Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1975
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: non GLP, only short summary available

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report date:
1976

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
yes
Remarks:
only a rough summary provided
GLP compliance:
no
Test type:
fixed dose procedure
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Dibutyl methylenedithiodi(acetate)
EC Number:
238-289-2
EC Name:
Dibutyl methylenedithiodi(acetate)
Cas Number:
14338-82-0
Molecular formula:
C13H24O4S2
IUPAC Name:
butyl 2-({[(2-butoxy-2-oxoethyl)sulfanyl]methyl}sulfanyl)acetate
Constituent 2
Reference substance name:
MBTester
IUPAC Name:
MBTester
Details on test material:
pure industrial product with purity >95% w/w
no detailed lot# information

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
2500, 5000, 7500, 10000 mg/kg bodyweight undiluted
No. of animals per sex per dose:
10
Control animals:
not specified
Details on study design:
no data

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
> 2 500 - <= 10 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: no deaths
Mortality:
no
Clinical signs:
no data
Body weight:
no data
Gross pathology:
no data

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Remarks:
Migrated information
Conclusions:
LD 50 > 10ml/kg bodyweight. No classification necessary