Registration Dossier
Registration Dossier
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EC number: 241-753-7 | CAS number: 17772-51-9
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1989
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Early study not conducted according to actual guidelines or GLP; experimental method reliable but limited or insufficient information on compound characterisation and analytics available.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Principles of method if other than guideline:
- 4 hours inhalation study; head-nose inhalation system.
- GLP compliance:
- no
- Test type:
- other: head-nose inhalation
- Limit test:
- yes
Test material
- Reference substance name:
- 3-hydroxy-2-(3-hydroxy-2-quinolyl)-1H-inden-1-one
- EC Number:
- 241-753-7
- EC Name:
- 3-hydroxy-2-(3-hydroxy-2-quinolyl)-1H-inden-1-one
- Cas Number:
- 17772-51-9
- Molecular formula:
- C18H11NO3
- IUPAC Name:
- 3-hydroxy-2-(3-hydroxyquinolin-2-yl)-1H-inden-1-one
- Test material form:
- other: solid
- Details on test material:
- Oxichinophthlon Stücke Ber. 100%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose/head only
- Vehicle:
- other: 1 wt% aerosil (E200)
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- Mean analytical concentration: 5.8 mg/l; MMAD: 4.1 µm
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- 5 mg/L air (analytical)
- Exp. duration:
- 4 h
Any other information on results incl. tables
No death occured; clinical observations: accelerated respiration, fur discolored with test substance, stagging unsteady gait.
Applicant's summary and conclusion
- Executive summary:
No death occured; clinical observations: accelerated respiration, fur discolored with test substance, stagging unsteady gait.
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