Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Dose descriptor:
50 mg/kg bw/day

Additional information

The subchronic application of the structural related ESBO to rats in doses up to 1.25 g/kg bw/d in the diet resulted in lower body weight gains in males. Liver weights were increased in rats fed either test article at 5% in diet; this increase was also observed in male rats fed either test article at 1%. Gross findings indicated a test article-related effect of ESBO on liver and kidney at 1% and 5%.

Rationale for read-across can be found in chapter 13

Repeated dose toxicity: via oral route - systemic effects (target organ) digestive: liver; urogenital: kidneys

Justification for classification or non-classification