Ethyl methyl sulphide

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1988

Report date:

1988

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

GLP compliance:

yes

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Ethyl methyl sulphide

EC Number:

210-868-4

EC Name:

Ethyl methyl sulphide

Cas Number:

624-89-5

Molecular formula:

C3H8S

IUPAC Name:

(methylsulfanyl)ethane

Details on test material:

METHYL ETHYL SULFIDE, Code: 1992,
Source: Pennwalt Corporation
Lot: T 28.

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

Albino rats, Spraque-Dawley. One control group and 1 test group each of 5 male and 5 female rats.

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

other: unchanged (no vehicle)

Details on inhalation exposure:

By inhalation of a test atmosphere containing vapour of the test substance.
4 hours continuous whole-body exposure.

Analytical verification of test atmosphere concentrations:

yes

Remarks:

Gas cromatography

Duration of exposure:

4 h

Concentrations:

21.72 mg/l

No. of animals per sex per dose:

5

Control animals:

yes

Details on study design:

14 days post exposure

Statistics:

Not appropriate

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC0

Effect level:

>= 21.72 mg/L air

Exp. duration:

4 h

Mortality:

There were no deaths during the study

Clinical signs:

other: (a) During exposure: No abnormalities. (b) During the observation period: No abnormalities

Body weight:

Slight loss of bodyweight or reduction of rate of bodyweight gain for one day following exposure.

Gross pathology:

Macroscopic pathology: Dark areas on lungs of 1 female rat exposed to METHYL ETHYL SULFIDE.

Other findings:

Food and water consumption: Food consumption was slightly reduced for 1 day following exposure. Possible slight elevation of water consumption for a few days following exposure in female rats only.
Lung weight to body weight ratio: The lung weight to body weight ratio for female rats exposed to METHYL ETHYL SULFIDE was higher than the control values. Males were unaffected.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: other: EU and GHS

Conclusions:

The 4h-LC0 in higher than 21.72 mg/l in both male and female rats

Executive summary:

In an acute inhalation toxicity study performed according to the OECD guideline # 403 and GLP, no mortality and clinical sign of toxicity was observed in male and female rats exposed to an atmosphere concentration of 21.72 mg/l (6988 ppm) of methyl ethyl sulfide for 4 hours. At necropsy, dark areas was observed on lungs of 1 female rat.