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EC number: 939-637-2 | CAS number: 1691195-92-2
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 26 mg/L
- EC10 or NOEC for freshwater algae:
- 9.2 mg/L
Additional information
In the Klimisch 1 GLP study from Kimmel (2013) the toxicity of Butanedioic acid, 2(or 3)-sulfo-, 4-[2-[(1-oxo(C12-C18(even numbered) and C18unsaturated)alkyl))amino]ethyl]esters, disodium salts to Desmodesmus subspicatus was determined in a static 72-Hour Algal Growth Inhibition Test. The test was performed according to OECD 201 and EU Method C.3. The nominal concentrations of 3.125, 6.25, 12.5, 25, 50 and 100 mg test item/L (corresponding to1.297, 2.59, 5.19, 10, 21 and 42 mg solid content/L) were tested in parallel with a control. Dose verification analysis was performed. The measured concentrations of the test item in the test media of the test concentrations of 3.125 to 100 mg test item/L (1.297 to 42 mg solid content/L) were between 93 to 111% of the nominal values at the start of the test and between 41 to 72% at the end of the test. Thus, the correct dosing of the test item was confirmed. During the test period of 72 hours, a decrease of test item concentration in the test media occurred. The biological results were related to the mean measured test item concentrations (calculated as the geometric means of the concentrations measured at the start and end of the test), i.e., mean measured 1.1, 2.2, 4.0, 8.4, 16 and 26 mg solid content for nominal concentrations of 1.297, 2.59, 5.19, 10, 21 and 42 mg solid content/L, respectively. In order to determine the growth of the cultures, the cultures were measured with the fluorescent method . The cell density was determined at 0, 24, 48 and 72 hours. The growth of the control cultures fulfilled the validity criteria from OECD 201 (2006). The 72 -hour ErC10 and ErC50 are 9.2 and > 26 mg solid content/L based on the mean measured concentration.
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