Registration Dossier
Registration Dossier
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EC number: 299-135-8 | CAS number: 93857-00-2
Endpoint summary
Administrative data
Description of key information
No data were available for the registered substance and the structurally
analogous substance trimethoxy(propyl)silane (CAS 1067-25-0) was
therefore used for read across. The test material was found not
sensitising in a reliable study, conducted according to OECD TG 406
(Huls AG, 1997).
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
In accordance with Column 2 of REACH Annex VIII sensitisation studies do not need to be conducted as tripotassium propylsilanetriolate is classified as corrosive due to its high pH. However, the following data from read-across substance are included for information.
Studies were chosen as key when the available study was of relevance and of sufficient quality for classification, labelling and for risk assessment.
In a key guinea pig skin sensitisation study (Buehler test), conducted in compliance with GLP and according to OECD TG 406, trimethoxy(propyl)silane was found to be a non-sensitiser. The sensitisation index was calculated to be 0% for the test group following challenge. Appropriate positive and solvent controls were included and gave expected results (Hüls AG, 1997).
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on the available read-across skin sensitisation data, tripotassium propylsilanetriolate is not classified for skin sensitisation according to Regulation (EC) No 1272/2008.
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