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Diss Factsheets

Administrative data

Endpoint:
toxicity to reproduction
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Study period:
2002
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Cited experiments were summarized in the European Chemicals Bureau Methyloxirane (Propylene Oxide) Risk Assessment Report. The original studies were not reviewed.
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
2002

Materials and methods

GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
propylene oxide
IUPAC Name:
propylene oxide
Constituent 2
Reference substance name:
Methyloxirane
EC Number:
200-879-2
EC Name:
Methyloxirane
Cas Number:
75-56-9
IUPAC Name:
2-methyloxirane

Results and discussion

Overall reproductive toxicity

Reproductive effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
The results of the studies described indicated that inhalation exposure to levels of up to 300 ppm over two generations did not produce any adverse effect on reproductive function.

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