to be a conservative surrogate for all other molybdenum substances, since it is a soluble substance and known to react slightly acidic in contact with aqueous media. However, no signs of respiratory irritation were observed in an acute inhalation toxicity study with MoO3(Leuschner, 2010) in which potential effects in the respiratory tract were assessed by means of extended histopathology of the respiratory tract. In addition, no significant substance-related effects were observed, indicating that respiratory irritation is not of specific concern for MoO3, nor for other molybdenum substances.
Justification for classification or non-classification
The registered substance does not require hazard classification for skin-, eye- or respiratory irritation/corrosivity, based on substance specific test data or based on a category/read-across approach.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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