Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 940-650-0 | CAS number: -
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
No data are available for the substance.
Effect on fertility: via oral route
- Endpoint conclusion:
- no study available
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
No data are available for the substance.
Effects on developmental toxicity
Description of key information
No data are available for the substance.
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
The substance is a salt that dissociates in aqueous matrix in its acid and alkaline constituents.
Considering the toxicological profile of the intermediate no information is available: for this reason the constituents of the substance itself (2-[4-(cyclopropanecarbonyl) phenyl]-2-methylpropanoic acid and cyclohexanamine) are taken into account in order to assess the two moiety singularly.
The acid moiety of CPKA-540 is not well known as reported due to the lack of literature data. By contrast, the alkaline moiety of CPKA-540 is acknowledged for its hazard as reported in Annex VI of CLP.
Cyclohexanamine is classified as Repro 2, H361.
It is reasonable considered that the sistemic toxicity of CPKA-540 is mantained as is the cyclohexanamine. Reproductive toxicity data on cyclohexanamine report a significant decrease in the number of implantation sites and in the number of liveborn fetuses, increased perinatal mortality and a significant reduction in weight gain of the offspring were observed in treated animals.
Therefore, according to Regulation (EC) n. 1272/2008, the substance of interest should be classified as Repro 2; H361.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
