Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

No data were available for the registered substance and the structurally analogous substance trimethoxy(propyl)silane (CAS 1067-25-0) was therefore used for read across. The test material was found not sensitising in a reliable study, conducted according to OECD TG 406 (Huls AG, 1997).

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

In accordance with Column 2 of REACH Annex VIII sensitisation studies do not need to be conducted as tripotassium propylsilanetriolate is classified as corrosive due to its high pH. However, the following data from read-across substance are included for information.

Studies were chosen as key when the available study was of relevance and of sufficient quality for classification, labelling and for risk assessment.

In a key guinea pig skin sensitisation study (Buehler test), conducted in compliance with GLP and according to OECD TG 406, trimethoxy(propyl)silane was found to be a non-sensitiser. The sensitisation index was calculated to be 0% for the test group following challenge. Appropriate positive and solvent controls were included and gave expected results (Hüls AG, 1997).

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

Based on the available read-across skin sensitisation data, tripotassium propylsilanetriolate is not classified for skin sensitisation according to Regulation (EC) No 1272/2008.