(S)-1,2-epoxypropane

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Study period:

2002

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Cited experiments were summarized in the European Chemicals Bureau Methyloxirane (Propylene Oxide) Risk Assessment Report. The original studies were not reviewed.

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

review article or handbook

Title:

Unnamed

Year:

2002

Materials and methods

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

propylene oxide

IUPAC Name:

propylene oxide

Constituent 2

Reference substance name:

Methyloxirane

EC Number:

200-879-2

EC Name:

Methyloxirane

Cas Number:

75-56-9

IUPAC Name:

2-methyloxirane

Applicant's summary and conclusion

Conclusions:

A single oral dose in the rat, by gavage, of 1,000 mg/kg resulted in 100% mortality, while no deaths occurred at 300 mg/kg. This suggests that the
LD50 is below 1,000 mg/kg and the slope of the dose-effect relationship is quite steep.

A rat LD50 of 1.14 mL/kg (950 mg/kg) has also been reported. In another study, the oral LD50 values for the rat, mouse and guinea pig were
reported to be 520 mg/kg, 630 mg/kg and 660 mg/kg, respectively. A guinea pig LD50 of 690 mg/kg has also been reported.