Registration Dossier
Registration Dossier
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EC number: 236-826-5 | CAS number: 13499-05-3
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Link to relevant study records
- Endpoint:
- toxicity to reproduction
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
- Reproductive effects observed:
- not specified
Reference
Effect on fertility: via oral route
- Endpoint conclusion:
- no study available
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
Hafnium tetrachloride undergoes rapid degradation in presence of water or humidity, it is therefore not stable in contact of moist skin or mucous membranes and degrades in HCl and in an equilibrium of HfOCl2 / HfO2.
Testing HfCl4 for long term toxicity and then reprotoxicity, is for this reason not relevant at all, but degradation products have to be considered.
Hydrogen chloride was already registered in the frame of REACh and is not classified for reprotoxicity.
HfOCl2 and HfO2, by read across with ZrOCl2 and ZrO2 (see justification for read across in toxicological summary section 7) are considered as not hazardous substances and are not classified at all for human health effects.
For these reasons, no study was performed with HfCl4 and all concerned endpoints are waived.
Short description of key information:
On the basis of column 2 of REACH annex VIII, and in accordance with REACH Annex XI, section 2, testing is technically not feasible since the registered substance is not stable and degrades instantaneously. In these conditions, the toxicity to the reproduction is not relevant and the substance needs to be estimated considering the toxicity of its degradation products, that is to say HCl and HfOCl2/ HfO2.
Effects on developmental toxicity
Description of key information
On the basis of column 2 of REACH annex VIII, and in accordance with REACH Annex XI, section 2, testing is technically not feasible since the registered substance is not stable and degrades instantaneously. In these conditions, the toxicity to the reproduction is not relevant and the substance needs to be estimated considering the toxicity of its degradation products, that is to say HCl and HfOCl2/ HfO2.
Link to relevant study records
- Endpoint:
- developmental toxicity
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
- Abnormalities:
- not specified
- Developmental effects observed:
- not specified
Reference
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
Hafnium tetrachloride undergoes rapid degradation in presence of water or humidity, it is therefore not stable in contact of moist skin or mucous membranes and degrades in HCl and in an equilibrium of HfOCl2 / HfO2.
Testing HfCl4 for long term toxicity and then reprotoxicity, is for this reason not relevant at all, but degradation products have to be considered.
Hydrogen chloride was already registered in the frame of REACh and is not classified for reprotoxicity.
HfOCl2 and HfO2, by read across with ZrOCl2 and ZrO2 (see justification for read across in toxicological summary section 7) are considered as not hazardous substances and are not classified at all for human health effects.
For these reasons, no study was performed with HfCl4 and all concerned endpoints are waived.
Justification for classification or non-classification
Hafnium tetrachloride undergoes rapid degradation in presence of water or humidity, it is therefore not stable in contact of moist skin or mucous membranes and degrades in HCl and in an equilibrium of HfOCl2 / HfO2.
Testing HfCl4 for toxicity to the reproduction is for this reason not relevant at all, in the same way, no classification is needed.
Nevertheless, degradation products have to be considered, and they are already classified :
- Hydrogen chloride was registered in the frame of REACh in 2010 and is not classified for reprotoxicity.
- HfOCl2 and HfO2, by read across with ZrOCl2 and ZrO2 (see justification for read across in toxicological summary section 7) are considered as not hazardous substances and are not classified at all for human health effects.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
