Registration Dossier

Diss Factsheets

Administrative data

Description of key information

No data were available for the registered substance and the structurally analogous substance trimethoxy(propyl)silane (CAS 1067-25-0) was therefore used for read across. The test material was found not sensitising in a reliable study, conducted according to OECD TG 406 (Huls AG, 1997).

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

In accordance with Column 2 of REACH Annex VIII sensitisation studies do not need to be conducted as tripotassium propylsilanetriolate is classified as corrosive due to its high pH. However, the following data from read-across substance are included for information.

Studies were chosen as key when the available study was of relevance and of sufficient quality for classification, labelling and for risk assessment.

In a key guinea pig skin sensitisation study (Buehler test), conducted in compliance with GLP and according to OECD TG 406, trimethoxy(propyl)silane was found to be a non-sensitiser. The sensitisation index was calculated to be 0% for the test group following challenge. Appropriate positive and solvent controls were included and gave expected results (Hüls AG, 1997).

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

Based on the available read-across skin sensitisation data, tripotassium propylsilanetriolate is not classified for skin sensitisation according to Regulation (EC) No 1272/2008.