Registration Dossier
Registration Dossier
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EC number: 244-691-9 | CAS number: 21981-33-9
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
Workers - Hazard for the eyes
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
The oral acute toxicity of 1,1,1,3,3 -pentachlorobutane was assessed by means of a fixed dose method. Rats were dosed at 5000, 2000, 500 and 50 mg/kg. Mortality was observed at >=500 mg/kg, with a LD50 determined within the range 50 -500 mg/kg.
When tested for local irritation, PCBa resulted irritating to the rabbit skin. On the other hand, only minimal irritation, not meeting the criteria for classification, was observed in rabbit eye.
A bacterial reverse mutation assay did not give positive results, indicating a low mutagenic potential of PCBa.
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