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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Study period:
1989
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Early study not conducted according to actual guidelines or GLP; experimental method reliable but limited or insufficient information on compound characterisation and analytics available.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1989

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
yes
Principles of method if other than guideline:
4 hours inhalation study; head-nose inhalation system.
GLP compliance:
no
Test type:
other: head-nose inhalation
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
3-hydroxy-2-(3-hydroxy-2-quinolyl)-1H-inden-1-one
EC Number:
241-753-7
EC Name:
3-hydroxy-2-(3-hydroxy-2-quinolyl)-1H-inden-1-one
Cas Number:
17772-51-9
Molecular formula:
C18H11NO3
IUPAC Name:
3-hydroxy-2-(3-hydroxyquinolin-2-yl)-1H-inden-1-one
Test material form:
other: solid
Details on test material:
Oxichinophthlon Stücke Ber. 100%

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
nose/head only
Vehicle:
other: 1 wt% aerosil (E200)
Analytical verification of test atmosphere concentrations:
yes
Duration of exposure:
4 h
Concentrations:
Mean analytical concentration: 5.8 mg/l; MMAD: 4.1 µm
No. of animals per sex per dose:
5 males and 5 females
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC0
Effect level:
5 mg/L air (analytical)
Exp. duration:
4 h

Any other information on results incl. tables

No death occured; clinical observations: accelerated respiration, fur discolored with test substance, stagging unsteady gait.

Applicant's summary and conclusion

Executive summary:

No death occured; clinical observations: accelerated respiration, fur discolored with test substance, stagging unsteady gait.